Signaling by NOTCH1 (Homo sapiens)

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2-11, 15-21, 23...11, 27, 8124, 645214, 40, 494, 7, 20, 35, 42...524639, 764, 7, 20, 35, 42...5, 18, 24, 6415, 576751575321, 46, 78, 849763, 6517, 71, 8016, 8263, 9326, 28, 31, 44, 5410, 50, 8619, 2366, 8326, 28, 31, 44, 54...362, 13, 48, 77, 94244, 7, 20, 35, 42...6897469, 41, 55, 69, 95619, 90, 912421, 46, 78, 8438, 70, 92cytosolnucleoplasmcytosolSignal sending cellSignal receiving cellDLL/JAG:NOTCH1HD+PEST DomainMutantsNICD1 UBC(533-608) UBC(153-228) HDAC11 UBC(609-684) DLL/JAG:NOTCH1 HDdomain mutantsUBC(77-152) NCOR1 DTX2 HEYL Gene NOTCH1HDdomainmutantfragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragmentsNOTCH1:NUMB:ITCHDTX1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML2 UBC(229-304) CREBBP UBB(153-228) HDAC2 HEY2 Gene NOTCH1 I1616T Extracellular Fragment p-NICD1 UBC(609-684) NOTCH1(1665-2555) NOTCH1(1665-2555) JAG1 CREBBP NOTCH1 CoactivatorComplex:CDK8:CCNCNICD1 RPS27A(1-76) KAT2B DLL1 RBPJ:SNW1MAML3 FBXW7gamma NOTCH1 I1616N Extracellular Fragment UBC(381-456) UBC(609-684) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RPS27A(1-76) DLL1 KAT2B UBB(77-152) JAG2 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBB(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBB(153-228) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) NUMBUBC(229-304) UBC(1-76) NOTCH1 L1574Q Extracellular Fragment DTX4 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RBX1 RBPJ DLL4 RPS27A(1-76) DTX2 NOTCH1 V1576E Extracellular Fragment MAML1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 I1680N S2 cleavage fragment UBC(77-152) NOTCH1 V1676D Transmembrane Fragment DTX1 UBB(77-152) NOTCH1 L1593P Extracellular Fragment NOTCH1 L1600P Extracellular Fragment UBC(609-684) MAMLD1 DLL4 UBC(1-76) TLE1 NUMB Zn2+ NOTCH1 CoactivatorComplex:HES5 GeneNICD1NOTCH1(1665-2555) NOTCH1 I1680N Transmembrane Fragment HDAC3 NCOR1 DTX1 MAML3 HEY2 UBC(153-228) SNW1 DTX1 KAT2A UBC(457-532) NOTCH1(1665-2555) HDAC7 NEXT1 Q2395* NOTCH1 F1592S Extracellular Fragment NOTCH1/Fringe-modified NOTCH1UbNOTCH1 I1680N Transmembrane Fragment DLL4 JAG2 UBC(153-228) NOTCH1(1665-1720) JAG1 MAML2 NOTCH1:DTXNOTCH1 L1574P Extracellular Fragment DLL4 MAML1 UBC(305-380) NOTCH1(1665-2555) TBL1XR1 NOTCH1:DLK1NOTCH1HES1 gene UBC(153-228) SKP1 DTX1 MAML1 UBC(1-76) UBC(305-380) DTX2 NOTCH1 I1616N Extracellular Fragment MAML1 NOTCH1(1665-2555) Ubiquitin ligaseUBA52(1-76) UBC(381-456) JAG2DTX4 NOTCH1 R1598P Extracellular Fragment NOTCH1 HD domain mutants DLL1FBXW7 DTX1 TLE1 SNW1 DTX2 DLL4:NOTCH1EP300 UBC(77-152) UBC(153-228) UBC(305-380) JAG1 RPS27A(1-76) UBB(153-228) RPS27A(1-76) HDAC5 NOTCH1 L1574Q Extracellular Fragment UBB(153-228) UBA52(1-76) NICD1UBC(153-228) UBC(229-304) KAT2A NOTCH1 I1616T Extracellular Fragment NOTCH1 R1598P Extracellular Fragment RPS27A(1-76) NEXT1MIB1 Signaling byTGF-beta ReceptorComplexHEY2 Gene NUMB PSEN2(1-297) MAMLMAML3 UBC(381-456) SNW1 