Influenza Life Cycle (Homo sapiens)

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63815, 19, 20, 57, 74763, 821, 30, 68, 804920, 53, 67, 8435, 75, 83, 8933, 44, 47, 8521, 53, 60, 84489511, 6551, 806432, 46, 879410, 37, 56, 78121158118114, 83, 88, 8955, 69928, 16, 18, 22, 26...275929, 9023, 9371, 7213, 39, 63, 70, 7361, 66, 715252417, 43, 52465, 80, 867, 15, 24, 912, 9625, 33, 365249, 2879nucleoplasmcytosolGolgi membraneendocytic vesicle membraneendoplasmic reticulum membranePA cRNPM1 PB2 Genomic RNA Segment 7 Influenza A ViralEnvelope InsertedInto The EndocyticVesicle MembranePOM121 RPL35A Genomic RNA Segment 4 P1 mRNA RNAPolymeraseII(phosphorylated):TFIIF:capped pre-mRNAInitiated vRNA-cRNAComplexGenomic RNA Segment 8 Genomic RNA Segment 5 NS1 mRNA Genomic RNA Segment 5 HAGenomic RNA Segment 4 ATP M1 RPS18 PA HA2 Segment 7 RNPH+Genomic RNA Segment 7 H+ Genomic RNA Segment 5 NUP93 vRNP:M1:NEP:NPNPviral mRNARibonucleoprotein(RNP) ComplexUTP vRNA (Genomic):NPComplexGenomic RNA Segment 8 NUP160 Genomic RNA Segment 4 Genomic RNA Segment 3 vRNA (Genomic):NPComplexM2 TetramerGenomic RNA Segment 8 PB1 CLTA RPL8 PB2 palmitylated M2 PB1 mRNAGenomic RNA Segment 6 NUP54 Influenza cRNA (complete) Segment 8 RNPSEH1L-2 XPO1 NUPL2 NP:Lipid RaftRPS21 PA RPLP1 NUP98-5 NDC1 RPL36AL NUP214 NEP/NS2 P1 mRNA NUP155 NUP93 Genomic RNA Segment 3 RPS27L NPGenomic RNA Segment 5 RPL13A POLR2K RPS19 NUP188 NUP35 Genomic RNA Segment 2 PB1 Genomic RNA Segment 6 HA folded, glycosylated, and palmitylated UTP Genomic RNA Segment 3 Genomic RNA Segment 6 Genomic RNA Segment 1 Glycosylated NA Genomic RNA Segment 7 NP NUP205 Genomic RNA Segment 8 Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol M1 mRNA HA1 NEP/NS2 Genomic RNA Segment 1 Genomic RNA Segment 6 Genomic RNA Segment 1 Genomic RNA Segment 8 Glycosylated NA NP Genomic RNA Segment 5 vRNP:M1:NEPNPGenomic RNA Segment 7 POLR2I M2 Genomic RNA Segment 3 RPL27 NUP153 Glycosylated NATetramerNA RPS8 POLR2J NP Genomic RNA Segment 4 RPL13 NP mRNA NS1 mRNA PA NP PB1 RPL31 NUP35 NUP160 RAE1 RPS29 Cys-tRNA(Cys) HA mRNA Genomic RNA Segment 3 PA 18S rRNA NUP210 Tyr-tRNA(Tyr) AAAS NTPpalmitylated M2 POLR2F RPL26L1 Genomic RNA Segment 5 NPAAAS PB1 Genomic RNA Segment 1 M1 HA1 NUP62 NA mRNA Genomic RNA Segment 5 Genomic RNA Segment 6 PB2 GTP RPS4Y1 Genomic RNA Segment 7 M2 TetramerGenomic RNA Segment 6 Genomic RNA Segment 7 PB2 Genomic RNA Segment 8 Genomic RNA Segment 6 PB1 Genomic RNA Segment 5 PA RPL4 NUP98-4 Ala-tRNA(Ala) NEP/NS2 PA Genomic RNA Segment 6 Glu-tRNA(Glu) Genomic RNA Segment 5 PB2 Genomic RNA Segment 5 NP Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol ATP Lipid Raft PA mRNA NEP/NS2 