Glycerophospholipid Biosynthetic Pathway (Homo sapiens)

From WikiPathways

Revision as of 17:10, 4 June 2016 by Egonw (Talk | contribs)
Jump to: navigation, search
12, 34, 65, 76Shark liver oil1-Alkenyl-2-acylglycerophosphocholine(Plasmenylcholine)25, 64, 78, 88, 92...1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine(Plasmanylethanolamine)113, 262, 2981-Alkyl-sn-glycerol 3-phosphate1-alkyl-2-acyl-sn-glycero-3-phosphocholine(Plasmanylcholine)1611-alkyl-2-acyl-sn-glycerol 3-phosphate(Plasmanic acid)21, 55, 2421-alkenyl-2-acylglycerophosphoethanolamine(Plasmenylethanolamine)Acylglycerone-phosphate reductase(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)EC 1.1.1.10124, 70, 88, 116, 188...Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferaseEC 2.3.1.-104, 2701-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase(Phosphatidate phosphatase)EC 3.1.3.4CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase(Ethanolaminephosphotransferase)EC 2.7.8.11-alkyl-2-acyl-sn-glycerophoethanolamine desaturase(Plasmanylethanolamine desaturase)EC 1.14.99.193, 43, 142, 172, 213...CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase(Diacylglycerol cholinephosphotransferase)EC 2.7.8.2116, 117Nitrogen group transferasaEC 2.6.-.-1-alkyl-2-acyl-sn-glycerol170NADPH + H+NADP(Coenzyme II)Acyl-CoACoA-SHPiCytidine diphosphate ethanolamine(CDP-ethanolamine)CMPO2 + NADH + H+2H2OCytochrome bCytidine 5'-diphosphocholine(CDP-choline)CMPCholineEthanolamine1-Alkyl-2-acetyl-sn-glycerol 3-phosphateAlkylglycerophosphate 2-O-acetyltransferaseEC 2.3.1.105225H2O79, 212, 243, 260PiAcetyl-CoACoA-SHAlkylacetylglycerophosphataseEC 3.1.3.591-Alkyl-2-acetyl-sn-glycerol5Diacylglycerol cholinephosphotransferase(Cholinephosphotransferase 1)EC 2.7.8.269, 122, 225, 265249, 292, 2991-alkyl-2-acetyl-sn-glycero-3-phosphocholine(Platelet Activating Factor, PAF)44, 58, 60, 82, 98...S-Adenosylmethionine(AdoMet)S-Adenosylhomocysteine(AdoHcy)N-MethyltransferaseEC 2.1.1.-Phospholipase CEC 3.1.4.3H2OEthanolamine phosphateEthanolaminephosphotransferaseEC 2.7.8.1CMP43, 164, 172, 202, 204...CDP-ethanolamineCDP-cholineCMP1-alkyl-sn-glycero-3-phosphocholine(Lyso PAF)81, 216Phospholipase A2EC 3.1.1.4Acyl group28, 45, 49, 105, 125...1-Alkylglycerophosphocholine O-acetyltransferaseEC 2.3.1.674, 90, 102, 130, 140...Acetyl-CoACoA-SH1-Alkyl-sn-glycerolAlkylglycerol kinaseEC 2.7.1.93170196ATPADPR-CH2-CH2-OH(Long chain fatty alcohol)CholineCytidine diphosphate choline(CDP-choline)15, 72, 96, 137, 143...triacyl-sn-glycerol(Triacylglycerol; TAG)18, 75, 93, 100, 121...Adenosine triphosphate(ATP)sn-glycerol-3-phosphate(glycerol-3-P)1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA)66, 195, 210, 282, 290135, 180, 235, 254PPiNAD+(Coenzyme I)Glycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.8Pyrimidine Metabolism31, 120, 162, 191, 248Fatty acyl-CoADihydroxyacetone phosphate1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG)110, 285146, 205, 211, 228GlycerolNADH + H+Fatty acid MetabolismPhosphocholine(Choline-P)72, 2711,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin)2, 54, 72, 174, 207...CoA-SH2-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA)9, 59, 131, 134, 168...GlycolysisAdenosine diphosphate(ADP)CTPPiATPADPGlycerol kinaseEC 2.7.1.30Acyl-CoA2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52Glycerol-3-phosphate 2-O-acyltransferaseEC 2.3.1.198267Acyl coenzyme A(Acyl-CoA)56, 62, 91, 139, 151...Coenzyme A(CoA-SH)Phosphatidate phosphataseEC 3.1.3.47, 11, 27, 37, 129...Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate cytidylyltransferaseEC 2.7.7.41Cytidine triphosphate(CTP)95, 155, 167, 244PPiCholine kinaseEC 2.7.1.3213, 106, 137, 178, 221...Choline-phosphate cytidylyltransferaseEC 2.7.7.1520, 137, 152, 301Diacylglycerol cholinephosphotransferaseEC 2.7.8.242, 68, 97, 148, 202...Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.1757, 84, 85, 111, 179...3 (S-adenosylhomocysteine)CMPAlkyldihydroxyacetonephosphate synthase(Alkyl-DHAP synthase)EC 2.5.1.261-Alkyldihydroxyacetone phosphate(Octanoyl DHAP)26, 32, 51, 147, 163...1-Acyl dihydroxyacetone phosphate(Acyl-DHAP)39, 200, 229, 23950, 293Coenzyme A(CoA-SH)R'-COOHDihydroxyacetone phosphate acyltransferaseEC 2.3.1.4263, 74, 99, 206, 259...1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG)40, 132, 197, 253Cardiolipin(DPG, CL)10, 29, 46, 52, 80...PiInositolPhosphatidylinositol3,4,5-triphosphate[PIP3(3',4',5')]1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)17, 71, 173, 198, 2276, 190, 201, 250Cytidine monophosphate(CMP)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate)(PGP)1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA)22, 1811D-myo-Inositol-1-PPhosphatidylinositol-4,5-bisphosphate[PIP2(4',5')]1, 35, 89, 94, 108...D-Glucose-6-PPhosphatidylinositol-4-phosphate(PIP)Glycerol-3-P33, 112, 138, 232, 240CMPATPADPATPADPATPADPCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5PhosphatidylglycerophosphataseEC 3.1.3.2716, 187, 215, 223, 247H2O19, 77Cardiolipin synthaseEC 2.7.8.-157, 199CDP-DAGCMPCDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.1136, 123, 133, 273, 2861-phosphatidylinositol 4-kinaseEC 2.7.1.678, 14, 41, 114, 233...1-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.15389, 192, 193, 217Glycolysis1,2-diacyl-sn-glycero-3-phosphoserine(PS)38, 53, 61, 124, 141...Phosphorylethanolamine1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE)873 (S-adenosyl-methionine)30, 53, 127, 145, 169...EthanolamineSerineCytidine diphosphate ethanolamine(CDP-ethanolamine)83, 101, 150, 256, 269CMPATPADPCTPPPiEthanolamineDiacylglycerol O-acyltransferaseEC 2.3.1.20Ethanolamine kinaseEC 2.7.1.8223, 48, 67, 73, 103...Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.1447, 109, 156, 165EthanolaminephosphotransferaseEC 2.7.8.1L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.2986, 136, 144, 164, 202...38, 53GlycolysisBiosynthesis pathwaysDegradation pathwaysPathway origin


Description

Glycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty amine, sphingosine, are glycerol-based phospholipids and the main component of biological membranes. The hydrophilic moieties in these amphipathic compounds may be as a simple as a single -OH at one end of the sterol ring system, or they may be more complex. Glycerophospholipds, as well as sphingolipids, contained polar or charged alcohols at their polar ends; some also contain phosphate groups.

In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. All glycerophospholipds are derivatives of phosphatidic acid and are named for their polar head groups (e.g., phosphatidylethanolamine and phosphatidylcholine). All have a negative charge on the phosphate group at pH 7.0. The head-goup alcohol may also contribute one or more charges at pH near 7.0. The fatty acids in glycerophospholipds can be any of a wide variety. They are different in different species, in different tissues of the same species, and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated fatty acid at C-1 and an unsaturated fatty acid at C-2, and, in general terms, the fatty acyl groups are generally 16 or 18 carbons long.

