Hematopoietic Stem Cell Differentiation (Homo sapiens)

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2TRIM29KCNH2RHOHNCKAP1LPIM1LEF1FOSGATA2HES6CSF3CD34TENXC2TASTAT5AVAV1IRF5LMO2CSF1IKZF1SPI1MUC1CBFA2T3CDH1S14L2HMGN5KLF1LYL1THBNFATC2MYBFOSBIL5ZNF835T3JAMLMO2GATA1RUN1T1PBX1HLFPRDM5ZFP37SCFTPOIL3EPOErythrocyteHematopoietic Stem Cell (HSC)MyeloblastMegakaryocyteCommon MyeloidProgenitorIL6IL1ACSF2IL1BSCFIL3CSF2CSF2CXCR4MXI11RIOK3ALK4MIR15A1MIR223MIR17MIR24AMIR155MIR181AMIR128AMIR10AMIR130AiHSC ReprogrammingFactorsMegakaryocyte-ErythrocytePrecursor (MEP)MIR16-1MIR45133MIR2213MIR222MIR15033TPOTPOErythrocyte ProgenitorPlateletsGATA1GATA1GATA1ABOCD41CD42CD34CD235aSPI1RUNX1NOTCH1MIR223MIR155MIR223MIR155MEP TranscriptionFactor MarkersErythrocyte TranscriptionFactor MarkersMEP-Erythocyte CommonTranscription FactorsFLI1UM279CD41GATA23NFE2CD61LOXL3TXKGATA5WNT11HEXIM1ZGLP1EGFTGFB1LBX2ELF1ZNF792RCAN1FLI1HEXIM2NLKMED12LZNF789F2RPADI4MEF2CCRLF3PIM2Megakaryocyte TranscriptionFactor MarkersEosinophilBasophilNeutrophilMonocyteIL3IL6SCFCSF2CSF3IL3IL6SCFCSF2CSF2IL3IL3IL6SCFCSF2


Description

Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.

Quality Tags

Ontology Terms

 

Bibliography

  1. Zhang L, Sankaran VG, Lodish HF; ''MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.''; Leukemia, 2012 PubMed Europe PMC
  2. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ; ''Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.''; Cell, 2014 PubMed Europe PMC
  3. Slavov SN, Gimenes Teixeira HL, Rego EM; ''The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.''; Braz J Med Biol Res, 2010 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
103039view11:57, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
102164view22:12, 4 December 2018Khanspersupdated xrefs for miRNAs
97552view14:50, 24 May 2018Mkutmonfix some of the uniprot identifiers
89818view11:53, 6 October 2016MkutmonModified description
84764view18:34, 16 March 2016KhanspersReverted to version '04:17, 18 November 2015' by Khanspers
84763view18:14, 16 March 2016WRothReverted to version '20:29, 28 September 2014' by WRoth
84762view18:14, 16 March 2016WRothReverted to version '22:37, 29 September 2014' by WRoth
84761view18:14, 16 March 2016WRothReverted to version '20:25, 28 September 2014' by WRoth
84760view18:14, 16 March 2016WRothReverted to version '20:28, 28 September 2014' by WRoth
84759view18:14, 16 March 2016WRothReverted to version '22:53, 29 September 2014' by WRoth
84758view18:14, 16 March 2016WRothReverted to version '20:39, 29 September 2014' by WRoth
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84731view18:12, 16 March 2016WRothReverted to version '20:06, 30 September 2014' by WRoth
84730view18:11, 16 March 2016WRothReverted to version '19:45, 30 September 2014' by WRoth
84729view18:11, 16 March 2016WRothReverted to version '18:39, 8 October 2014' by WRoth
84728view18:11, 16 March 2016WRothReverted to version '18:12, 14 October 2014' by WRoth
84727view18:11, 16 March 2016WRothReverted to version '22:43, 30 September 2014' by WRoth
84726view18:11, 16 March 2016WRothReverted to version '22:56, 30 September 2014' by WRoth
84725view18:11, 16 March 2016WRothReverted to version '19:21, 8 October 2014' by WRoth
84724view18:11, 16 March 2016WRothReverted to version '12:31, 17 November 2015' by WRoth
84723view18:11, 16 March 2016WRothReverted to version '14:50, 7 January 2015' by WRoth
83039view04:17, 18 November 2015MkutmonModified description
83013view12:31, 17 November 2015FehrhartUpdated miRNA IDs
78586view14:50, 7 January 2015MaintBotadded missing graphIds
77707view18:12, 14 October 2014KhanspersAdded interactions for negative effectors, changed node types, removed legend