RPS27A(77-156) Genomic RNA Segment 3 PB2 Trp-tRNA(Trp) Genomic RNA Segment 8 Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol palmitylated M2 Glycosylated NA NP Genomic RNA Segment 1 Influenza A ViralParticleRPS2 M2 M1 cRNPGenomic RNA Segment 7 NUP210 Genomic RNA Segment 8 NP 5S rRNA CALRPA Genomic RNA Segment 5 Genomic RNA Segment 3 NUP85 Genomic RNA Segment 2 Genomic RNA Segment 1 Genomic RNA Segment 2 Genomic RNA Segment 5 Genomic RNA Segment 2 Viral PolymeraseNuclear Pore Complex(NPC)POLR2G Genomic RNA Segment 3 Viral ProteinsRPS3A PB2 Genomic RNA Segment 3 NEP/NS2 Genomic RNA Segment 5 NP Genomic RNA Segment 2 Genomic RNA Segment 7 HA folded, glycosylated, and palmitylated Glycosylated NA M1RPS15A Genomic RNA Segment 4 RPS4Y2 NP PB1 Met-tRNA(Met) CANXGTP RANBP2 PA Glycosylated and folded HA Genomic RNA Segment 3 NP RPL7A RPL23A Genomic RNA Segment 8 NP viral mRNAPB1 mRNA Genomic RNA Segment 7 Genomic RNA Segment 8 NP Influenza H1N1 cRNA (extending) HA folded, glycosylated, and palmitylated RPL29 Genomic RNA Segment 2 PB2 NEP/NS2 Genomic RNA Segment 4 NUP50 POLR2H RPL32 NUP43 RPL28 Genomic RNA Segment 4 NUP107 Genomic RNA Segment 7 Segment 5 RNPGenomic RNA Segment 6 Glycosylated NA Genomic RNA Segment 2 GTP Influenza A ViralParticle Docked AtThe EndocyticVesicle MembraneWith An Open PorePB2 NP Genomic RNA Segment 2 HSP90AA1Genomic RNA Segment 1 NP PB1 Genomic RNA Segment 4 Genomic RNA Segment 6 NEP/NS2PB1 palmitylated M2 XPO1 vRNP:M1 for ExportGenomic RNA Segment 8 CTP HA mRNA PB2RPS7 PA POM121 PA NP Genomic RNA Segment 4 Genomic RNA Segment 2 RPL9 NUP85 NA NP HA1 Genomic RNA Segment 6 HA1 FAU Genomic RNA Segment 1 NUP205 Genomic RNA Segment 8 Genomic RNA Segment 4 KPNB1 PA NEP/NS2 PB1 PA mRNA NS2 mRNA HA1 Segment 3 RNPRPL6 Genomic RNA Segment 7 M1 RPSA Genomic RNA Segment 3 Influenza A ViralParticle Docked AtThe EndocyticVesicle MembraneSegment 2 RNPRPS16 PB1 PB2 NP mRNA RPL10L Genomic RNA Segment 7 CTP RPL23 PA vRNA (Genomic):NPComplexPA NEP/NS2 PAGenomic RNA Segment 1 Genomic RNA Segment 8 HA folded, glycosylated, and palmitylated Glycosylated NA RPS24 NP:Lipid RaftNUP188 Glycosylated,palmitylated andfolded HA trimerPB1KPNA1 Glycosylated NATetramerRPS12 KPNA1 SA RPL39 Genomic RNA Segment 6 Genomic RNA Segment 8 SARPS26 NUP188 M2 mRNApalmitylated M2 NUP214 Genomic RNA Segment 5 RAN Genomic RNA Segment 5 Lipid Raft Glycosylated NA Gly-tRNA(Gly) RPLP2 Genomic RNA Segment 1 Genomic RNA Segment 8 AAAS PA mRNA PB2 Viral PolymeraseNPRPL15 Gycosylated NATetramerPA NUP98-3 POM121 Genomic RNA Segment 2 Genomic RNA Segment 7 NEP/NS2 Genomic RNA Segment 5 Genomic RNA Segment 2 Glycosylated,palmitylated andfolded HAtrimer:Lipid