Cytosolic sensors of pathogen-associated DNA (Homo sapiens)

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51, 61, 7119, 6457, 63, 7416, 432, 36, 69, 876763, 74, 8149, 66, 8024, 3115, 24, 25, 27, 34...1, 18, 72, 817438, 86161041, 7755554821, 681723, 3228, 63, 859, 35, 42, 4812, 496, 30551, 18, 72, 811017553, 5, 24, 31, 39...55107, 81713, 29, 86174845, 53, 8419, 6444, 881982, 8658, 8640, 862, 37, 887, 8nucleoplasm(perinuclear vesicle)endoplasmic reticulumcytoplasmic vesicle lumencytosolUBC(457-532) UBC(609-684) p-4S,T404-IRF3POLR3GL RIPK3STING:p-S172-TBK1:IRF3DHX9/DHX36:CpGIRF3 H2OSTAT6 DTX4 bacterial dsDNAUBC(229-304) c-di-GMP K48polyUb-DDX41 dsDNA:ZBP1:pS-172-TBK:IRF3ATPUBC(229-304) NLRP4MYD88 p-4S,T404-IRF3 XRCC5 viral plus strand DNA with sticky 3' end Unmethylated CpG DNA UBC(305-380) dsDNA:IFI16p-S172-TBK1 dAMPMRE11A microbial dsDNAIFN- stimulatory DNA c-di-GMP ATPMRE11AMRE11 ligandNFkB ComplexATPTRIM32/TRIM56Double-stranded DNA Unmethylated CpG DNA viral dsDNA UBC(305-380) p-S477,S479-IRF7 viral dsDNA UBB(77-152) Unmethylated CpG DNA POLR1C IKBKG pS-172,K48polyUb-TBK1 p-S407,Y641-STAT6 DHX36 cGAS:dsDNAcGAS ligandKu70:Ku80heterodimerp-S172-TBK1 MYD88 UBC(77-152) TBK1bacterial dsDNA UbIRF3STAT6PPiviral dsDNAMB21D1DHX9 TMPDHX9 XRCC6 PRKDCPOLR2H UBC(381-456) ATPNFKBIB UBB(1-76) 2xp-S477,S479-IRF7p-S172-TBK1 GTPTRIM56 MRE11:dsDNAviral dsDNA IFI16ADPDDX41IFN- stimulatory DNA p-S407,Y641-STAT6dimerUnmethylated CpG DNA UBA52(1-76) c-di-AMP DTX4DHX36 IRF3 beta-catenin:IRF3:p300p-S407,Y641-STAT6K63polyUb-STING TBK1 bacterial dsDNA ATPPOLR3A ADPPRKDC UBA52(1-76) Phospho-NF-kappaBInhibitorUBC(77-152) UBC(457-532) ZBP1viral dsDNA DDX41 ligandIFI16 TREX1 p-S552-CTNNB1 viral dsRNA CHUK TRIM21 dsDNA:ZBP1:pS-172-TBK1UBC(533-608) ADPSTAT6 STING:c-di-GMPNFKB2(1-454) viral plus strand DNA with sticky 3' end TLR3 K63polyUb-STING RPS27A(1-76) c-GMP-AMP XRCC5 dsDNA:ZBP1:RIP1:RIP3viral dsDNA Unmethylated CpG DNA ATPLRRFIP1 ZBP1 STING:p-S172-TBK1POLR3E IRF3 K63polyUb-STING RPS27A(1-76) dsDNA:ZBP1:pS-172,K48polyUb-TBK1DHX9:CpGc-GMP-AMP XRCC5 IkBs:NFkBAGER ligands:AGERviral minus strand DNA with sticky 3' end UBC(153-228) TMEM173ATPPOLR2E LRR FLII-interactingprotein 1 dimerLRRFIP1 POLR3K DDX41:DDX41 ligandZBP1 K48polyUb-DDX41 AGER p-S172-TBK1 POLR3F p-S407,Y641-STAT6 NFKB1(1-433) microbial dsDNA UBC(609-684) UBC(153-228) DHX36:CpG:MyD88UBC(533-608) bacterial dsDNA SAA1(19-122) K63polyUb-STING RIPK1CHUK:IKBKB:IKBKGDDX58/IFIH1-mediatedinductionofinterferon-alpha/betamicrobial dsDNA poly(dA:dT) p-4S,T404-IRF3 UBC(229-304) HMGB1 Mg2+CRCP Promotor region of interferon beta p-S19,S23-NFKBIB