Vitamin D Receptor Pathway (Homo sapiens)

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56, 10, 13, 14, 18...transcriptionTREM1STSBCL6ITGAMLRRC25LPGAT1GenesTATA boxVDREVDRLigandRXRAVDRVDR ligandRXRAVDRLigandVDR target genes35, 54IRF4HLA-DRB1CLEC16AHSD17B2CDKAL1Col13A1TNFAIP3FGF23CYP24A1CST6DEFB4CD40PRKCQIRF5Il1rL1HLA-DQA1CLPTM1LCampTNFSF4STAMHIF1ACTLA4CLMNMXD1PTHTRPV5TRPV6CYP27B1PTGER4TNFSF11PRDM1RASGRP1SLC34A2CYP7A1CYP2B65821CYP2C921THBDKlotho geneCASP5TRAK1LRP5DUSP10SEMA3BKLK6SULT2A1SerpinB1NRIP1CYP3A4SPP1CEACEM1PTHrPS100A2BGLAPASAP2ID4SOSTDC1BTLACD14KLF4ALOX5IL12ACD97SLC37A2SATB1CBSLLRC8AMYO9BBDKRB1NINJ1NRIP1CD200CD9TPM1ALP1SLC2A4CYP1A1S100GATP2C2SLC8A1CALB1TGFB1STEAP4ADAMTS5TNFRSF11BHILPDAALPPL2CLDN2ATP2B1SULT1C2S100A9MED9LCE-1FABC D1CDX-2DACT2KNG1IRF8MX2NOX1TGFB2ORM2EPHB4ABC B1JUNBCYP2S1G6PDS100A8TIMP3CEPBACDC34GLT8D4CYP3A5CASP14ORM1LCE-1DABC A11EFNA5TIMP2KRTAP4KRT13KRT71KRTAP10-4S100A4SPRR1BS100A6KRTAP10-2KRTAP5-4LCE-2BKRT34KRTAP5-1KRT16KRTAP10-7KRT38KRTAP8-1SALL4EFCAB4AHNF1AEFCAB4BCYP2D6ID1KRTAP10-9DEFB109KRTAP12-2DEFB132CREG2COLEC11ZNF257CST1CA9PNOCDNERDND1CDKN1ALGALS9CDKN1BIL25SFRP1ADRA1BBMP6IGSF9BADRB2MEG8NFATC2CCND1CDKN2DGADD45ACCNE1CDKN2ACDK2CDKN2BCDKN2CCCNCMYCFOXO1IGFBP1IGFBP3PPARDIGFBP5G0S2