Eukaryotic membranes contain significant amounts of two other types of glycerophospholipids: Plasmalogens and Alkylacylglycerophospholipids. Plasmalogens contain a hydrocarbon chain linked to glycerol C-1 via vinyl ether linkage whereas alkylacylglycerophospholipids the alkyl substituent at glycerol C-1 is attached via an ether linkage. About 20% of mammalian glycerophospholipids are plasmalogens, this percentage varies both from species to species and from tissue to tissue within a given organism. While plasmalogens comprise only about 0.8% of the phospholipids in human liver, they account for around 23% of those in human nervous tissue. The alkylacylglycerophospholipids are less abundant than the plasmalogens, e.g., about 59% of ethanolamine glycerophospholipids of human heart are plasmalogens, whereas only 3.6% are alkylacylglycerophospholipids. However, in bovine erythrocytes, 75% of the ethanolamine glycerophospholipids are of alkylacyl type.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK; ''Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.''; Life Sci, 2008 PubMed
  2. Thompson RJ; ''The biosynthesis of cytidine diphosphate diacylglycerol in the mammalian cerebral cortex.''; Biochem Soc Trans, 1977 PubMed
  3. Vance DE; ''Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.''; Eur J Med Res, 1996 PubMed
  4. Ridgway ND; ''The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.''; Crit Rev Biochem Mol Biol, 2013 PubMed
  5. Nikawa J, Yamashita S; ''Yeast mutant defective in synthesis of phosphatidylinositol. Isolation and characterization of a CDPdiacylglycerol--inositol 3-phosphatidyltransferase Km mutant.''; Eur J Biochem, 1982 PubMed
  6. McGee TP, Skinner HB, Bankaitis VA; ''Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae.''; J Bacteriol, 1994 PubMed
  7. Chicco AJ, Sparagna GC; ''Role of cardiolipin alterations in mitochondrial dysfunction and disease.''; Am J Physiol Cell Physiol, 2007 PubMed
  8. Rüdiger M, Kolleck I, Putz G, Wauer RR, Stevens P, Rüstow B; ''Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures.''; Am J Physiol, 1998 PubMed
  9. D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA; ''The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.''; J Cell Sci, 2008 PubMed
  10. Ide H, Miller JC, Weinhold PA; ''Ethanolaminephosphotransferase in rat lung: selectivity for endogenous and exogenous diacylglycerol.''; Biochim Biophys Acta, 1988 PubMed
  11. Snyder F, Lee TC; ''1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphatase.''; Methods Enzymol, 1992 PubMed
  12. de Vet EC, Ijlst L, Oostheim W, Wanders RJ, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.''; J Biol Chem, 1998 PubMed
  13. Pagès C, Simon MF, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release.''; Prostaglandins Other Lipid Mediat, 2001 PubMed
  14. Rooney SA; ''Lung surfactant.''; Environ Health Perspect, 1984 PubMed
  15. Hirasawa K, Nishizuka Y; ''Phosphatidylinositol turnover in receptor mechanism and signal transduction.''; Annu Rev Pharmacol Toxicol, 1985 PubMed
  16. Lucken-Ardjomande Hasler S; ''Cholesterol, cardiolipin, and mitochondria permeabilisation.''; Anticancer Agents Med Chem, 2012 PubMed
  17. Arthur G, Page L; ''Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver.''; Biochem J, 1991 PubMed
  18. Sugimoto H, Banchio C, Vance DE; ''Transcriptional regulation of phosphatidylcholine biosynthesis.''; Prog Lipid Res, 2008 PubMed
  19. Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, Schlame M, Kobayashi T; ''De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.''; J Lipid Res, 2007 PubMed
  20. Debeer LJ, Declercq PE, Mannaerts GP; ''Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.''; FEBS Lett, 1981 PubMed
  21. Sorger D, Daum G; ''Triacylglycerol biosynthesis in yeast.''; Appl Microbiol Biotechnol, 2003 PubMed
  22. Patil VA, Greenberg ML; ''Cardiolipin-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed
  23. Antonsson B; ''Phosphatidylinositol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed
  24. Downes CP, Carter AN; ''Inositol lipids and phosphates.''; Curr Opin Cell Biol, 1990 PubMed
  25. Francescangeli E, Goracci G; ''The de novo biosynthesis of platelet-activating factor in rat brain.''; Biochem Biophys Res Commun, 1989 PubMed
  26. Roberti R, Mancini A, Freysz L, Binaglia L; ''Reversibility of the reactions catalyzed by cholinephosphotransferase and ethanolaminephosphotransferase solubilized from rat-brain microsomes.''; Biochim Biophys Acta, 1992 PubMed
  27. Blank ML, Lee YJ, Cress EA, Snyder F; ''Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production.''; J Biol Chem, 1988 PubMed
  28. Brindley DN, Pilquil C, Sariahmetoglu M, Reue K; ''Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.''; Biochim Biophys Acta, 2009 PubMed
  29. Balla T; ''Phosphatidylinositol 4-kinases.''; Biochim Biophys Acta, 1998 PubMed
  30. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I).''; Drugs, 1991 PubMed
  31. Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, Fernández-Checa JC; ''Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death.''; Biochim Biophys Acta, 2010 PubMed
  32. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed
  33. Vance JE, Tasseva G; ''Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.''; Biochim Biophys Acta, 2013 PubMed
  34. Ward KB, Pattabiraman N; ''Comparative anatomy of phospholipase A2 structures.''; Adv Exp Med Biol, 1990 PubMed
  35. Rüstow B, Kunze D; ''Diacylglycerol synthesized in vitro from sn-glycerol 3-phosphate and the endogenous diacylglycerol are different substrate pools for the biosynthesis of phosphatidylcholine in rat lung microsomes.''; Biochim Biophys Acta, 1985 PubMed
  36. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed
  37. Li Z, Vance DE; ''Phosphatidylcholine and choline homeostasis.''; J Lipid Res, 2008 PubMed
  38. Lake BD; ''Histochemical demonstration of cytosolic alpha-glycerophosphate dehydrogenase (EC 1.1.1.8) and mitochondrial alpha-glycerophosphate dehydrogenase (EC 1.1.99.5).''; J Neurol Sci, 1987 PubMed
  39. Chao W, Olson MS; ''Platelet-activating factor: receptors and signal transduction.''; Biochem J, 1993 PubMed
  40. Ohtsuka J, Nagata K, Lee WC, Ono Y, Fukuda R, Ohta A, Tanokura M; ''Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 PubMed
  41. van den Bosch H, Aarsman AJ, van Schaik RH, Schalkwijk CG, Neijs FW, Sturk A; ''Structural and enzymological properties of cellular phospholipases A2.''; Biochem Soc Trans, 1990 PubMed
  42. Murakami M, Lambeau G; ''Emerging roles of secreted phospholipase A(2) enzymes: an update.''; Biochimie, 2013 PubMed
  43. Thompson DH, Inerowicz HD, Grove J, Sarna T; ''Structural characterization of plasmenylcholine photooxidation products.''; Photochem Photobiol, 2003 PubMed
  44. Hartz CS, Schalinske KL; ''Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine.''; Nutr Rev, 2006 PubMed
  45. Arienti G, Goracci G, Porcellati G; ''Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.''; Neurochem Res, 1981 PubMed
  46. Tijburg LB, Geelen MJ, Van Golde LM; ''Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes.''; Biochem Biophys Res Commun, 1989 PubMed
  47. Leventis PA, Grinstein S; ''The distribution and function of phosphatidylserine in cellular membranes.''; Annu Rev Biophys, 2010 PubMed
  48. McMaster CR, Bell RM; ''CDP-choline:1,2-diacylglycerol cholinephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed
  49. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed
  50. Paoletti L, Elena C, Domizi P, Banchio C; ''Role of phosphatidylcholine during neuronal differentiation.''; IUBMB Life, 2011 PubMed
  51. Gibbons GF, Islam K, Pease RJ; ''Mobilisation of triacylglycerol stores.''; Biochim Biophys Acta, 2000 PubMed
  52. Muzia TI, Kulikov VN; ''[1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase is associated primarily with low density lipoproteins in human blood].''; Biokhimiia, 1991 PubMed
  53. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed
  54. Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N; ''Biosynthetic pathways of bioactive N-acylethanolamines in brain.''; CNS Neurol Disord Drug Targets, 2013 PubMed
