Spinal Cord Injury (Mus musculus)

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834Tnfsf13bLtb4r1Ptprz1NgfrPdynNOTnfsf13Cd47Plxna2LTB4Cspg4Ltb26593217Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2bPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4HcCxcl1Neutrophil ChemoattractantsCxcl129, 38NeurtrophilsMonocytesAqp4TT41LegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating33Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal AdensionsEpha413, 20TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)3Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp9TT11Chondroitin Sulfate ProteoglycansNcan36Slit1Axon RetractionSlit236Slit3Ntn1RgmaTTTTTTTTTTMmp9Mmp91111Mmp911TTTTTTCcr2Il1r138TTECM BreakdownECM BreakdownIl1aCxcl1Monocyte ChemoattractantsCxcl229, 38Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa1TT14TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors2Icam1SelpTTTTPlasticityKlk821TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfapTT11IntermediateFillament27Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Trp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition27IgG, IgMTrp53TT7TTTTGrin135Vim42TTT Cell Stimulating33FK50640Ppp3caTTFK50618FK50618Gap43TTFK50618Axonal RegenerationFkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb31MyelinInjury ResponseArachidonic acidPGH2PTGS24TT22ROSNox4Mir23bOlomoucine25Cdk1Gdnf31TTSema6aTT9Axonal GrowthInhibitionGja1ATP-Release15TTBdnfTTImmediate Response Genes3


This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.

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  1. Tohda C, Kuboyama T; ''Current and future therapeutic strategies for functional repair of spinal cord injury.''; Pharmacol Ther, 2011 PubMed
  2. Farooque M, Isaksson J, Olsson Y; ''Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice.''; Neuroreport, 1999 PubMed
  3. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI; ''Gene profiling in spinal cord injury shows role of cell cycle in neuronal death.''; Ann Neurol, 2003 PubMed
  4. Resnick DK, Graham SH, Dixon CE, Marion DW; ''Role of cyclooxygenase 2 in acute spinal cord injury.''; J Neurotrauma, 1998 PubMed
  5. Chu GK, Yu W, Fehlings MG; ''The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury.''; Neuroscience, 2007 PubMed
  6. Wu J, Stoica BA, Faden AI; ''Cell cycle activation and spinal cord injury.''; Neurotherapeutics, 2011 PubMed
  7. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S; ''''; , PubMed
  8. David S, Kroner A; ''Repertoire of microglial and macrophage responses after spinal cord injury.''; Nat Rev Neurosci, 2011 PubMed
  9. Shim SO, Cafferty WB, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM; ''PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition.''; Mol Cell Neurosci, 2012 PubMed
  10. ''''; , PubMed
  11. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ; ''Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury.''; J Neurotrauma, 2011 PubMed
  12. Cafferty WB, Duffy P, Huebner E, Strittmatter SM; ''''; , PubMed
  13. Puschmann TB, Turnley AM; ''''; , PubMed
  14. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, Shields CB, Xu XM; ''Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury.''; J Neuropathol Exp Neurol, 2007 PubMed
  15. Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T; ''Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.''; J Neurosci, 2012 PubMed
  16. Yu CG, Yezierski RP, Joshi A, Raza K, Li Y, Geddes JW; ''''; , PubMed
  17. Saiwai H, Ohkawa Y, Yamada H, Kumamaru H, Harada A, Okano H, Yokomizo T, Iwamoto Y, Okada S; ''The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury.''; Am J Pathol, 2010 PubMed
  18. Saganová K, Orendácová J, Sulla I Jr, Filipcík P, Cízková D, Vanický I; ''''; , PubMed
  19. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B; ''''; , PubMed
  20. Fabes J, Anderson P, Yáñez-Muñoz RJ, Thrasher A, Brennan C, Bolsover S; ''''; , PubMed
  21. Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S; ''Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.''; Neuroscience, 2007 PubMed
  22. Im YB, Jee MK, Choi JI, Cho HT, Kwon OH, Kang SK; ''''; , PubMed
  23. Sharma HS; ''''; , PubMed
  24. Lavezzi AM, Casale V, Oneda R, Weese-Mayer DE, Matturri L; ''Sudden Infant Death Syndrome and Sudden Intrauterine Unexplained Death: Correlation Between Hypoplasia of Raph√ج�Ω√ج�ΩΩ Nuclei and Serotonin Transporter Gene Promoter Polymorphism.''; Pediatr Res, 2009 PubMed
  25. Tian DS, Dong Q, Pan DJ, He Y, Yu ZY, Xie MJ, Wang W; ''''; , PubMed
  26. Adjan VV, Hauser KF, Bakalkin G, Yakovleva T, Gharibyan A, Scheff SW, Knapp PE; ''Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons.''; Neuroscience, 2007 PubMed
  27. Eng LF, Ghirnikar RS, Lee YL; ''Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).''; Neurochem Res, 2000 PubMed
  28. ''''; , PubMed
  29. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, Ohsaki H, Takeda E, Nishisho T; ''A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.''; J Neurochem, 2001 PubMed
  30. ''''; , PubMed
  31. Hashimoto M, Ito T, Fukumitsu H, Nomoto H, Furukawa Y, Furukawa S; ''Stimulation of production of glial cell line-derived neurotrophic factor and nitric oxide by lipopolysaccharide with different dose-responsiveness in cultured rat macrophages.''; Biomed Res, 2005 PubMed
  32. Myers SA, DeVries WH, Andres KR, Gruenthal MJ, Benton RL, Hoying JB, Hagg T, Whittemore SR; ''CD47 knockout mice exhibit improved recovery from spinal cord injury.''; Neurobiol Dis, 2011 PubMed
  33. Dekaban GA, Thawer S; ''Pathogenic antibodies are active participants in spinal cord injury.''; J Clin Invest, 2009 PubMed
  34. López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S; ''Phospholipase A2 superfamily members play divergent roles after spinal cord injury.''; FASEB J, 2011 PubMed
  35. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T; ''Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.''; J Proteome Res, 2006 PubMed
  36. Kitayama M, Ueno M, Itakura T, Yamashita T; ''Activated microglia inhibit axonal growth through RGMa.''; PLoS One, 2011 PubMed
  37. McKillop WM, Dragan M, Schedl A, Brown A; ''''; , PubMed
  38. Pineau I, Sun L, Bastien D, Lacroix S; ''Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion.''; Brain Behav Immun, 2010 PubMed
  39. ''''; , PubMed
  40. Saganová K, Gálik J, Blaško J, Korimová A, Račeková E, Vanický I; ''''; , PubMed
  41. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC; ''''; , PubMed
  42. Menet V, Prieto M, Privat A, Giménez y Ribotta M; ''''; , PubMed