Description

The vitamin D receptor (VDR, a.k.a. NR1I1) is a nuclear receptor that responds to binding of vitamin D and subsequently forms a dimer with RXR to induce transcription of its target genes. It mainly regulates genes cytochrome P450 genes involved in xenobiotic biotransformation.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed
  2. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed
  3. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed
  4. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed
  5. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed
  6. Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW; ''Molecular mechanisms of vitamin D action.''; Calcif Tissue Int, 2013 PubMed
  7. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed
  8. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed
  9. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed
  10. Carlberg C, Seuter S, de Mello VD, Schwab U, Voutilainen S, Pulkki K, Nurmi T, Virtanen J, Tuomainen TP, Uusitupa M; ''Primary vitamin D target genes allow a categorization of possible benefits of vitamin D3 supplementation.''; PLoS One, 2013 PubMed
  11. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed
  12. Lindsey S, Papoutsakis ET; ''The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.''; Br J Haematol, 2011 PubMed
  13. Pike JW, Meyer MB, Bishop KA; ''Regulation of target gene expression by the vitamin D receptor - an update on mechanisms.''; Rev Endocr Metab Disord, 2012 PubMed
  14. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC; ''A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.''; Genome Res, 2010 PubMed
  15. Nilsson S, Gustafsson JÅ; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed
  16. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed
  17. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed
  18. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed
  19. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed
  20. Yasunami Y, Hara H, Iwamura T, Kataoka T, Adachi T; ''C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.''; Drug Metab Dispos, 2004 PubMed
  21. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed
  22. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed
  23. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed
  24. Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, Schoonjans K, Verstuyf A; ''Vitamin D and energy homeostasis: of mice and men.''; Nat Rev Endocrinol, 2014 PubMed
  25. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed
  26. Chatterjee B, Echchgadda I, Song CS; ''Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1.''; Methods Enzymol, 2005 PubMed
  27. Ryynänen J, Seuter S, Campbell MJ, Carlberg C; ''Gene regulatory scenarios of primary 1,25-dihydroxyvitamin d3 target genes in a human myeloid leukemia cell line.''; Cancers (Basel), 2013 PubMed
  28. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed
  29. Matilainen M, Malinen M, Saavalainen K, Carlberg C; ''Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3.''; Nucleic Acids Res, 2005 PubMed
  30. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed
  31. Deeb KK, Trump DL, Johnson CS; ''Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.''; Nat Rev Cancer, 2007 PubMed
  32. Goeman F, De Nicola F, D'Onorio De Meo P, Pallocca M, Elmi B, Castrignanò T, Pesole G, Strano S, Blandino G, Fanciulli M, Muti P; ''VDR primary targets by genome-wide transcriptional profiling.''; J Steroid Biochem Mol Biol, 2014 PubMed
  33. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH; ''Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.''; Mol Endocrinol, 2005 PubMed
  34. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed
  35. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed
  36. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed
  37. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed
  38. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed
  39. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed
  40. Ryynänen J, Neme A, Tuomainen TP, Virtanen JK, Voutilainen S, Nurmi T, de Mello VD, Uusitupa M, Carlberg C; ''Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.''; Mol Nutr Food Res, 2014 PubMed
  41. ''''; , PubMed
  42. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed
  43. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed
  44. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed
  45. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed
  46. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.''; Proc Natl Acad Sci U S A, 2004 PubMed
  47. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed
  48. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed
  49. Carlberg C, Seuter S, Heikkinen S; ''The first genome-wide view of vitamin D receptor locations and their mechanistic implications.''; Anticancer Res, 2012 PubMed
  50. Wilfinger J, Seuter S, Tuomainen TP, Virtanen JK, Voutilainen S, Nurmi T, de Mello VD, Uusitupa M, Carlberg C; ''Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system.''; J Nutr Biochem, 2014 PubMed
  51. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed
  52. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed
  53. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed
  54. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed
  55. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed
  56. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  57. Carlberg C, Seuter S; ''A genomic perspective on vitamin D signaling.''; Anticancer Res, 2009 PubMed
  58. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed
  59. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed
  60. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed
  61. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed
  62. Seuter S, Ryynänen J, Carlberg C; ''The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages.''; J Steroid Biochem Mol Biol, 2014 PubMed
  63. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed
  64. Haussler MR, Jurutka PW, Mizwicki M, Norman AW; ''Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)2vitamin D3: genomic and non-genomic mechanisms.''; Best Pract Res Clin Endocrinol Metab, 2011 PubMed
  65. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.''; Nucl Recept, 2005 PubMed
  66. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed

