Pre-NOTCH Expression and Processing (Homo sapiens)

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1, 4, 15, 23, 32...4, 7, 41, 69, 112...1118, 62, 80941232351, 5329, 32, 39, 50, 702313788, 13115, 23, 59, 12314, 112, 12611494, 11815, 23, 48, 67, 139102, 13748, 98, 129, 13948, 98, 129, 13911, 31, 34, 38, 45...1021, 1263, 16, 33, 42, 55...43, 63, 96, 126, 13361, 8522, 1265, 112, 12112659118nucleoplasmGolgi lumencytosolendoplasmic reticulum lumenEIF2C3 EIF2C2 EIF2C3 NOTCH4(1337-2003) Pre-NOTCH2 TNRC6A MIR34C gene TFDP2 E2F3 TNRC6A EIF2C1 miR-34A NOTCH4(1337-2003) miR-200C ST3GAL3 TNRC6C NOTCH4(1337-2003) MIR34A gene TNRC6C EP300 EIF2C1 NOTCH3 mRNA EIF2C4 NOTCH1 gene TNRC6A miR-34 RISCGlc,Gal-GlcNAc-Fuc-Pre-NOTCH2 NOTCH3 CoactivatorComplexEIF2C4 EIF2C2 MOV10 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) miR-302A miR-34A Pre-NOTCH2EIF2C4 TNRC6A UDP-GlcMAML1 TNRC6C miR-449B ST3GAL4 miR-302A RISCTNRC6A 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) NOTCH1 CoactivatorComplexMAML3 TFDP1 TNRC6B Glc,GlcNAc-Fuc-Pre-NOTCH4 miR-34B MFNG NOTCH1 mRNAATP2A3 miR-34A FRINGE-modifiedNOTCHNOTCH1(1665-2555) EIF2C3 miR-200B TNRC6C CREBBP EIF2C3 TFDP1 MAML2 SNW1 ATP2A1-3Glc,Gal-GlcNAc-Fuc-Pre-NOTCHGlc,GlcNAc-Fuc-Pre-NOTCH3 TNRC6B EIF2C3 MAML2 FURIN19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) CCND1:CREBBP:NOTCH1GeneEIF2C1 E2F1/3:DP1/2:NOTCH1GeneEIF2C4 miR-181C Glc,GlcNAc-Fuc-Pre-NOTCH1 RBPJ NOTCH2 mRNA Pre-NOTCH4 EIF2C2 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) KAT2A FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) NOTCH2 mRNA:miR-34RISCEIF2C4 CREBBP NOTCH2(1582-2471) JUNTNRC6B TNRC6B 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) TNRC6C MOV10 miR-206 MOV10 NOTCH1 mRNA 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) miR-449 RISCEIF2C3 MIR34A gene TMED2UDPEIF2C2 E2F1/3:DP1/2TNRC6B UDP-GalmiR-449A NOTCH4 geneEIF2C3 TP53 B4GALT1 NOTCH1 mRNA EIF2C4 miR-150 RISCNOTCH1 mRNA:miR-449RISCEIF2C1 miR-200B/C RISCUDP18xFucT-FucS-NOTCH2(26-2471) TFDP2 Pre-NOTCHEIF2C4 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 POGLUT1EIF2C4 LFNG EIF2C1 12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) TNRC6B miR-34C Pre-NOTCH4CCND1 Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 TNRC6C MOV10 miR-181C MIR34B gene TNRC6C NOTCH3 mRNA Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCHEIF2C2 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 NOTCHEIF2C4 TNRC6C E2F1 EIF2C1 Glc,Fuc-Pre-NOTCHmiR-206 RISCEIF2C1 E2F3 MAMLD1 NOTCH3 mRNA:miR-150RISCTNRC6C NOTCH1mRNA:miR-200B/CRISCEIF2C4 MOV10 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) EIF2C2 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) Signaling by NOTCH1TNRC6B NOTCH4(1337-2003) EIF2C2 EIF2C1 CCND1:CREBBPTNRC6B miR-206 EIF2C2 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) GDP-FucMOV10 NOTCH4 mRNA CREBBP miR-34C TNRC6A EIF2C1 TNRC6B Glc,GlcNAc-Fuc-Pre-NOTCH2 MOV10 RBPJ NOTCH2 geneEIF2C3 NOTCH1(1665-2555) ST3GAL3/4/6miR-181C RISCTNRC6B ATP2A1 EIF2C3 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) MAMLD1 Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 TP53 TNRC6B EIF2C3 MAML1 CMP-Neu5AcEIF2C3 Pre-NOTCH1 TNRC6C TNRC6A Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 NICD1 TNRC6C miR-200C NOTCH3(1572-2321) NOTCH3 mRNANOTCH4 mRNA TNRC6A EIF2C4 NOTCH4 mRNA:miR-302ARISCCMPB4GALT1 homodimerRAB6ANOTCHEIF2C2 NOTCH2(1582-2471) miR-34B miR-200B FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) EIF2C1 TNRC6B EIF2C1 miR-449C miR-34C miR-449B ATP2A2 MIR34B gene NOTCH3(1572-2321) MOV10 TNRC6C Fringe-modifiedNOTCHNOTCH1(1665-2555) EIF2C2 NOTCH3(1572-2321) EIF2C2 FRINGE-modified NOTCH2 extracellular fragment (NECD2) EIF2C4 NOTCH3(1572-2321) EIF2C3 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) TNRC6C EIF2C2 miR-34B 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) FRINGE-modified NOTCH4 Extracellular fragment (NECD4) NOTCH2(1582-2471) MOV10 MIR34C gene CCND1 NOTCH4 mRNATNRC6B 10xFucT-4xFucS-NOTCH3(40-2321) TNRC6A miR-150 TNRC6A EIF2C2 12xFucT-6xFucS-NOTCH4(24-2003) SEL1LNOTCH1 mRNA:miR-34RISCmiR-150 Signaling by NOTCH4TNRC6B FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) Glc,GlcNAc-Fuc-Pre-NOTCHUDP-GlcNAcSignaling by NOTCH3UDPPre-NOTCH3 MOV10 TNRC6A TNRC6C 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) Pre-NOTCH1EIF2C3 EIF2C1 POFUT1EIF2C1 NICD3 ST3GAL6 TNRC6A 17xFucT-2xFucS-NOTCH1(19-2555) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 Signaling by NOTCH2Fringe familyNOTCH2(1582-2471) NOTCH1 mRNA FRINGE-modified NOTCH3 Extracellular fragment (NECD3) EIF2C4 miR-449A TNRC6A Pre-NOTCH3NOTCH1 geneEIF2C1 MIR34 genesEIF2C3 MOV10 E2F1 NOTCH3 genemiR-449C NOTCH4 mRNA:miR-181CRISCFuc-Pre-NOTCHTNRC6A GDPEIF2C4 TNRC6B MAML3 TNRC6C MOV10 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 EIF2C2 NOTCH1(1665-2555) TNRC6A Glc,Fuc-Pre-NOTCHEIF2C1 EIF2C4 MOV10 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) MOV10 NOTCH1 gene TP53 Tetramer:MIR34genesRFNG KAT2B NOTCH3 mRNA:miR-206RISCMOV10 NOTCH2 mRNAmiR-302A FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) EIF2C3 TP53 TetramerEIF2C2 12, 13, 18, 21, 35...1142, 6, 8-10, 12...48, 98, 129, 1391160114