PDGF Pathway (Homo sapiens)

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PERK1/2(MAPK3/MAPK1)MAP3K1(MEKK1)STAT1GRB2NFkBSHC1MP2K1(MEK 1)SH-PTP2(PTN11)AP-1(c-Jun)PDGFRBMAPK3PDGFBPDGFARASA1(GAP)SOS1MAPK1MAP2K4(JNKK1)PLCG1STAT3MAPK8(JNK1)H-Ras-1(Ras)RAF1PDGFA1-10NFkBSTAT1STAT3STAT3STAT1PPPPSTAT3STAT1PPPJAK1PPCyclic AMP(cAMP)DAGProstaglandin I2(PGI2)IP3COX2PIP2[4',5']Ca2+Phospholipid(containing arachidonic acid)PLA2G4A(cPLA2)Cell proliferationCachannel[Ca2+]iArachidonic acidELK1c-FosSRFNa+/H+exchangerH+NaPI3KPc-SrcPTIAM1Vav2Rac1RhoAPor1(ARF1P2)PAK1Vav1CDC42N-WASPFilopodiaFormationActin,Stress Fibersand AdhesionLamellipodiaFormationCell MigrationIKKAktPathwayIkB alphaPDegradation


Description

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  1. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC
  2. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC
  3. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC
  4. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC
  5. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC
  6. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC
  7. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC
  8. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC
  9. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC
  10. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107132view14:21, 17 September 2019MaintBotChEBI identifier normalization
106717view13:15, 17 September 2019MaintBotHMDB identifier normalization
106552view00:13, 6 September 2019KhanspersModified description
105476view05:22, 8 August 2019KhanspersModified description
103637view23:03, 22 March 2019AlexanderPicofixed xref datasource
101933view12:40, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
96312view09:02, 8 March 2018Mkutmonremove outdated pathway attributes
96257view16:14, 2 March 2018EgonwOntology Term : 'platelet-derived growth factor signaling pathway' added !
95977view15:52, 11 February 2018EgonwThese interactions are not mim-conversions.
82681view13:07, 22 October 2015EgonwReplace CAS numbers of CaCl2 with ChEBI identifiers for the actual metabolites.
80006view12:18, 30 April 2015Zariannotated and updated Id for ERK1/2 (MAPK3/MAPK1), H-Ras-1 (Ras) , MAP2K4 (JNKK1)
78551view10:30, 7 January 2015MaintBotadded missing graphIds
76331view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
72247view21:52, 29 October 2013Khanspersremoved GeneOntology xrefs from data nodes
72152view11:00, 25 October 2013EgonwAdded a ChEBI ID for 'phospholipid'.
72031view13:04, 24 October 2013Mkutmonfixed unconnected lines
71715view20:08, 17 October 2013MaintBotUpdated data sources
70400view23:27, 28 July 2013AmanzoWork in progress
70399view23:24, 28 July 2013AmanzoWork in progress
70398view23:17, 28 July 2013AmanzoPeriodical save, work in progress
70397view22:47, 28 July 2013AmanzoPeriodical save, work in progress
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70294view17:24, 16 July 2013AmanzoReferences added
70293view17:18, 16 July 2013AmanzoPeriodical save, work in progress
70292view17:05, 16 July 2013AmanzoOntology Term : 'cancer' added !
70291view17:05, 16 July 2013AmanzoOntology Term : 'Jak-Stat signaling pathway' added !
70290view17:02, 16 July 2013AmanzoModified description
70289view16:47, 16 July 2013AmanzoWork in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment

Ca

c h a n n e

l
Protein

Na+/H+

e x c h a n g e

r
Protein
AP-1 (c-Jun)GeneProductP05412 (Uniprot-TrEMBL)
Actin,

Stress Fibers

and Adhesion
PathwayWP306 (WikiPathways)
Akt PathwayPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
CDC42ProteinP60953 (Uniprot-TrEMBL)
COX2ProteinP00403 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cell MigrationPathway
Cell proliferationPathway
Cyclic AMP (cAMP)MetaboliteHMDB0000058 (HMDB)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DegradationPathway
ELK1GeneProductP19419 (Uniprot-TrEMBL)
Filopodia FormationPathway
GRB2ProteinP62993 (Uniprot-TrEMBL)
H+MetaboliteCHEBI:15378 (ChEBI)
H-Ras-1 (Ras)GeneProduct3265 (Entrez Gene)
IKKProteinO15111 (Uniprot-TrEMBL)
IP3MetaboliteCHEBI:16595 (ChEBI)
IkB alphaGeneProductP25963 (Uniprot-TrEMBL)
JAK1ProteinP23458 (Uniprot-TrEMBL)
Lamellipodia FormationPathway
MAP2K4 (JNKK1)GeneProduct6416 (Entrez Gene)
MAP3K1 (MEKK1)GeneProductQ13233 (Uniprot-TrEMBL)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8 (JNK1)GeneProductP45983 (Uniprot-TrEMBL)
MP2K1 (MEK 1)GeneProductQ02750 (Uniprot-TrEMBL)
N-WASPProteinO00401 (Uniprot-TrEMBL)
NFkBGeneProduct4790 (Entrez Gene)
NFkBGeneProduct4790 (KEGG Genes)
NaMetaboliteCHEBI:29101 (ChEBI)
P

D G F

A
GeneProduct5154 (Entrez Gene)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PI3KProteinP27986 (Uniprot-TrEMBL)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4A (cPLA2)GeneProductENSG00000116711 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
Phospholipid (containing arachidonic acid)MetaboliteCHEBI:16247 (ChEBI)
Por1 (ARF1P2)ProteinP53365 (Uniprot-TrEMBL)
Prostaglandin I2 (PGI2)MetaboliteHMDB0001335 (HMDB)
RAF1ProteinP04049 (Uniprot-TrEMBL)
RASA1(GAP)GeneProductENSG00000145715 (Ensembl)
Rac1ProteinP63000 (Uniprot-TrEMBL)
RhoAProteinP61586 (Uniprot-TrEMBL)
SH-PTP2 (PTN11)GeneProductQ06124 (Uniprot-TrEMBL)
SHC1ProteinP29353 (Uniprot-TrEMBL)
SOS1ProteinQ07889 (Uniprot-TrEMBL)
SRFGeneProductP11831 (Uniprot-TrEMBL)
STAT1ProteinP42224 (Uniprot-TrEMBL)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TIAM1ProteinQ13009 (Uniprot-TrEMBL)
Vav1ProteinP15498 (Uniprot-TrEMBL)
Vav2ProteinP52735 (Uniprot-TrEMBL)
[Ca2+]iMetaboliteCHEBI:29108 (ChEBI)
c-FosGeneProductP01100 (Uniprot-TrEMBL)
c-SrcProteinP12931 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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