Glycosaminoglycan metabolism (Homo sapiens)

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60, 1163648, 97, 14254, 98, 126, 134, 1442474779, 136, 14083, 11228, 11116, 40, 66, 76, 78...1, 10, 21, 421329717, 23, 52, 1042, 20, 11995, 15126, 12163, 924710219, 64, 118, 15391, 11391, 11330, 55, 11012850, 6854, 98, 126, 134, 144107, 125, 14356, 61, 67, 77, 14949, 71, 108, 1141319672, 127, 1479, 11, 82, 8413, 18, 514612379, 136, 14050, 15243, 58, 70, 73, 75...5, 12, 8739, 115, 129731, 130, 145363, 59, 11725, 27, 10917, 23, 52, 1046514, 10383, 11217, 24, 52, 105, 1226, 13550, 152106, 12029, 33, 86, 88, 15415, 34, 69, 937495, 15157, 90, 139458, 32, 35, 44, 85...54, 98, 126, 134, 14414119, 64, 118, 15314, 1032, 20, 11913262, 993, 59, 11741, 1011235, 12, 872283, 11280, 12858, 70, 753, 59, 1173637, 533, 59, 1174, 137cytosolGolgi lumenGolgi lumenlysosomal lumenSDC3 GlcA-Gal-Gal-Xyl-HSPG2 PAPSKeratan(2)-PGGPC1 KS(2)-LUM HS(3)-GPC5 H2OHeparan(2)-SDC4 KS(2)-FMOD HS(6)-SDC1 KERA H2OGlcAHS(1)-SDC1 chondroitin(1)-DCN HS6STsGLB1 HS(2)-PGs HS(6)-GPC6 chondroitin(1)-NCAN PPiD2,4(S)2-PG CHST5 GlcA-Gal-Gal-Xyl-SDC4 UDP-GlcNAcNDSTsD4S-PGsHS(6)-SDC4 CHST3,7HS(4)-GPC3 HS(2)-PGsSO4(2-)CHST9,11,12,13HYAL1-like proteinsHeparan sulfatechain(7)GlcA-Gal-Gal-Xyl-VCAN H2OH2OChEBI:63519 chainD2,4(S)2-NCAN PAPSHS(5)-GPC5 STAB2(1136-2551) Keratan(4)-PGCEMIPGal-Xyl-GPC2 Heparan(2)-GPC5 PAPSKS(2)-ACAN HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+B4GALT4 ST3GAL3 GALNS oligomerHS(5)-HSPG2 Heparan(1)-GPC6 Heparan-HSPG2 Heparan-SDC4 Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-GalHS(6)-GPC3 CSPGsKS(1)-OGN GPC5(25-?) HS(2)-GPC6 HA polymerHS(6)-GPC3 H2OCHST2,5,6NDST4 LYVE1 B3GAT dimersGlcA-Gal-Gal-Xyl-BGN SLC9A1 HS(2)-GPC1 IDS dimerBCAN Heparan-SDC3 HEXB(122-311) CHST15GPC5(25-?) B3GALT6D4S-PGs CHST2 NCAN Keratan(3)-LUM UDP-GlcNAc Gal-glycan KERA H2ON-glycan OMD HS(2)-SDC4 C6S-BCAN CHST7 HS(1)-GPC3 KS(2)-KERA HARsGlcNAcHS(6)-GPC1 PAPSS1 Heparan(3)-PGsGUSB HS6ST2 Gal-Gal-Xyl-SDC3 PAPSO4(2-)HYAL1-like proteinsXylS-CSPG5 HS(1)-SDC3 HS/HPIN-PGsHS(6)-GPC5 Gal-GlcNAc(S)-Gal-GlcNAc(S)-GalHSPGsD4S-PGs GlcNAc(S)-Gal-GlcNAc(S)-GalCD44 ChEBI:63516 