Brain-Derived Neurotrophic Factor (BDNF) signaling pathway (Homo sapiens)

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VAV3MAPK9PCDK5R1SHC2MAPK8PMAPK3Y204T202ط®آ³-secretasecomplexCa2+ELMOEndocytosis-dependentOxidativeneuronalnecrosisIKKmembraneboundBrain-derived neurotrophic factor signaling pathwayDegradationSelectivepostsynapticdevelopmentNeuriteoutgrowthReduction inphosphorylationLamellipodia formationand increasedneurite outgrowthSynaptic plasticityDissociationProteinsynthesisBCL2L11IkkGIKK1IKK2CYFIP1NCK1NCK2SHC1PPLCG1Y783PTPN11PCDH2TRAF6CTNNB1Y654SQSTM1FYNY420SHC3PNGFRNCAM1Y734TIAM1Y829LINGO1RANBP9DOK5PSHC4PGRB2SIRPAPKCNA3PFRS2PGRIN2BPFRS3PDOCK3PNTRK1PRAC1CDKL5PSORT1NGFBDNFGRIA2CREB1S133NSFGNB2L1GABRB3S433S432PPP2CACRTC1KSR1MAP2K2PMAPK1Y187T185MAP2K1PSH2B2PFOXO3S253T32MTORS2448KIDINS220PRPS6KB1T444S447T412EIF4EBP1T37T46AKT1T308S473BADS75S99SH2BPGSK3BS9GRIN1PIRS2PMAPK7T219Y221IRS1PTSC2T1462GRIA1PCAMK4PCAMK2PEEF2ACACBS78PRKAA2T172MAPTS202S195S198ELK1PIGF2BP1Y396PTK2BY402RAF1S338VAV2Y172CDK5Y15NFATC4NCF2NCF1NFATC4CYNUCYNUSTAT5BCDC42CNR1NTRK3PIK3R1NTF3BDNFPDPK1S241MAP3K1ADAM17MAPK10PHRASGTPRPS6S236S235S240S244EIF4EPPIK3R2IP3SRCFOXO3PIP2DAGSTAT5ANFKB1RELAS529NFKB1RELAS529NFKBIAS32S36JUNPCASP3ProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through multiple reactionsTranslocation UbiquitinationPTM stateProtein-protein interactionDephosphorylationLEGENDPhosphorylationNucleusCytoplasmPlasma membraneCYPMNUProteolytic cleavageMoleculeCalcificationNeuronal growth,differentiation,and protectionInhibition ofapoptosisNitric oxideproductionApoptosisInhibition ofapoptosisRPS6KA3S386S227YBX1S102RPS6KA1S380S221RPS6KA5S376CAMK1T177MAPK14T180Y182RASGRF1DPYSL2T514APCPTPRFDLG1GRIP1GRIA3RHOGPAKKCNN2PCFL1PBDNFBDNFPIP2PIP3PIK3CACalmodulinSOSCAMKKCalcineurinPRKAA1T196EnhancedfatoxidationReduction in FOXO3 shuttleto nucleus anddecrease in BIMMAP2K5MAP3K2MEF2CMEF2ACerebellargranuleneuronalsurvivalCYNURAP1AMAPK7T219Y221CYNURegulation of surface expression of AMPA receptorsPKCRegulation ofsynaptic plasticitySTAT5BSTAT5AGrowthconemotilityCYNURegulation of Pre-synapticplasticity CYNUCYNUHuman airwaysmooth muscle cellproliferationRelease of RNG105from RNA granulesJAK2PSTAT1STAT3PPMajor pelvicganglia neuriteoutgrowthCEBPBFOSEGR1EGR2Cortical dendrite differentiationMARCKSPPRKCDY311CDK5dependentregulation of CDC42activityRadial migrationof corticalneuronsNTRK2S495Y722NTRK2Y723K811In secretorygranulesROSGSK3BS9MicrotubuleassemblyCSNK2A1RAB3AGTPcAMPPKASPP1ALPLBMP2EIF2S1EIF2S2MAPK3Y204T202MAPK1T185Y187SYN1PNeurotransmitterreleasemembraneboundBDNFBDNFBDNFAutocrinesignalingExtracellularECRPS6KA5S376ECCYDendritic developmentAxonal growthand branchingp75 NTR