History

View all...
CompareRevisionActionTimeUserComment
94793view23:03, 5 October 2017AlexanderPicoConverted lines
94783view22:35, 5 October 2017AlexanderPicoConverted lines
86976view14:30, 15 July 2016MkutmonOntology Term : 'vitamin D signaling pathway' added !
84568view12:16, 3 March 2016Mkutmonfix literature references
84567view12:11, 3 March 2016Mkutmonfix literature references
84566view11:46, 3 March 2016Mkutmonadded missing graph ids
80091view11:56, 6 May 2015Kim de NooijerAdd literature to the VDR target genes
80090view11:32, 6 May 2015Kim de NooijerLiterature
79998view08:07, 30 April 2015Kim de NooijerAdd VDR target genes
79876view10:36, 23 April 2015Kim de NooijerAdding VDR target genes
79875view10:30, 23 April 2015Kim de NooijerAdding VDR target genes
79534view14:49, 24 March 2015RiannefijtenModified description
79533view14:46, 24 March 2015Riannefijtenadded reference, fixed unconnected lines, changed pathway nodes to labels
79493view13:35, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'agonist'.
79478view12:47, 23 March 2015FehrhartUpdate GenID and comments
79477view12:45, 23 March 2015FehrhartUpdate Gen IDs and comments
78514view10:29, 7 January 2015MaintBotadded missing graphIds
78252view22:03, 17 December 2014KhanspersModified title
78224view15:27, 14 December 2014MaintBotUpdated the GPML schema.
78219view15:08, 14 December 2014MaintBotModified title
78090view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABC A11GeneProduct79963 (Entrez Gene)
ABC B1GeneProduct5243 (Entrez Gene)
ABC D1GeneProduct215 (Entrez Gene)
ADAMTS5GeneProduct11096 (Entrez Gene)
ADRA1BGeneProduct147 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALP1GeneProduct248 (Entrez Gene)
ALPPL2GeneProduct251 (Entrez Gene)
ASAP2GeneProduct8853 (Entrez Gene)
ATP2B1GeneProduct490 (Entrez Gene)
ATP2C2GeneProduct9914 (Entrez Gene)
BCL6GeneProduct604 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
BGLAPGeneProduct632 (Entrez Gene)
BMP6GeneProduct654 (Entrez Gene)
BTLAGeneProduct151888 (Entrez Gene)
CA9GeneProduct768 (Entrez Gene)
CALB1GeneProduct12307 (Entrez Gene)
CASP14GeneProduct23581 (Entrez Gene)
CASP5GeneProduct838 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CCNCGeneProduct892 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CD200GeneProduct4345 (Entrez Gene)
CD40GeneProduct958 (Entrez Gene)
CD97GeneProduct976 (Entrez Gene)
CD9GeneProduct928 (Entrez Gene)
CDC34GeneProduct997 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKAL1GeneProduct54901 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CDX-2GeneProduct1045 (Entrez Gene)
CEACEM1GeneProduct634 (Entrez Gene)
CEPBAGeneProduct1050 (Entrez Gene)
CLDN2GeneProduct9075 (Entrez Gene)
CLEC16AGeneProduct23274 (Entrez Gene)
CLMNGeneProduct79789 (Entrez Gene)
CLPTM1LGeneProduct81037 (Entrez Gene)
COLEC11GeneProduct78989 (Entrez Gene)
CREG2GeneProduct200407 (Entrez Gene)
CST1GeneProduct1469 (Entrez Gene)
CST6GeneProduct1474 (Entrez Gene)
CTLA4GeneProduct1493 (Entrez Gene)
CYP1A1GeneProduct1543 (Entrez Gene)
CYP24A1GeneProduct1591 (Entrez Gene)
CYP27B1GeneProduct1594 (Entrez Gene)
CYP2B6GeneProduct1555 (Entrez Gene) cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9GeneProduct1559 (Entrez Gene) cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6GeneProduct1565 (Entrez Gene)
CYP2S1GeneProduct29785 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP3A5GeneProduct1577 (Entrez Gene)
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1
CampGeneProduct820 (Entrez Gene)
Col13A1GeneProduct1305 (Entrez Gene)
DACT2GeneProduct168002 (Entrez Gene)
DEFB109GeneProduct100286963 (Entrez Gene)
DEFB132GeneProduct400830 (Entrez Gene)
DEFB4GeneProduct1673 (Entrez Gene)
DND1GeneProduct373863 (Entrez Gene)
DNERGeneProduct92737 (Entrez Gene)
DUSP10GeneProduct11221 (Entrez Gene)
EFCAB4AGeneProduct283229 (Entrez Gene)
EFCAB4BGeneProduct84766 (Entrez Gene)
EFNA5GeneProduct1946 (Entrez Gene)
EPHB4GeneProduct2050 (Entrez Gene)
FGF23GeneProduct8074 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
G0S2GeneProduct50486 (Entrez Gene)