RaftComplexAminoacyl-tRNAPAGenomic RNA Segment 5 vRNA (genomic)Genomic RNA Segment 5 capped pre-mRNA PB1 CTP Genomic RNA Segment 1 viral mRNAPhe-tRNA(Phe) Genomic RNA Segment 2 PA PB1 M1 5.8S rRNA Viral PolymeraseGenomic RNA Segment 8 vRNA TranscriptionComplexPOLR2L Genomic RNA Segment 6 NA mRNA Genomic RNA Segment 3 Genomic RNA Segment 2 M1 PB2 mRNA NUP153 NS1 mRNANUP133 M1HSPA1AGenomic RNA Segment 2 Genomic RNA Segment 6 NUP98-4 Genomic RNA Segment 6 Genomic RNA Segment 3 Genomic RNA Segment 8 Genomic RNA Segment 6 Genomic RNA Segment 6 NP NUP98-4 RNPComplex:KaryopherinalphaNP M2 NUP54 M1 Nup45 NA mRNA PA NP Asn-tRNA(Asn) GTF2F1 PA Genomic RNA Segment 6 NP NANUP93 Genomic RNA Segment 4 NEP/NS2 PB2 RPS10 RAE1 Inter-Membrane Spanning HA2 M1 Genomic RNA Segment 4 NA NUP107 Genomic RNA Segment 2 PB1Genomic RNA Segment 4 Genomic RNA Segment 7 Genomic RNA Segment 5 PB2 Genomic RNA Segment 6 NUPL1-2 RPL30 Mature intronlesstranscript derivedmRNA with m7G capremovedNP RPS23 NA mRNA NUP37 Genomic RNA Segment 3 Genomic RNA Segment 8 Initiated cRNA-vRNAComplexPB2 NEP/NS2 HA1 Genomic RNA Segment 8 PB1 Genomic RNA Segment 5 NA GTF2F2 XPO1NEP/NS2 Genomic RNA Segment 4 Genomic RNA Segment 7 NS2 mRNA RAE1 Genomic RNA Segment 6 NUP43 Genomic RNA Segment 8 PB1 PB2 Genomic RNA Segment 7 Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol NUPL2 M1 Genomic RNA Segment 1 Genomic RNA Segment 1 NEP/NS2 M1 Pro-tRNA(Pro) Genomic RNA Segment 8 80S ribosomeGenomic RNA Segment 1 NP Genomic RNA Segment 6 PB2 PA NUP85 PB2 ClathrinGenomic RNA Segment 7 Glycosylated NA PA SA Genomic RNA Segment 5 Glycosylated NAGenomic RNA Segment 5 His-tRNA(His) Influenza A ViralParticleGenomic RNA Segment 8 NEP/NS2 SAHA1 RPL36 Viral PolymerasePB2 Genomic RNA Segment 2 M2NUP54 NUP88 Leu-tRNA(Leu) NP Lipid Raft PB1 RANBP2 palmitylated M2TetramerRibonucleoprotein(RNP) ComplexM1 mRNA Mature intronlesstranscript derivedmRNAGenomic RNA Segment 4 NP HA1 Genomic RNA Segment 2 Genomic RNA Segment 6 Influenza cRNA (complete) NUP35 RPL19 Host Derived LipidBilayer MembraneRich InSphingolipids AndCholesterolM1 PB1 Genomic RNA Segment 3 palmitylated M2 PB1 RPL11 Genomic RNA Segment 1 NEP/NS2 NS2 mRNAGycosylated NATetramer:Lipid RaftRPS9 Genomic RNA Segment 7 NP M2 mRNA PB1 RPL36A TPR RPL41 KPNB1 M2 Genomic RNA Segment 7 PA Genomic RNA Segment 2 PB1 NP RPL35 PB2 RPL22 RPS17 Genomic RNA Segment 8 Lys-tRNA(Lys) NS1NUP98-3 Genomic RNA Segment 7 Influenza cRNA (complete) NUP98-5 NEP/NS2 NS1 mRNA Viral ProteinsNEP/NS2NS1 mRNA Genomic RNA Segment 8 PB1 PB1 Glycosylated andfolded HARPL40 NUP205 Glycosylated andfolded HA trimerPA NUP37 Genomic RNA Segment 6 NUP153 NUPL2 Genomic RNA Segment 