Signaling by ERBB2 (Homo sapiens)

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49, 52, 69, 72, 73, 94...67606010550, 11640, 53, 1026760607060991111528916038, 1286, 13, 12147, 50, 57, 76, 1161, 4, 29, 30, 42...2110, 66, 10690, 931038, 39, 12813, 66, 106, 11416, 40, 53, 122929189115, 878526, 8960555111059192plasma membranecytosolplasma membraneUBA52(1-76) CDC37 Active AKTNRAS ATPATPp-Y877-ERBB2 SHC1:PhosphorylatedERBB2 heterodimersp-6Y,Y1112-ERBB2 Phosphorylated p-6Y-ERBB2 heterodimers UBB(1-76) Ubp-7Y,Y1112-ERBB2 RPS27A(1-76) NRG2 Phosphorylated p-Y877-ERBB2 heterodimers SOS1 STUB1DAGs ADPPhosphorylated p-Y877-ERBB2 heterodimers UBC(229-304) NRG1 UBC(381-456) UBB(77-152) EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3KPhosphorylatedERBB2:ERBB3heterodimersERBB4 JM-A CYT-1 isoform PLCG1 p-S29,3Y-SHC1-2 ERBB3-1 ATPMATK p-7Y,Y1112-ERBB2 UBB(153-228) UBC(457-532) GRB2-1 UBB(77-152) NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3KEGF NRG1 UBB(1-76) p-10Y-ERBB3-1 DAG Phosphorylated p-Y877-ERBB2 heterodimers p-T566,T710,S729-PRKCE CDC37 Ca2+ UBC(77-152) ERBB2 UBC(153-228) ActivatedPRKCA(PRKCD,PRKCE)Phosphatidylserine UBB(1-76) UBC(305-380) RPS27A(1-76) ERBB2 UBC(533-608) ERBB3-1 UBC(229-304) Phosphorylated p-Y877-ERBB2 heterodimers UBC(533-608) EGF UBC(609-684) UBC(77-152) MEMO1 UBC(305-380) GRB7 ATPMyrG-p-Y426-YES1 RPS27A(1-76) GTP p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform ATPCUL5NRAS p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform Phosphorylated p-6Y-ERBB2 heterodimers UBC(305-380) active p-T507,S645,S664-PRKCD RHOA UBC(457-532) UBC(153-228) NRG1/2:ERBB3H2OUBC(381-456) ERBB3-1 RHOA UBC(77-152) PIP3 activates AKTsignalingp-6Y-EGFR Neuregulins GRB2-1 SOS1 p21 RAS:GTPUBC(1-76) p-Y,Y877-ERBB2 p-6Y,Y1112-ERBB2 UBC(609-684) EGF UBC(305-380) UBC(609-684) RNF41 Phosphorylatedp-6Y-ERBB2heterodimersNRG1 Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers NRG2 UBB(153-228) p-6Y-EGFR PIK3R1 Ub-ERBB3EGF:p-EGFR:p-ERBB2:GRB2:GAB1UBB(153-228) NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41p-7Y-ERBB2 UBA52(1-76) GDPUBC(533-608) PhosphorylatedERBB2:EGFRheterodimersUBC(381-456) UBC(77-152) UBA52(1-76) EGF:p-EGFR:p-ERBB2:PLCG1p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform CDC37 Phosphorylated p-6Y-ERBB2 heterodimers UBC(381-456) UBC(1-76) PIK3CA p-Y-ERBB2 PhosphorylatedERBB2:ERBB4cyt1heterodimersGAB1 PIK3CA GRB7UBC(77-152) UBC(77-152) RPS27A(1-76) UBC(77-152) NRG2 UBA52(1-76) RPS27A(1-76) Phosphorylated