Signaling by NOTCH1 (Homo sapiens)

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1, 3, 5, 6, 10...12, 243, 38, 47, 7313, 35, 79, 102, 1033829, 78, 116803926451, 54, 1075, 14, 31, 71, 818038944416, 11832, 49, 64, 66, 67, 77...455918, 7530, 96, 11710, 596, 23, 27, 34, 4832, 49, 64, 66, 67, 77...2, 8883, 84399928, 52, 701185932, 49, 64, 66, 67, 77...2619, 69, 9230, 4310, 15, 33, 59912, 95995, 9, 14, 31, 71...3, 38, 47, 7350, 101, 104Signal receiving cellSignal sending cellcytosolcytosolnucleoplasmp-NICD1 UBB(153-228) NCOR1 UBC(229-304) NOTCH1 L1574P Extracellular Fragment DLL1 FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) DTX2 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment DLL4 NOTCH1(1665-2555) NOTCH1(1665-2555) ATPDTX4 DLL1 NOTCH1 I1616N Extracellular Fragment UBB(153-228) HDAC9 HIF1AKAT2B UBC(457-532) SNW1 UBC(381-456) UBC(381-456) UBB(153-228) CNTN1UBC(77-152) UBC(1-76) APH1B NOTCH1 I1718T Transmembrane Fragment DTX1 NICD1 NCOR2 UBC(381-456) RBPJ NOTCH1 P2474Afs*4 Transmembrane Fragment JAG2:NOTCH1NOTCH1 Q2440* Transmembrane Fragment UBC(381-456) JAG1 FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) UBB(1-76) ITCH NOTCH1 L1600P Extracellular Fragment DLL/JAG:NOTCH1CDK8:CCNCUBC(533-608) UBC(305-380) DTX2 UBB(1-76) UBC(533-608) ARRB1 UBC(533-608) RPS27A(1-76) DTX1 ARRBDLL1 ADAM17 MAMLJAG1 NCOR1 NOTCH1 L1596H Extracellular Fragment DLL1 NEXT1 Q2395* NOTCH1UBA52(1-76) NOTCH1 P2514Rfs*4 Transmembrane Fragment TBL1XR1 DLL4 DLL/JAG:NOTCH1 HDdomain mutantsUBB(77-152) NOTCH1 L1574P Extracellular Fragment UBC(229-304) NOTCH1 I1616T Extracellular Fragment RPS27A(1-76) NOTCH1 A1701P Transmembrane Fragment NOTCH1(1665-2555) UBB(1-76) DLL1 UBB(1-76) NOTCH1(1665-2555) DLL1 UBB(1-76) NOTCH1(1665-2555) JAG1 UBC(457-532) UBC(457-532) TBL1XR1 NOTCH1(1665-2555) UBC(1-76) MAML3 NOTCH1(1665-2555) DTXNOTCH1 R1598P Extracellular Fragment NOTCH1:DLK119xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) Ub-DLL/JAG:NOTCH1HD+PEST DomainMutantsNOTCH1DLL4 DLL/JAG:NOTCH1HD+PEST DomainMutantsNOTCH1 V1676D Transmembrane Fragment UBB(1-76) UBB(1-76) DTX1 UBC(153-228) NCOR2 UBB(1-76) UBC(609-684) NOTCH1(1665-2555) NOTCH1 P2474Afs*4 Transmembrane Fragment NUMB HDAC1 DTX4 TBL1X UBC(229-304) NOTCH1 L1574Q Extracellular Fragment UBC(77-152) HIF1A UBB(153-228) NEXT1 P2514Rfs*4 UBC(1-76) NOTCH1 L1678P Transmembrane Fragment FBXW7gamma DTX2 UBB(1-76) HES1:TLEMAMLD1 NOTCH1 L1596H Extracellular Fragment UBC(381-456) DTX4 DTX2 NOTCH1 L1574Q Extracellular Fragment MYC geneHES5NOTCH1 HD+PEST Domain Mutant Fragments 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) CUL1 UBC(609-684) NOTCH1 R1598P Extracellular Fragment NICD1 NOTCH1 CoactivatorComplex:CDK8:CCNCJAG2 NOTCH1 I1680N Transmembrane Fragment NEXT1 PEST domainmutantsMAML2 NOTCH1 F1592S Extracellular Fragment CCNC HDAC5 KAT2B UBC(381-456) DTX2 NICD1:DTXTLE2 HDAC8 Ub-NOTCH1:DTX:ARRBUBC(381-456) NOTCH1 Q2395* Transmembrane Fragment DTX1 HES5 gene NOTCH1(1665-2555) NOTCH1 HD domain mutants NOTCH1 I1616T Extracellular