chainHS(6)-SDC2 XylS-BCAN CHST14Heparan(3)-SDC3 Keratan(3)-FMOD KS(2)-OGN PAPSS1,2GalHS(6)-GPC4 GPC1 IDUAGal-Gal-Xyl-GPC3 B3GAT1 D2,4(S)2-BGN H2OGLCEHYAL1 Heparan(4)-GPC4 B3GAT3 XylS-SDC2 HS3ST6 HS core proteinsPAPSKS(2)-OMD chondroitin(3)-DCN dermatan-core proteins HS(3)-PGs FMOD KS(2)-PRELP ST3GAL6 B3GNT3 KSPG(2)Heparan(3)-GPC5 UDP-GlcNAc, UDP-Glcchondroitin(3)-BCAN Gal-glycan FMOD D2,4(S)2-BCAN KS core proteinsBGALUDPaldehydo-L-iduronicacidUDPGPC3(25-?) ATPH+ST3GAL4 D2,4,4(S)3-BCAN XYLT2 chondroitin(2)-CSPG5 HS(6)-SDC1 SLC26A2 HGSNAT oligomerXylS-SDC3 XylS-GPC5(25-?) KS(2)-KERA DSEL SGSHKeratan(2)-FMOD UDP-GlcAKS(1)-LUM Heparan sulfatechain(3)GlcA-Gal-Gal-Xyl-HSproteinsB4GALT3 Heparan(1)-GPC3 H2OD2,4,4(S)3-NCAN HS(3)-HSPG2 HS(5)-SDC1 UDPSLC26A1 ABCC5Gal-Gal-Xyl-GPC5 KS(1)-OMD C6S-NCAN KS(2)-OMD HS(5)-SDC4 B4GALT1 Gal-Gal-Xyl-DCN DSE,DSEL substratesUDP-GalNAcHPSE dimerHS(5)-PGsHPSE(36-109) GalHS2ST1Gal-Gal-Xyl-SDC4 chondroitin(1)-coreproteinsC6S-PGC4S-VCAN Gal-Gal-Xyl-proteinsHS(3)-GPC3 HS(6)-GPC4 PAPUDP-Glc D2,4,4(S)3-PGs Chondroitin chainsB3GNT4 SDC1 C4S-PG Heparan(4)-GPC1 GlcA-β1,3-GlcNAcxylosyl-coreproteinsD2,4(S)2-DCN GlcA-Gal-Gal-Xyl-GPC6 L-AspCHSY3 Heparan(2)-SDC2 UDP-Glc KS(2)-OMD SDC4 Heparan sulfatechain(1)UDPD4S-NCAN Heparan-AGRN UDPKeratan(4)-FMOD HS(6)-GPC2 PAPSS2 HSPG2(22-4391) GPC6 SDC1 keratansulfate1,4-beta-D-galactosidaseXylS-GPC1 PAPHeparan(2)-PGsHS3STsulfotransferasesCD44 Heparan(3)-GPC4 GlcA-Gal-Gal-Xyl-SDC3 SLC9A1:p-CHP:Ca2+HS(6)-GPC5 SO4(2-)HMMR Mn2+ GPC2 ST3GAL1-4,6D4S-CSPG4 IDUAHS3ST4 GlcA-Gal-Gal-Xyl-CSPG4 Heparan(2)-GPC4 Heparan-GPC6 C4S-NCAN HA APSchondroitin(3)-NCAN Heparan(3)-SDC2 PAPSGlcA-Gal-Gal-Xyl-HSPG2 Gal-glycan OGN KS(1)-KERA Keratan(3)-OMD CSE-CSPG5 HS(2)-SDC1 HS(4)-GPC2 SDC2 Heparan chain(2)D2,4,4(S)3-PGs Keratan(3)-PRELP Gal-Xyl-GPC1 XylS-SDC4 DSPGsHS(5)-PGs HAS3 SLC26A1,2GPC1 GlcNAcAGRN(30-2045) SLC35B2 CS/HS precursorGal-Xyl-GPC5 HPSE(158-543) GlcA-Gal-Gal-Xyl-CSproteinsHeparan sulfatechain(4)CHST9-2 LYVE1 CHPF,CHSY1,CHSY3CHSY3 PAPHA N-glycan LUM B4GALT7DCN ChEBI:63515 chainHeparan(4)-SDC3 Heparan(2)-SDC1 LYVE1 Ac-CoAHeparan(3)-GPC1 D-xyloseHS3ST5 C4S-PGHeparan-GPC4 