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102465view05:52, 24 December 2018EgonwFixed a reference.
102464view05:51, 24 December 2018EgonwFixed a data source.
87679view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
79927view12:02, 27 April 2015EveloReplaced human C5 gene with mouse homologe Hc
79915view10:57, 27 April 2015EveloCorrected datasource for: ENSG00000106804 (was gene cards, should have been ensembl)
78436view10:26, 7 January 2015MaintBotadded missing graphIds
71041view01:36, 25 September 2013DMicaelModified description
69986view22:01, 11 July 2013MaintBotupdated to 2013 schema
59003view20:15, 21 February 2013MaintBotUpdated Ensembl data source
57151view12:39, 23 January 2013EgonwUsed "PubChem-compound"
55957view00:47, 29 December 2012NsalomonisSpecify description
55952view00:20, 29 December 2012Nsalomonisre-sized fonts and spacing for image export
55943view22:52, 28 December 2012NsalomonisOntology Term : 'traumatic neurosis' added !
55942view22:51, 28 December 2012NsalomonisOntology Term : 'spinal cord disease' added !
55941view22:51, 28 December 2012NsalomonisOntology Term : 'astrocyte of the spinal cord' added !
55940view22:49, 28 December 2012NsalomonisNew pathway

External references


View all...
NameTypeDatabase referenceComment
AcanGeneProductENSMUSG00000030607 (Ensembl)
Anxa1GeneProductENSMUSG00000024659 (Ensembl)
Aqp4GeneProductENSMUSG00000024411 (Ensembl)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Arg1GeneProductENSMUSG00000019987 (Ensembl)
BcanGeneProductENSMUSG00000004892 (Ensembl)
BdnfGeneProductENSMUSG00000048482 (Ensembl)
Btg2GeneProductENSMUSG00000020423 (Ensembl)
Casp3GeneProductENSMUSG00000031628 (Ensembl)
Ccl2GeneProductENSMUSG00000035385 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Ccng1GeneProductENSMUSG00000020326 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Cd47GeneProductENSMUSG00000055447 (Ensembl)
Cdk1GeneProductENSMUSG00000019942 (Ensembl)
Cdk2GeneProductENSMUSG00000025358 (Ensembl)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Chst11GeneProductENSMUSG00000034612 (Ensembl)
Col2a1GeneProductENSMUSG00000022483 (Ensembl)
Col4a1GeneProductENSMUSG00000031502 (Ensembl)
Cspg4GeneProductENSMUSG00000032911 (Ensembl)
Cxcl10GeneProductENSMUSG00000034855 (Ensembl)
Cxcl1GeneProductENSMUSG00000029380 (Ensembl)
Cxcl2GeneProductENSMUSG00000058427 (Ensembl)
E2f1GeneProductENSMUSG00000027490 (Ensembl)
E2f5GeneProductENSMUSG00000027552 (Ensembl)
Efnb2GeneProductENSMUSG00000001300 (Ensembl)
Egr1GeneProductENSMUSG00000038418 (Ensembl)
Epha4GeneProductENSMUSG00000026235 (Ensembl)
FK506Metabolite104987-11-3 (CAS)
Fcgr2bGeneProductENSMUSG00000026656 (Ensembl)
Fkbp1aGeneProductENSMUSG00000032966 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Gadd45aGeneProductENSMUSG00000036390 (Ensembl)
Gap43GeneProductENSMUSG00000047261 (Ensembl)
GdnfGeneProductENSMUSG00000022144 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Gja1GeneProductENSMUSG00000050953 (Ensembl)
