Pregnane X Receptor pathway (Homo sapiens)

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11, 12, 48TranscriptionDrug and steroid metabolismLigandPhase 2 metabolismMulti-drug resistanceOtherRXRASRPX2SRCNR1I2NCOA3NRIP1HSP90AA1PSMC5NCOA2PPARGC1AUnknownNR1I229LigandHSP90AA1CoregulatorsGenesTATA boxXRERXRANR1I2LigandDNAJC7DNAJC7CYP3A722UGT1A6UGT1A343UGT1A94343CYP2A622UGT1A4PXR target genes438, 10SLCO1B18SRPX2NCOA3FOXO141CYP4F12CYP3A4822UGT1A1ABCC48NRIP18CYP2B622GSTA2PSMC58PPARGC1ANCOA1NCOA2ABCB1Coregulators8CYP2C922CYP3A522CYP2C19SULT2A122ABCC213ABCC33737


Description

The Pregnane X receptor (PXR, a.k.a. NR1I2) is a nuclear receptor whose primary function is sensing xenobiotics. It regulates the gene expression of genes that encode proteins involved in detoxification and clearance of xenobiotics.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
94905view23:29, 12 October 2017Khanspersremoving empty comment
94792view23:02, 5 October 2017AlexanderPicoConverted lines
94782view22:31, 5 October 2017AlexanderPicoConverted lines
88344view16:04, 1 August 2016FehrhartOntology Term : 'xenobiotic metabolic pathway' added !
79556view12:58, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79537view14:56, 24 March 2015RiannefijtenModified description
79536view14:54, 24 March 2015Riannefijtenchanged pathway nodes to labels
79535view14:52, 24 March 2015Riannefijtenadded reference, fixed unconnected lines
79479view12:49, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for pregnane X receptor agonist.
78484view10:28, 7 January 2015MaintBotadded missing graphIds
78257view22:19, 17 December 2014KhanspersModified title
78218view15:07, 14 December 2014MaintBotUpdated the GPML schema.
78217view15:06, 14 December 2014MaintBotModified title
78089view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
DNAJC7GeneProductENSG00000168259 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
LigandMetaboliteCHEBI:77318 (ChEBI)
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NR1I2GeneProductENSG00000144852 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SULT2A1GeneProductENSG00000105398 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
Unknown

Annotated Interactions

No annotated interactions

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