Fragment NOTCH1 L1596H Extracellular Fragment UBC(77-152) UBC(381-456) NOTCH1(1665-2555) UBA52(1-76) UBC(457-532) NOTCH1 I1616N Extracellular Fragment KAT2A SNW1 RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(1-76) UBC(457-532) DLL4 RPS27A(1-76) ITCHRBPJ MAMLD1 SKP1 MAMLD1 UBC(457-532) UBC(229-304) UBC(229-304) DLL4 MAML1 TLE3-3 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML1 JAG2 HDAC5 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 R1598P Extracellular Fragment SNW1 NOTCH1(1665-2555) RPS27A(1-76) UBC(153-228) HDAC9 UBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RPS27A(1-76) PSEN1(299-467) KAT2A UBC(229-304) UBB(77-152) NOTCH1 A1701P Transmembrane Fragment UBC(533-608) JAG1 ITCHUBB(77-152) UBC(609-684) ARRB1 UBC(381-456) UBC(1-76) TLE2 Pre-NOTCH Expressionand ProcessingTLE3-3 NOTCH1(1721-1753)DTX1 NOTCH1UBC(609-684) UBB(77-152) UBA52(1-76) UBC(609-684) NOTCH1 L1574P Extracellular Fragment NOTCH1 Q2440* Transmembrane Fragment UBB(77-152) NCOR:HDAC:TBL1UBC(305-380) NOTCH1 I1718T S2 cleavage fragment MAML1 UBB(77-152) DTX2 KAT2A DLL4 UBC(229-304) DLL1 UBC(533-608) HEY1 UBC(77-152) DLL1 DTX4 HEY2 NOTCH1 L1600P Extracellular Fragment RPS27A(1-76) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) HDAC6 UBB(153-228) UBC(153-228) PSEN1(1-298) UBC(609-684) UBC(229-304) UBB(77-152) UBB(153-228) KAT2B KAT2A TLE4 UBC(229-304) JAG1 gamma-secretasecomplexUBA52(1-76) UBC(77-152) CDK8 NOTCH1(1665-2555) UBC(533-608) HDAC2 ITCH HEY1 gene UBC(609-684) HDAC10 UBB(153-228) TLE1 UBB(1-76) NOTCH1 I1616T Extracellular Fragment ARRB2 RPS27A(1-76) UBB(77-152) UBC(77-152) ITCH NOTCH1UBB(77-152) CREBBP MIB2 SNW1 UBB(1-76) HES5 geneUbNICD1:RBPJ:SNW1ARRB1 UBC(153-228) NOTCH1(1665-2555) UBC(229-304) MAML2 JAG1 JAG2 UBB(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML3 MAML1 DLL1NOTCH1 L1593P Extracellular Fragment DLL1 MIB/NEURLUBC(153-228) HEY1 gene UBA52(1-76) FBXW7alpha UBC(381-456) NUMB NOTCH1:DLL/JAGUBC(609-684) MAMLD1 UBB(77-152) JAG1 JAG2 HDAC8 Ub-NOTCH1:NUMB:ITCHKAT2A UBC(457-532) DTX:ITCHNOTCH1(1665-2555) NOTCH1HDdomainmutants/Ub-DLL/JAG:NOTCH1 HD domain mutantsUBC(609-684) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) Ub-DLL/JAG:NOTCH1fragmentUBC(457-532) CNTN1:NOTCH1:DTXJAG1 UBC(305-380) CUL1 NOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1 CoactivatorComplexUBC(1-76) RBPJ UBC(305-380) CREBBP UBC(457-532) Ub-p-NICD1NOTCH1:DTX:ARRBTLE4 CREBBP UBC(1-76) Mitotic G1-G1/SphasesJAG1 Ub-DTX:ITCHHDAC1 NOTCH1 P2514Rfs*4 Transmembrane Fragment NOTCH1 V1576E Extracellular Fragment UBC(305-380) DLL1 UBB(77-152) DLL4 DLL4 JAG1 JAG2 UBC(1-76) UBC(457-532) NOTCH1 L1600P Extracellular Fragment ITCH JAG1 NOTCH1:DTXPSEN2(1-297) MAML1 CREBBP FBXW7:SKP1:CUL1:RBX1UBC(1-76) UbDLL4 NOTCH1(1665-2555) UBC(153-228) NOTCH1HD+PESTDomainMutantFragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant FragmentsRPS27A(1-76) JAG1:NOTCH1MAML2 MAMLD1 NEURL NOTCH1 L1678P Transmembrane Fragment NOTCH1 CoactivatorComplex:HEY GenesFRINGE-modified NOTCH1 