  55. de Vet EC, Hilkes YH, Fraaije MW, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide.''; J Biol Chem, 2000 PubMed
  56. Scherer M, Schmitz G; ''Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin.''; Chem Phys Lipids, 2011 PubMed
  57. Goñi FM, Alonso A; ''Structure and functional properties of diacylglycerols in membranes.''; Prog Lipid Res, 1999 PubMed
  58. Wu G, Vance DE; ''Choline kinase and its function.''; Biochem Cell Biol, 2010 PubMed
  59. Mott GE, Brinkley AW; ''Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium.''; J Bacteriol, 1979 PubMed
  60. André A, Tessier C, Brétillon L, Sébédio JL, Chardigny JM; ''In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis.''; Brain Res Mol Brain Res, 2005 PubMed
  61. Whatley RE, Clay KL, Chilton FH, Triggiani M, Zimmerman GA, McIntyre TM, Prescott SM; ''Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells.''; Prostaglandins, 1992 PubMed
  62. Koynova R, Caffrey M; ''Phases and phase transitions of the hydrated phosphatidylethanolamines.''; Chem Phys Lipids, 1994 PubMed
  63. Henneberry AL, Wistow G, McMaster CR; ''Cloning, genomic organization, and characterization of a human cholinephosphotransferase.''; J Biol Chem, 2000 PubMed
  64. Schlegel RA, Williamson P; ''P.S. to PS (phosphatidylserine)--pertinent proteins in apoptotic cell clearance.''; Sci STKE, 2007 PubMed
  65. Moolenaar WH; ''Lysophosphatidic acid, a multifunctional phospholipid messenger.''; J Biol Chem, 1995 PubMed
  66. Siegel A, Baker RR; ''Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia.''; Biochem Cell Biol, 1996 PubMed
  67. Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Ben Mamoun C; ''Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.''; FEMS Microbiol Rev, 2011 PubMed
  68. Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S; ''Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.''; J Biol Chem, 2009 PubMed
  69. Sukumaran S, Barnes RI, Garg A, Agarwal AK; ''Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.''; J Mol Endocrinol, 2009 PubMed
  70. Piantadosi C, Ishaq KS, Wykle RL, Snyder F; ''Synthesis and characterization of 1-O-alkyldihydroxyacetone phosphates and derivatives.''; Biochemistry, 1971 PubMed
  71. Graham TR, Burd CG; ''Coordination of Golgi functions by phosphatidylinositol 4-kinases.''; Trends Cell Biol, 2011 PubMed
  72. MacDonald PM, McMurray WC; ''Partial purification and properties of mammalian phosphatidylglycerophosphatase.''; Biochim Biophys Acta, 1980 PubMed
  73. Shin J, Thompson DH; ''Direct synthesis of plasmenylcholine from allyl-substituted glycerols.''; J Org Chem, 2003 PubMed
  74. Coleman R, Bell RM; ''Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.''; J Biol Chem, 1977 PubMed
  75. Coleman RA; ''Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine.''; Methods Enzymol, 1992 PubMed
  76. de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, Wanders RJ; ''Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.''; J Lipid Res, 1999 PubMed
  77. Heacock AM, Agranoff BW; ''CDP-diacylglycerol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed
  78. Carman GM, Han GS; ''Roles of phosphatidate phosphatase enzymes in lipid metabolism.''; Trends Biochem Sci, 2006 PubMed
  79. Henneberry AL, McMaster CR; ''Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.''; Biochem J, 1999 PubMed
  80. Cornell RB; ''Cholinephosphotransferase from mammalian sources.''; Methods Enzymol, 1992 PubMed
  81. Pagès C, Simon M, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release(1).''; Prostaglandins, 2001 PubMed
  82. Nakagawa T, Harada N, Miyamoto A, Kawanishi Y, Yoshida M, Shono M, Mawatari K, Takahashi A, Sakaue H, Nakaya Y; ''Membrane topology of murine glycerol-3-phosphate acyltransferase 2.''; Biochem Biophys Res Commun, 2012 PubMed
  83. Downes P, Michell RH; ''Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function.''; Cell Calcium, 1982 PubMed
  84. Huang CL; ''Complex roles of PIP2 in the regulation of ion channels and transporters.''; Am J Physiol Renal Physiol, 2007 PubMed
  85. Kent C; ''Eukaryotic phospholipid biosynthesis.''; Annu Rev Biochem, 1995 PubMed
  86. Rabert U, Völkl A, Debuch H; ''Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver.''; Biol Chem Hoppe Seyler, 1986 PubMed
  87. Idahl LA, Lembert N; ''Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells.''; Biochem J, 1995 PubMed
  88. Yang CY, Frohman MA; ''Mitochondria: signaling with phosphatidic acid.''; Int J Biochem Cell Biol, 2012 PubMed
  89. Mavis RD, Vang MJ; ''Optimal assay and subcellular location of phosphatidylglycerol synthesis in lung.''; Biochim Biophys Acta, 1981 PubMed
  90. Snyder F; ''CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor.''; Biochim Biophys Acta, 1997 PubMed
  91. Lee TC, Qian CG, Snyder F; ''Biosynthesis of choline plasmalogens in neonatal rat myocytes.''; Arch Biochem Biophys, 1991 PubMed
  92. Kooijman EE, Burger KN; ''Biophysics and function of phosphatidic acid: a molecular perspective.''; Biochim Biophys Acta, 2009 PubMed
  93. Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T; ''Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.''; J Neurochem, 2011 PubMed
  94. Favrelière S, Barrier L, Durand G, Chalon S, Tallineau C; ''Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum.''; Lipids, 1998 PubMed
  95. Spencer DA; ''An update on PAF.''; Clin Exp Allergy, 1992 PubMed
  96. Lacal JC; ''Choline kinase: a novel target for antitumor drugs.''; IDrugs, 2001 PubMed
  97. Cabezas MC, Erkelens DW; ''Triglycerides and atherosclerosis: to feast or fast.''; Neth J Med, 2000 PubMed
  98. Quest AF, Ghosh S, Xie WQ, Bell RM; ''DAG second messengers: molecular switches and growth control.''; Adv Exp Med Biol, 1997 PubMed
  99. Zhao Y, Natarajan V; ''Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.''; Biochim Biophys Acta, 2013 PubMed
  100. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro.''; J Biol Chem, 1982 PubMed
  101. Tzagournis M; ''Triglycerides in clinical medicine. A review.''; Am J Clin Nutr, 1978 PubMed
  102. Schümperli M, Pellaux R, Panke S; ''Chemical and enzymatic routes to dihydroxyacetone phosphate.''; Appl Microbiol Biotechnol, 2007 PubMed
  103. Rosonina E, Manley JL; ''From transcription to mRNA: PAF provides a new path.''; Mol Cell, 2005 PubMed
  104. Jones AR, Gillan L; ''Metabolism of glycerol 3-phosphate by mature boar spermatozoa.''; J Reprod Fertil, 1996 PubMed
  105. Kawasaki K, Nishijima M; ''[Biosynthesis and function of phosphatidylglycerol and cardiolipin in animal cells].''; Tanpakushitsu Kakusan Koso, 1999 PubMed
  106. Gonzalvez F, Gottlieb E; ''Cardiolipin: setting the beat of apoptosis.''; Apoptosis, 2007 PubMed
  107. Vance JE; ''Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.''; J Lipid Res, 2008 PubMed
  108. Zhang L, Mao YS, Janmey PA, Yin HL; ''Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.''; Subcell Biochem, 2012 PubMed
  109. Biermann J, Just WW, Wanders RJ, Van Den Bosch H; ''Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes.''; Eur J Biochem, 1999 PubMed
  110. Santiago OM, Rosenberg LI, Monaco ME; ''Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes.''; Biochem J, 1993 PubMed
  111. Xu YF, O K, Choy PC; ''Plasmenylcholine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphocholine) biosynthesis in guinea-pig heart and liver: cholinephosphotransferase is a bifunctional enzyme for the synthesis of phosphatidylcholine and plasmenylcholine.''; Biochem J, 1994 PubMed
  112. Bewley GC, Cook JL; ''Molecular structure, developmental regulation, and evolution of the gene encoding glycerol-3-phosphate dehydrogenase isozymes in Drosophila melanogaster.''; Prog Clin Biol Res, 1990 PubMed
  113. Ofman R, Hogenhout EM, Wanders RJ; ''Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1999 PubMed
  114. Mrá�ek T, Drahota Z, Houštěk J; ''The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.''; Biochim Biophys Acta, 2013 PubMed
  115. Glaser KB, Mobilio D, Chang JY, Senko N; ''Phospholipase A2 enzymes: regulation and inhibition.''; Trends Pharmacol Sci, 1993 PubMed
  116. Salamon RS, Backer JM; ''Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases.''; Bioessays, 2013 PubMed
