Hair Follicle Development: Cytodifferentiation (Part 3 of 3) (Homo sapiens)

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33S100A4DKK3KRT15LGR5JUNNf-kappaBKITLGKLK6FOSLHX2WIF1DSC2NFKB1SFRP1GJB6PERPNR3C1IGFSOX2PROM1ZFP145NFATC1GSDMACD200RUNX3DSG1NogginBMP6SPINK5SOSTDC1RBPJB-cateninELANETP63Smad1CUX1SOX9FOXE1TCF3FOXQ1BMPPathwayNOTCH1WntPathwayShhPathwayNotchPathwayIGFBP5Hair FollicleDifferentiationGli2GATA3DKK1KRTsSmad4DSG4HOXC12Hair ShaftPigmentationHair FollicleDifferentiationHair FollicleShapeMSX1BMPPathwayNotchPathwayCD34BCL11BLRIG1PHLDA1FSTNotch2SCF/c-kitSignalingEdaPathwaySPINK6GPRC5DKLK4KLK13KLK14KRTAP8-1KRTAP15KRTAP3-3KRTAP6-1KRTAP2-4FOSBADAMTS20TP63ShhPathwayLEF1BMPR1AWntPathwayB-cateninWnt5aWNT5AKRT19DKK4EGFRCTGFFZD1GAS1Bmp4Bmp6FGFTGFBInterferon gammaLEF1Notch1EGR2ADAM17DLX3HOXC13FOXN1MSX2HRCASP14KLK5KLK7ADAM17TCF4LGR5Stem CellCompartment33


Description

Hair follicle cytodifferentiation is the third main step in hair follicle development and leads to the formation of the bulbous peg. Source: Notch signaling and the developing hair follicle, by Geneviève Aubin-Houzelstein

Quality Tags

Ontology Terms

 

