White fat cell differentiation (Mus musculus)

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1-3, 5Differentiated adipocytePreadipocyteStat5aCreb1Klf4Ddit3 (CHOP)Evi1CebpbCebpdFoxo1RaraGata2Klf15Srebf1Zfp423FBSKlf5RoraTcf7l1Stat5bLxr (Nr1h3)Nr2f2PpargEbf1Gata3Egr2 (Krox20)catenin (Ctnna1)Wnt10bCebpaIrf3cAMPTle34Ins1GlucocorticoidsNr3c1 (GR)Irf4Klf2


The transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

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Ontology Terms



  1. Rosen ED, Spiegelman BM; ''Molecular regulation of adipogenesis.''; Annu Rev Cell Dev Biol, 2000 PubMed Europe PMC Scholia
  2. Siersbæk R, Nielsen R, Mandrup S; ''Transcriptional networks and chromatin remodeling controlling adipogenesis.''; Trends Endocrinol Metab, 2012 PubMed Europe PMC Scholia
  3. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, Waszak SM, Corsinotti A, Udin G, Holcombe W, Rudofsky G, Trono D, Wolfrum C, Deplancke B; ''Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network.''; Elife, 2014 PubMed Europe PMC Scholia
  4. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P; ''TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis.''; Cell Metab, 2011 PubMed Europe PMC Scholia
  5. Rosen ED, MacDougald OA; ''Adipocyte differentiation from the inside out.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia


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107201view14:29, 17 September 2019MaintBotChEBI identifier normalization
90848view19:48, 14 December 2016KhanspersOntology Term : 'white fat cell' added !
90847view19:48, 14 December 2016KhanspersOntology Term : 'CL:0000136' removed !
87861view11:57, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
79490view13:27, 23 March 2015EgonwAnnotated "glucocorticoids" with its ChEBI identifier.
78731view12:26, 20 January 2015Bart Smeetsminor graphical change
78730view12:25, 20 January 2015Bart SmeetsAdded cellular component to indicate more clearly that the depicted processes happen in a preadipocyte
78408view10:25, 7 January 2015MaintBotadded missing graphIds
78295view15:44, 23 December 2014EgonwCorrected the @Type annotation of a gene.
78102view22:59, 2 December 2014MaintBot
78070view14:38, 26 November 2014SchwaliePeriodical save, work in progress
78069view14:15, 26 November 2014SchwalieCorrected paths
78068view14:06, 26 November 2014SchwaliePeriodical save, work in progress
78046view20:46, 20 November 2014MaintBotOntology Term : 'fat cell' added !
78045view16:30, 20 November 2014SchwalieNew pathway

External references


View all...
NameTypeDatabase referenceComment
CebpaGeneProduct12606 (Entrez Gene)
CebpbGeneProduct12608 (Entrez Gene)
CebpdGeneProduct12609 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
Ddit3 (CHOP)GeneProduct13198 (Entrez Gene)
Ebf1GeneProduct13591 (Entrez Gene)
Egr2 (Krox20)GeneProduct13654 (Entrez Gene)
Evi1GeneProduct14013 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
Gata2GeneProduct14461 (Entrez Gene)
Gata3GeneProduct14462 (Entrez Gene)
GlucocorticoidsMetaboliteCHEBI:24261 (ChEBI)
Ins1GeneProduct16333 (Entrez Gene)
Irf3GeneProduct54131 (Entrez Gene)
Irf4GeneProduct16364 (Entrez Gene)
Klf15GeneProduct66277 (Entrez Gene)
Klf2GeneProduct16598 (Entrez Gene)
Klf4GeneProduct16600 (Entrez Gene)
Klf5GeneProduct12224 (Entrez Gene)
Lxr (Nr1h3)GeneProduct22259 (Entrez Gene)
Nr2f2GeneProduct11819 (Entrez Gene)
Nr3c1 (GR)GeneProduct14815 (Entrez Gene)
PpargGeneProduct19016 (Entrez Gene)
RaraGeneProduct19401 (Entrez Gene)
RoraGeneProduct19883 (Entrez Gene)
Srebf1GeneProduct20787 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Tcf7l1GeneProduct21415 (Entrez Gene)
Tle3GeneProduct21887 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Zfp423GeneProduct94187 (Entrez Gene)
cAMPMetaboliteCHEBI:17489 (ChEBI)
catenin (Ctnna1)GeneProduct12385 (Entrez Gene)

Annotated Interactions

No annotated interactions

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