UBB(1-76) POLR3H STING:cGAMPp-S172-TBK1 APP(672-711) IRF3 viral dsDNA S100A12 K48polyUb-DDX41:TRIM21UbUBC(381-456) UBC(1-76) p-S407-STAT6TMEM173 IRF3 UBA52(1-76) IKBKG UBC(381-456) p-T,4S-IRF3:p-T,4S-IRF3TRIM21UBA52(1-76) POLR3B p-2S-IRF7:p-2S-IRF7STING:STINGUBC(1-76) dsDNA:ZBP1UBC(381-456) p-S552-CTNNB1DHX9:CpG:MyD88p-T,4S-IRF3:p-T,4S-IRF3STING activatorsUBB(77-152) MYD88UBB(153-228) PRKDC UBB(77-152) UbpS-172,K48polyUb-TBK1 ZBP1 Peptide Double-stranded DNA c-di-GMP MB21D1 viral dsDNA UBB(153-228) TREX1 RIPK3 bacterial dsDNA TICAM1 NLRP4:DTX4:STING:p-S172-TBK1:IRF3DHX9 ADPmicrobial dsDNA bacterial dsDNA UBC(609-684) Unmethylated CpG DNA ATPviral dsDNA viral dsDNA NFKB1(1-433) p-S176,S180-IKKA RELA RIPK1 TBK1 UBC(533-608) NLRP4 viraldsRNA:TLR3:TRIF:RIP1Unmethylated CpG DNAc-di-GMP c-di-AMP NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1NLRP4Promotor region ofinterferon betaPOLR1D AT-rich dsDNA5'-ppp-AU-rich dsRNAPOLR2K STING:STINGUBC(153-228) STING:TBK1:STAT6ADPUBC(609-684) POLR3C DHX9/DHX36:CpG:MyD88dCMPMg2+ POLR3G EP300 viral dsDNA ZBP1 ZBP1 ADPUbIFI16 DDX41 bacterial dsDNA K63polyUb-STING bacterial dsDNA dsDNA:LRRFIP1:beta-cateninDNA-PK:microbialdsDNAZBP1 STING:TBK1:IRF3K63polyUb-STING bacterial dsDNA p-S172-TBK1 bacterial dsDNA POLR2F CREBBP, EP300K63polyUb-STING bacterial dsDNA TREX1 dimerc-GMP-AMPUBC(1-76) NFkB Complexp-4S,T404-IRF3 IRF3microbial dsDNA UBC(229-304) TBK1STING:p-S172-TBK1:STAT6viral dsDNA MRE11A UBB(153-228) TRIM32 DHX36:CpGIKBKB DHX36p-S177,S181-IKBKB p-S552-CTNNB1microbial dsDNA K63polyUb-STING EP300 ADPDTX4 UBC(153-228) DHX36 TRIM32 ADPPOLR3D RPS27A(1-76) S100B XRCC6 DHX36 NFKBIA bacterial dsDNA ATPviral dsDNA UBC(457-532) K63polyUb-STINGDHX9 DTX4viral dsDNA UBC(1-76) CREBBP UBB(77-152) ATPCTNNB1 UBB(1-76) NLRC3LRRFIP1 RELA NFKB2(1-454) DHX9c-di-GMPviral minus strand DNA with sticky 3' end RELA UBC(77-152) Double-stranded DNA bacterial dsDNA TMEM173 UBB(1-76) UBB(153-228) STING:TRIM32/TRIM56N-epsilon-(1-(1-carboxy)ethyl)lysine RIPK1 XRCC6 NECML p-S477,S479-IRF7 ADPdsDNA:LRRFLII-interactingprotein 1dimerNFKB1(1-433) UBC(77-152) UBC(305-380) K63polyUb-STING TRIM56 UBC(457-532) viral dsDNA DDX41 dGMPviral dsDNA RPS27A(1-76) Activated IKKComplexp-S32,S36-NFKBIA UBC(305-380) STING:p-S172,K48polyUb-TBK1:IRF3p-S407,Y641-STAT6dimerRNA Polymerase IIIHoloenzymeATPviral DNA with 3'sticky endsK63polyUb-STING POLR2L MYD88 bacterial dsDNA APP(672-713) NFKB2(1-454) c-di-AMP CTNNB1NLRP4 UBC(533-608) CREBBP ADPp-S172-TBK1 TREX1:viral DNA68104, 47, 7566, 8055558140818159, 8626, 543322, 6447, 751087724491016, 204019672411, 14, 60, 62, 65...101717