Grin1GeneProductENSMUSG00000026959 (Ensembl)
HcGeneProductENSMUSG00000026874 (ENSEMBL)
Icam1GeneProductENSMUSG00000037405 (Ensembl)
IfngGeneProductENSMUSG00000055170 (Ensembl)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProductENSMUSG00000026072 (Ensembl)
Il2GeneProductENSMUSG00000027720 (Ensembl)
Il4GeneProductENSMUSG00000000869 (Ensembl)
Il6GeneProductENSMUSG00000025746 (Ensembl)
Klk8GeneProductENSMUSG00000064023 (Ensembl)
LTB4Metabolite169 (PubChem-compound)
Lilrb3GeneProductENSMUSG00000058818 (Ensembl)
Ltb4r1GeneProductENSMUSG00000046908 (Ensembl)
LtbGeneProductENSMUSG00000024399 (Ensembl)
MagGeneProductENSMUSG00000036634 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mir23bGeneProductENSMUSG00000065599 (Ensembl)
Mmp12GeneProductENSMUSG00000049723 (Ensembl)
Mmp9GeneProductENSMUSG00000017737 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
NOMetabolite145068 (PubChem-compound)
NcanGeneProductENSMUSG00000002341 (Ensembl)
NgfrGeneProductENSMUSG00000000120 (Ensembl)
Nos1GeneProductENSMUSG00000029361 (Ensembl)
Nos2GeneProductENSMUSG00000020826 (Ensembl)
Nox4GeneProductENSMUSG00000030562 (Ensembl)
Nr4a1GeneProductENSMUSG00000023034 (Ensembl)
Ntn1GeneProductENSMUSG00000020902 (Ensembl)
OlomoucineMetaboliteHMDB35233 (HMDB)
OmgGeneProductENSMUSG00000049612 (Ensembl)
PGH2MetaboliteHMDB01381 (HMDB)
PTGS2GeneProduct469616 (Entrez Gene)
PdynGeneProductENSMUSG00000027400 (Ensembl)
Pla2g2aGeneProductENSMUSG00000058908 (Ensembl)
Pla2g5GeneProductENSMUSG00000041193 (Ensembl)
Pla2g6GeneProductENSMUSG00000042632 (Ensembl)
Plxna2GeneProductENSMUSG00000026640 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl)
Prb1GeneProductENSMUSG00000067543 (Ensembl)
PrkcaGeneProductENSMUSG00000050965 (Ensembl)
PtpraGeneProductENSMUSG00000027303 (Ensembl)
Ptprz1GeneProductENSMUSG00000068748 (Ensembl)
Rb1GeneProductENSMUSG00000022105 (Ensembl)
RgmaGeneProductENSMUSG00000070509 (Ensembl)
RhoaGeneProductENSMUSG00000007815 (Ensembl)
RhobGeneProductENSMUSG00000054364 (Ensembl)
RhocGeneProductENSMUSG00000002233 (Ensembl)
Rock2GeneProductENSMUSG00000020580 (Ensembl)
Rtn4GeneProductENSMUSG00000020458 (Ensembl)
Rtn4rGeneProductENSMUSG00000043811 (Ensembl)
SelpGeneProductENSMUSG00000026580 (Ensembl)
Sema6aGeneProductENSMUSG00000019647 (Ensembl)
Slit1GeneProductENSMUSG00000025020 (Ensembl)
Slit2GeneProductENSMUSG00000031558 (Ensembl)
Slit3GeneProductENSMUSG00000056427 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
Tacr1GeneProductENSMUSG00000030043 (Ensembl)
Tgfb1GeneProductENSMUSG00000002603 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Tnfsf13GeneProductENSMUSG00000089669 (Ensembl)
Tnfsf13bGeneProductENSMUSG00000031497 (Ensembl)
Trp53GeneProductENSMUSG00000059552 (Ensembl)
VcanGeneProductENSMUSG00000021614 (Ensembl)
VimGeneProductENSMUSG00000026728 (Ensembl)
Xylt1GeneProductENSMUSG00000030657 (Ensembl)
Zfp36GeneProductENSMUSG00000044786 (Ensembl)
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions

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