  117. Fagone P, Jackowski S; ''Phosphatidylcholine and the CDP-choline cycle.''; Biochim Biophys Acta, 2013 PubMed
  118. Macfarlane MG; ''Phosphatidylglycerols and lipoamino acids.''; Adv Lipid Res, 1964 PubMed
  119. Brown A, Snyder F; ''Alkyldihydroxyacetonephosphate synthase.''; Methods Enzymol, 1992 PubMed
  120. Nikawa J, Yamashita S; ''Phosphatidylinositol synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed
  121. Reue K, Brindley DN; ''Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.''; J Lipid Res, 2008 PubMed
  122. Farese RV Jr, Cases S, Smith SJ; ''Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.''; Curr Opin Lipidol, 2000 PubMed
  123. Dircks LK, Sul HS; ''Mammalian mitochondrial glycerol-3-phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed
  124. Edwards YH, Shaw MA; ''The isozymes of membrane-associated enzymes: acetylcholinesterase, succinate dehydrogenase, and glycerol-3-phosphate dehydrogenase.''; Isozymes Curr Top Biol Med Res, 1983 PubMed
  125. Vance DE, Walkey CJ, Agellon LB; ''Why has phosphatidylethanolamine N-methyltransferase survived in evolution?''; Biochem Soc Trans, 1998 PubMed
  126. Giudici ML, Hinchliffe KA, Irvine RF; ''Phosphatidylinositol phosphate kinases.''; J Endocrinol Invest, 2004 PubMed
  127. van den Bout I, Divecha N; ''PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.''; J Cell Sci, 2009 PubMed
  128. Roberti R, Binaglia L, Francescangeli E, Goracci G, Porcellati G; ''Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine through ethanolaminephosphotransferase activity in the neuronal and glial cells of rabbit in vitro.''; Lipids, 1975 PubMed
  129. Tijburg LB, Geelen MJ, van Golde LM; ''Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver.''; Biochim Biophys Acta, 1989 PubMed
  130. Saulnier-Blache JS; ''[Lysophosphatidic acid: a "bioactive" phospholipid].''; Med Sci (Paris), 2004 PubMed
  131. Suh BC, Hille B; ''Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.''; Curr Opin Neurobiol, 2005 PubMed
  132. Bru R, Blöchliger E, Luisi PL; ''sn-1,2-diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme.''; Arch Biochem Biophys, 1993 PubMed
  133. Jiang F, Kelly BL, Hagopian K, Greenberg ML; ''Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe.''; J Biol Chem, 1998 PubMed
  134. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T; ''A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.''; J Biol Chem, 2007 PubMed
  135. Vance JE, Steenbergen R; ''Metabolism and functions of phosphatidylserine.''; Prog Lipid Res, 2005 PubMed
  136. Secades JJ, Lorenzo JL; ''Citicoline: pharmacological and clinical review, 2006 update.''; Methods Find Exp Clin Pharmacol, 2006 PubMed
  137. Ueda H, Matsunaga H, Olaposi OI, Nagai J; ''Lysophosphatidic acid: chemical signature of neuropathic pain.''; Biochim Biophys Acta, 2013 PubMed
  138. Baker RR; ''Enzymes of platelet activating factor synthesis in brain.''; Neurochem Res, 1995 PubMed
  139. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed
  140. Tufano MA, Biancone L, Rossano F, Capasso C, Baroni A, De Martino A, Iorio EL, Silvestro L, Camussi G; ''Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells.''; Eur J Biochem, 1993 PubMed
  141. Xu FY, O K, Choy PC; ''Biosynthesis of plasmenylethanolamine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) in the guinea pig heart.''; J Lipid Res, 1997 PubMed
  142. Carman GM; ''Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli.''; Biochim Biophys Acta, 1997 PubMed
  143. Yamashita S, Hosaka K; ''Choline kinase from yeast.''; Biochim Biophys Acta, 1997 PubMed
  144. Klingenberg M; ''Cardiolipin and mitochondrial carriers.''; Biochim Biophys Acta, 2009 PubMed
  145. Arenth PM, Russell KC, Ricker JH, Zafonte RD; ''CDP-choline as a biological supplement during neurorecovery: a focused review.''; PM R, 2011 PubMed
  146. Vance JE; ''Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism.''; Prog Nucleic Acid Res Mol Biol, 2003 PubMed
  147. Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G; ''Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.''; Acta Biochim Biophys Sin (Shanghai), 2009 PubMed
  148. van Heusden GP, van den Bosch H; ''The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase.''; Eur J Biochem, 1978 PubMed
  149. Insall RH, Weiner OD; ''PIP3, PIP2, and cell movement--similar messages, different meanings?''; Dev Cell, 2001 PubMed
  150. Hoch FL; ''Cardiolipins and biomembrane function.''; Biochim Biophys Acta, 1992 PubMed
  151. Han XL, Gross RW; ''Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs.''; Biochemistry, 1990 PubMed
  152. Ishidate K, Matsuo R, Nakazawa Y; ''CDP-choline: 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. II. Photoaffinity labeling by radioactive CDP-choline analogs.''; Biochim Biophys Acta, 1992 PubMed
  153. Mackenzie CG, Reiss OK, Moritz E, Mackenzie JB; ''Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways.''; J Lipid Res, 1976 PubMed
  154. Clement JM, Kent C; ''CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.''; Biochem Biophys Res Commun, 1999 PubMed
  155. Tijburg LB, Vermeulen PS, van Golde LM; ''Ethanolamine-phosphate cytidylyltransferase.''; Methods Enzymol, 1992 PubMed
  156. Schug ZT, Gottlieb E; ''Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.''; Biochim Biophys Acta, 2009 PubMed
  157. Baker RR, Chang HY; ''Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex.''; Biochim Biophys Acta, 1996 PubMed
  158. Diagne A, Fauvel J, Record M, Chap H, Douste-Blazy L; ''Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig.''; Biochim Biophys Acta, 1984 PubMed
  159. Snyder F; ''Alkylglycerol phosphotransferase.''; Methods Enzymol, 1992 PubMed
  160. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI; ''Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action.''; Biochemistry (Mosc), 2010 PubMed
  161. Snyder F; ''Metabolic processing of PAF.''; Clin Rev Allergy, 1994 PubMed
  162. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S; ''Role of mitochondria in toxic oxidative stress.''; Mol Interv, 2005 PubMed
  163. Paltauf F; ''Isolation of soluble proteins capable of stimulating aerobic plasmalogen biosynthesis.''; Eur J Biochem, 1978 PubMed
  164. Nikawa J, Yamashita S; ''Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae.''; Eur J Biochem, 1984 PubMed
  165. Shenker BJ, Ali H, Boesze-Battaglia K; ''PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases.''; Curr Pharm Des, 2011 PubMed
  166. Aoki J, Inoue A, Okudaira S; ''Two pathways for lysophosphatidic acid production.''; Biochim Biophys Acta, 2008 PubMed
  167. Kawasaki K, Kuge O, Yamakawa Y, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells.''; Biochem J, 2001 PubMed
  168. Ishidate K, Matsuo R, Nakazawa Y; ''CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor.''; Lipids, 1993 PubMed
  169. Kocsis MG, Weselake RJ; ''Phosphatidate phosphatases of mammals, yeast, and higher plants.''; Lipids, 1996 PubMed
  170. Talmud PJ; ''Genetic determinants of plasma triglycerides: impact of rare and common mutations.''; Curr Atheroscler Rep, 2001 PubMed
  171. Sinha RK, Subrahmanyam G; ''Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.''; Indian J Biochem Biophys, 2007 PubMed
  172. Nojima S; ''Platelet-activating factor (PAF): an introduction.''; Lipids, 1991 PubMed
  173. Carrasco S, Mérida I; ''Diacylglycerol, when simplicity becomes complex.''; Trends Biochem Sci, 2007 PubMed
  174. Cole LK, Vance JE, Vance DE; ''Phosphatidylcholine biosynthesis and lipoprotein metabolism.''; Biochim Biophys Acta, 2012 PubMed
  175. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon.''; Biochim Biophys Acta, 1981 PubMed
  176. Lewis RN, McElhaney RN; ''The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes.''; Biochim Biophys Acta, 2009 PubMed
  177. Singh H, Beckman K, Poulos A; ''Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.''; J Lipid Res, 1993 PubMed
  178. Blank ML, Spector AA, Kaduce TL, Lee TC, Snyder F; ''Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.''; Biochim Biophys Acta, 1986 PubMed
