Osteoblast (Mus musculus)

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OsteoblastNucleusPDGF RaPTH receptorSodiumPTH receptorRANK ligandFGF-23Parathyroid hormoneBone sialoproteinPhosphateParathyroid hormoneOsteoprotegerinSoluble RANK ligandCollagen 1Bone sialoproteinavb3 integrinFGF-23OsteocalcinOsteoprotegerinVitamin DVitamin DPDGF-BBPDGF-BBNPT3PDGF RbPDGF RaPDGF Rb


Osteoblasts are specialized, terminally differentiated uninucleated cells responsible for bone formation. Their activity is tightly regulated by external stimuli, originating from e.g. the parathyroid glands, osteocytes, etc. Along with osteoclasts, which are responsible for bone degradation, osteoblasts are key regulators of the shape and volume of bone tissue.

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106873view13:35, 17 September 2019MaintBotHMDB identifier normalization
97779view13:52, 7 June 2018AMTanModified description
97777view13:45, 7 June 2018AMTanOntology Term : 'osteoblast' added !
72001view11:51, 24 October 2013MkutmonChanged Unknown -> DataNode type + connected lines
69072view18:09, 8 July 2013MaintBotUpdated to 2013 gpml schema
67553view11:25, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
41255view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
32997view19:19, 30 September 2009MaintBotadded two metabolites
21177view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Osteoblasts]] moved to [[Pathway:WP238]]: Moved to stable identifier
20400view21:21, 3 November 2008AlexanderPicofixed species info
10478view19:59, 30 January 2008KhanspersModified categories
10350view01:50, 23 January 2008AlexanderPico[[Pathway:Mus musculus:Osteoblast]] moved to [[Pathway:Mus musculus:Osteoblasts]]
10343view01:36, 23 January 2008EhsiaoGPML Import (Author=Grant Yang)

External references


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NameTypeDatabase referenceComment
Bone sialoproteinGeneProduct12907 (Entrez Gene)
Collagen 1GeneProduct12842 (Entrez Gene)
FGF-23GeneProduct64654 (Entrez Gene)
NPT3GeneProduct218103 (Entrez Gene)
OsteocalcinGeneProduct12097 (Entrez Gene)
OsteoprotegerinGeneProduct18383 (Entrez Gene)
PDGF RaGeneProduct18595 (Entrez Gene)
PDGF RbGeneProduct18596 (Entrez Gene)
PTH receptorGeneProduct19228 (Entrez Gene)
Parathyroid hormoneGeneProduct19226 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
RANK ligandGeneProduct21943 (Entrez Gene)
SodiumMetaboliteHMDB0000588 (HMDB)
Soluble RANK ligandGeneProduct
Vitamin DGeneProduct
avb3 integrinGeneProduct

Annotated Interactions

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