PIP3 activates AKT signaling (Homo sapiens)

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5, 32, 45, 96, 184118, 20260, 81, 152130289265, 32879, 128, 32517, 44, 48, 50, 31827813020, 28565, 187, 204, 243, 293151, 30539, 95147, 30916, 216127151, 30534, 116, 175, 233, 3031813, 24, 49, 73, 77...265, 328113, 287229130, 265, 328130, 265, 32816416, 21652, 73, 133, 290110, 214113, 151, 2873021659, 105, 139, 256280221, 277nucleoplasmcytosolPI(3,4,5)P3 PI5PPP2Ap-T309,S474-AKT2 PI(4,5)P2 ESR2 p-Y-IRS1 p-T32,S253,S315-FOXO3 AKT2 PIK3R1 IL1RL1 PIK3R1 PiPP2A-B56-beta,gammap-S9-GSK3B p-T202,Y204-MAPK3 p-T32,S197,S262-FOXO4 IER3ADPSignaling by the BCell Receptor (BCR)PPP2R5C XL147 PIK3CB PDPK1PDGFA-2 ADPADPBKM120 ATPTRAF6 PPP2R5D THEM4 ATPp-S368-PPP2R5B p-Y394-LCK BEZ235 p-T, p-S-AKTp-S15,S356-RPS6KB2CDKN1A p-8Y-FGFR1c IRAK4 p-Y307-PP2AAKT3 PI(3,4,5)P3 PPP2R5C HGF(495-728) PI3Kmutants,Activator:PI3Kp-7Y-KIT AKT:PIP3PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimersp-S474-AKT2 CD86 IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6NRG2 FGF23(25-251) RHOG p-S473-AKT1 E17Kmutant:PIP2XL147 p-T305,S472-AKT3 p-8Y-FGFR1b PIP5K1C XL765 GRB2-1 p-T308,S473-AKT1E17KPHLPP (Mn2+cofactor)p-Y63,Y79,Y110-TRAT1 PIK3R2 BKM120 Activator:PI3Kp-Y,Y877-ERBB2 RPS6KB2PPP2R5C IL1RAP-1 VAV1 FOXO3 AKT/AKT1 E17K mutantp-Y191-CD28 FGF18 p-T-CDKN1A/Bp-S-AKT:PIP3KL-2 AKT:PIP3:THEM4/TRIB3PTENPPP2CB p-Y419-SRC-1 AKT1 Mn2+ p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform p-T309,S474-AKT2 RAC1 MTOR p-T145-CDKN1A ATPEGF Intrinsic Pathwayfor Apoptosisp-T309-AKT2 perifosine p-S351-NR4A1PPP2R1A PI(3,4,5)P3 FGF5-1 PPP2R1B GTP Signaling by FGFRTRIB3 FGF20 Signaling by PDGFPPP2R1B p-11Y-PDGFRA GSK3B GSK1059615 PiGalNAc-T178-FGF23(25-251) PPP2R1B TCR signalingCREB1AKT1 E17K p-S337-PPP2R5C Signaling by EGFRRAC2 PPP2R1A p-Y307-PPP2CB PDPK1 p-T185,Y187-MAPK1 RHOG wortmannin p-Y180-ICOS AKT3 H2Op-S472-AKT3 p-6Y-INSR(763-1382) p-S133-CREB1perifosine ADPBEZ235 ER alpha46 FGF8-1 p-T26,S184-FOXO6 p-6Y-FRS2 H2Op-T308,S473-AKT1 RAC2 ESTG CDKN1A,CDKN1Bp-S473-AKT1 E17K p-7Y-ERBB2 PPP2R5B Pip-S472-AKT3 PIK3R3 RAC1:GTP,RAC2:GTP,RHOG:GTPFGF22 GSK1059615 PI3K Inhibitors:PI3KMYD88 p-T202,Y204-MAPK3 Signaling by METAKT3 p-Y-ERBB2 wortmannin CD80 AKT inhibitorsTSC2PPP2CB PPP2R1A HS RAC1 PPP2R5C AKTAKT1 PIK3R2 ATPp-T185,Y187-MAPK1 ER alpha36 p-6Y-EGFR PI(3,4,5)P3BGT226 p-T308,S473-AKT1 PIK3CA p-S196-CASP9(1-416)PDPK1:PIP2RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alphaPI3K inhibitorsp-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6)KL-1 ADPNR4A1p-T23-CHUKPIP4K2C