MAMLD1 UBB(1-76) NOTCH1 I1616N Extracellular Fragment SNW1 DNER UBC(77-152) NOTCH1 Q2440* Transmembrane Fragment RBPJ UBC(77-152) NOTCH1 L1574P Extracellular Fragment NOTCH1(1665-2555) UBC(1-76) NOTCH1 I1680N Transmembrane Fragment UBC(1-76) MAMLD1 Ub-DLL/JAG:NOTCH1 HDdomain mutantsUBB(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) CREBBP NEXT1 P2474Afs*4 UBC(457-532) UBB(77-152) MAML2 DTX4 DLL4 UBB(77-152) UBC(1-76) HDAC8 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RPS27A(1-76) NOTCH1 V1576E Extracellular Fragment MIB2 NOTCH1 V1676D Transmembrane Fragment UBC(609-684) RBPJ UbHES1 geneRBPJ UBC(153-228) HIF1A ITCHARRB1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 I1718T S2 cleavage fragment NOTCH1 L1574Q Extracellular Fragment UBC(229-304) UBC(381-456) EP300 HES5 Gene UBC(229-304) NOTCH1/Fringe-modified NOTCH1DLL1 UBC(533-608) UBC(381-456) MAML1 NOTCH1 L1600P Extracellular Fragment UBC(533-608) DTX4 CNTN1NOTCH1 Q2395* Transmembrane Fragment UBC(457-532) Ub-DTX:ITCHHEYL Gene JAG2 UBA52(1-76) UBB(77-152) UBC(153-228) UBC(533-608) NOTCH1 Q2440* Transmembrane Fragment UBC(229-304) HES1:TLEHDAC8 DLK1 NOTCH1 HD+PEST Domain Mutant Fragments NOTCH1 V1676D Transmembrane Fragment Ub-DLL/JAG:NOTCH1fragmentNOTCH1 L1600P Extracellular Fragment DLL4 p-NICD1:FBXW7:SKP1:CUL1:RBX1UBA52(1-76) NOTCH1(1665-2555) NOTCH1UBC(77-152) UBC(77-152) Ub-NOTCH1:DTX:ARRBUBC(1-76) ARRB2 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) SNW1 CREBBP UBC(457-532) DLK1UBC(457-532) CUL1 HIF1AFRINGE-modified NOTCH1 Extracellular Fragment (NECD1) UBC(1-76) NEURL 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DTX4 UBC(77-152) ITCH KAT2B UBC(381-456) JAG1 UBC(609-684) NOTCH1(1665-2555) TBL1XR1 UBC(305-380) APH1A KAT2A HDAC1 UBB(77-152) NOTCH1 F1592S Extracellular Fragment ITCH MAMLD1 UBB(1-76) JAG1 UBB(153-228) NOTCH1 A1701P S2 cleavage fragment HDAC1 EP300 NOTCH1 Q2395* Transmembrane Fragment p-NICD1UBB(1-76) UBC(609-684) JAG2 DLL/JAGNOTCH1(1665-2555) MAML3 NOTCH1 L1596H Extracellular Fragment UBC(609-684) UBC(77-152) DLL4 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DNERUBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DLL1 SNW1 TLE4 TBL1X DTX4 NOTCH1 L1593P Extracellular Fragment UBB(153-228) FBXW7:SKP1:CUL1:RBX1UBC(305-380) JAG1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DTX1 UBC(533-608) UBA52(1-76) KAT2B DTX1 UBB(1-76) UBC(533-608) UBC(153-228) UBC(305-380) NOTCH1 L1600P Extracellular Fragment CUL1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DLL4 TLE2 UBC(457-532) UBC(153-228) NICD1 UBC(305-380) JAG1 NOTCH1(1665-2555) JAG1 UBC(229-304) MAML3 HDAC10 RPS27A(1-76) ADAM10 TLE3-3 RBX1 TLE3-3 NOTCH1 Q2440* Transmembrane Fragment UBC(305-380) NOTCH1HDdomainmutants/Ub-DLL/JAG:NOTCH1 HD domain mutantsUBC(1-76) EP300 UBC(305-380) UBB(1-76) KAT2B UBC(533-608) UBB(77-152) UBC(153-228) MAML1 SKP1 UBB(77-152) UBC(381-456) NOTCH1:DLL/JAGJAG2 UBB(153-228) DLL1 UBC(77-152) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HDAC6 