RAF/MAP kinase cascade (Homo sapiens)

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12, 26, 34, 45, 57...36, 94, 105, 116, 151...4, 12, 100, 117109, 130, 132, 139, 189...37, 53, 66, 76, 90...8, 30, 46, 70, 104...142, 177, 26368, 91, 26825, 143, 20950, 162, 19557, 72, 184, 19912, 223, 2545, 8, 104, 129, 161...45, 81142, 177, 250, 2637, 106, 132, 19910, 15, 18, 30, 33...132, 20712, 26, 27, 40, 63...77, 79, 82, 132, 27012, 223, 25425, 143, 20946, 76, 2218, 14, 23, 45, 50...95, 122, 131, 16746, 76, 22114, 23, 46, 132, 181...109, 130, 132, 139, 189...27, 46, 63, 7611, 12, 29, 42, 56...77, 79, 86142, 177, 2631, 62, 71, 14813, 14, 75, 108, 172...11, 12, 56, 99, 126...81, 13214826, 30, 41, 44, 114...135, 149, 24069, 102, 133, 137, 205...plasma membraneplasma membraneendosome lumenplasma membranenucleoplasmGolgi lumencytosolplasma membraneAPBB1IP KRAS ADPactivatedRAF:scaffold:p-2SMAP2K:MAPK complexWDR83:LAMTOR2:LAMTOR3IL17RD ATPp-5Y-RET p-S338,Y341,T491,S494,S621 RAF1 p-S311,Y552 KSR1 FGB p-S299,S302,T452,T455,S576 ARAF p-Y-SHC2 PSMF1 PHBp-S311,S406KSR1:MARK3MAPK3 p-S299,S302,T452,T455,S576 ARAF PI(4,5)P2 p-Y427-SHC1 ARTN Signaling by PDGFWDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexUBC(533-608) p-S299,S302,T452,T455,S576 ARAF PP2ASYNGAP1 MARK3 p-12Y-PDGFRB CNKSR2 MARK3 p-S311,Y552 KSR1 PPP2CA p-Y349,Y350-SHC1 KRAS Signaling by the BCell Receptor (BCR)HRAS p-S218,S222-MAP2K1 Ca2+ p-S338,Y341,T491,S494,S621 RAF1 H2OPSMD7 PAQR3 BRAP p-S445,S729-BRAF PSME4 MAP2K2 p-T,Y MAPK monomersand dimersFN1(32-2386) p-Y-IRS1 GRB2-1 p-S218,S222-MAP2K1 p-Y239,Y240,Y317-SHC1-2 YWHAB dephosphorylated"receiver" RAF/KSR1FGG NRAS p-S311,Y552 KSR1 p-7Y-ERBB2 NCAM signaling forneurite out-growthSignaling by FGFR1p-S445,T599,S602,S729 BRAF p-6Y-EGFR p-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 ITGA2B(32-1039) p-6Y-ERBB2 Signaling by InsulinreceptorCSK KSR2 DAP12 interactionsp-T202,Y204-MAPK3 p-S445,S729-BRAF H2OVWF(23-763) activated RAFhomo/heterodimerKRAS p-T,Y MAPK monomersand dimersHRAS p-T202,Y204-MAPK3 MARK3 KITLG-1(26-190) p-S445,T599,S602,S729 BRAF p21 RAS:GTP:BRAPp-2S MAP2Khomo/heterodimersp-8Y-FGFR1b PPP2R5E inactive RAFsp-S445,T599,S602,S729 BRAF p-8Y-FGFR1c MARK3 p-S222,S226-MAP2K2 p-5Y,S1119-TEK GTP MARK3 p-S338,Y341,T491,S494,S621 RAF1 p-S338,Y341,T491,S494,S621 RAF1 PSMB6 SPRED1 RAP1A CNKSR2 PSMD8 MAP2K1 ATPp-S222,S226-MAP2K2 p-S445,S729-BRAF NRAS PSMC5 BRAPp-T185,Y187-MAPK1 YWHAB ADPMARK3 FGF22 CALM1 UBC(77-152) GRIN2B p-S299,S302,T452,T455,S576 ARAF FN1(32-2386) p-5Y-LAT-2 FGF1 H2OActivated FGFR2c homodimer bound to FGF PSMA1 Signaling by ERBB4PPP5Cp-S365,S445,S729 BRAF FGF4 RAP1B NRAS AKAP9 p-S299,S302,T452,T455,S576 ARAF SPRED dimer:ub-NF1UBA52(1-76) cytosolic MAPK DUSPsPiUBC(305-380) p-S218,S222-MAP2K1 L-Glu p21RAS:GTP:dephosphorylated RAF1 homo/heterodimerHRAS PSMD12 CNKSR1 VCL p-S338,Y341,T491,S494,S621 RAF1 ACTN2 p-S445,T599,S602,S729 BRAF PSMB1 RASAL3 p-S311,S406KSR1:MARK3:YWHABdimerp-Y-SHC3 DAG p21 RAS:GDPp-S311,Y552 KSR1 CNKSR2 MARK3 SPTBN5 p-S259,S621-RAF1 DUSP16 ITGB3 KRAS p-6Y-FGFR3b p-S445,S729-BRAF ARRB1 Signaling by EGFRNRAS H2ODUSP9 RASA2 p21RAS:GTP:'activator'RAF:YWHAB dimerp-S338,Y341,T491,S494,S621 RAF1 p-S222,S226-MAP2K2 HRAS p-Y530-SRC p-2S MAP2K homo/heterodimers NRTN MARK3 KSR2 PSMC6 p-Y530-SRC VCL KSR1:MARK3p-S338,Y341,T491,S494,S621 RAF1 YWHAB RASGRF1 RAP1B p-S311,Y552 KSR1 nuclear MAPK DUSPsPEA15UBB(77-152) p-S311 KSR1 RAPGEF2 p-S214,S576 ARAF UBC(1-76) HRAS HS IL2RG F-actin CNKSR2 RASA3 APBB1IP p-S338,Y341,T491,S494,S621 RAF1 p-T,Y MAPK dimers p-S259,S621-RAF1 SPTAN1 NRAS NRAS KRAS MAP2K1 PDGFB(82-241) RASGEF1A ADPp-S445,T599,S602,S729 BRAF PSMD3 p-S311 KSR1 PiIQGAP1 p-5Y-FGFR4 GTP YWHAB p-S311,S406 KSR1 VWF(23-763) PSMC1 NRAS ADPPSMA2 p-S214,S576 ARAF CNKSR1 p-S218,S222-MAP2K1 HRAS FGF5-1 PPP2R5C Neuregulins ITGB3 GalNAc-T178-FGF23(25-251) p-S445,T599,S602,S729 BRAF MAPK3 IL17RD:p-2SMAP2Ks:MAPKsFGA p-S338,Y341,T491,S494,S621 RAF1 Phosphorylated p-Y877-ERBB2 heterodimers p-S222,S226-MAP2K2 ITGA2B(32-1039) LAMTOR2 Phosphorylated ERBB2:ERBB4cyt1 heterodimers HRAS DUSP5 JAK3 TLN1 p-S299,S302,T452,T455,S576 ARAF IL17RDp-T185,Y187-MAPK1 p21RAS:GTP:activatedRAF1homo/heterodimer:PEBP1ITGA2B(32-1039) p-Y530-SRC p-Y-IRS2 SPTBN1 PSMB7 ANGPT1 FGF18 SPRED3 MAPK3 UbGRIN1 p-S311,Y552 KSR1 UBC(457-532) Gly PSMA3 HBEGF(63-148) p-S299,S302,T452,T455,S576 ARAF PDGFA-1 UBB(77-152) Mg2+ RASA4 TLN1 KL-1 UBB(1-76) MARK3 YWHAB ub-BRAP CSK ARRB1 p-T185,Y187-MAPK1 