IL-3 signaling pathway (Homo sapiens)

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Protein1Regulation of gene expressionReceptorIL-3 Signaling PathwayEnzyme complexmRNAProteinLigandMAPK8IL3RAENPP3TGFB1CD69VAV1MAPK1IL8FOSCD86BCL2CCR3HCKSYKFYNIL5RALYNTEC1PPPPPPPPYWHABGRB2PRKACAPINPP5DIL3RABADPPIK3R2STAT5BBCL2L1PSOS1CSF2RBSTAT5AMAP2K1PYWHAQPSRCPAKT1PTPN6PCRKLCBLBCL2HRASJAK2GTPIL3RAPMAPK3RAF1PPJAK1PGAB2PCSF2RBPIK3R1SHC1RAPGEF1STAT3PTPN11PPIK3CDMAPK1FOSMAPK3PJUNSTAT5BPSTAT5APSTAT3CYNUCYNUCYNUCYNUInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageIL3


Interleukin 3 (IL-3) is a potent growth factor belonging to the super family of cytokines. IL-3 is a 20- 32kDa glycoprotein involved in the process of hematopoiesis. It is involved in the proliferation and differentiation of pleuripotent hematopoietic stem cells, progenitor cells and their mature progeny. IL-3 is a growth factor for B lymphocytes. It also activates monocytes and augments survival and propagation of mast cells, eosinophils and stromal cells. IL-3 is secreted predominantly by activated T lymphocytes in response to immunological stimuli and to a lesser extent by mast cells and eosinophils. IL-3 exerts influence on different biological activities, primarily hematopoiesis by associating with the IL-3 receptor. This receptor is a heterodimeric complex and consists of an alpha chain- IL3RA and a beta chain CSF2RB, shared with the receptors for granulocyte macrophage colony stimulating factor and Interleukin-5. When IL-3 binds to CSF2RB receptor, adapter proteins like SHC1, GRB2 and SOS1 are recruited to activate HRAS. HRAS stimulates RAF1 which further activates MAP2K1 and finally MAPK1 and MAPK3. The signals generated through this pathway are then transmitted to the nucleus leading to the activation of various transcription factors such as JUN and FOS which are involved in the regulation of cell growth and differentiation. IL-3 mediated activation of HRAS also inhibits apoptosis through phosphatidyl inositol 3 kinase/ AKT pathway. The activation of AKT1 in response to IL-3 stimulation leads to the phosphorylation of the apoptotic regulator, BCL2-associated agonist of cell death (BAD), its binding to 14-3-3 and sequestration into the cytoplasm. IL-3 stimulation activates Janus kinase 2 (JAK2) by its phosphorylation. JAK2 in turn phosphorylates signal transducer and activator of transcription 5A and 5B. These translocate to the nucleus, serving the purpose of transcription factor for early genes as well as a feedback inhibitor of the JAK-STAT pathway. IL-3, in addition, is known to activate various tyrosine kinases such as LYN, FYN, SRC, SYK, TEC1 and HCK. The interactions and intersections between canonical and noncanonical IL-3 signaling systems are depicted in the pathway map.

Please access this pathway at NetSlim database.

If you use this pathway, please cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

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  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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116632view11:21, 9 May 2021EweitzModified title
115919view16:58, 20 March 2021EgonwCopied the NetPath paper into the literature list
115914view14:27, 20 March 2021EgonwModified description
108324view21:02, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78583view14:50, 7 January 2015MaintBotadded missing graphIds
72139view09:43, 25 October 2013Mkutmonadded datasources to some proteins
67374view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-3 signaling pathway' added !
63210view20:57, 8 May 2013MaintBotUpdating gpml version
61833view17:22, 19 April 2013MaintBotfixed xrefs
61676view21:17, 16 April 2013MaintBotAdded missing Data Source
48436view14:30, 24 May 2012NetPathModified description
44845view09:46, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44623view18:01, 22 September 2011KhanspersUpdating content to NetSlim
44107view20:30, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44027view22:56, 22 August 2011KhanspersAdded category
44026view22:55, 22 August 2011KhanspersModified description
44025view22:53, 22 August 2011KhanspersUpdating pathway from NetSlim
41196view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35642view21:30, 12 February 2010KhanspersModified description
21281view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-3 NetPath 15]] moved to [[Pathway:WP286]]: Moved to stable identifier
8170view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-3 NetPath 15]] moved to [[Pathway:Homo sapiens:IL-3 NetPath 15]]: Renaming species
7705view16:11, 18 December 2007MaintBotfixed category names
7244view12:41, 4 November 2007MaintBotAdded categories to GPML
6336view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-3_NetPath_15]]

External references


View all...
NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
BADProtein572 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
BCL2L1Protein598 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CCR3Protein1232 (Entrez Gene)
CD69Protein969 (Entrez Gene)
CD86Protein942 (Entrez Gene)
CRKLProtein1399 (Entrez Gene)
CSF2RBProtein1439 (Entrez Gene)
ENPP3Protein5169 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HCKProtein3055 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
IL3Protein3562 (Entrez Gene)
IL3RAProtein3563 (Entrez Gene)
IL5RAProtein3568 (Entrez Gene)
IL8Protein3576 (Entrez Gene)
INPP5DProtein3635 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
LYNProtein4067 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
PIK3CDProtein5293 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PRKACAProtein5566 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPN6Protein5777 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RAPGEF1Protein2889 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
SYKProtein6850 (Entrez Gene)
TGFB1Protein7040 (Entrez Gene)
VAV1Protein7409 (Entrez Gene)
YWHABProtein7529 (Entrez Gene)
YWHAQProtein10971 (Entrez Gene)

Annotated Interactions

No annotated interactions

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