PIP3 activates AKT signaling (Homo sapiens)

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42, 27357, 24136, 226162, 253, 26015811555, 85, 89, 90, 93...121, 156, 236, 278, 28499264, 2672, 107172, 201, 28822, 102, 165, 223, 225265, 31147, 129, 166, 24812272188181, 206170, 175, 29616220110943, 67, 70, 127, 30173, 275172, 2883, 5201114, 294, 306172, 28881, 20686, 93, 106, 26357, 241, 27524172, 201, 288235573, 275nucleoplasmcytosolPIK3R1 p-S-AKT:PIP3PIK3CD RICTOR p-S473-AKT1 E17Kmutant:PIP2AKT HS TSC2FOXO4-1 PI(4,5)P2H2OAKT inhibitors:AKTp-Y63,Y79,Y110-TRAT1 PI(3,4,5)P3 PTEN RegulationADPIntrinsic Pathwayfor Apoptosisp-T23-CHUKPTEN mRNA:miR-26ARISCATPPDPK1:PIP3GDC0941 TNRC6B IL33 BADINSR(28-758) PiXL147 KITLG-1(26-190) TP53 Tetramerp-T309-AKT2 Triciribine p-T308,S473-AKT1GDC0941 AKT1Regulation of TP53Expression andDegradationPP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimersp-S109-MKRN1mTOR signallingPIK3R1 ADPPIK3R2 Signaling by METTCR signalingp-S133-CREB1Signaling by ERBB4XL765 EIF2C1 AKT1 E17Kmutant:PIP2Active AKTPIK3R3 HGF(495-728) PHLPP1 FGF16 PPP2R5C PI(3,4,5)P3 p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform PPP2CB GalNAc-T178-FGF23(25-251) ATPmiR-26A1 Activator:PI3K PPP2CB FGF19 MKRN1p-T185,Y187-MAPK1 AKT1 E17KADPPPP2R5C CREB1ATPAKT2 FGF3 AKT:PIP3PP2A-B56-beta,gammaPIP5K1A-CSignaling by the BCell Receptor (BCR)p-Y307-PPP2CA NRG1 HGF(32-494) PDPK1:p-S473-AKT1E17K mutant:PIP2PTEN gene p-12Y-PDGFRB PPP2R1A PIP5K1A p-T305-AKT3 p-T309,S474-AKT2 LY294002 p-S473-AKT1 E17K ADPp-T24,S256,S319-FOXO1 BEZ235 CD86 ATPp-T-AKTPI3K mutants TNRC6C FGF4 Signaling by FGFRPDPK1 ATPActivator:PI3K Neuregulins GSK1059615 PI(3,4,5)P3 Costimulation by theCD28 familyATPH2Op-S472-AKT3 FOXO1 PPP2R5B PI(3,4,5)P3 PPP2R5D ATPIRAK4 THEM4/TRIB3ADPPI3K Inhibitors:PI3KPPP2CB Mitotic G1-G1/SphasesAKT1 PPP2R5C p-S368-PPP2R5B,p-S337-PPP2R5CPI(4,5)P2 p-Y394-LCK BEZ235 PPP2CA PIP4K2B AKT1 E17K 4xHC-INS(90-110) EGF PI(4,5)P2 Activated FGFR2c homodimer bound to FGF PIP4K2 dimersAKT3 PiPTENPPP2R5E TRAF6 PI4PPPP2R5E TORC2 complexTNRC6C IL33:IL1RL1:IL1RAP-1:MYD88:IRAK1,IRAK4,TRAF6IL1RAP-1 p-S99-BADRAF/MAP kinasecascadeXL147 p-6Y-CD19 Triciribine FGF6 PPP2CA p-Y191-CD28 FGF8-1 p-S368-PPP2R5B p-T308-AKT1 PIP4K2C KLB PTEN mRNAPRR5 TNRC6A p-Y-ERBB2 p-7Y-ERBB2 p-S472-AKT3 FGF5-1 p-Y180-ICOS Activator:PI3KAKT1S1p-T185,Y187-MAPK1 FOXO3 CASP9(1-416)wortmannin PP2A-A:PP2A-CLY294002 MAPKAP1 FGF2(10-155) p-6Y-EGFR Signaling by PDGFPIP5K1B PPP2R1B miR-26A2 p-Y546,Y584-PTPN11 ATPmiR-26A1 p-S9/21-GSK3FGF1 PPP2CA