UBB(153-228) NOTCH1 P2474Afs*4 Transmembrane Fragment NOTCH1 HD+PEST Domain Mutants MAML3 JAG2 NOTCH1:DTX:ARRBUBC(1-76) JAG2:NOTCH1JAG1 ITCH UBB(77-152) HDAC11 NICD1:HIF1ADTX4 NCSTN NOTCH1 L1596H Extracellular Fragment MAML1 DLL4 UBC(457-532) ITCHDLL4 CNTN1 UBC(609-684) EP300HEY GenesFBXW7 UBC(457-532) JAG2 UBB(153-228) UBC(305-380) RBPJ DLL1 NOTCH1 L1593P Extracellular Fragment UBC(77-152) UBA52(1-76) UBC(77-152) JAG1 TLE2 NOTCH1 L1574P Extracellular Fragment DTX4 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UbUBC(153-228) UBA52(1-76) UBB(153-228) JAG2 APH1B FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) HDAC4 DTX2 HDAC10 UBC(381-456) NOTCH1 R1598P Extracellular Fragment CCNC KAT2A DTX4 EP300 NOTCH1 L1593P Extracellular Fragment Ub-DLL/JAG:NOTCH1HD+PEST DomainMutantsNOTCH1(1665-2555) DTX2 DLL1 NCOR2 UBC(533-608) Ub-NOTCH1:NUMB:ITCHNEXT1 P2514Rfs*4 UBC(229-304) UbRBPJ:NCORcorepressor complexSNW1 DLL1 NOTCH1 L1600P Extracellular Fragment NOTCH1 L1600P Extracellular Fragment NOTCH1(1665-2555) gamma-secretasecomplexDTX1 ARRB1 UBC(305-380) UBC(305-380) UBC(229-304) HEYL ADAM17 JAG1UBC(533-608) DTX2 NOTCH1HD+PESTDomainMutantFragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant FragmentsNOTCH1 V1576E Extracellular Fragment DLL1 DLL4UBC(229-304) UBC(77-152) NOTCH1(1665-1720) NOTCH1(1665-2555) NICD1 NOTCH1(1665-2555) NOTCH1 L1574P Extracellular Fragment UBB(1-76) ITCH UBC(609-684) UBC(1-76) UBB(153-228) NOTCH1 I1616N Extracellular Fragment JAG1 NOTCH1 P2514Rfs*4 Transmembrane Fragment PSENEN NEURL1B DTX2 UBC(229-304) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) NOTCH1 CoactivatorComplex:HEY GenesUBC(381-456) CCNC 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBA52(1-76) UBC(153-228) NOTCH1 L1574P Extracellular Fragment NICD1:RBPJ:SNW1KAT2A UBC(229-304) UBA52(1-76) HEY1 Gene NOTCH1(1665-2555) UBB(77-152) DTX2 UBC(381-456) UBC(305-380) p-NICD1 HES1 UBC(77-152) UBC(457-532) JAG2 UBC(533-608) NOTCH1(1665-2555) Mitotic G1-G1/SphasesRPS27A(1-76) PCAFCDK8:CCNCNOTCH1 L1596H Extracellular Fragment RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DTX2 RPS27A(1-76) RBPJ DNER:NOTCH1:DTX19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 A1701P Transmembrane Fragment MYC geneNOTCH1 L1600P Extracellular Fragment KAT2B HDAC2 HES1UBB(1-76) UBB(77-152) UBC(1-76) HES5 GeneRBPJ NOTCH1(1665-2555) TLENOTCH1NOTCH1(1665-2555) UBA52(1-76) UBB(77-152) SNW1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NICD1 UBB(153-228) NOTCH1HD+PESTDomainMutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain MutantsUBB(1-76) NOTCH1 L1678P Transmembrane Fragment KAT2A UBC(1-76) UBB(1-76) ADPDLL1 HES5NOTCH1 F1592S Extracellular Fragment UBB(77-152) MAMLD1 DLL1 ARRB1 DLL1 NOTCH1NOTCH1 P2474Afs*4 Transmembrane Fragment NOTCH1 L1574P Extracellular Fragment ATPNOTCH1 I1718T Transmembrane Fragment UBC(1-76) NOTCH1(1665-2555) NOTCH1 A1701P Transmembrane Fragment