Pregnane X receptor pathway (Homo sapiens)

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29, 34, 38Drug and steroid metabolismPhase 2 metabolismMulti-drug resistanceTranscriptionOtherLigandNCOA3PSMC5SRCNCOA2NRIP1HSP90AA1SRPX2RXRAPPARGC1ANR1I2NR1I242LigandHSP90AA1CoregulatorsGenesTATA boxXRERXRANR1I2LigandDNAJC7DNAJC7CYP3A721UGT1A6UGT1A336UGT1A936CYP2A63621UGT1A436PXR target genes6, 35SLCO1B16SRPX2NCOA3FOXO1CYP4F129CYP3A46UGT1A121ABCC46NRIP16CYP2B621GSTA2PSMC56PPARGC1ANCOA1NCOA2ABCB16CoregulatorsCYP2C921CYP3A5CYP2C1921SULT2A12139ABCC27ABCC37


Description

The Pregnane X receptor (PXR, a.k.a. NR1I2) is a nuclear receptor whose primary function is sensing xenobiotics. It regulates the gene expression of genes that encode proteins involved in detoxification and clearance of xenobiotics.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116466view10:07, 7 May 2021EweitzModified title
110712view14:51, 28 May 2020Fehrhartremoved unknown node
106535view00:00, 6 September 2019KhanspersModified description
105789view19:47, 15 August 2019KhanspersModified description
94905view23:29, 12 October 2017Khanspersremoving empty comment
94792view23:02, 5 October 2017AlexanderPicoConverted lines
94782view22:31, 5 October 2017AlexanderPicoConverted lines
88344view16:04, 1 August 2016FehrhartOntology Term : 'xenobiotic metabolic pathway' added !
79556view12:58, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79537view14:56, 24 March 2015RiannefijtenModified description
79536view14:54, 24 March 2015Riannefijtenchanged pathway nodes to labels
79535view14:52, 24 March 2015Riannefijtenadded reference, fixed unconnected lines
79479view12:49, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for pregnane X receptor agonist.
78484view10:28, 7 January 2015MaintBotadded missing graphIds
78257view22:19, 17 December 2014KhanspersModified title
78218view15:07, 14 December 2014MaintBotUpdated the GPML schema.
78217view15:06, 14 December 2014MaintBotModified title
78089view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
DNAJC7GeneProductENSG00000168259 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
LigandMetaboliteCHEBI:77318 (ChEBI)
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NR1I2GeneProductENSG00000144852 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SULT2A1GeneProductENSG00000105398 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)

Annotated Interactions

No annotated interactions

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