G6PDGeneProduct2539 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GLT8D4GeneProduct727936 (Entrez Gene)
HIF1AGeneProduct3091 (Entrez Gene)
HILPDAGeneProduct29923 (Entrez Gene)
HLA-DQA1GeneProduct3117 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HNF1AGeneProduct6927 (Entrez Gene)
HSD17B2GeneProduct3294 (Entrez Gene)
ID1GeneProduct3397 (Entrez Gene)
ID4GeneProduct3400 (Entrez Gene)
IGFBP1GeneProduct3484 (Entrez Gene)
IGFBP3GeneProduct3486 (Entrez Gene)
IGFBP5GeneProduct3488 (Entrez Gene)
IGSF9BGeneProduct22997 (Entrez Gene)
IL12AGeneProduct3592 (Entrez Gene)
IL25GeneProduct64806 (Entrez Gene)
IRF4GeneProduct3662 (Entrez Gene)
IRF5GeneProduct3663 (Entrez Gene)
IRF8GeneProduct3394 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
Il1rL1GeneProduct9173 (Entrez Gene)
JUNBGeneProduct3726 (Entrez Gene)
KLF4GeneProduct9314 (Entrez Gene)
KLK6GeneProduct5653 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
KRT13GeneProduct3860 (Entrez Gene)
KRT16GeneProduct3868 (Entrez Gene)
KRT34GeneProduct3885 (Entrez Gene)
KRT38GeneProduct8687 (Entrez Gene)
KRT71GeneProduct112802 (Entrez Gene)
KRTAP10-2GeneProduct386679 (Entrez Gene)
KRTAP10-4GeneProduct386672 (Entrez Gene)
KRTAP10-7GeneProduct386675 (Entrez Gene)
KRTAP10-9GeneProduct386676 (Entrez Gene)
KRTAP12-2GeneProduct353323 (Entrez Gene)
KRTAP4GeneProduct85285 (Entrez Gene)
KRTAP5-1GeneProduct387264 (Entrez Gene)
KRTAP5-4GeneProduct387267 (Entrez Gene)
KRTAP8-1GeneProduct337879 (Entrez Gene)
Klotho geneGeneProduct9365 (Entrez Gene)
LCE-1DGeneProduct353134 (Entrez Gene)
LCE-1FGeneProduct353137 (Entrez Gene)
LCE-2BGeneProduct26239 (Entrez Gene)
LGALS9GeneProduct3965 (Entrez Gene)
LLRC8AGeneProduct505605 (Entrez Gene)
LPGAT1GeneProduct9926 (Entrez Gene)
LRP5GeneProduct4041 (Entrez Gene)
LRRC25GeneProduct126364 (Entrez Gene)
LigandMetaboliteCHEBI:48705 (ChEBI)
MED9GeneProduct55090 (Entrez Gene)
MEG8GeneProduct79104 (Entrez Gene)
MX2GeneProduct4600 (Entrez Gene)
MXD1GeneProduct4084 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYO9BGeneProduct4650 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
NINJ1GeneProduct4814 (Entrez Gene)
NOX1GeneProduct27035 (Entrez Gene)
NRIP1GeneProduct8204 (Entrez Gene)
ORM1GeneProduct5004 (Entrez Gene)
ORM2GeneProduct5005 (Entrez Gene)
PNOCGeneProduct5368 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PRDM1GeneProduct639 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PTGER4GeneProduct5734 (Entrez Gene)
PTHGeneProduct5741 (Entrez Gene)
PTHrPGeneProduct5744 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
S100A2GeneProduct6273 (Entrez Gene)
S100A4GeneProduct6275 (Entrez Gene)
S100A6GeneProduct6277 (Entrez Gene)
S100A8GeneProduct6279 (Entrez Gene)
S100A9GeneProduct6280 (Entrez Gene)
S100GGeneProduct795 (Entrez Gene)
SALL4GeneProduct57167 (Entrez Gene)
SATB1GeneProduct6304 (Entrez Gene)
SEMA3BGeneProduct7869 (Entrez Gene)
SFRP1GeneProduct6422 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SLC34A2GeneProduct10568 (Entrez Gene)
SLC37A2GeneProduct219855 (Entrez Gene)
SLC8A1GeneProduct6546 (Entrez Gene)
SOSTDC1GeneProduct25928 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
SPRR1BGeneProduct6699 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STEAP4GeneProduct79689 (Entrez Gene)
STSGeneProduct412 (Entrez Gene)
SULT1C2GeneProduct6819 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
SerpinB1GeneProduct1992 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)
TIMP2GeneProduct7077 (Entrez Gene)
TIMP3GeneProduct7078 (Entrez Gene)
TNFAIP3GeneProduct7128 (Entrez Gene)
TNFRSF11BGeneProduct4982 (Entrez Gene)
TNFSF11GeneProduct8600 (Entrez Gene)
TNFSF4GeneProduct7292 (Entrez Gene)
TPM1GeneProduct7168 (Entrez Gene)
TRAK1GeneProduct22906 (Entrez Gene)
TREM1GeneProduct54210 (Entrez Gene)
TRPV5GeneProduct56302 (Entrez Gene)
TRPV6GeneProduct55503 (Entrez Gene)
VDR ligandMetaboliteCHEBI:48705 (ChEBI) T3
VDRGeneProduct7421 (Entrez Gene) vitamin D (1,25- dihydroxyvitamin D3) receptor
ZNF257GeneProduct113835 (Entrez Gene)

Annotated Interactions

No annotated interactions

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