DLL/JAG:NOTCH1RPS27A(1-76) UBC(381-456) UBC(533-608) DTX4 NICD1 UBC(609-684) UBC(457-532) HDAC3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) JAG2 NOTCH1 P2474Afs*4 Transmembrane Fragment KAT2A NOTCH1(1665-2555) UBC(457-532) NOTCH1 I1616T Extracellular Fragment MAML2 UBC(533-608) NICD1 UBC(305-380) UBB(1-76) CDK8 NOTCH1 L1678P Transmembrane Fragment NOTCH1 L1678P Transmembrane Fragment UBA52(1-76) UBC(229-304) MAML3 UBC(77-152) HEY1 UBC(533-608) ARRB2 UBB(77-152) TLE4 RBPJ MYC gene JAG1 NOTCH1(1665-2555) DTX:ITCH19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 CoactivatorComplex:MYC GeneSNW1 Pre-NOTCH Expressionand ProcessingUBC(457-532) UBB(153-228) UBB(1-76) NOTCH1(1665-2555) MAMLD1 UBC(153-228) HEYNOTCH1 L1600P Extracellular Fragment NOTCH1(1665-1720) NOTCH1 CoactivatorComplex:HES1 GeneNOTCH1 L1574P Extracellular Fragment NOTCH1 F1592S Extracellular Fragment NOTCH1 V1676D S2 cleavage fragment NOTCH1 P2514Rfs*4 Transmembrane Fragment DLL4 NOTCH1:DTXUBC(609-684) UBB(1-76) UBC(533-608) HDAC5 UBB(1-76) UBC(381-456) NOTCH1 I1718T Transmembrane Fragment HDAC7 UBA52(1-76) DLL4 CDK8 UBC(381-456) NOTCH1(1665-2555) HDAC4 TBL1X NOTCH1 V1576E Extracellular Fragment RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) FBXW7gamma UBC(153-228) NOTCH1(1665-2555) UBC(533-608) UBB(153-228) RPS27A(1-76) NOTCH1 L1574Q Extracellular Fragment DLL1 ARRBUbADAM10/17:Zn2+NEXT1 PEST domainmutants19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NICD1 RPS27A(1-76) UBC(609-684) JAG2 DLL4 UBC(77-152) UBC(305-380) UBC(229-304) UBC(457-532) Ub-DLL/JAG:NOTCH1UBC(457-532) UBC(457-532) UBC(1-76) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) JAG1:NOTCH1UBC(457-532) UBA52(1-76) UBA52(1-76) RBPJ NOTCH1(1665-2555) DTX1 NCOR:HDAC:TBL1RPS27A(1-76) UBC(1-76) MAML2 NOTCH1(1721-1753)19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBC(229-304) NEXT1 Q2440* UBB(1-76) CREBBP NOTCH1 HD domain mutant fragments UBC(381-456) UBC(609-684) UBB(1-76) DLL1 UBA52(1-76) JAG2 MAMLD1 ARRB2 DLL4 UBC(229-304) UBC(153-228) NICD1:DTXUBB(1-76) UBB(77-152) MAML2 CREBBPHDAC6 UBB(77-152) RPS27A(1-76) HEY1 Gene 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(533-608) UBC(381-456) UBC(229-304) UBC(381-456) UBC(305-380) NOTCH1 R1598P Extracellular Fragment UBC(1-76) NOTCH1 L1596H Extracellular Fragment UBB(77-152) UBC(457-532) HDAC9 MAML2 NOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1 CoactivatorComplexMYCUBA52(1-76) KAT2B FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) Ub-p-NICD1CNTN1:NOTCH1:DTXUBB(153-228) CREBBP UBC(609-684) NOTCH1 I1616T Extracellular Fragment UBC(381-456) JAG2 DTXNOTCH1 Q2395* Transmembrane Fragment UBC(153-228) NOTCH1 L1574P Extracellular Fragment NOTCH1 I1718T Transmembrane Fragment NOTCH1 L1678P S2 cleavage fragment JAG2 JAG1 EP300 NOTCH1 A1701P Transmembrane Fragment NICD1 MIB/NEURLNCOR2 JAG1 DLL1:NOTCH1UBB(153-228) UBC(77-152) NOTCH1HDAC9 UBA52(1-76) UBC(533-608) 7329, 8413124, 641111175241111112, 22, 25, 30, 32...