p-Y307-PPP2CB p-T32,S253,S315-FOXO3 PPP2R5A p-Y307-PP2AMK2206 p-Y419-SRC-1 p-6Y-FRS2 PPP2R5B p-S196-CASP9(1-416)p-S351-NR4A1Activated FGFR2b homodimer bound to FGF MDM2AKT/AKT1 E17K mutantp-S166,S188-MDM2PDPK1 PPP2R5B Active AKTFGF23(25-251) MYD88 p-11Y-PDGFRA EIF2C2 ADPCDKN1A AKT:PIP3:THEM4/TRIB3IL1RL1 PI5PFGF18 p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform PDGFA-2 p-Y-IRS2 AKT3 PIK3CB p-T32,S142,S207-FOXO4-2 AKTp-S197,S262,T32-FOXO4 IER3LCK KL-2 FGF9 AKT3 TRIB3 PPP2R1B p-6Y-FGFR3c BGT226 BKM120 EIF2C3 FGF22 PI(3,4,5)P3 p-T,Y MAPK dimersPI(4,5)P2 CD80 AKT2 miR-26A2 PPP2R1A PDPK1:PIP2GRB2-1 IER3 p-S474-AKT2 CHUKBGT226 2xHC-INS(25-54) GSK1059615 p-S21-GSK3A FYN ADPp-6Y-ERBB2 EGF TNRC6A p-7Y,Y1112-ERBB2 p-10Y-ERBB3-1 PPP2R1A MTOR ADPPDGFB(82-241) PPP2R1A PDPK1GAB1 p-4Y-PIK3AP1 PIK3CA PPP2R5B GRB2-1 NR4A1AKT1 p-T305,S472-AKT3 Mn2+ EIF2C4 MOV10 p-S183,T246-AKT1S1KL-1 THEM4 perifosine PPP2R1B MOV10 XL765 ATPp-Y,Y877-ERBB2 PPP2R5D PDPK1 PI3Kmutants,Activator:PI3KRPS6KB2EIF2C1 FOXO1,FOXO3,FOXO4PTEN mRNA TP53 RegulatesMetabolic GenesCDKN1B PHLPP (Mn2+cofactor)ATPPPP2R1B GSK3B AKT1 E17K FGF17-1 THEM4 p-T157-CDKN1B p-T308,S473-AKT1 EIF2C4 MK2206 p-6Y-EGFR TP53 Tetramer:PTENGenemiR-26A RISCPP2Ap-S9-GSK3B GSK3A TP53 p-T308,S473-AKT1 p-S337-PPP2R5C p-T308,S473-AKT1E17KVAV1 p-S15,S356-RPS6KB2PI(3,4,5)P3PPP2CA FGF20 p-S473-AKT1 E17K PPP2R1A Signalling by NGFp-Y1234,Y1235,Y1349,Y1356-MET PX-866 AKT2 MLST8 AKT1 E17K p-S473-AKT1 p-5Y-FGFR4 p-T145-CDKN1A p-T-CDKN1A/BFGF10 PI3K mutants PIP4K2A PTEN geneEIF2C2 IRAK1 PPP2R5C p-T202,Y204-MAPK3 ActivatedSRC,LCK,EGFR,INSRGSK3PPP2R1B PX-866 perifosine p-6Y-INSR(763-1382) AKT1 TP53 AKT inhibitorsp-6Y-FGFR3b PDGFA-1 p-T305,S472-AKT3 p-S-AKT:PDPK1:PIP3PI3K inhibitorsBKM120 PiPDPK1 p-S939,T1462-TSC2Signaling by SCF-KITPDGFB (82-190) FOXO4-2 p-T309,S474-AKT2 ADPp-S474-AKT2 wortmannin p-6Y,Y1112-ERBB2 PHLPP2 p-7Y-KIT PIP5K1C p-FOXO1,p-FOXO3,p-FOXO4PPP2CB AKT p-Y-IRS1 Signaling by EGFRp-8Y-FGFR1c p-S473-AKT1 TRIB3 ADPEIF2C3 NRG2 CDKN1A,CDKN1BEGF-like ligands PPP2R5A p-T202,Y204-MAPK3 H2OTNRC6B p-8Y-FGFR1b Signaling by ERBB2p-5Y-GAB1 PI(4,5)P2 8610, 13, 14, 20, 21, 38...17455, 112172172196, 228, 26830216, 27, 33, 41, 58...26389, 315227861064417, 45, 60, 82, 131...9, 40, 62, 63, 194...321, 3262459317229827917218655, 89, 90, 93, 112...66, 271, 317, 3181726, 12, 48, 116, 178...126, 136, 140162902782988, 19, 34, 37, 39...73, 27555, 11230217293132, 224, 242108, 179, 200, 249, 256...2633073, 5, 15, 23, 26...17289, 3151, 4, 7, 11, 25...902458617410630731, 192, 299227115186