Spinal Cord Injury (Homo sapiens)

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2151MIFTNFSF13LGALS3AQP1LEPCDC42LTB4RCSPG4PDYNPTPRZ1LTB4NOAPEX1NGFRAIF1TNFSF13BCD47PLXNA2C1QBLTBFECHP1548361610447343640381230Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZFP36FCGR2APRB1PTPRAIL1BZFP36NOS2TNFNR4A150IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5CXCL1Neutrophil ChemoattractantsCXCL82, 54NeurtrophilsMonocytesAQP4TT27LegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating18Activated Microglia/Macrophages(Transient)RepairIL1BNOS2TNFARG1TOXIC FERROUSIRONFocal Adensions17, 31EPHA4TTEPHNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)49CCNG1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP9TT11Chondroitin Sulfate ProteoglycansNCAN23SLIT1Axon RetractionSLIT223SLIT3NTN1RGMATTTTTTTTTTMMP911MMP911MMP9TT11TTTTCCR2IL1R1TT54ECM BreakdownECM BreakdownIL1ACXCL1Monocyte Chemoattractants2, 54CXCL2CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA115TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors41ICAM1SELPTTTTPlasticityKLK846TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAPTT11IntermediateFillament14CDK4TACR1E2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationTP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition14IgG, IgMTP5322TTTTTTGRIN126VIM28TTT Cell Stimulating18FK506PPP3CA9TTFK506FK5061919GAP43TTFK506Axonal Regeneration19FKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB345MyelinInjury ResponseArachidonic acidPGH2PTGS21TT53ROSNOX4MIR23BOlomoucine35CDK1GDNF42TTSEMA6A34TTAxonal GrowthInhibitionGJA1ATP-Release6TTBDNFTTImmediate Response Genes2-Methoxyestradiol4916TTRAC1TTTTAstroctyeFOXO3TT20CDKN1B20TTN2 Glial Precursor37EGFRPD 16839333TT43CASP3TTTT