Pre-NOTCH Expression and Processing (Homo sapiens)

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1, 24, 27, 33, 38...72, 105, 147929, 21, 49, 13522, 61, 139, 142102, 132, 17472, 11063, 100, 103, 176127, 85, 130, 147, 153...58, 60, 81, 134, 1631096115, 46, 48, 53, 57...241039, 49, 103, 176, 1821036165, 115152, 162928, 10, 23, 30, 67...1226, 33, 72, 155, 16013972125, 137, 14710024, 1091, 1576338, 721579, 21, 49, 13548nucleoplasmcytosolGolgi lumenendoplasmic reticulum lumenRUNX1:NOTCH4 genemiR-34C Glc,Gal-GlcNAc-Fuc-Pre-NOTCHMOV10 H2AFX Ack10-HIST1H3A TNRC6B miR-34B NOTCH3(1572-2321) ATPUDPNOTCH2 mRNA:miR-34RISCH2AFV miR-34C NOTCH1 gene Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 UDP-GlcEIF2C4 NOTCH1(1665-2555) miR-206 TP53 H2BFS RFNG EIF2C4 NOTCH3 mRNA miR-34C EIF2C1 HIST1H2AC NOTCH4 gene AGO2 MOV10 NOTCH2 mRNAMOV10 Glc,GlcNAc-Fuc-Pre-NOTCH1 Glc,GlcNAc-Fuc-Pre-NOTCH2 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 SNW1 NOTCH1 mRNA:miR-34RISCHIST1H2BM miR-449B AGO2 MIR34 genesHIST1H2AD B4GALT1 homodimerUDPHIST1H2BM EIF2C1 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) ST3GAL4 TNRC6A HIST1H2BO ELF3TNRC6C NOTCH1 gene H2AFB1 NOTCH2(1582-2471) TNRC6C HIST1H2BB H2AFB1 EIF2C1 HIST2H2AA3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) TNRC6C SIRT6:Nucleosome:NOTCH1,NOTCH4 geneGlc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 TNRC6B Pre-NOTCH2 CMP-Neu5AcHIST1H2BK HIST2H3A NOTCH1(1665-2555) HIST1H2BO CREBBP TNRC6B AGO2 TFDP2 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) NOTCH1 gene,NOTCH4genep-S68-ELF3:NOTCH3geneNOTCH2 geneKAT2B TNRC6C NOTCH1 mRNASNW1 TFDP1 NOTCH1 gene TNRC6C HIST1H2BJ H3F3A HIST3H2BB Glc,GlcNAc-Fuc-Pre-NOTCHTNRC6C FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) TNRC6B NICD3 HIST1H2BH miR-200C HIST1H4 EIF2C3 TNRC6B TNRC6B CREBBP HIST1H2BA miR-181C MAMLD1 HIST1H2BL MIR34B gene RBPJ KAT2A EIF2C1 HIST1H2BB TP53 TNRC6B TNRC6C NOTCH4 mRNA HIST1H2BA TP53 Tetramer:MIR34genesCREBBP E2F3 TNRC6B HIST2H2BE HIST1H2AC EIF2C3 2'-O-acetyl-ADP-riboseHIST1H2BB NICD1 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) TNRC6A HIST1H2BD NOTCH1(1665-2555) CCND1:CREBBP:NOTCH1GeneNOTCH3 mRNAH2BFS HIST1H2BK EIF2C3 EIF2C4 HIST1H2BJ FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) HIST1H2AJ TNRC6B NOTCH3 mRNA:miR-206RISCHIST1H2BC EIF2C3 AGO2 MOV10 Glc,Fuc-Pre-NOTCHMIR34C gene HIST1H2BD MAML1 E2F1 Pre-NOTCH4FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) TNRC6B EIF2C1 MAML3 miR-34A HIST2H2AA3 HIST1H4 HIST1H2BH H2AFJ NOTCH4(1337-2003) EIF2C4 miR-34B miR-181C RISCMFNG GDPAGO2 TNRC6A AGO2 HIST1H2BN HIST1H2AB AGO2 TNRC6A EIF2C4 GDP-FucAGO2 KAT2A MIR34A gene Pre-NOTCH1Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 HIST1H2BC TNRC6C MOV10 AGO2 miR-302A CREBBP HIST1H2BO H2AFV EP300 EP300 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) FRINGE-modifiedNOTCHmiR-150 MAML1 POGLUT1E2F3 NOTCH3 geneSignaling by NOTCH1H2AFZ 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) AcK10-H3F3A EIF2C3 NOTCH1 mRNA H2AFJ NICD1 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) ST3GAL3 NOTCH1 mRNA:miR-449RISCNOTCH1 gene HIST1H2AC TNRC6C ADPNOTCH1 coactivatorcomplex:NOTCH3 geneSIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 genemiR-200C 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) NOTCH2 mRNA