MyD88-independent TLR4 cascade (Homo sapiens)

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5415, 38, 6435, 5929, 61, 66, 693, 6, 12, 19, 4619, 24, 28, 3525, 43, 4635495, 11, 13, 17, 52...25, 46, 5114, 30, 4917, 52, 53, 652, 339, 6432, 36, 394, 17, 34, 48, 52...503, 35, 563610, 32, 41, 53, 6026, 5324, 37, 4742, 4524, 47endosome lumencytosolnucleoplasmK63polyUb-RIPK1 TRIF:TRAM:TLR4:LY96:LPS:CD14RPS27A(1-76) TAB2 TICAM1 BIRC3 TICAM1 UBC(533-608) TLR4 activatedTLR4/TLR3:TRIF:K63-pUb-TRAF6:free K63-linked pUb:TAK1complexLPS TICAM1 TLR3 TLR3 TICAM1 TICAM1 K63polyUb-TRAF3 LY96 LPS K63pUb-TANK:K63pUb-TRAF3:TRIF:activated TLR3/TLR4UBC(609-684) MyrG-p-S16-TICAM2 TICAM1 UBC(229-304) TLR4 LY96 LY96 TLR3 UBC(381-456) TICAM1 LY96 TAB3 CASP8(217-374) p-S477,S479-IRF7 MyrG-p-S16-TICAM2 TLR4 LY96 TLR4 UBC(305-380) TAB1 IKBKB K63polyUb-TRAF3 LPS TICAM1 TICAM1 TLR3 RIPK1 viral dsRNA TAB1 p-S172-IKBKE GPIN-CD14(20-345) K63polyUb-TRAF3 MyrG-p-S16-TICAM2 IKBKG TRIF:activated TLR3/TLR4 IRF3,IRF7activatedTLR3/TLR4:TRIF:RIP1:FADD:pro-caspase-8GPIN-CD14(20-345) LPS TICAM1 RIPK1phosphorylated IRF3and/or IRF7 dimerGPIN-CD14(20-345) RIP3:TRIF:activatedTLR3/TLR4RIPK3 K63polyUbTICAM1 LY96 UBB(77-152) viral dsRNA UBC(457-532) TICAM1 TLR4 UBE2V1 LPS TRIF:activatedTLR3/TLR4GPIN-CD14(20-345) TICAM1 TLR3 viral dsRNA activatedTLR3/4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK-TBK1/p-IKKiRPS27A(1-76) UBC(229-304) UBC(153-228) LY96 UBC(533-608) FADD TANKUBC(609-684) UBE2N TLR4 MyrG-p-S16-TICAM2 TICAM1 TANK UBE2D3 activatedTLR3/4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7UBC(533-608) activatedTLR4/TLR3:TRIF:K63-pUb-RIP1:IKKcomplexUBC(77-152) GPIN-CD14(20-345) K63polyUb UbTLR3 TBK1 ADPTLR4 GPIN-CD14(20-345) K63polyUb-TRAF3:TRIF:activated TLR3/TLR4viral dsRNA TLR3 K63polyUb-TRAF6 activatedTLR4/TLR3:TRIF:K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complexGPIN-CD14(20-345) RPS27A(1-76) TLR3 TAB1 CHUK TAB1:TAB2,TAB3:TAK1UBA52(1-76) MyrG-p-S16-TICAM2 viral dsRNA :TLR3GPIN-CD14(20-345) MyrG-p-S16-TICAM2 TLR3 GPIN-CD14(20-345) TICAM1 SARM-1pUb-TRAF6:TAB1:TAB2/TAB3:free polyubiquitin chain : phospho-TAK1MyrG-p-S16-TICAM2 TICAM1TLR4 TLR4 MyrG-p-S16-TICAM2 LY96 K63polyUb-TRAF6 ADPTICAM1 IRF7 activatedTLR4/TLR3:TRIF:K63-pUb-TRAF6K63polyUb-TANK TLR3 TICAM1 UBC(533-608) RIP1:TRIF:activatedTLR3/TLR4p-4S,T404-IRF3 TLR3 TICAM1 p-4S,T404-IRF3 IRF3 GPIN-CD14(20-345) CASP8(1-479)LPS K63polyUb TLR3 UBB(1-76) TICAM1 UBC(457-532) UBC(1-76) GPIN-CD14(20-345) LPS TLR4 UBA52(1-76) p-S172-IKBKE TICAM1 MyrG-p-S16-TICAM2 TICAM1 TAB2 viral