Spinal Cord Injury (Homo sapiens)

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2151NOPDYNFECHP1C1QBNGFRCDC42LGALS3LTBLEPLTB4RLTB4CSPG4AIF1PLXNA2TNFSF13APEX1MIFAQP1PTPRZ1TNFSF13BCD47384036487441234510303616Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZFP36FCGR2APRB1PTPRAIL1BZFP36NOS2TNF50NR4A1IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5CXCL1Neutrophil ChemoattractantsCXCL82, 54NeurtrophilsMonocytesAQP427TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating18Activated Microglia/Macrophages(Transient)RepairIL1BNOS2TNFARG1TOXIC FERROUSIRONFocal AdensionsEPHA417, 31TTEPHNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)49CCNG1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP9TT11Chondroitin Sulfate ProteoglycansNCAN23SLIT1Axon RetractionSLIT223SLIT3NTN1RGMATTTTTTTTTTMMP9MMP91111MMP9TT11TTTTCCR2IL1R154TTECM BreakdownECM BreakdownIL1ACXCL1Monocyte Chemoattractants2, 54CXCL2CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA115TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion FactorsICAM141SELPTTTTPlasticityKLK8TT46MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAP11TTIntermediateFillament14CDK4TACR1E2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationTP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition14IgG, IgMTP5322TTTTTTGRIN126VIMTT28T Cell StimulatingFK50618PPP3CA9TTFK506FK5061919GAP43TTFK506Axonal Regeneration19FKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB345MyelinInjury ResponseArachidonic acidPGH2PTGS21TT53ROSNOX4MIR23BOlomoucine35CDK1GDNF42TTSEMA6ATT34Axonal GrowthInhibitionGJA1ATP-Release6TTBDNFTTImmediate Response Genes492-MethoxyestradiolTT16RAC1TTTTAstroctyeFOXO3TT20CDKN1B20TTN2 Glial Precursor37EGFRPD 168393TT3343CASP3TTTT