Heparan sulfatechain(6)D2,4(S)2-PG HS(3)-PGs HS(3)-PGsC6S-CSPG5 GlcNAc-Gal-GlcNAc(S)-GalSDC2 SO4(2-)GlcA-Gal-Gal-Xyl-DCN DCN chondroitin(1)-CSPG5 CHST6 Heparan(1)-PGsD2,4(S)2-CSPG4 CHPF2 KS(1)-FMOD GlcA-Gal-Gal-Xyl-SDC1 C4S-PGs Heparan chain(1)SLC35B2,3H2OD2,4,4(S)3-VCAN H2OKeratan(2)-KERA HS/HPIN-PGsSTAB2(1136-2551) Heparan(2)-AGRN HS(2)-AGRN HAS1,2,3Heparan(4)-SDC4 UDP-GlcNAc, UDP-GlcKeratan(1)-LUM CHPF HYAL3 Heparan sulfatechain(5)H2OGalNAcKSPG(2)UDPchondroitin(3)-CSPG4 UDPHeparan(1)-AGRN HEXA,BCSPGsC6S chain PAPSCSE-VCAN chondroitin(3)-coreproteinsGal-glycan ACAN HYAL3 CHST12 HS(6)-SDC2 KS(2)-OGN HS(6)-AGRN H2OCSGALNACT2 D4S-PGs PAPSChEBI:63517 chainHS(6)-HSPG2 Heparan(1)-SDC2 Keratan(4)-KERA HS(1)-GPC5 HS3ST5 chondroitin(3)-VCAN HS(5)-GPC3 Asparagine N-linkedglycosylationHeparan sulfatechain(2)Heparan-GPC1 Keratan(3)-KERA UDP-GalC4S/C6S chainsDSE,DSELNAGLU(59-743)Gal-Xyl-SDC4 Heparan(1)-SDC4 HS3ST3B1 GlcNAcGPC2 chondroitin(1)-CSPG4 Gal-Xyl-VCAN SO4(2-)D2,4,4(S)3-PGs Heparan-SDC1 GPC6 HS(3)-SDC4 uridine5'-monophosphateCHST14 substratesGLB1 UDP-GlcNAcHeparan-PGsD4S-BCAN HS(4)-PGs GlcA-b1,3-GlcNAcUDP-GalGlcA-Gal-Gal-Xyl-AGRN KS(2)-PRELP HS(3)-GPC1 H2OGal-Gal-Xyl-CSPG4 HS(6)-SDC4 Ca2+ C4S chain Heparan sulfatechainHeparan(2)-SDC3 Gal-Xyl-BGN HS(2)-SDC3 C4S-DCN SGSHC6S-CSPG4 H2OCa2+ CSPG4 GlcA-Gal-Gal-Xyl-GPC2 Gal-Gal-Xyl-SDC1 ST3GAL2 KS(2)-FMOD HS(6)-GPC2 Heparan-GPC2 XylS-SDC1 UDPGPC2 CHST1D2,4,4(S)3-PGsHeparan(4)-AGRN Heparan(4)-PGsD4S-VCAN D2,4,4(S)3-CSPG4 Keratan(4)-OGN SDC3 EXT1:EXT2Heparan(4)-GPC2 HS(4)-HSPG2 GAG core proteinsHS(4)-SDC1 SLC35D2HAHeparan(1)-GPC1 GlcA-Gal-Gal-Xyl-GPC2 Gal-glycan-proteinHS(5)-SDC2 HS(3)-SDC1 (HA)2Gal-Xyl-BCAN Gal-Xyl-GPC4 KS(2)-LUM GUSB tetramerCSPGsCSE-PG HS(6)-GPC6 B4GALT2 CHST3 NAGLU(59-743)KS(2)-KERA Heparan(1)-SDC1 HS(1)-PGsGlcA-Gal-Gal-Xyl-DCN UDP-GlcAHS(5)-GPC4 Heparan-SDC2 HS(3)-SDC2 GlcA-Gal-Gal-Xyl-GPC1 H2OUDP-XylHeparan(3)-SDC4 Keratan(3)-OGN CHST11 B4GAT1 HS(4)-SDC2 GPC5(25-?) HSPGsAGRN(30-2045) Heparan(2)-GPC6 HS(5)-PGs Keratan(4)-PRELP HS(6)-SDC4 Gal-Gal-Xyl-CSPG5 H2Ochondroitin(3)-CSPG5 Heparan(3)-GPC6 GLB1L chondroitin(2)-BCAN C4S-BCAN Gal-glycan OMD HS(4)-PGs