  179. Hjelmstad RH, Morash SC, McMaster CR, Bell RM; ''Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases.''; J Biol Chem, 1994 PubMed
  180. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J; ''Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.''; Biochemistry, 1993 PubMed
  181. Nakagawa Y, Waku K; ''The metabolism of glycerophospholipid and its regulation in monocytes and macrophages.''; Prog Lipid Res, 1989 PubMed
  182. van den Bosch H, de Vet EC; ''Alkyl-dihydroxyacetonephosphate synthase.''; Biochim Biophys Acta, 1997 PubMed
  183. Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC; ''Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 PubMed
  184. Axelrod J; ''Phospholipase A2 and G proteins.''; Trends Neurosci, 1995 PubMed
  185. Lapetina EG, Crouch MF; ''The relationship between phospholipases A2 and C in signal transduction.''; Ann N Y Acad Sci, 1989 PubMed
  186. Detopoulou P, Nomikos T, Fragopoulou E, Antonopoulou S, Kotroyiannis I, Vassiliadou C, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C; ''Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.''; Clin Biochem, 2009 PubMed
  187. Ishidate K; ''Choline/ethanolamine kinase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed
  188. Arthur G, Page L, Mock T, Choy PC; ''The catabolism of plasmenylcholine in the guinea pig heart.''; Biochem J, 1986 PubMed
  189. Dobrowsky RT, Ballas LM; ''Peroxisomal dihydroxyacetone phosphate acyltransferase. Effect of acetaldehyde on the intact and solubilized activity.''; J Biol Chem, 1987 PubMed
  190. Agranoff BW, Hajra AK; ''The acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis in mouse liver and Ehrlich ascites tumor cells.''; Proc Natl Acad Sci U S A, 1971 PubMed
  191. Willier S, Butt E, Grunewald TG; ''Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.''; Biol Cell, 2013 PubMed
  192. Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA; ''Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.''; J Biol Chem, 2005 PubMed
  193. El-Bassiouni EA, Piantadosi C, Snyder F; ''Metabolism of alkyldihydroxyacetone phosphate in rat brain.''; Biochim Biophys Acta, 1975 PubMed
  194. Hsuan JJ, Minogue S, dos Santos M; ''Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate.''; Adv Cancer Res, 1998 PubMed
  195. Yin H, Zhu M; ''Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases.''; Free Radic Res, 2012 PubMed
  196. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS; ''A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.''; J Biol Chem, 2006 PubMed
  197. Longmuir KJ, Johnston JM; ''Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development.''; Biochim Biophys Acta, 1980 PubMed
  198. Rauchová H, Drahota Z; ''Inhibition of the glycerol 3-phosphate oxidation by free fatty acids.''; Int J Biochem, 1984 PubMed
  199. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed
  200. Kumaran D, Bonanno JB, Burley SK, Swaminathan S; ''Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires".''; Proteins, 2006 PubMed
  201. Nieto ML, Velasco S, Sanchez Crespo M; ''Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.''; J Biol Chem, 1988 PubMed
  202. Delage E, Puyaubert J, Zachowski A, Ruelland E; ''Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms.''; Prog Lipid Res, 2013 PubMed
  203. Yamashita S, Hosaka K, Miki Y, Numa S; ''Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase.''; Methods Enzymol, 1981 PubMed
  204. Paradies G, Petrosillo G, Paradies V, Ruggiero FM; ''Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging.''; Free Radic Biol Med, 2010 PubMed
  205. Chang J, Musser JH, McGregor H; ''Phospholipase A2: function and pharmacological regulation.''; Biochem Pharmacol, 1987 PubMed
  206. Roberti R, Vecchini A, Freysz L, Masoom M, Binaglia L; ''An improved procedure for the purification of ethanolaminephosphotransferase. Reconstitution of the purified enzyme with lipids.''; Biochim Biophys Acta, 1989 PubMed
  207. Nakanishi K, Yasugi E, Morita H, Dohi T, Oshima M; ''Plasmenylethanolamine in human intestinal mucosa detected by an improved method for analysis of phospholipid.''; Biochem Mol Biol Int, 1994 PubMed
  208. Das AK, Hajra AK; ''Estimation of acyldihydroxyacetone phosphate and lysophosphatidate in animal tissues.''; Biochim Biophys Acta, 1984 PubMed
  209. Wykle RL, Schremmer JM; ''Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine.''; Biochemistry, 1979 PubMed
  210. Brown AJ, Glish GL, McBay EH, Snyder F; ''Alkyldihydroxyacetonephosphate synthase mechanism: 18O studies of fatty acid release from acyldihydroxyacetone phosphate.''; Biochemistry, 1985 PubMed
  211. Houtkooper RH, Vaz FM; ''Cardiolipin, the heart of mitochondrial metabolism.''; Cell Mol Life Sci, 2008 PubMed
  212. de Vet EC, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase.''; Cell Biochem Biophys, 2000 PubMed
  213. Ishii S, Shimizu T; ''Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.''; Prog Lipid Res, 2000 PubMed
  214. Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I; ''Mammalian phosphatidylinositol 4-kinases.''; IUBMB Life, 2003 PubMed
  215. Schlame M, Hostetler KY; ''Cardiolipin synthase from mammalian mitochondria.''; Biochim Biophys Acta, 1997 PubMed
  216. McMaster CR, Bell RM; ''CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed
  217. Thompson DH, Shin J, Boomer J, Kim JM; ''Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions.''; Methods Enzymol, 2004 PubMed
  218. Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJ; ''Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent.''; Obes Res, 2005 PubMed
  219. Lee TC, Malone B, Blank ML, Fitzgerald V, Snyder F; ''Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets.''; J Biol Chem, 1990 PubMed
  220. Kent C; ''CTP:phosphocholine cytidylyltransferase.''; Biochim Biophys Acta, 1997 PubMed
  221. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed
  222. Kay JG, Grinstein S; ''Sensing phosphatidylserine in cellular membranes.''; Sensors (Basel), 2011 PubMed
  223. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''PAF. A review of its effects, antagonists and possible future clinical implications (Part II).''; Drugs, 1991 PubMed
  224. Verheij HM, Slotboom AJ, de Haas GH; ''Structure and function of phospholipase A2.''; Rev Physiol Biochem Pharmacol, 1981 PubMed
  225. Schlame M, Greenberg ML; ''Cardiolipin synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed
  226. Gupta CM, Radhakrishnan R, Khorana HG; ''Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.''; Proc Natl Acad Sci U S A, 1977 PubMed
  227. Snyder F, Blank M, Lee TC, Robinson M, Woodard D; ''Measurement of key enzyme activities involved in the metabolism of platelet activating factor.''; Methods Enzymol, 1987 PubMed
  228. Clayton EL, Minogue S, Waugh MG; ''Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.''; Mol Neurobiol, 2013 PubMed
  229. De Matteis MA, Wilson C, D'Angelo G; ''Phosphatidylinositol-4-phosphate: The Golgi and beyond.''; Bioessays, 2013 PubMed
  230. Kay JG, Grinstein S; ''Phosphatidylserine-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed
  231. Moolenaar WH, van Meeteren LA, Giepmans BN; ''The ins and outs of lysophosphatidic acid signaling.''; Bioessays, 2004 PubMed
  232. Claypool SM, Koehler CM; ''The complexity of cardiolipin in health and disease.''; Trends Biochem Sci, 2012 PubMed
  233. Liteplo RG, Sribney M; ''The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate.''; Biochim Biophys Acta, 1980 PubMed
  234. Takenawa T, Itoh T, Fukami K; ''Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation.''; Chem Phys Lipids, 1999 PubMed
  235. Farooqui AA, Yang HC, Horrocks LA; ''Plasmalogens, phospholipases A2 and signal transduction.''; Brain Res Brain Res Rev, 1995 PubMed
  236. Baker RR; ''Lipid acetylation reactions and the metabolism of platelet-activating factor.''; Neurochem Res, 2000 PubMed
  237. Czech MP; ''PIP2 and PIP3: complex roles at the cell surface.''; Cell, 2000 PubMed
  238. Tie A, Bakovic M; ''Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.''; J Lipid Res, 2007 PubMed
  239. Vance DE, Walkey CJ, Cui Z; ''Phosphatidylethanolamine N-methyltransferase from liver.''; Biochim Biophys Acta, 1997 PubMed