NRAS PPP2R5A Interleukin-3, 5 andGM-CSF signalingp-S338,Y341,T491,S494,S621 RAF1 DUSP8 MAPKsp-S311 KSR1 p-S222,S226-MAP2K2 FGF8-1 GTP KRAS UBC(153-228) p-S218,S222-MAP2K1 Signaling by SCF-KITPSMD4 p-S445,T599,S602,S729 BRAF p-S311,Y552 KSR1 PiDUSP6 DUSP1 IQGAP1 p-S445,T599,S602,S729 BRAF dephosphorylatedinactive RAFS:YWHABdimerRAS GAPsp-S299,S302,T452,T455,S576 ARAF YWHAB IQGAP1 RPS27A(1-76) dephosphorylatedinactive RAFsFGG GTP p-7Y-KIT PSMB8 MAPK1 RASGRP1 High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 p-T,Y MAPKs ADPCNKSR1 SPRED dimer:NF1NRAS GDNF HRAS MAPK1 MAPK1 PPP2R5D GDPp-T,Y MAPKsGFRA1 PSMD10 MAPK1 YWHAB GTP MAP2K2 GTP ATPKSR1 FGF9 NRAS DUSP2 PSMA4 26S proteasomeUBC(305-380) YWHAB PAQR3NGF signalling viaTRKA from theplasma membranePSMD1 UBC(1-76) PSMA8 UBA52(1-76) SYNGAP1 MARK3 p-S338,Y341,T491,S494,S621 RAF1 CSK UBB(153-228) PSPN RASA1 KSR1 KRAS MAPK1 KL-2 p-S218,S222-MAP2K1 GTP NF1(2-2839) p-S445,T599,S602,S729 BRAF PPP2R5B KSR2 p-6Y-FGFR3c Mg2+ NCAM1 p-S445,T599,S602,S729 BRAF MAPK3 p-Y194,Y195,Y272-SHC1-1(156-583) p-S299,S302,T452,T455,S576 ARAF KLB p-6Y-PTK2 p-S621-RAF1 PAQR3:inactive RAFsMAPK1 p21RAS:GTP:activatedRAF1homo/heterodimerp-S445,T599,S602,S729 BRAF p-Y239,Y240,Y317-SHC1-2 MAPK3 RASAL1 p-T,Y MAPK monomersand dimers:PEA15WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complexADPKBTBD7 UbCUL3 WDR83 PSMC3 p-T202,Y204-MAPK3 Mn2+ p-S445,T599,S602,S729 BRAF p-S311 KSR1 MARK3 p21RAS:GTP:homo/heterodimerized RAF complexp-S576 ARAF IL2 PPP2CB PSMD5 RASA3 SPTA1 KBTBD7:CUL3:RBX1p-T,Y MAPK dimersPDGFA-2 PSMB2 GTP RASA2 FGF19 PPP2R1A LAMTOR2 p-Y349,Y350,Y427-SHC1 CNKSR1 p-ERBB4cyt1 homodimers UBC(609-684) PPP2R5B p-Y341,T491,S494,S621 RAF1 p-S445,S729-BRAF p-11Y-PDGFRA PEBP1 FGA UBB(153-228) NRAS DAB2IP APBB1IP p-S299,S302,T452,T455,S576 ARAF PSMB11 NRAS TLN1 SPRED3 hyperphosphorylatedBRAFDUSP4 GFRA4 HRAS SPRED3 p-S299,S302,T452,T455,S576 ARAF RAS GEFsp-T287-CAMK2B MAPK monomers anddimersPSMB10 Mn2+ RAP1A p-S338,Y341,T491,S494,S621 RAF1 FGF20 MARK3 p-S218,S222-MAP2K1 p-S445,T599,S602,S729 BRAF FGB p-S299,S302,T452,T455,S576 ARAF Ca2+ SPRED2 p-S445,T599,S602,S729 BRAF Signaling by FGFR4APBB1IP LAMTOR3 KRAS NRAS Fc epsilon receptor(FCERI) signalingp-S311 