p-Y877-ERBB2 heterodimers UBC(1-76) p-6Y,Y1112-ERBB2 Ub-ERBB2:ERBB2IP:HSP90:CDC37Phosphorylated ERBB2:ERBB4cyt1 heterodimers UBC(153-228) Neuregulins PTPN12p-6Y,Y1112-ERBB2 PI(4,5)P2p-6Y-EGFR UBA52(1-76) UBC(77-152) Phosphorylated p-Y877-ERBB2 heterodimers GTP UBC(381-456) p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2p-6Y-ERBB2 PTK6 p-6Y-EGFR ERBB3-1 p-Y349,Y350,Y427-SHC1-1 EGF PTPN18 ADPUBB(77-152) Phosphorylatedp-Y877-ERBB2heterodimersUBC(1-76) UBB(1-76) pT497,T638,S657-PRKCA PTPN18 p-6Y-EGFR Heterodimers ofp-ERBB2dephosphorylated atY1248p-4Y-PLCG1HRAS ERBB4 JM-B CYT-1 isoform NRG1 p-S139,3Y-SHC1-1,p-S29,3Y-SHC1-2:PTPN12PTPN12 UBC(77-152) ADPUBA52(1-76) p-10Y-ERBB3-1 PhosphorylatedERBB2:ERBB4heterodimersATPMATKUBC(609-684) ADPp21 RAS:GDPGRB2-1 PTK6UBB(1-76) p-7Y,Y1112-ERBB2 PIK3CA UBC(381-456) NRG2 ERBB3:RNF41Neuregulins UBC(457-532) CDC37 NRG1/2NRG1 p-6Y,Y1112-ERBB2 UBC(609-684) Phosphorylated p-Y877-ERBB2 heterodimers p-T309,S474-AKT2 UBB(1-76) EGF UBA52(1-76) p-ERBB2heterodimers:MEMO1UBA52(1-76) p-7Y,Y1112-ERBB2 RPS27A(1-76) UBC(1-76) p-ERBB2heterodimers:PTK6NRG1 RNF41GRB2-1 ERBB2IP UBC(1-76) UBC(457-532) NRG1 ADPLigand-ActivatedEGFR/ERBB3/ERBB4ADPUBC(457-532) Signaling by PTK6EGF UBB(1-76) NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1ATPPip-6Y-EGFR UBC(609-684) PIK3CA:PIK3R1PhosphorylatedERBB2:EGFRheterodimers:PTPN18p-Y877-ERBB2heterodimersp-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 p-T305,S472-AKT3 GRB2:GAB1PIK3CA UBC(305-380) UBB(77-152) EGF UBB(1-76) Ub-RNF41EGFR UBC(381-456) NRG2 p-6Y-EGFR UBA52(1-76) ERBB2 NRG2 ERBB2IP PTPN18p-S29,3Y-SHC1-2 UBB(153-228) p-S139,3Y-SHC1-1 p-Y-ERBB2 UBB(153-228) NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7SOS1 p-Y,Y877-ERBB2 RPS27A(1-76) PIK3R1 UBC(229-304) p-10Y-ERBB3-1 HRAS Ub-RNF41:p-USP8UBB(77-152) p-T945-USP8Phosphorylated p-6Y-ERBB2 heterodimers UBC(533-608) UBA52(1-76) p-Y419/420/426-N-myristoyl-SRC/FYN/YES1UBC(305-380) UBC(381-456) Phosphorylated p-Y877-ERBB2 heterodimers p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform HSP90AA1 UBC(153-228) p-7Y-ERBB2 p-6Y-EGFR GRB2-1 EGF-like ligands ERBB3-1 Phosphorylated ERBB2:ERBB4cyt2 heterodimers UBB(153-228) RAF/MAP kinasecascadeKRAS NRG1 UBC(305-380) CDC37UBC(153-228) EGF:p-EGFR:p-ERBB2:GRB2:SOS1p-Y349,Y350-SHC1 EGFR GTP UBC(229-304) UBB(1-76) MEMO1 UBC(533-608) UBC(1-76) EGF p-Y239,Y240,Y317-SHC1-2 p-Y-ERBB2 SOS1 HSP90AA1 UBB(77-152) UBC(457-532) NRG1 p-Y342-PTK6NRG2 