HIST1H2BC RAB6ATMED2H2AFZ NOTCH4 mRNA AcK10-H3F3A 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) MOV10 HIST2H2AC Glc,GlcNAc-Fuc-Pre-NOTCH4 miR-449A UDP-GalTNRC6A EIF2C4 HIST2H2BE AGO2 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) POFUT1FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) HIST1H3A Signaling by NOTCH414xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) FURINFRINGE-modified NOTCH4 Extracellular fragment (NECD4) H2AFJ CCND1 NOTCH1mRNA:miR-200B/CRISCATP2A1 MOV10 MAML2 NOTCH3(1572-2321) ST3GAL6 HIST1H4 TNRC6B EIF2C1 PRKCIHIST2H2AC NOTCH3 mRNA miR-200B UDPTNRC6C ATP2A1-3NOTCH3 gene Pre-NOTCH3EIF2C1 HIST1H2BL Fuc-Pre-NOTCHEIF2C4 SIRT6 MOV10 TNRC6C HIST1H2AJ NOTCH2(1582-2471) NOTCH3(1572-2321) TP53 TetramerHIST2H2AC miR-181C EIF2C3 NOTCH4 geneGlc,GlcNAc-Fuc-Pre-NOTCH3 Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 TNRC6A AGO2 EIF2C1 TNRC6A NOTCH1 CoactivatorComplex12xFucT-6xFucS-NOTCH4(24-2003) MOV10 TNRC6C H2AFX Ack10-HIST2H3A EIF2C4 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) HIST1H2AB UDP-GlcNAcEIF2C4 Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 EIF2C1 HIST1H2AD ATP2A3 HIST1H2BA HIST1H2AD EIF2C1 NOTCH1(1665-2555) miR-200B KAT2B EIF2C1 NOTCH4 gene E2F1/3:DP1/2:NOTCH1GeneMIR34A gene TNRC6C EIF2C3 TNRC6B miR-200B/C RISCp-S68-ELF3 E2F1 TNRC6A TFDP1 RUNX1Signaling by NOTCH3RUNX1 HIST3H2BB ST3GAL3/4/6NOTCHHIST1H2BN TNRC6A NAD+NOTCH1 mRNA EIF2C3 RBPJ EIF2C3 TNRC6B 10xFucT-4xFucS-NOTCH3(40-2321) H2AFX miR-449C Fringe familyATP2A2 miR-449C EIF2C1 EIF2C3 NOTCH4(1337-2003) NOTCH2(1582-2471) 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) AGO2 18xFucT-FucS-NOTCH2(26-2471) B4GALT1 H2AFB1 MOV10 HIST1H2BN NOTCH1 mRNA miR-449B MOV10 EIF2C1 HIST1H2BM Fringe-modifiedNOTCHTFDP2 SIRT6NOTCH1 geneAGO2 Ack10-HIST1H3A HIST2H2AA3 H2AFV EIF2C4 MOV10 MAML2 12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) EIF2C4 NOTCH3 gene TNRC6B miR-34A AGO2 miR-150 CCND1 miR-34B Pre-NOTCH3 CMPmiR-34 RISCNOTCH4(1337-2003) Ack10-HIST2H3A HIST1H2BH CCND1:CREBBPNOTCH4 mRNA MAML3 NOTCH1 gene p-S68-ELF3LFNG NOTCHRBPJ HIST1H2BD MAML2 NOTCH4 mRNA:miR-302ARISCTNRC6B HIST1H2BJ Pre-NOTCH2H2BFS miR-206 TNRC6C MOV10 Nucleosome (H3K9ac)miR-206 RISCSignaling by NOTCH2MOV10 MOV10 EIF2C1 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCHMAML3 EIF2C4 MIR34B gene EIF2C4 EIF2C3 12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) Pre-NOTCH1 Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 HIST2H2BE MAMLD1 MAMLD1 FRINGE-modified NOTCH2 extracellular fragment (NECD2) EIF2C3 NOTCH1 mRNA NOTCH2(1582-2471) HIST1H2AB 17xFucT-2xFucS-NOTCH1(19-2555) NOTCH3 mRNA:miR-150RISCmiR-34A TNRC6A NOTCH4 gene Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 EIF2C3 HIST1H2BK EIF2C3 HIST3H2BB TNRC6C EIF2C3 TNRC6A TNRC6A H2AFZ miR-302A RISCEIF2C1 NOTCH4 mRNANOTCH4 gene MIR34C gene AGO2 TNRC6A NOTCH3 coactivatorcomplexPre-NOTCH4 miR-449 RISCmiR-449A NOTCH4(1337-2003) JUNHIST1H2BL SIRT6 TNRC6A Pre-NOTCHmiR-302A EIF2C4 miR-150 RISCSEL1LNOTCH3(1572-2321) E2F1/3:DP1/2TNRC6A HIST1H2AJ NOTCH4 mRNA:miR-181CRISCNOTCH1 mRNA,NOTCH4mRNA18xFucT-16xGlcS-FucS-NOTCH2(26-2471) EIF2C4 Glc,Fuc-Pre-NOTCHMAML1 FRINGE-modified NOTCH3 Extracellular fragment (NECD3) 1391228, 25, 28, 31, 32, 36...922, 4, 7, 13, 16...61479, 21, 49, 1353, 11, 12, 29, 56...14, 17, 19, 42, 51...512248