HS3STsD2,4(S)2-PGs Heparan(3)-GPC3 IDS(34-455) CSE-PGC6S-PG Gal-Gal-Xyl-BCAN chondroitin(2)-DCN HS(2)-GPC2 Heparan(1)-GPC4 H2OHeparan(1)-HSPG2 C4S-CSPG5 KS(2)-PRELP HS(4)-GPC1 (HA)50HYAL2 CoA-SHXYLT1, XYLT2GlcA-Gal-Gal-Xyl-BCAN Heparan(2)-GPC3 Gal-Gal-Xyl-AGRN PRELP STAB2(1136-2551) SDC1 N-glycan PRELP GPC4 HS(4)-SDC4 HS(6)-HSPG2 UDP-GalNAcVCAN HS(5)-GPC2 C4S chain UDP-GlcAHS(3)-GPC6 HS(1)-PGs D2,4(S)2-PGs PAPSHS(3)-GPC2 GlcAB3GNT1,2,3,4,7SO4(2-)GlcA-b1,3-GlcNAcXylS-DCN Gal-Gal-Xyl-GPC2 HS(1)-SDC2 DSE,DSEL productsHS6ST1 Gal-glycan PRELP SDC3 HS(2)-SDC2 XYLT1 p-CHP1 Heparan(4)-GPC5 XylS-GPC2 GlcA-Gal-Gal-Xyl-GPC4 Ca2+ SO4(2-)Heparan-GPC3 HAS2 PAPAc-CoAUDP-GalCMPGal-Xyl-DCN HS(6)-AGRN XylS-GPC3(25-?) KS(2)-LUM chondroitin(1)-BGN D2,4,4(S)3-BGN GlcA-Gal-Gal-Xyl-SDC1 GlcA-Gal-Gal-Xyl-proteinsHS/HPIN-PGs GlcA-Gal-Gal-Xyl-VCAN EXT1 CSE-BCAN N-glycan FMOD XylS-HSPG2(22-4391) D4S-CSPG5 IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xylbeta-xylosidaseHS(6)-GPC6 HS(5)-SDC3 BGALCHEBI:63868 chainGal-Xyl-HSPG2 CSGALNACTHS(4)-GPC6 HMMR GlcA-Gal-Gal-Xyl-BCAN D2,4(S)2-VCAN Heparan(3)-GPC2 HS(6)-HSPG2 ACAN CHST13 CSE-NCAN D4S-DCN Ca2+ Heparan-GPC5 HSPG2(22-4391) GlcA-Gal-Gal-Xyl-GPC1 Gal-Gal-Xyl-GPC4 NDST3 HS(5)-AGRN GlcA-Gal-Gal-Xyl-GPC4 Keratan(2)-ACAN HS(6)-GPC2 UDPCSE-BGN HS3ST3A1 KS(1)-PRELP Heparan(1)-GPC5 H2OPAPSO4(2-)Keratan(1)-PGHeparan(4)-HSPG2 GPC4 N-glycan OGN Gal-Xyl-SDC2 Heparan(3)-HSPG2 Gal-Xyl-NCAN C4S-PG HYAL2 Keratan(4)-LUM GlcA-Gal-Gal-Xyl-GPC5 CSE-PG CSE-CSPG4 XylS-CSPG4 CHSY1 C4S-CSPG4 Gal-GlcNAc(S)-Galchondroitin(2)-VCAN HS(2)-HSPG2 HS(5)-GPC1 D4S-PGs Gal-Xyl-proteinsHS(1)-GPC4 D2,4(S)2-CSPG5 GlcNAcHS(1)-GPC1 UDPHS(4)-GPC4 Gal-Xyl-CSPG4 GlcA-Gal-Gal-Xyl-CSPG5 LUM Gal-Gal-Xyl-NCAN PAPGPC6 HAS1 BGN SDC2 KS(2)-OGN Keratan(1)-OMD CSPG4 HS(3)-GPC4 HEXB(315-556) ChEBI:63515 chain D2,4,4(S)3-PGs SDC4 KSPG(1)Heparan(2)-GPC1 H2OH2OGLB1L GlcA-Gal-Gal-Xyl-SDC2 HS(1)-HSPG2 Heparan(1)-SDC3 GPC3(25-?) ARSB:Ca2+AGRN(30-2045) XylS-VCAN p-CHP1 HS core proteinsKeratan(4)-OMD HSPG2(22-4391) HA:HAR:HYAL2Chondroitin chainKeratan(1)-FMOD Heparan(1)-GPC2 DSPGschondroitin(1)-BCAN GPC3(25-?) UDPHS6ST3 HS(2)-GPC5 GlcA-Gal-Gal-Xyl-NCAN