Aryl Hydrocarbon Receptor (Homo sapiens)

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311516, 284, 30, 53225042445149, 5483619443445, 56STAT114CyNuHSP9029ActivationTCDD16CyNuNEDD8SUMO7CyNuCyNuProteinNucleusProteinRETEGFRPAHCCL1p300CYP1A1XRENqo1Nrf2TCDDERVEGFEBNA-3proliferation and tumorigenesis DRE regionpRbHsp90Calcium ChannelZAC1p27Kip1AIPKLF6ARNT24, 3533L575016, 28, 325227AIP84612, 4155P36, 3810, 47, 534215, 18, 25AHRP233, 29AHRAHR16HSP9011, 40HSP9026C-myc13TATAEGFR PathwayTNF-α4CDC37c-srcP54RAF1PMAP2K1PERK1/2COX-2SRC-122Rel Ap50Rel Ap50p3009SRC-1AngiogenesisERAP140RIP140CYP1A1CD36LplNrf26Fgf21GstsGclcOxidative StressRIP140NF-1NCOA7SMRT2CYP1A24337CYP1B11, 23Estrogen MetabolismEnzyme ComplexProteinReceptorLigandmRNASmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculep21cip1CDK217, 21RbE2F1Cell cycle inhibitionDetoxification of Xenobiotics and metabolism of xenobioticsCell SurvivalAHRRp30039FAS/ FAS-L (Apoptosis)NRASHRASKRASTCDDPAH15, 18, 2524, 357Cell Survivalmodulation of Estrogen receptor signalling


Description

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity.

AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes

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Bibliography

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History

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CompareRevisionActionTimeUserComment
91687view13:42, 29 March 2017DeSlAnnotation update for several datanodes
91671view13:20, 29 March 2017DeSlAnnotation update for angiogenesis
89793view10:53, 6 October 2016Mkutmonfixed special character in datanode label
88982view09:41, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
88981view09:40, 18 August 2016MirellaKalafatiReverted to version '08:09, 17 August 2016' by MirellaKalafati
88901view08:13, 17 August 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
88900view08:09, 17 August 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
88899view08:09, 17 August 2016MirellaKalafatiOntology Term : 'DOID:5395' removed !
85335view16:12, 7 May 2016EgonwReplaced a mim-conversion with Arrow.
79995view21:04, 29 April 2015ZariAnnotated EBNA-3,COX-2,ERK1/2 , CYP1A1 and Gsts
78547view10:30, 7 January 2015MaintBotadded missing graphIds
76318view06:58, 2 July 2014Mkutmonfixed datasource for pRb datanode
73592view16:10, 3 February 2014Prakamya1986Modified description
73591view16:06, 3 February 2014Prakamya1986Modified description
73590view15:53, 3 February 2014Prakamya1986Specify description
73436view16:30, 28 January 2014Prakamya1986Specify description
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73434view16:16, 28 January 2014Prakamya1986Periodical save, work in progress
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73333view15:59, 21 January 2014Prakamya1986Periodical save, work in progress
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73331view15:28, 21 January 2014Prakamya1986Periodical save, work in progress
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73074view10:48, 23 December 2013Prakamya1986Periodical save, work in progress
73073view10:38, 23 December 2013Prakamya1986Periodical save, work in progress
73072view10:36, 23 December 2013Prakamya1986Specify description
73071view08:52, 23 December 2013Prakamya1986Specify description
73070view07:30, 23 December 2013Prakamya1986Specify description
73069view07:27, 23 December 2013Prakamya1986Specify description
73068view07:24, 23 December 2013Prakamya1986Periodical save, work in progress
73067view07:14, 23 December 2013Prakamya1986Periodical save, work in progress
73056view17:24, 21 December 2013Prakamya1986Specify description
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73054view17:21, 21 December 2013Prakamya1986Specify description

External references

DataNodes

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NameTypeDatabase referenceComment
AHRGeneProduct196 (Entrez Gene)
AHRRGeneProduct57491 (Entrez Gene)
AIPGeneProductENSG00000110711 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
AngiogenesisPathwayWP1539 (WikiPathways)
C-mycProtein4609 (Entrez Gene)
CCL1GeneProduct6346 (Entrez Gene) PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
CD36GeneProduct948 (Entrez Gene)
CDC37GeneProduct11140 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
COX-2GeneProduct5743 (Entrez Gene)
CYP1A1Protein1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP1B1GeneProduct1545 (Entrez Gene)
Calcium Channel
Cell SurvivalPathway
Cell Survival Pathway
Cell cycle inhibitionPathway
DRE regionComplex
Detoxification of Xenobiotics and metabolism of xenobiotics Pathway
E2F1GeneProduct1869 (Entrez Gene)
EBNA-3Protein17494212 (Entrez Gene)
EGFR PathwayPathwayWP1910 (WikiPathways)
EGFRGeneProduct1956 (Entrez Gene)
ERProtein2099 (Entrez Gene) Estrogen Receptor
ERAP140Protein135112 (Entrez Gene) Official Symbol= NCOA7
ERK1/2 Protein5594 (Entrez Gene)
Estrogen MetabolismPathwayWP697 (WikiPathways)
FAS/ FAS-L (Apoptosis)PathwayWP254 (WikiPathways)
Fgf21Protein26291 (Entrez Gene)
GclcProtein2729 (Entrez Gene)
GstsProtein27306 (Entrez Gene)
HRASGeneProductENSG00000174775 (Ensembl)
HSP90GeneProduct3320 (Entrez Gene)
Hsp90Protein3320 (Entrez Gene)
KLF6GeneProduct1316 (Entrez Gene)
KRASGeneProductENSG00000133703 (Ensembl)
LplProtein4023 (Entrez Gene) lipoprotein lipase
MAP2K1GeneProductENSG00000169032 (Ensembl)
NCOA7Protein135112 (Entrez Gene)
NF-1Protein4763 (Entrez Gene)
NRASGeneProductENSG00000213281 (Ensembl)
Nqo1Protein1728 (Entrez Gene)
Nrf2GeneProduct4780 (Entrez Gene)
Oxidative Stress PathwayWP408 (WikiPathways)
P23GeneProductENSG00000110711 (Ensembl)
PAHMetabolite33848 (ChEBI)
RAF1GeneProductENSG00000132155 (Ensembl)
RETProtein5979 (Entrez Gene)
RIP140Protein8204 (Entrez Gene)
RbGeneProduct5925 (Entrez Gene)
Rel AGeneProduct5970 (Entrez Gene)
SMRTProtein9612 (Entrez Gene)
SRC-1GeneProduct84722 (Entrez Gene)
TATAComplex
TCDDMetabolite28119 (ChEBI)
TNF-αGeneProduct7124 (Entrez Gene)
VEGFGeneProduct7422 (Entrez Gene)
XRExenobiotic responsive element
ZAC1Protein5325 (Entrez Gene)
c-srcProtein6714 (Entrez Gene)
modulation of Estrogen receptor signallingPathwayWP712 (WikiPathways)
p21cip1GeneProduct1026 (Entrez Gene)
p27Kip1GeneProduct1027 (Entrez Gene)
p300Protein2033 (Entrez Gene)
p50GeneProduct4790 (Entrez Gene)
pRbProteinP06400 (Uniprot-TrEMBL)
proliferation and tumorigenesis Pathway

Annotated Interactions

No annotated interactions

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