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABOGeneProductENSG00000175164 (Ensembl)
ALK4GeneProductENSG00000135503 (Ensembl)
C2TAGeneProductP33076 (Uniprot-TrEMBL)
CBFA2T3GeneProductENSG00000129993 (Ensembl)
CD235aGeneProductENSG00000170180 (Ensembl)
CD34GeneProduct
CD34GeneProductP28906 (Uniprot-TrEMBL)
CD41GeneProductENSG00000005961 (Ensembl)
CD42GeneProductENSG00000169704 (Ensembl)
CD61GeneProduct3690 (Entrez Gene)
CDH1GeneProductCDH1 (Uniprot-TrEMBL)
CRLF3GeneProductCRLF3 (Uniprot-TrEMBL)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EGFGeneProductEGF (Uniprot-TrEMBL)
ELF1GeneProductELF1 (Uniprot-TrEMBL)
EPOGeneProductENSG00000130427 (Ensembl)
F2RGeneProductF2R (Uniprot-TrEMBL)
FLI1GeneProductENSG00000151702 (Ensembl)
FLI1GeneProductFLI1 (Uniprot-TrEMBL)
FOSBGeneProductP53539 (Uniprot-TrEMBL)
FOSGeneProductENSG00000170345 (Ensembl)
GATA1GeneProductENSG00000102145 (Ensembl)
GATA2GeneProductENSG00000179348 (Ensembl)
GATA2GeneProductP23769 (Uniprot-TrEMBL)
GATA5GeneProductGATA5 (Uniprot-TrEMBL)
HES6GeneProductQ96HZ4 (Uniprot-TrEMBL)
HEXIM1GeneProductHEXIM1 (Uniprot-TrEMBL)
HEXIM2GeneProductHEXIM2 (Uniprot-TrEMBL)
HLFGeneProductHLF (Uniprot-TrEMBL)
HMGN5GeneProductP82970 (Uniprot-TrEMBL)
IKZF1GeneProductENSG00000185811 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRF5GeneProductQ13568 (Uniprot-TrEMBL)
KCNH2GeneProductENSG00000055118 (Ensembl)
KLF1GeneProductENSG00000105610 (Ensembl)
LBX2GeneProductLBX2 (Uniprot-TrEMBL)
LEF1GeneProductQ9UJU2 (Uniprot-TrEMBL)
LMO2GeneProductENSG00000135363 (Ensembl)
LMO2GeneProductLMO2 (Uniprot-TrEMBL)
LOXL3GeneProductLOXL3 (Uniprot-TrEMBL)
LYL1GeneProductENSG00000104903 (Ensembl)
MED12LGeneProductMED12L (Uniprot-TrEMBL)
MEF2CGeneProductMEF2C (Uniprot-TrEMBL)
MIR10ARnaMIMAT0000253 (miRBase mature sequence)
MIR128ARnaENSG00000207654 (Ensembl)
MIR130ARnaENSG00000208009 (Ensembl)
MIR150RnaENSG00000207782 (Ensembl)
MIR155RnaMIMAT0000165 (miRBase mature sequence)
MIR15AGeneProductENSG00000283785 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR17RnaMIMAT0000070 (miRBase mature sequence)
MIR181ARnaENSG00000207759 (Ensembl)
MIR221RnaENSG00000207870 (Ensembl)
MIR222RnaENSG00000207870 (Ensembl)
MIR223GeneProductENSG00000284567 (Ensembl)
MIR24ARnaENSG00000207617 (Ensembl)
MIR451RnaMIMAT0001631 (miRBase mature sequence)
MUC1GeneProductP15941 (Uniprot-TrEMBL)
MXI1GeneProductENSG00000119950 (Ensembl)
MYBGeneProductENSG00000118513 (Ensembl)
NCKAP1LGeneProductENSG00000123338 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFE2GeneProductENSG00000123405 (Ensembl)
NLKGeneProductNLK (Uniprot-TrEMBL)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PADI4GeneProductPADI4 (Uniprot-TrEMBL)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PIM1GeneProductP11309 (Uniprot-TrEMBL)
PIM2GeneProductPIM2 (Uniprot-TrEMBL)
PRDM5GeneProductPRDM5 (Uniprot-TrEMBL)
RCAN1GeneProductRCAN1 (Uniprot-TrEMBL)
RHOHGeneProductQ15669 (Uniprot-TrEMBL)
RIOK3GeneProductENSG00000101782 (Ensembl)
RUN1T1GeneProductRUN1T1 (Uniprot-TrEMBL)
RUNX1GeneProductENSG00000159216 (Ensembl)
S14L2GeneProductO76054 (Uniprot-TrEMBL)
SCFGeneProductENSG00000049130 (Ensembl)
SPI1GeneProductENSG00000066336 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
T3JAMGeneProductQ9Y228 (Uniprot-TrEMBL)
TENXGeneProductP22105 (Uniprot-TrEMBL)
TGFB1GeneProductTGFB1 (Uniprot-TrEMBL)
THBGeneProductP10828 (Uniprot-TrEMBL)
TPOGeneProductENSG00000115705 (Ensembl)
TRIM29GeneProductENSG00000137699 (Ensembl)
TXKGeneProductTXK (Uniprot-TrEMBL)
UM279Metabolite
  • http://www.google.com/patents/CA2862140A1?cl=en
  • Patented derivative of Pyrimido[4,5-b]indole
VAV1GeneProductENSG00000141968 (Ensembl)
WNT11GeneProductWNT11 (Uniprot-TrEMBL)
ZFP37GeneProductZFP37 (Uniprot-TrEMBL)
ZGLP1GeneProductZGLP1 (Uniprot-TrEMBL)
ZNF789GeneProductZNF789 (Uniprot-TrEMBL)
ZNF792GeneProductZNF792 (Uniprot-TrEMBL)
ZNF835GeneProductQ9Y2P0 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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