CHPF C6S-DCN KS(2)-FMOD GlcA-Gal-Gal-Xyl-CSPG5 HS(5)-GPC6 BGN CSPG5 Heparan(2)-GPC2 HS(4)-AGRN Heparan(4)-GPC6 chondroitin(2)-coreproteinsKS(2)-ACAN UDP-GlcAGlcA-Gal-Gal-Xyl-AGRN HS(6)-SDC2 Keratan(1)-KERA XylS-BGN CSGALNACT1 D2,4,4(S)3-CSPG5 HEXA,BGlcA-Gal-Gal-Xyl-CSPG4 Gal-Xyl-SDC3 HEXA C6S-PGs GlcA-Gal-Gal-Xyl-BGN HEXB(122-311) Gal-Gal-Xyl-VCAN USTBCAN XylS-NCAN chondroitin(1)-VCAN Heparan(3)-SDC1 SDC4 HS(6)-GPC5 UDPchondroitin(3)-core proteins KS(1)-ACAN HS(2)-GPC4 HS(6)-SDC1 IDS(456-550) Keratan(1)-PRELP GlcA-Gal-Gal-Xyl-SDC4 H2OOMD Keratan(3)-PGGlcA-Gal-Gal-Xyl-GPC5 Gal-Gal-Xyl-GPC6 PAPUDPHS(3)-AGRN Gal-Gal-Xyl-HSPG2 Keratan(3)-ACAN Heparan(4)-SDC2 C6S-PG GlcA-Gal-Gal-Xyl-SDC2 B4GALT1-6 homodimerschondroitin(2)-BGN B3GNT7 HS(4)-PGsCMP-Neu5AcGlcA-Gal-Gal-Xyl-SDC3 B3GAT2 C6S chain Gal-Xyl-SDC1 XylS-AGRN(30-2045) XylS-GPC6 HS3ST2 NDST1 UDP-GalHPSE2(1-592)uridine5'-monophosphateUDP-GlcNAc XylS-GPC4 DSPGsGal-Gal-Xyl-GPC1 linker chain(2)N-glycan ACAN CSE-PGs PAPSATPHS(6)-SDC3 UDPB4GALT5 Gal-Xyl-GPC6 HS(1)-PGs HS(4)-SDC3 C4S-BGN SLC35B3 D4S-BGN Gal-glycan LUM D2,4,4(S)3-DCN D2,4(S)2-PGUDPST3GAL1 Heparan(2)-HSPG2 B3GNT2 H2OKeratan(2)-PRELP HS(6)-GPC4 CHSY1 CHPF,CHPF2,CHSY1,CHSY3HS(2)-PGs HS3ST1ADPGlcNAc-GlcA-GlcNAcCHST14 productsKSPG(2)Gal-Xyl-GPC3 OxA-ARSB (HA)50GPC4 PAPSN-glycan KERA H2ONCAN GlcAHEXB(315-556) PAPHS(6)-SDC3 HYAL1 H+HS(4)-GPC5 CD44 VCAN GlcA-Gal-Gal-Xyl-NCAN dermatan-core proteins HS/HPIN-PGs Keratan(2)-OGN HYAL2Gal-Xyl-AGRN Keratan(1)-ACAN HS(3)-SDC3 GlcA-Gal-Gal-Xyl-GPC3 H2OGlcA-Gal-Gal-Xyl-GPC3 HS(6)-SDC3 GlcA-Gal-Gal-Xyl-GPC6 C6S-BGN OxA-GNSchondroitin(2)-NCAN H2Ochondroitin(2)-CSPG4 HS3ST1 OGN HS(1)-AGRN Keratan(2)-OMD Heparan(3)-AGRN HS(1)-GPC6 Gal-Gal-Xyl-SDC2 CSPG5 CH3COO-Keratan(1)-OGN KS(2)-ACAN Heparan(4)-SDC1 HEXA GalNAcNDST2 HS(1)-SDC4 chondroitin(3)-BGN C4S-PG PAPSUDP-GalKeratan(2)-LUM B4GALT6 D4S-PGs SLC9A1 CSE-DCN Gal-Gal-Xyl-BGN Keratan(4)-ACAN HS(6)-AGRN HS/HPIN-PGsEXT2 CS/DS core proteinsHS(6)-GPC3 aldehydo-L-iduronicacidN-glycan-proteinUDP-GlcNAcHS(6)-GPC1 HS(1)-GPC2 Heparan(4)-GPC3 C6S-VCAN DSE Chondroitin chain HS(2)-GPC3 Gal-Xyl-CSPG5 PAPHMMR HS(6)-GPC1 CoA-SH38, 89, 138, 148