UBB(153-228) UBC(533-608) UBC(153-228) UBC(381-456) NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 ERBB2IPUBB(1-76) GRB2-1 Phosphorylated p-6Y-ERBB2 heterodimers UBC(153-228) UBB(77-152) p-T308,S473-AKT1 KRAS UBC(1-76) Phosphorylated p-6Y-ERBB2 heterodimers p-7Y,Y1112-ERBB2 p-Y,Y877-ERBB2 p-Y,Y877-ERBB2 UBC(77-152) UBC(153-228) NRG1/2:p-ERBB3:p-ERBB2:PI3KUBB(153-228) UBC(533-608) ERBB2 NRG2 NRG1 HSP90AA1 UBC(1-76) HSP90RPS27A(1-76) Phosphorylated ERBB2:ERBB4cyt2 heterodimers NRGs/EGFLs:ERBB4:ERBB2 PhosphorylatedERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18ERBB4 JM-A CYT-2 isoform p-6Y,Y1112-ERBB2 UBC(305-380) Phosphorylated p-6Y-ERBB2 heterodimers UBC(533-608) p-10Y-ERBB3-1 PIK3R1 UBC(305-380) p-Y,Y877-ERBB2 UBC(229-304) PIK3R1 ADPEGF RNF41 EGF-like ligands EGF ADPUBC(457-532) NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 DIAPH1 UBC(609-684) UBC(609-684) MyrG-p-Y419-SRC UBC(305-380) UBC(305-380) RNF41 p-Y349,Y350-SHC1 ERBB3-1 GRB2-1 NRG2 ATPGRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersPiERBB2:ERBB2IP:HSP90:CDC37UBC(609-684) UBC(457-532) RHO GTPases ActivateForminsUBB(153-228) UBC(533-608) DAG and IP3signalingGDP UBB(1-76) DIAPH1 p-Y,Y877-ERBB2 p-Y-ERBB2 UBB(153-228) UBC(1-76) Phosphorylated p-6Y-ERBB2 heterodimers p-ERBB2heterodimers:MEMO1:RHOA:GTP:DIAPH1MyrG-p-Y420-FYN p-10Y-ERBB3-1 p-6Y-ERBB2 H2OUbERBB2IP NRG2 UBC(229-304) ADPNRGs/EGFLs:ERBB4:p-Y877-ERBB2 UbERBB3-1UBC(229-304) PI(3,4,5)P3UBC(229-304) SHC1UBC(153-228) Phosphorylated ERBB2:ERBB4cyt1 heterodimers EGF-like ligands p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimersEGF UBC(381-456) ERBB2 heterodimersGTPp-7Y,Y1112-ERBB2 p-6Y-EGFR MEMO1p-Y1023,Y1139,Y1221,Y1222-ERBB2 UBC(457-532) Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers UBB(77-152) ATPp-3Y-SHC1-1,p-3Y-SHC1-2GAB1 UBB(153-228) UBC(533-608) NRG1 UBC(1-76) p-Y-ERBB2 RPS27A(1-76) UBC(229-304) ADPUbUBA52(1-76) p-6Y,Y1112-ERBB2 UBC(381-456) UBC(153-228) NRG2 UBC(533-608) GRB2-1:SOS1UBB(77-152) UBB(77-152) RNF41 RPS27A(1-76) p-10Y-ERBB3-1 UBC(77-152) p-T945-USP8 UBB(77-152) p-10Y-ERBB3-1 UBC(457-532) p-ERBB2heterodimers:MATKNRG1 UbUBC(153-228) Ub-ERBB2:ERBB2IP:Ub-HSP90:CDC37UBC(457-532) p-ERBB2 heterodimersNRG1/2:Ub-p-10Y-ERBB3:p-ERBB2EGFR UBC(229-304) ATPp-7Y,Y1112-ERBB2 p-S139,3Y-SHC1-1 UBC(609-684) PLCG1EGF RHOA:GTP:DIAPH1RPS27A(1-76) UBC(609-684) NRG2 SHC1 UBC(229-304) HSP90AA1 p-Y-ERBB2 USP8GAB1 40, 53, 1223, 14, 17, 18, 33...8, 23, 25, 31, 32, 35...534, 1232, 9, 12, 15, 19...4457, 45, 639280