KSR1:MARK3PI(4,5)P2 PSME3 SPRED1 DUSP8 p21RAS:GTP:p-S621RAF1homo/heterodimerGTP p-Y364,Y418,Y536-IL2RB Ca2+ RAF/MAPK scaffoldsUBC(229-304) PPP2R1A GRIN2A Pip-S445,S729-BRAF UBC(381-456) FGF2(10-155) PI(4,5)P2 p-S299,S302,T452,T455,S576 ARAF p-S338,Y341,T491,S494,S621 RAF1 p-T133-RASGRP3 F-actin SOS1 PSMC2 p-S311,Y552 KSR1 FGB UBB(1-76) EGF-like ligands p-S299,S302,T452,T455,S576 ARAF HRAS GTP Ca2+ p-S311 KSR1 RASAL1 FGF23(25-251) RASGRF2 p-S338,Y341,T491,S494,S621 RAF1 GRIN2D HRAS p-S576 ARAF p-S311 KSR1 MAP2K2 p-S576 ARAF p-S299,S302,T452,T455,S576 ARAF NF1(2-2839) p-S445,T599,S602,S729 BRAF FGF17-1 YWHAB MAPK monomers anddimersMAPKs NRAS SPRED1 VCL H2OYWHAB p21 RAS:GTPARRB1 PSMD2 p-S299,S302,T452,T455,S576 ARAF HRAS SPRED2 Pip-Y419-SRC ATPKRAS p-S445,S729-BRAF p-S299,S302,T452,T455,S576 ARAF SPRED dimerWDR83 PSMD11 MAPK3 Interleukin-2signalingRASGRP4 p-S311,Y552 KSR1 KRAS p-S311,Y552 KSR1 KRAS Signaling by Type 1Insulin-like GrowthFactor 1 Receptor(IGF1R)PEBP1SPTBN4 FGB GTP p-S445,S729-BRAF p-S445,S729-BRAF p-T287-CAMK2D RASAL2 p-S311,Y552 KSR1 p-S621-RAF1 p-T287-CAMK2G VWF(23-763) YWHAB PSMB5 KRAS p-2S MAP2K1:p-2SMAPK2K2 heterodimerIL17RD:p-2SMAP2Ks:p-T,Y MAPKsPSMA7 Activated FGFR2b homodimer bound to FGF p-S259,S621-RAF1 p-S621-RAF1 VWF(23-763) GTP NRAS p-S621-RAF1 PPP2CB GTP SPRED2 NeurotransmitterReceptor BindingAnd DownstreamTransmission In The Postsynaptic CellARRB2 p-S445,T599,S602,S729 BRAF PSD-95 NF1(2-2839)PEA15 p-S299,S302,T452,T455,S576 ARAF GFRA2 RAP1B p-S338,Y341,T491,S494,S621 RAF1 PPP2R5A YWHAB ADPGTPEGF CSK p-S338,Y341,T491,S494,S621 RAF1PSME1 ITGA2B(32-1039) UBC(457-532) GTP FGF3 YWHAB F-actin Mg2+ p-2S,T MAP2K1:p-2SMAPK2K2 heterodimerp-T286-CAMK2A ARRB2 p-S621-RAF1 RASAL2 ATPYWHAB GTP MAPK3 p-S311,Y552 KSR1 Phosphorylated ERBB2:ERBB4cyt2 heterodimers PPP2R5E p-S338,Y341,T491,S494,S621 RAF1 ITGB3 p-5Y-FRS3 HRAS p-S222,S226-MAP2K2 H2OUBC(77-152) PPP2R5C LAMTOR2 KSR2 RASGRF2 RASA1 p-S222,S226-MAP2K2 p-S576 ARAF p-S445,T599,S602,S729 BRAF p-S365,S445,S729 BRAF PSMB4 FGF6 RASAL3 p-S338,Y341,T491,S494,S621 RAF1 DUSP7 HRAS PPP2R1B NRAS FGA ub-NF1(2-2839) p-S311KSR1:MARK3:YWHABdimerF-actin p-S445,S729-BRAF PPP2R5D FGG p-S311,Y552 KSR1 p-S311,Y552 KSR1 RAP1A p-S338,Y341,T491,S494,S621 