Bibliography

  1. Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma'ayan A, Rendl M; ''Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.''; Dev Cell, 2012 PubMed Europe PMC
  2. Fantauzzo KA, Kurban M, Levy B, Christiano AM; ''Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.''; PLoS Genet, 2012 PubMed Europe PMC
  3. Collu GM, Hidalgo-Sastre A, Brennan K; ''Wnt-Notch signalling crosstalk in development and disease.''; Cell Mol Life Sci, 2014 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
104845view14:36, 20 June 2019Fehrhartadded crosstalk between Wnt and Notch pathways
104841view14:25, 20 June 2019Fehrhart
97324view19:05, 9 May 2018KhanspersModified description
97323view19:00, 9 May 2018Khanspersupdated xrefs, connected interactions
96296view16:13, 7 March 2018Fehrhartconnected lines
88632view14:41, 12 August 2016JmeliusOntology Term : 'PW:0000003' removed !
88631view14:41, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
88628view14:36, 12 August 2016JmeliusOntology Term : 'signaling pathway' added !
78512view10:29, 7 January 2015MaintBotadded missing graphIds
77665view07:44, 4 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77312view22:14, 14 August 2014DanieltrinunesMinimal gene name corretion
77311view22:08, 14 August 2014DanieltrinunesModified title
77310view22:08, 14 August 2014DanieltrinunesModified title
77309view22:07, 14 August 2014DanieltrinunesNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM17GeneProductP78536 (Uniprot-TrEMBL)
ADAMTS20GeneProductP59510 (Uniprot-TrEMBL)
B-cateninGeneProductP35222 (Uniprot-TrEMBL)
BCL11BGeneProductQ9C0K0 (Uniprot-TrEMBL)
BMP PathwayPathwayWP1425 (WikiPathways)
BMP6ProteinP22004 (Uniprot-TrEMBL)
BMPR1AGeneProductP36894 (Uniprot-TrEMBL)
Bmp4ProteinP12644 (Uniprot-TrEMBL)
Bmp6ProteinP22004 (Uniprot-TrEMBL)
CASP14GeneProductP31944 (Uniprot-TrEMBL)
CD200GeneProductP41217 (Uniprot-TrEMBL)
CD34ProteinP28906 (Uniprot-TrEMBL)
CTGFProteinP29279 (Uniprot-TrEMBL)
CUX1GeneProductP39880 (Uniprot-TrEMBL)
DKK1GeneProductO94907 (Uniprot-TrEMBL)
DKK3ProteinQ9UBP4 (Uniprot-TrEMBL)
DKK4ProteinQ9UBT3 (Uniprot-TrEMBL)
DLX3GeneProductO60479 (Uniprot-TrEMBL)
DSC2ProteinQ02487 (Uniprot-TrEMBL)
DSG1ProteinQ02413 (Uniprot-TrEMBL)
DSG4ProteinQ86SJ6 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
EGR2ProteinP11161 (Uniprot-TrEMBL)
ELANEGeneProductP08246 (Uniprot-TrEMBL)
Eda PathwayPathway
FGFGeneProduct
FOSBProteinP53539 (Uniprot-TrEMBL)
FOSProteinP01100 (Uniprot-TrEMBL)
FOXE1ProteinO00358 (Uniprot-TrEMBL)
FOXN1ProteinO15353 (Uniprot-TrEMBL)
FOXQ1GeneProductQ9C009 (Uniprot-TrEMBL)
FSTProteinP19883 (Uniprot-TrEMBL)
FZD1ProteinQ9UP38 (Uniprot-TrEMBL)
GAS1ProteinP54826 (Uniprot-TrEMBL)
GATA3GeneProductP23771 (Uniprot-TrEMBL)
GJB6GeneProductO95452 (Uniprot-TrEMBL)
GPRC5DProteinQ9NZD1 (Uniprot-TrEMBL)
GSDMAGeneProductQ96QA5 (Uniprot-TrEMBL)
Gli2ProteinP10070 (Uniprot-TrEMBL)
HOXC12GeneProductP31275 (Uniprot-TrEMBL)
  • (1, 2, 3 & 4) mx, cuticle, cx and md
  • (1) As embryonic hf morphogenesis reaches completion (P9), expression of the Hoxc13 is detected in the hair-shaft forming compartments of the matrix, cuticle, cortex and medulla.
  • (1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1.
HOXC13GeneProductO60479 (Uniprot-TrEMBL)
  • (1, 2, 3 & 4) mx, cuticle, cx and md
  • (1) As embryonic hf morphogenesis reaches completion (P9), expression of the Hoxc13 is detected in the hair-shaft forming compartments of the matrix, cuticle, cortex and medulla.
  • (1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1.
HRGeneProductO43593 (Uniprot-TrEMBL) Mx,Cx,Bulb
Hair Follicle DifferentiationPathway
Hair Follicle ShapePathway
Hair Shaft PigmentationPathway
IGFBP5GeneProductP24593 (Uniprot-TrEMBL)
IGFProteinP05019 (Uniprot-TrEMBL)
Interferon gammaProteinP01579 (Uniprot-TrEMBL)
JUNProteinP05412 (Uniprot-TrEMBL)
KITLGGeneProductP21583 (Uniprot-TrEMBL)
KLK13ProteinQ9UKR3 (Uniprot-TrEMBL)
KLK14ProteinQ9P0G3 (Uniprot-TrEMBL)
KLK4ProteinQ9Y5K2 (Uniprot-TrEMBL)
KLK5ProteinQ9Y337 (Uniprot-TrEMBL)
KLK6ProteinQ92876 (Uniprot-TrEMBL)
KLK7ProteinP49862 (Uniprot-TrEMBL)
KRT15GeneProductP19012 (Uniprot-TrEMBL)
KRT19GeneProductP08727 (Uniprot-TrEMBL)
KRTAP15ProteinQ3LI76 (Uniprot-TrEMBL)
KRTAP2-4ProteinQ9BYR9 (Uniprot-TrEMBL)
KRTAP3-3GeneProductQ9BYR6 (Uniprot-TrEMBL)
KRTAP6-1ProteinQ3LI64 (Uniprot-TrEMBL)
KRTAP8-1ProteinQ8IUC2 (Uniprot-TrEMBL)
KRTsGeneProduct(1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1
LEF1ProteinQ9UJU2 (Uniprot-TrEMBL)
LGR5ProteinO75473 (Uniprot-TrEMBL)
LHX2ProteinP50458 (Uniprot-TrEMBL)
LRIG1ProteinQ96JA1 (Uniprot-TrEMBL)
MSX1ProteinP28360 (Uniprot-TrEMBL) Mx,Cx,Bulb
MSX2ProteinP35548 (Uniprot-TrEMBL) Mx,Cx,Bulb
NFATC1GeneProductO95644 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NOTCH1GeneProduct
NR3C1GeneProductP04150 (Uniprot-TrEMBL)
Nf-kappaBProteinP19838 (Uniprot-TrEMBL)
NogginProteinQ9BZE4 (Uniprot-TrEMBL)
Notch PathwayPathwayWP268 (WikiPathways)
Notch1GeneProductP46531 (Uniprot-TrEMBL)
Notch2GeneProductQ04721 (Uniprot-TrEMBL)
PERPProteinQ96FX8 (Uniprot-TrEMBL)
PHLDA1GeneProductQ8WV24 (Uniprot-TrEMBL)
PROM1ProteinO43490 (Uniprot-TrEMBL)
RBPJGeneProductQ06330 (Uniprot-TrEMBL)
RUNX3ProteinQ13761 (Uniprot-TrEMBL)
S100A4GeneProductP26447 (Uniprot-TrEMBL)
SCF/c-kit SignalingPathway
SFRP1ProteinQ8N474 (Uniprot-TrEMBL)
SOSTDC1GeneProductQ6X4U4 (Uniprot-TrEMBL)
SOX2ProteinP48431 (Uniprot-TrEMBL)
SOX9GeneProductP48436 (Uniprot-TrEMBL)
SPINK5GeneProductQ9NQ38 (Uniprot-TrEMBL)
SPINK6GeneProductQ6UWN8 (Uniprot-TrEMBL)
Shh PathwayPathway
Shh PathwayPathwayWP4249 (WikiPathways)
Smad1ProteinQ15797 (Uniprot-TrEMBL)
Smad4ProteinQ13485 (Uniprot-TrEMBL)
Stem Cell Compartment
TCF3GeneProductP15923 (Uniprot-TrEMBL)
TCF4GeneProductP15884 (Uniprot-TrEMBL)
TGFBProteinP01137 (Uniprot-TrEMBL)
TP63ProteinQ9H3D4 (Uniprot-TrEMBL)
WIF1ProteinQ9Y5W5 (Uniprot-TrEMBL)
WNT5AProteinP41221 (Uniprot-TrEMBL)
Wnt PathwayPathwayWP428 (WikiPathways)
Wnt5aProteinP41221 (Uniprot-TrEMBL)
ZFP145GeneProduct

Annotated Interactions

No annotated interactions

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