Farnesoid X Receptor Pathway (Homo sapiens)

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40Bile acid & xenobiotics transportBile acid detoxificationTranscriptionOtherBile acid conjugationBile acid neosynthesis12121212NR1H419FXR ligandNR1H419RXRALigandGenesTATA boxNR1H4RXRA19LigandFXRENR1H4Ligand19RXRAUGT2B4SULT2A1SLC27A5SLC10A1CYP7A118NR0B2FGF192448IRS2ABCB11BAATCYP3A4FKBP518IP6K3ABCB4NR0B2PPARGC1ASLCO2B124CYP8B1FXR Target genes


Description

The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
106413view21:58, 28 August 2019KhanspersModified description
105593view04:46, 10 August 2019KhanspersModified description
94789view22:59, 5 October 2017AlexanderPicoConverted lines
94785view22:42, 5 October 2017AlexanderPicoConverted lines
88056view13:48, 25 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
79602view05:58, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79524view09:51, 24 March 2015RiannefijtenModified description
79523view09:49, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed grouping "pathways" to labels
79485view13:10, 23 March 2015FehrhartUpdate Gen IDs and comments
79476view12:40, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78255view22:12, 17 December 2014KhanspersModified title
78226view15:31, 14 December 2014MaintBotUpdated the GPML schema.
78221view15:26, 14 December 2014MaintBotModified title
78092view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB11GeneProduct8647 (Entrez Gene) ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4GeneProduct5244 (Entrez Gene) ATP-binding cassette, sub-family B (MDR/TAP), member 4
BAATGeneProduct570 (Entrez Gene) bile acid CoA:amino acid N-acyltransferase
CYP3A4GeneProduct1576 (Entrez Gene) cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1
CYP8B1GeneProduct1582 (Entrez Gene) cytochrome P450, family 8, subfamily B, polypeptide 1
FGF19GeneProduct9965 (Entrez Gene) fibroblast growth factor 19
FKBP5GeneProduct2289 (Entrez Gene) FK506 binding protein 5
FXR ligandMetaboliteCHEBI:48705 (ChEBI) T3
IP6K3GeneProduct117283 (Entrez Gene) inositol hexakisphosphate kinase 3
IRS2GeneProduct8660 (Entrez Gene) insulin receptor substrate 2
LigandMetaboliteCHEBI:48705 (ChEBI)
NR0B2GeneProduct8431 (Entrez Gene) nuclear receptor subfamily 0, group B, member 2
NR1H4GeneProduct9971 (Entrez Gene) nuclear receptor subfamily 1, group H, member 4
PPARGC1AGeneProduct10891 (Entrez Gene) peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
SLC10A1GeneProduct6554 (Entrez Gene) solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC27A5GeneProduct10998 (Entrez Gene) solute carrier family 27 (fatty acid transporter), member 5
SLCO2B1GeneProduct11309 (Entrez Gene) solute carrier organic anion transporter family, member 2B1
SULT2A1GeneProduct6822 (Entrez Gene) sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
UGT2B4GeneProduct7363 (Entrez Gene) UDP glucuronosyltransferase 2 family, polypeptide B4

Annotated Interactions

No annotated interactions

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