dsRNA TLR3 CASP8(1-479) viral dsRNA viral dsRNA LY96 UBB(1-76) p-S172-TBK1 IRF7 K63polyUb-TRAF6 TLR4 UBC(381-456) TICAM1 TLR4 LY96 UBC(305-380) UbTAB3 TICAM1 phosphorylated IRF3and/or IRF7 dimeractivatedTLR3/TLR4:TRIF:RIP1:FADDLPS MyrG-p-S16-TICAM2 LPS p-4S,T404-IRF3,p-S477,S479-IRF7UBB(1-76) UBC(229-304) RPS27A(1-76) GPIN-CD14(20-345) TLR3 UBB(153-228) MAP3K7 TAB1 UBC(457-532) LY96 CHUK:IKBKB:IKBKGATPUBC(77-152) LPS IRF3 UBA52(1-76) viral dsRNA TICAM1 TRAF6TLR4 IKBKG MyrG-p-S16-TICAM2 TAB2 LPS TICAM1 viral dsRNA TLR3 MyrG-p-S16-TICAM2 PTPN11LPS MyrG-p-S16-TICAM2 p-S477,S479-IRF7 UBB(77-152) viral dsRNA K63polyUb-TANK TLR4 MAP kinaseactivation in TLRcascadeTRAF6 viral dsRNA TICAM1 TICAM1 UBC(609-684) K63polyUb-RIPK1 LPS MyrG-p-S16-TICAM2 p-S477,S479-IRF7 LY96 TRAM:TLR4:LY96:LPS:CD14LY96 viral dsRNA UBC(153-228) MyrG-p-S16-TICAM2 IKBKE LY96 TRAF3 TICAM1 LPS TICAM1 IKK related kinasesTBK1/IKK epsilonTLR3 CHUK LY96 UBC(77-152) SARM:TRIF:activatedTLR3/TLR4UBC(1-76) CASP8(385-479) MyrG-p-S16-TICAM2 UBC(77-152) RIP1 ubiqutinligasesTICAM1 MyrG-p-S16-TICAM2 p-T184,T187-MAP3K7 p-4S,T404-IRF3 viral dsRNA K63polyUb-TANK TLR4 TANK:K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4RIPK1 UBE2D2 TICAM1 TAK1 activates NFkBby phosphorylationand activation ofIKKs complexviral dsRNA active caspase-8ADPTLR4 K63polyUb-TRAF6 GPIN-CD14(20-345) TRAF6LPS GPIN-CD14(20-345) LPS LY96 ATPK63polyUb-TRAF3 TICAM1 TICAM1 BIRC2 UBB(153-228) GPIN-CD14(20-345) UBB(1-76) viral dsRNA GPIN-CD14(20-345) viral dsRNA viral dsRNA TRIF:activatedTLR3/TLR4TICAM1 viral dsRNA TICAM1 UBC(153-228) GPIN-CD14(20-345) TLR3 UBC(1-76) TRAF3:TRIF:activatedTLR3/TLR4RIPK1 RIPK1 TICAM1 UBB(153-228) RIPK3TRAF6 LPS UBC(153-228) UBB(77-152) GPIN-CD14(20-345) UBC(229-304) TICAM1 UBC(305-380) MyrG-p-S16-TICAM2 TLR4 TICAM1 ATPGPIN-CD14(20-345) FADD TLR4 TICAM1 RIPK1 UBB(77-152) FADDLY96 activatedTLR4/TLR3:TRIF:TRAF6IKBKB p-T184,T187-MAP3K7 TLR4 TICAM1 LY96 TRAF3UBC(381-456) MAP3K7 activatedTLR4/TLR3:TRIF:K63-pUb-RIP1TLR3 GPIN-CD14(20-345) UBC(305-380) TAB3 MyrG-p-S16-TICAM2 UBC(1-76) LY96 MyrG-p-S16-TICAM2 K63polyUbLY96 UBB(153-228) K63polyUb viral dsRNA TAB2 Ubviral dsRNA LY96 SARM-1 LPS MyrG-p-S16-TICAM2 viral dsRNA TLR3 LPS p-S172-TBK1 TLR3 UBA52(1-76) UBC(609-684) LPS TAB3 K63polyUb-TRAF3 TLR4 UBC(381-456) UBC(457-532) TLR4 LPS TLR3 UBE2D1 viraldsRNA:TLR3:TRIFGPIN-CD14(20-345) 52, 5332, 3964506442, 4618, 625039, 42, 47, 63, 674732, 395026, 38, 5322, 26, 32, 53, 6746-48, 6326, 38, 538455026, 38, 5326, 33826, 52, 53, 5547227, 571, 21, 4420, 4023, 27, 31, 58816, 68