Extracellular Fragment (NECD1) HES1 UBB(1-76) HDAC3 MAML1 NOTCH1 I1680N Transmembrane Fragment NOTCH1 CoactivatorComplex:MYC Gene19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(153-228) UBC(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NICD1 MAML2 UBC(77-152) NOTCH1 L1574Q Extracellular Fragment MAMLD1 EP300ADAM10/17:Zn2+Ub-DLL/JAG:NOTCH1UBC(153-228) UBB(153-228) UBC(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1HDdomainmutantfragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragmentsNOTCH1(1665-2555) EP300 HDAC6 NCSTN UBC(609-684) MAML3 NOTCH1 F1592S Extracellular Fragment UBC(153-228) RBPJ NOTCH1(1665-2555) HDAC3 DTX1 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1t(7;9)(NOTCH1:M1580_K2555)MAML1 SNW1 UBC(305-380) NOTCH1:DTXUBB(1-76) UBC(77-152) UBA52(1-76) RBX1 UBC(609-684) ADAM10 EP300 UBC(457-532) DTX4 NOTCH1 I1718T Transmembrane Fragment NICD1 UBC(305-380) MAML2 UBA52(1-76) FBXW7gamma JAG2 ARRB2 UBB(77-152) MAML2 JAG2 UBC(1-76) KAT2B RPS27A(1-76) NOTCH1(1665-2555) JAG1 TBL1X DNER:NOTCH1:DTXJAG2 NOTCH1 L1600P Extracellular Fragment DLL4:NOTCH1Ubiquitin ligaseUBB(77-152) UBB(77-152) HEY2 gene p-NICD1:FBXW7:SKP1:CUL1:RBX1NOTCH1 R1598P Extracellular Fragment UBC(229-304) PSENEN MAMLD1 UBC(153-228) NOTCH1:NUMB:ITCHUBC(457-532) NOTCH1 F1592S Extracellular Fragment DTX4 NOTCH1 L1574P Extracellular Fragment MIB1 NOTCH1(1665-1720) DNER 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) KAT2A UBB(153-228) UBC(153-228) NOTCH1 L1600P Extracellular Fragment CNTN1 DLL4 DLL4 MYCNICD1 RPS27A(1-76) UBC(533-608) NOTCH1 V1576E Extracellular Fragment 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 L1600P Extracellular Fragment NOTCH1(1665-2555) UBC(457-532) UBC(381-456) RPS27A(1-76) NOTCH1(1665-1720) UBB(1-76) CREBBP DTX1 JAG1 TLEUBB(1-76) UBC(381-456) UBC(381-456) JAG2 Signaling byTGF-beta ReceptorComplexHEYHES1 geneUBC(305-380) NOTCH1(1665-2555) DTX1 HES1 gene NOTCH1 L1678P S2 cleavage fragment HDAC2 CREBBPHDAC7 UBC(153-228) UBC(381-456) NOTCH1 L1593P Extracellular Fragment UbUBC(609-684) UBC(533-608) RBPJ APH1A CREBBP UBA52(1-76) NOTCH1t(7;9)(NOTCH1:M1580_K2555) fragmentNOTCH1 I1680N S2 cleavage fragment NUMBSNW1 UBB(153-228) UBC(533-608) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(609-684) UBC(77-152) NOTCH1 CoactivatorComplex:HES5 GeneUBC(229-304) NOTCH1 A1701P Transmembrane Fragment RBPJ:NCORcorepressor complexUBC(381-456) NOTCH1(1665-2555) Zn2+ DTX4 NOTCH1 L1574P Extracellular Fragment p-NICD1NOTCH1 CoactivatorComplex:HES1 GeneJAG2 UBC(229-304) DTX1 NOTCH1(1665-2555) UBC(305-380) JAG1NICD1 UBC(305-380) NOTCH1 I1680N Transmembrane Fragment HEYL Gene KAT2B FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) KAT2B UBC(533-608) UBB(153-228) DLK1UBC(609-684) MYC gene KAT2B UBC(1-76) UBA52(1-76) NOTCH1 Q2440* Transmembrane Fragment NOTCH1 V1676D S2 cleavage fragment RPS27A(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NEXT1 P2474Afs*4 HEY2 gene 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HDAC11 NOTCH1(1665-1720) UBB(1-76) RBPJ NOTCH1/Fringe-modified NOTCH1UBA52(1-76) NOTCH1 I1718T Transmembrane Fragment JAG2UBC(533-608) UBC(229-304) NOTCH1 Q2395* Transmembrane Fragment UBC(305-380) DLK1 UBB(153-228) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) NOTCH1 A1701P S2 cleavage fragment UBC(533-608) JAG1 UBC(305-380) NOTCH1UBC(1-76) KAT2A HES1JAG2 UBC(533-608) UBA52(1-76) NOTCH1 L1593P Extracellular Fragment UBC(457-532) UBC(153-228) UBC(381-456) RBPJ HEYL UBC(305-380) UBC(533-608) HEYL Gene NOTCH1(1665-2555) NOTCH1 L1574P Extracellular Fragment NEURL1B UBB(153-228) UBC(153-228) UBC(229-304) NEXT1 Q2440* JAG2 EP300 NICD1UBA52(1-76) UBC(457-532) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) HEY GenesNOTCH1HD+PESTDomainMutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain MutantsFBXW7alpha EP300 NOTCH1 L1600P Extracellular Fragment UBC(153-228) UBB(77-152) NOTCH1 L1574P Extracellular Fragment NICD1:HIF1ANOTCH1 L1574P Extracellular Fragment UBC(77-152) NOTCH1 Q2395* Transmembrane Fragment ARRB2 UBC(77-152) NOTCH1 L1593P Extracellular Fragment UBC(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) MAML2 UBC(609-684) NOTCH1 V1576E Extracellular Fragment RBPJ HDAC11 DTX1 UBC(381-456) UBA52(1-76) UBA52(1-76) UBC(77-152) UBC(229-304) DLL1:NOTCH1CCNC NOTCH1 L1600P Extracellular Fragment NOTCH1 V1576E Extracellular Fragment UBB(153-228) NOTCH1 V1676D Transmembrane Fragment UBC(305-380) PCAFJAG2 NOTCH1/Fringe-modified NOTCH1DLL1 UBC(153-228) NICD1 NOTCH1 L1574Q Extracellular Fragment DLL419xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) UBA52(1-76) HDAC4 UBC(77-152) TLE1 NOTCH1 L1678P Transmembrane Fragment DLL4 NOTCH1 I1616N Extracellular Fragment UBC(457-532) SNW1 DNERSKP1 HDAC7 HDAC4 MAML3 RPS27A(1-76) DLL4 NOTCH1(1665-1720) DTX2 UBA52(1-76) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(77-152) DLL/JAGUBC(1-76) DTX4 NOTCH1 V1676D Transmembrane Fragment NOTCH1(1665-2555) UBC(305-380) NOTCH1(1665-2555) NOTCH1 HD domain mutant fragments NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment HDAC10 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) RBX1 RPS27A(1-76) NOTCH1 F1592S Extracellular Fragment MAML3 UBC(457-532) NOTCH1 P2474Afs*4 Transmembrane Fragment NICD1Ub-DLL/JAG:NOTCH1 HDdomain mutantsRPS27A(1-76) UBC(1-76) RPS27A(1-76) DTX2 NICD1 MAML3 NOTCH1(1665-2555) UBB(77-152) UBB(77-152) UBB(1-76) UBC(229-304) NOTCH1 I1616N Extracellular Fragment UBC(77-152) UBC(77-152) UbUbNEXT1SNW1 p-NICD1 JAG2 UBB(153-228) DLL1 DLL1 NOTCH1 I1616T Extracellular Fragment EP300 DTX2 EP300 UBB(153-228) DTX2 DTX4 UBC(609-684) RBPJ UBC(305-380) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) UBC(533-608) UBC(533-608) NICD1 PSEN2(298-448) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) DTX4 NOTCH1(1665-2555) ADPNOTCH1 HD+PEST Domain Mutants SNW1 RBPJ:SNW1NOTCH1 L1596H Extracellular Fragment UBC(609-684) CDK8 UBA52(1-76) DLL1 DLL4 UBC(533-608) MAML3 UBC(1-76) 80442121442110, 5959214421217, 11, 17, 22, 37...4, 8, 20, 25, 41...21212121362121973, 11599