CASP9(1-416)RAC2 LY294002 Mitotic G1-G1/SphasesAKT1 E17K ATPmTOR signallingp-T,p-S-AKTPPP2R5B PPP2R5B PIP5K1A PPP2R5A PI(4,5)P2 p-Y546,Y584-PTPN11 p-5Y-FGFR4 PIK3R1 p-4Y-PIK3AP1 Triciribine Activator:PI3K RAC1 p-7Y,Y1112-ERBB2 Costimulation by theCD28 familyp-Y307-PPP2CA p-S368-PPP2R5B,p-S337-PPP2R5CPDPK1 Regulation of TP53Expression andDegradationMKRN1ADPActivatedSRC,LCK,EGFR,INSRPPP2R1B PHLPP2 FGF16 IRAK1 ADPp-10Y-ERBB3-1 PI(3,4,5)P3 PTEN RegulationPPP2CA PI(4,5)P2 ATPp-6Y-ERBB2 ATPAKT Activated FGFR2b homodimer bound to FGF BGT226 p-S9/21-GSK3FGF6 XL765 PPP2CA FOXO4 Metabolism of nitricoxidep-T-AKTPI(4,5)P2AKT1 E17KPIP5K1A-Cp-T308-AKT1 INSR(28-758) PPP2CA PIK3R1 MK2206 p-6Y-CD19 TRIB3 PPP2R1A p-T305-AKT3 THEM4 ATPLCK GTP PX-866 4xHC-INS(90-110) p-6Y-EGFR PPP2R5B ATPAKT2 MDM2p-S473-AKT1 E17K Signaling by SCF-KITPDGFA-1 GSK3A p-S473-AKT1 ADPp-6Y,Y1112-ERBB2 p-T308,S473-AKT1FGF9 PDPK1:p-S473-AKT1E17K mutant:PIP2GAB1 PPP2R1A AKT PI(3,4,5)P3 AKT1NRG1 KITLG-1(26-190) KLB p-T24,S256,S319-FOXO1 AKT1S1p-12Y-PDGFRB p-S474-AKT2 FGF3 RHOG p-S21-GSK3A CDKN1B AKT2 PIP5K1B PIP4K2 dimersPP2A-A:PP2A-CPI(3,4,5)P3 Activated FGFR2c homodimer bound to FGF PIK3CA GRB2-1 AKT inhibitors:AKTPIK3CD AKT1 E17K 2xHC-INS(25-54) FYN PI4PPPP2R5E Triciribine p-S-AKT:PDPK1:PIP3PPP2CB Neuregulins H2OActivator:PI3K MyrG-p-Y419-SRC p-Y-IRS2 p-6Y-FGFR3c ADPESR1 PPP2CA Signaling by ERBB2PIP4K2A PIP4K2B p-S473-AKT1 GDC0941 PDPK1:PIP3PPP2CB PPP2R5E PI3K alphaSignaling by ERBB4p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform THEM4/TRIB3CHUKGDC0941 FGF1 FOXO6 FOXO1 RICTOR LY294002 p-S183,T246-AKT1S1PIK3CA PIK3R2 FGF4 ADPPDGFB(82-241) PRR5 PI3K mutants HGF(32-494) PI(4,5)P2 p-S99-BADPDPK1 p-S939,T1462-TSC2p-T305,S472-AKT3 FGF10 EGF-like ligands BADGTP PPP2R1B PIK3R3 p-T157-CDKN1B EGF TORC2 complexp-5Y-GAB1 p-Y1234,Y1235,Y1349,Y1356-MET p-6Y-FGFR3b PPP2R5A FGF19 RAF/MAP kinasecascadePHLPP1 AKT1 p-T,Y MAPK dimersPIK3R3 FGF17-1 AKT1 E17Kmutant:PIP2MLST8 GSK3MAPKAP1 FOXO1,FOXO3,FOXO4,(FOXO6)IER3 PPP2R5D PDPK1 MK2206 FGF2(10-155) PI3K mutants p-S166,S188-MDM2PDGFB (82-190) ATPSignaling by NTRKsp-S109-MKRN1IL33 PX-866 2651317323, 62, 68, 92, 97...176, 195, 2953, 24, 73, 77, 148...7713310, 18, 156, 193, 215...1382, 101, 153, 160, 165...121265265311, 22, 29, 35, 36, 54...3148, 252292292245235775229051381, 6, 7, 15, 25...21114, 51, 1408, 9, 19, 21, 27...148, 25213, 186, 31024512, 33, 53, 63, 82...735224, 15422913326513157, 232, 2384, 42, 55, 271290290151, 30526521123531, 38, 43, 58, 87...24, 154223, 234111, 161, 28426586, 103, 162, 240, 250...26575330225