RAF1 p-S299,S302,T452,T455,S576 ARAF GTP UBC(609-684) p-S311 KSR1 NF1(2-2839) FGF10 p-S445,S729-BRAF activatedRAF:scaffold:p-2SMAP2K:p-2T MAPKcomplexUBC(533-608) SPTBN2 p-S445,S729-BRAF PI(4,5)P2 p-Y530-SRC p-S338,Y341,T491,S494,S621 RAF1 PSMD6 PP2AMAP2K1 RAF activatingkinasesLAMTOR3 PPP2R1B Cell surfaceinteractions at thevascular wallFN1(32-2386) p-S445,S729-BRAF p-S445,T599,S602,S729 BRAFp-S299,S302,T452,T455,S576 ARAF p-Y-SHC1 ADPMg2+ ITGB3 BRAP p-S445,S729-BRAF IL2RA MAP3K11ARRB2 ARRB2 PDGFB SPTB p-S299,S302,T452,T455,S576 ARAF RASA4 GTP p-Y420-FYN KRAS FGF16 MARK3 p-S445,T599,S602,S729 BRAF Phosphorylated p-6Y-ERBB2 heterodimers p-S311,Y552 KSR1 PSMC4 PSMD13 YWHAB KRAS GRIN2C GFRA3 p21 RAS:GTP:ub-BRAPp-T,Y MAPK dimers DUSP10 RBX1 BRAP:KSR1:MARK3PSMD9 PSMA5 PSMD14 RAP1A hyperphosphorylatedRAF1p-S338,Y341,T491,S494,S621 RAF1 p-S445,S729-BRAF FGG p-S311 KSR1 p-S338,Y341,T491,S494,S621 RAF1 Ca2+ PSME2 ATPp21 RAS:GTP:RAS GAPsp-Y-JAK1 MARK3 PSMA6 GTP Mn2+ p-S365,S445,S729 BRAF PPP2CA RPS27A(1-76) p-S445,T599,S602,S729 BRAF p-T184-RASGRP1 p-S445,T599,S602,S729 BRAF Signaling by FGFR2p-S214,S576 ARAF p-T202,Y204-MAPK3 MAPK1 GDP p-T,Y MAPK dimers ATPYWHAB JAK2 HRAS WDR83 KRAS GTP p-S222,S226-MAP2K2 DUSP10 p-S311,S406 KSR1 p-S311,Y552 KSR1 p-T185,Y187-MAPK1 TLN1 KRAS activatedRAF:scaffold:MAP2K:MAPK complexPSMB9 DUSP16 LAMTOR3 IL17RD UBC(229-304) HRAS p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform p-T202,Y204-MAPK3 p-S,218, S222,T292 MAP2K1 p21RAS:GTP:activatedRAFhomo/heterodimercomplexesPTPRA YWHAB dimer'activator'RAF:YWHAB dimerUBC(381-456) YWHAB p-6Y-FRS2 p-T,Y MAPKs IQGAP1 UBC(153-228) inactive RAFs:YWHABdimerFGA p-S338,Y341,T491,S494,S621 RAF1 Mn2+ p21RAS:GTP:activatedRAFhomo/heterodimersATPRAP1B DAB2IP ARRB1 NEFL p-T,Y MAPKs PiMAP2Khomo/heterodimersPSMB3 p-T185,Y187-MAPK1 FN1(32-2386) Signaling by FGFR3p-S338,Y341,T491,S494,S621 RAF1 Signaling by ERBB2VCL 22, 38, 43, 55, 59...84, 136, 141, 2583, 6, 24, 35, 49...7732, 74, 112, 118, 163...47, 61, 78, 97, 15026619, 58, 144, 146, 160...15216, 21, 52, 168, 197...31, 121, 227, 246763, 6, 24, 35, 49...3, 6, 24, 35, 49...12788123, 2592199, 20, 65, 87, 229...119, 24828, 196, 202, 2602353, 6, 24, 35, 49...92, 138, 233772, 17, 39, 48, 51...