Arachidonic acid metabolism (Homo sapiens)

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1173, 4108, 10914, 533440, 7523, 73, 8710, 388, 76887021, 29, 39, 8231, 10724, 10250, 1036, 67, 9825, 27, 902, 11036, 37, 1041115, 42, 49, 8368, 12032, 9233, 4665, 66, 9781, 11962, 93, 10628, 35, 72, 1116358, 8488112, 11561, 1115, 42, 49, 8365, 66, 9758, 84638948, 59, 74, 94, 9594135517, 6610116, 47, 80, 9581, 119961228, 51, 71, 72, 1111, 11, 52, 865688241, 11819, 6058, 84765, 66, 91, 9744, 5754100, 10599, 11443, 7722, 306, 67, 9841879, 85, 116182015, 61, 64, 11122, 7326, 4531, 1079, 12158, 848869, 78nuclear envelopeendoplasmic reticulum lumencytosollipid dropletFAAHALOX12B CYP4A11 AANADPHp-S505,S727-PLA2G4A PON1,2,3:2xCa2+dimers15k-PGE2 GSSGCYP4F8 H2OH2O(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoic acid H+O2EPHX2 H2OPTGDS15-oxoETE6k-PGF1a5S-HpETEH2OCYP2C9 H+15k-PGD2/E2/F2aCYP2U1 H+DHET(1)TXN-S2H2NAD+ GPX1/2/4H2ODPEP3 ATPH+H2OGSHAAFe2+ H2OMg2+ CBR1LTA415R-HETEPTGES trimerNADP+H+O215k-PGE2 5-oxoETEFe2+ TrXB3 12-oxoETEALOX12 ALOX5:ALOX5AP:LTC4S6t,12epi-LTB4 Ca2+ CYP1A1 CYP2C9 15k-PGD2 CYP(5)18cooh-LTB4AEAZn2+ dhk-PGE2/F2aH2OCYP2C8 DPEPNADPHNADPHH2OTXN-S2H+GSHCYP1B1 ALOX15 ALOX5AP GGT5(388-586) GGT1, 5 dimersCa2+ ALOX12:Fe2+H+Fe2+ O2H2Oarachidyl esterheme b NADPH15k-PGF2a NADP+CYP2C8 CYP4A11 ADPH2Odelta12-PGJ2PGF2acelecoxibNADP+15-HEDHLTA4H:Zn2+GSSGPCGPX1/2/4O2EXD4TXDH5,6-EETPGD2ALOX15 ALOXE3AKR1C3Ca2+ NADPH 6t/6t,12epi-LTB4CYP8B1 PTGES3 5-HETELTBXAS1CYP4A11 15k-PGF2a PTGES2(88-377) GPX1/2/419-HETEPGE2H2OCYP2C19 NAD+PTGS2 dimerAc-PTGS1 dimerHXA3CYP4F22 acetylsalicylateAc-PTGS2 dimerPTGS1 Fe2+ H2OZn2+ heme b ALOX12 GSH (5Z,8Z,11Z)-14,15-dihydroxyicosatrienoic acid CYP(1)NADPHGSH PTGS1 dimerPGD2 EXA4GPX2 5,6-EET celecoxib 20OH-LTB4GPX4(?-197) TrXA3/B3PC GSHCYP1B1 O2PTGS2 15S-HpETENAD+NADHFe2+ O2ActivePLA2:phosphatidylcholineNADP+ALOX15:Fe2+H2O16-HETE LTC4S GGT1(1-380) PTGES PGB220cho-LTB4NADPH15k-PGE2/F2aHPGDS H2OCYP1A2 NADP+GSHe-H+8,9-EET GGTL-Glu12S-HpETETXA2CYP1A2 (5Z,11Z,14Z)-8,9-dihydroxyicosatrienoic acid EPHX2 dimerALOX15/15BNADPHNADP+LTD4NADP+NAD(P)HPTGS2:celecoxibO-acetyl-L-serine-PTGS2 NAD(P)+CYP4F2 H2OALDHNADP+ CYP1A1 CYP1B1 ETAH2OGPX2 PGD2EXC4ABCC1PTGES2(88-377),PTGES3CYP4F2 15d-PGJ215d-PGA2Fe2+ ALOX5:Ca2+:Fe2+17-HETE NADP+O2NADP+heme b CYP1A1 PGE2 2-LysophosphatidylcholinePGH211epi-PGF2a20-HETELTC4MDANADP+PTGS2 ALOX12B:Fe2+NADPHp-S272,T222,T334-MAPKAPK2PTGIS,CYP8B1PGJ2O2Fe2+ H2OH+Cytochrome P450(CYP4F2/4F3 based)H2OARACOHDPEP1,2,3 dimersO2NADPHdhk-PGF2a 20cooh-LTB4LTC4LTE4PGD2/E2/F2aFAAH2NADH5-HEDH12S-HETEH2OPON2 PGF2a TXB2PGH2H+NADH Acyl-CoALTA4H 18-HETE 5S-HETEFe2+ L-selenocysteine residue-GPX1 HXB3 11dh-TXB2GPX4(?-197) O2NADP+PTGR2AADPEP2 PTGS1 H2O15S-HETEH2OPTGR1CYP(4)H+HXA3/B38,9-EET PGC2L-selenocysteine residue-GPX1 AWAT1ETAH2OCYP4F11 dhk-PGE2 12-oxoLTB4NADPHPTGS2 ALOX12:Fe2+H2OTrXA3 15d-PGD214,15-EET L-selenocysteine residue-GPX1 PON1 ALOX15 5,6-DHET AEAAKR1C3H+p-S272-ALOX5:Ca2+:Fe2+CYP(3)GlyLTB4H2ONADPHCYP1A1 CYP1A2 O-acetyl-L-serine-PTGS1 CYP4F3 CYP1B1 heme b PTGIS CYP4B1 H+FAM213B12R-HETEGGT1(381-569) 11,12-EET GSSGH2OCYP4A22 H+MNAH2OCoA-SH14,15-EET GGT5(1-387) ALOX5 HPGD dimerCYP1A1 HPGDS dimerCYP(2)CYP2U1 HXA3 PON3 NADP+12S-HHT6t-LTB4 PGA2ALOX12 Ca2+ PGI216/17/18-HETEp-S272-ALOX5 HPGD ARADPEP1 CYP1B1 p-S272-ALOX5 CYP1A2 Ca2+ GlyHXEHH+CYP1A2 8,9/11,12/14,15-EETCYP2C19 EXE411,12-EET PGE212R-HpETE5-HETEALOX12/15H2OsalicylateALOX15B Fe2+ GPX2 CYP2J2 H+heme b NADPHL-GluGPX4(?-197) CYP2J2 PGG2EET(1)1032234113737373