  240. Kawasaki K, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from cultured mammalian cells.''; Methods Mol Biol, 2003 PubMed
  241. Ansell GB, Metcalfe RF; ''Studies on the CDP-ethanolamine-1,2-diglyceride ethanolaminephosphotransferase of rat brain.''; J Neurochem, 1971 PubMed
  242. Secades JJ, Frontera G; ''CDP-choline: pharmacological and clinical review.''; Methods Find Exp Clin Pharmacol, 1995 PubMed
  243. Taguchi T, Arai H; ''[Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic].''; Seikagaku, 2012 PubMed
  244. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed
  245. Ford DA, Gross RW; ''Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.''; Proc Natl Acad Sci U S A, 1989 PubMed
  246. Snyder F; ''Metabolism of platelet activating factor and related ether lipids: enzymatic pathways, subcellular sites, regulation, and membrane processing.''; Prog Clin Biol Res, 1988 PubMed
  247. Shin JJ, Loewen CJ; ''Putting the pH into phosphatidic acid signaling.''; BMC Biol, 2011 PubMed
  248. Blank ML, Fitzgerald V, Lee TC, Snyder F; ''Evidence for biosynthesis of plasmenylcholine from plasmenylethanolamine in HL-60 cells.''; Biochim Biophys Acta, 1993 PubMed
  249. Large WA, Saleh SN, Albert AP; ''Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.''; Cell Calcium, 2009 PubMed
  250. Honda Z, Ishii S, Shimizu T; ''Platelet-activating factor receptor.''; J Biochem, 2002 PubMed
  251. Rock CO, Snyder F; ''Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.''; J Biol Chem, 1974 PubMed
  252. Hajra AK, Datta SC, Ghosh MK; ''Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes.''; Methods Enzymol, 1992 PubMed
  253. Hosaka K, Schiele U, Numa S; ''Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity.''; Eur J Biochem, 1977 PubMed
  254. Schlame M, Ren M; ''The role of cardiolipin in the structural organization of mitochondrial membranes.''; Biochim Biophys Acta, 2009 PubMed
  255. Waugh MG; ''Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.''; Cancer Lett, 2012 PubMed
  256. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed
  257. Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A; ''Diacylglycerol acyltransferases: Potential roles as pharmacological targets.''; Pharmacol Ther, 2008 PubMed
  258. Thomas JR, Dwek RA, Rademacher TW; ''Structure, biosynthesis, and function of glycosylphosphatidylinositols.''; Biochemistry, 1990 PubMed
  259. Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M; ''The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.''; J Biol Chem, 2007 PubMed
  260. Vance DE, Li Z, Jacobs RL; ''Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.''; J Biol Chem, 2007 PubMed
  261. Zhang Y, Du G; ''Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.''; Biochim Biophys Acta, 2009 PubMed
  262. Messner MC, Albert CJ, Hsu FF, Ford DA; ''Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.''; Chem Phys Lipids, 2006 PubMed
  263. Claypool SM; ''Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function.''; Biochim Biophys Acta, 2009 PubMed
  264. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M; ''Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.''; Biochem J, 2004 PubMed
  265. Nakashima A, Hosaka K, Nikawa J; ''Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant.''; J Biol Chem, 1997 PubMed
  266. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA; ''Occurrence and functions of the phosphatidylinositol cycle in the myocardium.''; Mol Cell Biochem, 1992 PubMed
  267. Frentzen M; ''Phosphatidylglycerol and sulfoquinovosyldiacylglycerol: anionic membrane lipids and phosphate regulation.''; Curr Opin Plant Biol, 2004 PubMed
  268. Maurice A, Malgat M; ''Phosphatidylethanolamine: ceramide-ethanolaminephosphotransferase activity in synaptic plasma membrane vesicles. Influence of some cations and phospholipid environment on transferase activity. Further proof of its location.''; Int J Biochem, 1993 PubMed
  269. Gamper N, Shapiro MS; ''Target-specific PIP(2) signalling: how might it work?''; J Physiol, 2007 PubMed
  270. Kashiwada M, Lu P, Rothman PB; ''PIP3 pathway in regulatory T cells and autoimmunity.''; Immunol Res, 2007 PubMed
  271. Jambou R, El-Assaad F, Combes V, Grau GE; ''Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.''; Int J Biochem Cell Biol, 2009 PubMed
  272. Snyder F, Fitzgerald V, Blank ML; ''Biosynthesis of platelet-activating factor and enzyme inhibitors.''; Adv Exp Med Biol, 1996 PubMed
  273. Zimmerman GA, Elstad MR, Lorant DE, Mclntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley RE; ''Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.''; Adv Exp Med Biol, 1996 PubMed
  274. Polokoff MA, Bell RM; ''Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase.''; Biochim Biophys Acta, 1980 PubMed
  275. Nagan N, Zoeller RA; ''Plasmalogens: biosynthesis and functions.''; Prog Lipid Res, 2001 PubMed
  276. Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ; ''Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone.''; Biochim Biophys Acta, 2013 PubMed
  277. Mancini A, Roberti R, Binaglia L, el Missiri A, Freysz L; ''Factors affecting the stability of detergent-solubilized cholinephosphotransferase and ethanolaminephosphotransferase.''; Membr Biochem, 1993 PubMed
  278. Pascual F, Carman GM; ''Phosphatidate phosphatase, a key regulator of lipid homeostasis.''; Biochim Biophys Acta, 2013 PubMed
  279. Janardhan S, Srivani P, Sastry GN; ''Choline kinase: an important target for cancer.''; Curr Med Chem, 2006 PubMed
  280. Stremmel W, Ehehalt R, Staffer S, Stoffels S, Mohr A, Karner M, Braun A; ''Mucosal protection by phosphatidylcholine.''; Dig Dis, 2012 PubMed
  281. Hjelmstad RH, Bell RM; ''The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene.''; J Biol Chem, 1990 PubMed
  282. Garcia C, Montero M, Alvarez J, Sanchez Crespo M; ''Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid.''; J Biol Chem, 1993 PubMed
  283. Vance DE; ''Physiological roles of phosphatidylethanolamine N-methyltransferase.''; Biochim Biophys Acta, 2013 PubMed
  284. Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA; ''Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.''; Toxicol Pathol, 2012 PubMed
  285. Turkish A, Sturley SL; ''Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed
  286. Gehrmann T, Heilmeyer LM Jr; ''Phosphatidylinositol 4-kinases.''; Eur J Biochem, 1998 PubMed
  287. Kannan L, Knudsen J, Jolly CA; ''Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity.''; Biochim Biophys Acta, 2003 PubMed
  288. Horibata Y, Hirabayashi Y; ''Identification and characterization of human ethanolaminephosphotransferase1.''; J Lipid Res, 2007 PubMed
  289. Meyers RE, Cantley LC; ''Phosphatidylinositol 4-kinases. Assays and product analysis.''; Methods Mol Biol, 1998 PubMed
  290. Das AK, Milam JE, Reddy RC, Hajra AK; ''Facile syntheses of acyl dihydroxyacetone phosphates and lysophosphatidic acids having different acyl groups.''; J Lipid Res, 2006 PubMed
  291. Divecha N; ''Lipid kinases: charging PtdIns(4,5)P2 synthesis.''; Curr Biol, 2010 PubMed
  292. Webber KO, Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Methods Enzymol, 1992 PubMed
  293. Clark JD, Schievella AR, Nalefski EA, Lin LL; ''Cytosolic phospholipase A2.''; J Lipid Mediat Cell Signal, 1995 PubMed
  294. Carman GM, Kelley MJ; ''CDPdiacylglycerol synthase from yeast.''; Methods Enzymol, 1992 PubMed
  295. Kwiatkowska K; ''One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.''; Cell Mol Life Sci, 2010 PubMed
  296. Kulikov VI, Muzya GI; ''The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions.''; Biochemistry (Mosc), 1998 PubMed
  297. Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed
  298. Yost CC, Weyrich AS, Zimmerman GA; ''The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.''; Biochimie, 2010 PubMed
  299. Kume K, Shimizu T; ''cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.''; Biochem Biophys Res Commun, 1997 PubMed
  300. Waku K, Sugiura T, Nakagawa Y; ''Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages.''; Adv Prostaglandin Thromboxane Leukot Res, 1985 PubMed
  301. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed

History

View all...
CompareRevisionActionTimeUserComment
98103view11:11, 20 July 2018DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
95594view14:18, 5 January 2018DeSlChanged part of the layout for readability of this pathway.
93096view15:17, 28 July 2017DeSlChanged all the PubChem Substance ID's (around 13) to more stereospecific IDs.
93077view08:52, 28 July 2017ElisaFixed unconnected lines and changed arrows in the legend from interactions to graphical elements
93029view16:02, 26 July 2017DeSlChanged hydrate ID from PubChem compounds to correct HMDB ID for D-glucose-6-P
92861view15:19, 10 July 2017EgonwFixed PubChem compound ID (was salt, now pure compound).
85647view17:10, 4 June 2016EgonwFixed the PubChem SID.
84117view10:00, 16 January 2016EgonwFixed a typo in the label.
83825view11:17, 14 December 2015EgonwRemoved data source info from identifiers.
76320view07:17, 2 July 2014Mkutmonadded chebi identifiers to metabolites annotated with GO terms
71989view11:13, 24 October 2013MkutmonChanged Unknown -> Metabolite for 3 (S-adenosyl-methionine) and 3 (S-adenosylhomocysteine)
71699view19:49, 17 October 2013MaintBotUpdated data sources
70448view22:31, 1 August 2013AmanzoPeriodical save, work in progress
70447view22:21, 1 August 2013AmanzoPeriodical save, work in progress
70404view16:13, 29 July 2013AmanzoWork in progress
70403view16:07, 29 July 2013AmanzoPeriodical save, work in progress
70390view16:04, 26 July 2013AmanzoPeriodical save, work in progress
70389view23:52, 25 July 2013AmanzoWork in progress
70388view23:42, 25 July 2013AmanzoPeriodical save, work in progress
70387view23:32, 25 July 2013AmanzoPeriodical save, work in progress
70384view17:34, 23 July 2013AmanzoWork in progress
70381view23:33, 21 July 2013AmanzoPeriodical save, work in progress
70380view23:22, 21 July 2013AmanzoPeriodical save, work in progress
70379view23:12, 21 July 2013AmanzoPeriodical save, work in progress
70378view23:02, 21 July 2013AmanzoPeriodical save, work in progress
70377view22:52, 21 July 2013AmanzoPeriodical save, work in progress
70376view22:42, 21 July 2013AmanzoPeriodical save, work in progress
70375view22:32, 21 July 2013AmanzoPeriodical save, work in progress
70374view22:21, 21 July 2013AmanzoPeriodical save, work in progress
70373view22:11, 21 July 2013AmanzoPeriodical save, work in progress
70372view22:01, 21 July 2013AmanzoPeriodical save, work in progress
70371view21:51, 21 July 2013AmanzoPeriodical save, work in progress
70370view21:41, 21 July 2013AmanzoPeriodical save, work in progress
70369view00:17, 21 July 2013AmanzoWork in progress
70368view00:14, 21 July 2013AmanzoPeriodical save, work in progress
70367view00:04, 21 July 2013AmanzoPeriodical save, work in progress
70366view23:53, 20 July 2013AmanzoPeriodical save, work in progress
70365view23:43, 20 July 2013AmanzoPeriodical save, work in progress
70364view23:33, 20 July 2013AmanzoPeriodical save, work in progress
70363view23:23, 20 July 2013AmanzoPeriodical save, work in progress
70362view23:13, 20 July 2013AmanzoPeriodical save, work in progress
70361view23:02, 20 July 2013AmanzoPeriodical save, work in progress
70360view22:52, 20 July 2013AmanzoPeriodical save, work in progress
70359view22:42, 20 July 2013AmanzoPeriodical save, work in progress
70358view20:57, 20 July 2013AmanzoWork in progress
70357view19:14, 19 July 2013AmanzoModified description
70356view17:40, 19 July 2013AmanzoOntology Term : 'glycerolipid metabolic pathway' added !
70355view17:34, 19 July 2013AmanzoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate (CDP-DAG, CMP-PA)MetaboliteLMGP13010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphate (Phosphatidic acid; PA)MetaboliteLMGP10010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)Metabolite24701490 (PubChem-substance)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate) (PGP)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (PG)Metabolite24701488 (PubChem-substance)
1,2-diacyl-sn-glycero-3-phosphocholine (PC, Lecithin)MetaboliteLMGP01010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (PE)MetaboliteLMGP02010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoserine (PS)MetaboliteLMGP03010000 (LIPID MAPS)
1,2-diacyl-sn-glycerol (1,2-diacylglycerol; 1,2-DAG)MetaboliteLMGL02010000 (LIPID MAPS)
1-Acyl dihydroxyacetone phosphate (Acyl-DHAP)MetaboliteHMDB11750 (HMDB)
1-Alkenyl-2-acylglycerophosphocholine (Plasmenylcholine)Metabolite4209 (PubChem-substance)
1-Alkyl-2-acetyl-sn-glycerol 3-phosphateMetaboliteCHEBI:17555 (ChEBI)
1-Alkyl-2-acetyl-sn-glycerolMetabolite6564 (PubChem-substance)
1-Alkyl-sn-glycerol 3-phosphateMetabolite92741300 (PubChem-substance)
1-Alkyl-sn-glycerolMetabolite92741300 (PubChem-substance)
1-Alkyldihydroxyacetone phosphate (Octanoyl DHAP)Metabolite53481029 (PubChem-compound)
1-Alkylglycerophosphocholine O-acetyltransferase EC 2.3.1.67ProteinP14555 (Uniprot-TrEMBL)
1-alkenyl-2-acylglycerophosphoethanolamine (Plasmenylethanolamine)Metabolite7325 (PubChem-substance)
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (Platelet Activating Factor, PAF)MetaboliteCHEBI:36707 (ChEBI)
1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase

(Phosphatidate phosphatase)

EC 3.1.3.4
ProteinQ92539 (Uniprot-TrEMBL)
1-alkyl-2-acyl-sn-glycero-3-phosphocholine (Plasmanylcholine)MetaboliteCHEBI:36702 (ChEBI)
1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine (Plasmanylethanolamine)MetaboliteCHEBI:36712 (ChEBI)
1-alkyl-2-acyl-sn-glycerol 3-phosphate (Plasmanic acid)MetaboliteCHEBI:37296 (ChEBI)
1-alkyl-2-acyl-sn-glycerolMetabolite17756737 (PubChem-compound)
1-alkyl-2-acyl-sn-glycerophoethanolamine desaturase

(Plasmanylethanolamine desaturase)

