PIP3 activates AKT signaling (Homo sapiens)

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64, 93, 135, 14996, 10978, 19533, 39, 43, 70, 81...31, 5331140, 17074, 86, 1391494193, 2041, 42, 6663, 7113976, 84, 109838954, 722174, 8611317922, 29, 35, 69, 1031643, 100, 168, 18276, 8474, 86, 13996, 10957, 67, 116, 142, 1883717126, 118, 17874, 8611, 21, 14719975, 17913931, 53cytosolnucleoplasmGDC0941 IER3 p-T23-CHUKp-T145-CDKN1A PIK3R1 FGF23(25-251) AKT1 E17K PI4PHS TNRC6A TNRC6A EGF RAF/MAP kinasecascadePDPK1:PIP2BKM120 p-T202,Y204-MAPK3 ActivatedSRC,LCK,EGFR,INSRPPP2CA PPP2CB p-S9-GSK3B p-S197,S262,T32-FOXO4 FGF4 p-6Y-EGFR p-Y-IRS2 ATPMTOR BGT226 FGF2(10-155) PPP2R5A PTEN:Mg2+p-7Y-ERBB2 ATPp-T-CDKN1A/BXL765 ADPXL147 Triciribine FGF18 GDC0941 ADPPRR5 p-T202,Y204-MAPK3 PDGFA-1 PTEN mRNA:miR-26ARISCPPP2CA CHUKp-S368-PPP2R5B p-S133-CREB1PIP4K2A TSC2p-Y191-CD28 p-10Y-ERBB3-1 p-6Y-EGFR AKT3 CDKN1A/BPPP2R5C LCK PPP2R5C MK2206 p-S368-PPP2R5B,p-S337-PPP2R5CH2Op-T309-AKT2 PiEIF2C1 VAV1 FGF22 NRG1 p-12Y-PDGFRB TP53 CD80 PPP2R5D THEM4 AKT2 Signaling by FGFRp-T185,Y187-MAPK1 AKT1 E17K PI3K mutants PPP2R5B PDGFA-2 p-S166,S188-MDM2p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform FGF16 FGF1 MLST8 AKT PI(3,4,5)P3 EGF-like ligands Intrinsic Pathwayfor ApoptosisPIK3R3 AKT:PIP3FOXO4-2 LY294002 ATPATPp-Y-IRS1 PPP2R5A PIP5K1A PPP2R5C PI(4,5)P2 THEM4/TRIB3p-6Y-FRS2 p-T305,S472-AKT3 Neuregulins Costimulation by theCD28 familyPPP2R5C p-T32,S142,S207-FOXO4-2 PI(3,4,5)P3 PPP2R1B ATPMOV10 PPP2CB H2OFOXO3 MAPKAP1 GalNAc-T178-FGF23(25-251) PDPK1:p-S473-AKT1E17K mutant:PIP2CASP9(1-416)GRB2-1 EIF2C2 CDKN1B perifosine p-T305,S472-AKT3 FGF17-1 ADPAKT inhibitors:AKTPP2A-B56-beta,gammamiR-26A2 MOV10 p-6Y-ERBB2 KITLG-1(26-190) INSR(28-758) PHLPP2 BADp-S183,T246-AKT1S1p-T157-CDKN1B PIP5K1C PI3Kmutants,Activator:PI3KPI5Pp-7Y-KIT PIK3CD TRIB3 PP2AFGF5-1 Pip-Y307-PPP2CB Activated FGFR2c homodimer bound to FGF EGF Signaling by SCF-KITPHLPP (Mn2+cofactor)Mn2+ p-S15,S356-RPS6KB2ADPGAB1 PPP2CA PIP5K1B PTEN GenePI3K inhibitorsFGF10 PDPK1 miR-26A RISCPDGFB(82-241) PI(3,4,5)P3 Activated FGFR2b homodimer bound to FGF TP53 Tetramer:PTENGenep-FOXO1,p-FOXO3,p-FOXO4GSK1059615 PPP2R5E PDPK1 p-T,Y MAPK dimers2xHC-INS(25-54) p-S473-AKT1 TP53 p-S473-AKT1 E17K PI(3,4,5)P3 TP53 TetramerGRB2-1 RICTOR