4 Genomic RNA Segment 3 Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol M1 mRNA NA Genomic RNA Segment 8 Cleaved HA InfluenzaA Viral ParticleNUP43 NUP50 palmitylated M2 M1 NUP37 Genomic RNA Segment 3 RPL17 H+Nup45 Genomic RNA Segment 1 Genomic RNA Segment 1 RPS6 NP NP UTP PB1 Genomic RNA Segment 6 NP Genomic RNA Segment 5 M1 mRNA Genomic RNA Segment 1 Genomic RNA Segment 4 Genomic RNA Segment 3 NARPL21 NUP50 Glycosylated NA PB2 POM121C RPL3L TPR GDP NUP155 Genomic RNA Segment 1 RPS20 RPL37A RPL22L1 RPL10A HA2 M1 Genomic RNA Segment 4 M2 Genomic RNA Segment 6 PA Mature intronless transcript derived mRNA NP Genomic RNA Segment 7 M2 mRNAGenomic RNA Segment 2 TPR RPS3 Genomic RNA Segment 1 NEP/NS2 POLR2C Segment 1 RNPViral PolymeraseHA folded, glycosylated, and palmitylated Genomic RNA Segment 7 Genomic RNA Segment 2 IPO5p-S5-POLR2A PB2 PB1 Genomic RNA Segment 4 Genomic RNA Segment 2 HA folded, glycosylated, and palmitylated Genomic RNA Segment 4 NP RPL34 NUP210 NS2 mRNA PA mRNA Thr-tRNA(Thr) PA RPL10 PB2 P1 mRNA RAN PA Genomic RNA Segment 3 NS1 NEP/NS2PA HA2 Genomic RNA Segment 1 Initiated vRNATranscriptionComplexNUP160 Genomic RNA Segment 1 Genomic RNA Segment 1 CLTC Nuclear Pore Complex(NPC)PB2 Genomic RNA Segment 4 RPS14 PA RPS27 PA Genomic RNA Segment 3 NEP/NS2 Genomic RNA Segment 5 HA2 PB1 M1 mRNAGenomic RNA Segment 4 RPS5 M1 Inter-Membrane Spanning HA2 M1 Gln-tRNA(Gln) PB1 RPS25 PB2 RPS28 RPL38 Inter-Membrane Spanning HA2 Nup45 RPL7 PB2 Arg-tRNA(Arg) Genomic RNA Segment 1 GTP PA Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol NP Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol Genomic RNA Segment 7 Genomic RNA Segment 8 Genomic RNA Segment 3 NP Genomic RNA Segment 2 RAN:GTPGlycosylated,palmitylated andfolded HAtrimer:Lipid RaftComplexPA Genomic RNA Segment 8 Ile-tRNA(Ile) M1 Lipid Raftpalmitylated M2TetramerNPRANBP2 NS2 mRNAPB1 PB1 Influenza cRNA(complete)vRNP destined forExportAcidified InfluenzaA Viral ParticleDocked At TheEndocytic VesicleMembrane With AnOpen PoreNUP133 PB1 RPL3 Genomic RNA Segment 3 Genomic RNA Segment 7 NDC1 RPLP0 PB2 NP Genomic RNA Segment 4 Glycosylated andfolded HA trimerNUP155 NUP133 Crm1:Ran GTPase:GDPGenomic RNA Segment 2 PA Genomic RNA Segment 1 DNAJC3RPL24 Genomic RNA Segment 5 M1 PB2 Genomic RNA Segment 8 KPNA1HA mRNA Lipid Raft Genomic RNA Segment 4 RPL18A PB2 GRSF1Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol PA PB1 PA NUPL1-2 Genomic RNA Segment 7 RPL12 PB2 PB2 RPL39L Segment 4 RNPGenomic RNA Segment 7 Lipid Raft Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol Glycosylated NA M2 mRNA NDC1 HA1 RPL27A RPL26 Genomic RNA Segment 3 Genomic RNA Segment 4 