Structural Pathway of Interleukin 1 (IL-1) (Homo sapiens)

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1-78cyclinD1etc.IL1,8,6, TNFa, IFNg, COX2, iNOSIRAK4TRAF6B-defensin2 etcIL1R1TranslationERK1IL1AHSP27MAPKAPK2TAB1ModificationMKK3NF-kappaB p65MYD88TOLLIPIRAK2CellCycleJNK1MSK1NF-kappaB p50 TAK1NF-kappaB p105ELK1MEKK3NIKIkapaBalphaIRF7IRAK1IFNalpha/betaIKKalphaMBPTPL2MEKK1MAPKp38betaIL1BIL1RAPTAB2TAB3MKK6MKK4MKK7MKK1MKK2IKKgammaIKKbetaMAPKp38alphaJNK2JNK3ERK2IkappaBbetaATF2Mnk1c-Junc-Fosc-MycMnk2CREB341Histone H3eIF-4E


Description

Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470

IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads).

doi:10.1371/journal.pcbi.1003470.g002

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Ontology Terms

 

Bibliography

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  1. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR; ''A new nomenclature for IL-1-family genes.''; Trends Immunol, 2001 PubMed
  2. Dunn E, Sims JE, Nicklin MJ, O'Neill LA; ''Annotating genes with potential roles in the immune system: six new members of the IL-1 family.''; Trends Immunol, 2001 PubMed
  3. Lawson C, Al-Akoum M, Maheux R, Akoum A; ''Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions.''; Reproduction, 2007 PubMed
  4. Chang L, Karin M; ''Mammalian MAP kinase signalling cascades.''; Nature, 2001 PubMed
  5. Martinon F, Mayor A, Tschopp J; ''The inflammasomes: guardians of the body.''; Annu Rev Immunol, 2009 PubMed
  6. Pizarro TT, Cominelli F; ''Cloning IL-1 and the birth of a new era in cytokine biology.''; J Immunol, 2007 PubMed
  7. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O; ''The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer.''; PLoS Comput Biol, 2014 PubMed
  8. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM; ''O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.''; EMBO J, 2012 PubMed

History

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CompareRevisionActionTimeUserComment
87707view09:09, 25 July 2016MkutmonOntology Term : 'interleukin-1 signaling pathway' added !
87592view08:01, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
80029view12:23, 1 May 2015EgonwAdded the Ensembl ID for MKK3.
80007view12:30, 30 April 2015Zariannotated TPL2 ,kappaB p65 gene
79580view21:44, 25 March 2015Zari
76330view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
76319view06:59, 2 July 2014Mkutmonfixed datasource for IkappaBbeta datanode
73794view17:04, 24 February 2014AndraAdded the main reference
73793view17:02, 24 February 2014Andracorrected encoding errors of greek alphabet letters
73790view16:55, 24 February 2014Andra
73725view15:49, 19 February 2014AndraAdded references
73724view15:45, 19 February 2014AndraAdded identifiers
73723view15:11, 19 February 2014AndraModified description
73722view15:11, 19 February 2014AndraModified description
73721view14:49, 19 February 2014AndraNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
TAK1GeneProductENSG00000135341 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
B-defensin2
etc
Pathway
CREB341GeneProduct
Cell CyclePathway
ELK1GeneProductENSG00000126767 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
HSP27GeneProductENSG00000160633 (Ensembl)
Histone H3GeneProductQ66I33 (Uniprot-TrEMBL)
IFNalpha/betaPathway
IKKalphaGeneProductENSG00000213341 (Ensembl)
IKKbetaGeneProductENSG00000104365 (Ensembl)
IKKgammaGeneProductENSG00000136560 (Ensembl)
IL1,8,6, TNFa, IFNg, COX2, iNOSPathway
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000115008 (Ensembl)
IL1R1GeneProductENSG00000115594 (Ensembl)
IL1RAPGeneProductENSG00000196083 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK2GeneProductENSG00000134070 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IkapaBalphaGeneProductP25963 (Uniprot-TrEMBL)
IkappaBbetaGeneProductQ15653 (Uniprot-TrEMBL)
JNK1GeneProductP45983 (Uniprot-TrEMBL)
JNK2GeneProductP45984 (Uniprot-TrEMBL)
JNK3GeneProductP53779 (Uniprot-TrEMBL)
MAPKAPK2GeneProductENSG00000162889 (Ensembl)
MAPKp38alphaGeneProductENSG00000112062 (Ensembl)
MAPKp38betaGeneProductENSG00000185386 (Ensembl)
MBPGeneProductENSG00000197971 (Ensembl)
MEKK1GeneProductENSG00000095015 (Ensembl)
MEKK3GeneProductENSG00000198909 (Ensembl)
MKK1 GeneProductENSG00000169032 (Ensembl)
MKK2 GeneProductENSG00000126934 (Ensembl)
MKK3 GeneProductENSG00000034152 (Ensembl)
MKK4 GeneProductENSG00000065559 (Ensembl)
MKK6GeneProductENSG00000108984 (Ensembl)
MKK7 GeneProductENSG00000076984 (Ensembl)
MSK1GeneProductENSG00000100784 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
Mnk1GeneProductENSG00000079277 (Ensembl)
Mnk2GeneProductENSG00000099875 (Ensembl)
ModificationPathway
NF-kappaB p105GeneProductP19838 (Uniprot-TrEMBL)
NF-kappaB p50GeneProduct
NF-kappaB p65GeneProductENSG00000173039 (Ensembl)
NIKGeneProductENSG00000006062 (Ensembl)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TAB3GeneProductENSG00000157625 (Ensembl)
TOLLIPGeneProductENSG00000078902 (Ensembl)
TPL2GeneProductENSG00000107968 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TranslationPathway
c-FosGeneProductENSG00000170345 (Ensembl)
c-JunGeneProductENSG00000050748 (Ensembl)
c-MycGeneProductENSG00000136997 (Ensembl)
cyclinD1 etc.Pathway
eIF-4EGeneProductENSG00000151247 (Ensembl)

Annotated Interactions

No annotated interactions

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