PI(3,4,5)P3PIK3R1 AKT1ADPADPperifosine p-5Y-FGFR4 PIP4K2C Activator:PI3K PPP2R5D TNRC6C AKT1 PPP2R1A Mitotic G1-G1/SphasesPIK3CB p-T308,S473-AKT1 PI3K mutants XL147 PI(4,5)P2 p-S21-GSK3A miR-26A2 PI3K Inhibitors:PI3KCD86 AKT2 EIF2C2 AKT1 GSK1059615 p-T308,S473-AKT1ATPPPP2R1B EIF2C3 FOXO4-1 p-Y-ERBB2 Mg2+ PPP2CB FGF8-1 NRG2 AKT1S1TP53 RegulatesMetabolic GenesPPP2R5B PIK3CA MK2206 PX-866 PTEN miR-26A1 p-11Y-PDGFRA AKT2 p-Y394-LCK p-S9/21-GSK3EIF2C4 PX-866 PPP2R1B ATPMDM2p-T308,S473-AKT1E17KActive AKTCREB1p-S474-AKT2 wortmannin AKT1 E17Kmutant:PIP2p-S351-NR4A1wortmannin ADPSignaling by ERBB2Signaling by PDGFKL-2 PPP2CA BGT226 EIF2C3 LY294002 p-S196-CASP9(1-416)FYN BKM120 p-8Y-FGFR1c p-S939,T1462-TSC2p-S473-AKT1 E17Kmutant:PIP2ADPPPP2R5E PDPK1 p-Y546,Y584-PTPN11 PTEN mRNARPS6KB2ATPAKTPPP2R5B p-T24,S256,S319-FOXO1 p-T309,S474-AKT2 H2Op-6Y-INSR(763-1382) FOXO1 p-T308-AKT1 PDPK1Signaling by the BCell Receptor (BCR)AKT1 E17K AKT inhibitorsp-T-AKTFGF6 p-6Y-CD19 PPP2R1A AKT3 p-Y419-SRC-1 EIF2C4 PDPK1 AKT/AKT1 E17K mutantADPEIF2C1 p-S472-AKT3 p-6Y-FGFR3b ADPp-Y307-PPP2CA ATPAKT1 E17KAKT:PIP3:THEM4/TRIB3GSK3p-S473-AKT1 E17K GSK3A PPP2CB p-S472-AKT3 PI(3,4,5)P3 PIK3R2 FGF19 THEM4 p-S99-BADp-S-AKT:PIP3p-T32,S253,S315-FOXO3 ATPPIP4K2 dimersTriciribine p-Y,Y877-ERBB2 IER3PPP2R1A KL-1 NR4A1p-T185,Y187-MAPK1 PI(4,5)P2PPP2R5B PI(4,5)P2 p-S474-AKT2 GSK3B AKT1 p-S473-AKT1 PTEN Gene AKT3 4xHC-INS(90-110) Activator:PI3KActive AKTFGF20 PDPK1:PIP3FGF3 miR-26A1 p-T309,S474-AKT2 PPP2R1B Activator:PI3K p-6Y-FGFR3c p-S337-PPP2R5C TNRC6C PDGFB PP2A-A:PP2A-CPHLPP1 BEZ235 TNRC6B p-T308,S473-AKT1 KLB p-S-AKT:PDPK1:PIP3PPP2R1A Signaling by EGFRPTEN mRNA BEZ235 FOXO1,FOXO3,FOXO4p-T305-AKT3 XL765 PIP4K2B PPP2R1A TRIB3 PPP2R1B Signaling by ERBB4p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform p-8Y-FGFR1b CDKN1A Signalling by NGFp-Y63,Y79,Y110-TRAT1 TORC2 complexTNRC6B p-Y307-PP2APiPIP5K1A-CPP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimersPI(4,5)P2 AKT FGF9 152539123, 20339, 98, 114, 123, 135...7413149123, 2031657474114136, 156135186149136, 15618632, 68, 90, 117, 128...491655, 9, 12, 21, 24...74936422114641595, 144, 20536, 46, 82, 88, 106...18, 20, 40, 52, 175...93984998746416, 28, 30, 34, 38...2, 23, 146, 15996, 1093947, 108, 1922521135744, 6-8, 10...17, 447477, 91, 151