Genomic RNA Segment 8 Genomic RNA Segment 2 Genomic RNA Segment 1 HA folded and glycosylated Genomic RNA Segment 3 PA NUP98-3 RPS15 Genomic RNA Segment 3 M2 PB1 Segment 6 RNPSialic Acid BoundInfluenza A ViralParticleNP KPNB1M1 Genomic RNA Segment 3 M1 RPL5 PB2 NUP62 Influenza A ViralParticle With AFusion CompetentHA2NTPPA Genomic RNA Segment 6 Glycosylated andfolded HA trimerRPS13 PB1 Genomic RNA Segment 3 Genomic RNA Segment 2 vRNA (Genomic):NPComplexPOLR2D Genomic RNA Segment 5 PB2 NEP/NS2 PB1 Val-tRNA(Val) NP Genomic RNA Segment 6 Nuclear Pore Complex(NPC)ATP Genomic RNA Segment 7 PB1 Genomic RNA Segment 1 M1 NTPPB1 PA NUP107 PiNP Genomic RNA Segment 5 NP Genomic RNA Segment 2 Glycosylated NATetramerM1 PA RPS11 RPS4X PB2 Genomic RNA Segment 2 POLR2E POM121C Genomic RNA Segment 8 PB2 PB1-F2PB1 Genomic RNA Segment 1 HA2 NUP62 Genomic RNA Segment 3 NP 7-methylguanosine cap Host Derived Lipid Bilayer Membrane Rich In Sphingolipids And Cholesterol Genomic RNA Segment 4 HA folded and glycosylated NP NP mRNA KPNA1Genomic RNA Segment 7 Genomic RNA Segment 4 Genomic RNA Segment 1 NP mRNA Genomic RNA Segment 7 KPNA1 28S rRNA Elongated vRNA-mRNAComplexGenomic RNA Segment 8 Glycosylated NA PB2 Asp-tRNA(Asp) Genomic RNA Segment 3 Genomic RNA Segment 8 Glycosylated NA PB1 PA Genomic RNA Segment 2 vRNA (Genomic):NPComplexNA NP PB2 NUP214 Genomic RNA Segment 4 M2 Genomic RNA Segment 4 SEH1L-2 M2 RNP:Karyopherinalpha:Karyopherinbeta complexPOM121C Genomic RNA Segment 3 Genomic RNA Segment 2 NEP/NS2 Genomic RNA Segment 6 M1Genomic RNA Segment 4 Genomic RNA Segment 3 NS2 mRNA NUP88 RPL14 Genomic RNA Segment 1 Genomic RNA Segment 6 M2 TetramerNUP88 PB2 HA mRNA Genomic RNA Segment 2 Genomic RNA Segment 6 PA Ser-tRNA(Ser) vRNA (Genomic):NPComplexNUP98-5 Genomic RNA Segment 2 PB2 Genomic RNA Segment 1 vRNP Export ComplexM1 Inter-Membrane Spanning HA2 Genomic RNA Segment 4 Genomic RNA Segment 5 Genomic RNA Segment 5 Genomic RNA Segment 7 PB1 PB2Genomic RNA Segment 3 PB1 PA Lipid Raft NP RNP pre-assemblycomplexNUPL1-2 M2 PB1 PB2 NEP/NS2 M2 Gycosylated NATetramer:Lipid RaftPB1 NP Genomic RNA Segment 4 PB2 Genomic RNA Segment 5 RPL18 M2 mRNA POLR2B NEP/NS2 KPNB1Genomic RNA Segment 1 PA NP NP Genomic RNA Segment 7 Genomic RNA Segment 6 Genomic RNA Segment 7 Genomic RNA Segment 8 NEP/NS2 HA1 Genomic RNA Segment 5 M1Glycosylated,palmitylated andfolded HA trimerGenomic RNA Segment 4 RNP:Karyopherinalpha:Karyopherinbeta complexM1 PB2 Genomic RNA Segment 6 M2 mRNA Sialic Acid BoundInfluenza A ViralParticleRPL37 SEH1L-2 Intracellularassembly complexViral PolymeraseGenomic RNA Segment 2 Genomic RNA Segment 5 PB1 31, 40, 41, 5031, 40, 41, 5031, 40, 41, 50777777