EC 1.14.99.19
Protein1.14.99.19 (Enzyme Nomenclature)
1-alkyl-sn-glycero-3-phosphocholine (Lyso PAF)MetaboliteCHEBI:36702 (ChEBI)
1-phosphatidylinositol 4-kinase EC 2.7.1.67ProteinQ9BTU6 (Uniprot-TrEMBL)
1-phosphatidylinositol 4-phosphate 5-kinase EC 2.7.1.68ProteinQ99755 (Uniprot-TrEMBL)
1D-myo-Inositol-1-PMetabolite5288642 (PubChem-compound)
2-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA)MetaboliteLMGP10050000 (LIPID MAPS)
2-acylglycerol-3-phosphate O-acyltransferase EC 2.3.1.52Protein2.3.1.52 (Enzyme Nomenclature)
2H2OMetabolite
3 (S-adenosyl-methionine)Metabolite34756 (PubChem-compound)
3 (S-adenosylhomocysteine)Metabolite439155 (PubChem-compound)
ADPMetabolite6022 (PubChem-compound)
ATPMetabolite5957 (PubChem-compound)
Acetyl-CoAMetabolite444493 (PubChem-compound)
Acyl coenzyme A (Acyl-CoA)Metabolite3342 (PubChem-substance)
Acyl groupMetabolite
Acyl-CoAMetabolite3342 (PubChem-substance)
Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase EC 2.3.1.-Protein2.3.1.- (Enzyme Nomenclature)
Acylglycerone-phosphate reductase

(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)

EC 1.1.1.101
ProteinP40471 (Uniprot-TrEMBL)
Adenosine diphosphate (ADP)Metabolite6022 (PubChem-compound)
Adenosine triphosphate (ATP)Metabolite5957 (PubChem-compound)
Alkylacetylglycerophosphatase EC 3.1.3.59Protein3.1.3.59 (Enzyme Nomenclature)
Alkyldihydroxyacetonephosphate synthase

(Alkyl-DHAP synthase)

EC 2.5.1.26
ProteinO00116 (Uniprot-TrEMBL)
Alkylglycerol kinase EC 2.7.1.93Protein2.7.1.93 (Enzyme Nomenclature)
Alkylglycerophosphate 2-O-acetyltransferase EC 2.3.1.105Protein2.3.1.105 (Enzyme Nomenclature)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-cholineMetabolite3601 (PubChem-substance)
CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase

(Diacylglycerol cholinephosphotransferase)

EC 2.7.8.2
ProteinQ9Y6K0 (Uniprot-TrEMBL)
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EC 2.7.8.5ProteinQ32NB8 (Uniprot-TrEMBL)
CDP-diacylglyreol-inositol 3-phosphatidyltransferase EC 2.7.8.11ProteinO14735 (Uniprot-TrEMBL)
CDP-ethanolamineMetabolite123727 (PubChem-compound)
CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase

(Ethanolaminephosphotransferase)

EC 2.7.8.1
ProteinQ92539 (Uniprot-TrEMBL)
CMPMetabolite6131 (PubChem-compound)
CTPMetabolite6176 (PubChem-compound)
Cardiolipin (DPG, CL)MetaboliteCHEBI:28494 (ChEBI)
Cardiolipin synthase EC 2.7.8.-ProteinQ9UJA2 (Uniprot-TrEMBL)
Choline kinase EC 2.7.1.32ProteinQ9Y259 (Uniprot-TrEMBL)
Choline-phosphate cytidylyltransferase EC 2.7.7.15ProteinQ9Y259 (Uniprot-TrEMBL)
CholineMetabolite305 (PubChem-compound)
CholineMetabolite305 (PubChem-substance)
CoA-SHMetabolite6816 (PubChem-compound)
Coenzyme A (CoA-SH)Metabolite6816 (PubChem-compound)
Cytidine 5'-diphosphocholine (CDP-choline)Metabolite3601 (PubChem-substance)
Cytidine diphosphate choline (CDP-choline)Metabolite25202509 (PubChem-compound)
Cytidine diphosphate ethanolamine (CDP-ethanolamine)Metabolite123727 (PubChem-compound)
Cytidine monophosphate (CMP)Metabolite6131 (PubChem-compound)
Cytidine triphosphate (CTP)Metabolite6176 (PubChem-compound)
Cytochrome bMetaboliteCHEBI:38551 (ChEBI)
D-Glucose-6-PMetabolite44134741 (PubChem-compound)
Diacylglycerol O-acyltransferase EC 2.3.1.20ProteinQ86VF5 (Uniprot-TrEMBL)
Diacylglycerol cholinephosphotransferase

(Cholinephosphotransferase 1)

EC 2.7.8.2
ProteinP17898 (Uniprot-TrEMBL)
Diacylglycerol cholinephosphotransferase EC 2.7.8.2ProteinQ8WUD6 (Uniprot-TrEMBL)
Dihydroxyacetone phosphate acyltransferase EC 2.3.1.42ProteinO15228 (Uniprot-TrEMBL)
Dihydroxyacetone phosphateMetabolite668 (PubChem-compound)
Ethanolamine kinase EC 2.7.1.82ProteinQ9Y259 (Uniprot-TrEMBL)
Ethanolamine phosphateMetabolite1015 (PubChem-compound)
Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14ProteinQ99447 (Uniprot-TrEMBL)
EthanolamineMetabolite700 (PubChem-compound)
Ethanolaminephosphotransferase EC 2.7.8.1ProteinQ9Y6K0 (Uniprot-TrEMBL)
Fatty acid MetabolismPathway00071 (KEGG Pathway)
Fatty acyl-CoAMetabolite24701368 (PubChem-substance)
Glycerol kinase EC 2.7.1.30ProteinP32189 (Uniprot-TrEMBL)
Glycerol-3-PMetabolite7048686 (PubChem-compound)
Glycerol-3-phosphate 2-O-acyltransferase EC 2.3.1.198ProteinO80437 (Uniprot-TrEMBL)
Glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8ProteinP21695 (Uniprot-TrEMBL)
GlycerolMetabolite753 (PubChem-compound)
GlycolysisPathway00010 (KEGG Pathway)
H2O
InositolMetabolite892 (PubChem-compound)
L-serine-phosphatidylethanolamine phosphatidyltransferase EC 2.7.8.29ProteinP48651 (Uniprot-TrEMBL)
N-Methyltransferase EC 2.1.1.-Protein2.1.1.- (Enzyme Nomenclature)
NAD+ (Coenzyme I)Metabolite5892 (PubChem-compound)
NADH + H+Metabolite439153 (PubChem-compound)
NADP (Coenzyme II)Metabolite5886 (PubChem-compound)
NADPH + H+Metabolite5884 (PubChem-compound)
Nitrogen group transferasa EC 2.6.-.-Protein2.6.-.- (Enzyme Nomenclature)
O2 + NADH + H+Metabolite
PPiMetabolite
Phosphatidate cytidylyltransferase EC 2.7.7.41ProteinO95674 (Uniprot-TrEMBL)
Phosphatidate phosphatase EC 3.1.3.4ProteinQ14693 (Uniprot-TrEMBL)
Phosphatidylethanolamine N-methyltransferase EC 2.1.1.17ProteinQ9UBM1 (Uniprot-TrEMBL)
Phosphatidylglycerophosphatase EC 3.1.3.27ProteinQ8WUK0 (Uniprot-TrEMBL)
Phosphatidylinositol-4,5-bisphosphate [PIP2(4',5')]MetaboliteCHEBI:18348 (ChEBI)
Phosphatidylinositol-4,5-bisphosphate 3-kinase EC 2.7.1.153ProteinQ42338 (Uniprot-TrEMBL)
Phosphatidylinositol-4-phosphate (PIP)MetaboliteCHEBI:58178 (ChEBI)
Phosphatidylinositol3,4,5-triphosphate [PIP3(3',4',5')]MetaboliteLMGP09010001 (LIPID MAPS)
Phosphocholine (Choline-P)Metabolite1014 (PubChem-compound)
Phospholipase A2 EC 3.1.1.4ProteinP14555 (Uniprot-TrEMBL)
Phospholipase C EC 3.1.4.3Protein3.1.4.3 (Enzyme Nomenclature)
PhosphorylethanolamineMetabolite1015 (PubChem-compound)
Pi
Pyrimidine MetabolismPathway00240 (KEGG Pathway)
S-Adenosylhomocysteine (AdoHcy)Metabolite439155 (PubChem-compound)
S-Adenosylmethionine (AdoMet)Metabolite34756 (PubChem-compound)
SerineMetabolite5951 (PubChem-compound)
Shark liver oil
sn-glycerol-3-phosphate (glycerol-3-P)Metabolite7048686 (PubChem-compound)
triacyl-sn-glycerol (Triacylglycerol; TAG)MetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

Personal tools