Trans-sulfuration pathway (Homo sapiens)

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1DNA, proteins, metabolitesCBSCTHCTHGOT1L-GlutamateAHCYMAT2BL-CysteinePyruvateTetrahydrofolate (THF)ATP5-Methyl-THFMPSTGlutathioneL-MethionineL-HomocysteineMethylated productsCSADDNMT1TaurineADPS-Adenosylmethionine (SAMe)GCLMMTRS-Adenosylhomocysteine (SAH)GCLMPhosphate


Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

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Ontology Terms



  1. Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC


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72015view12:34, 24 October 2013Mkutmonfixed unconnected lines
71260view21:29, 16 October 2013MaintBotAutomated update of data sources
68972view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
58509view19:10, 14 February 2013MaintBotModified title
56801view16:40, 14 January 2013Leonjohn2008Ver 2.3
56754view18:58, 13 January 2013Leonjohn2008Ver 2.2
56678view21:17, 11 January 2013Leonjohn2008Ver 2.1
56671view19:59, 11 January 2013Leonjohn2008Ver 2.0
56670view19:45, 11 January 2013Leonjohn2008Ontology Term : 'glutathione metabolic pathway' added !
56669view19:41, 11 January 2013Leonjohn2008Modified description
56668view19:36, 11 January 2013Leonjohn2008Specify description
53107view01:14, 30 October 2012MaintBotModified categories
52961view03:00, 25 October 2012Leonjohn2008Ver 1.3
52960view02:51, 25 October 2012Leonjohn2008Ver 1.3
52959view02:50, 25 October 2012Leonjohn2008Ver 1.3
52956view02:01, 25 October 2012Leonjohn2008Ver 1.2
52955view01:48, 25 October 2012Leonjohn2008Periodical save, work in progress
52954view01:37, 25 October 2012Leonjohn2008Periodical save, work in progress
52937view19:43, 24 October 2012Leonjohn2008ver 1.0
52936view19:39, 24 October 2012Leonjohn2008Periodical save, work in progress
52933view19:27, 24 October 2012Leonjohn2008Specify description
52931view18:49, 24 October 2012Leonjohn2008Periodical save, work in progress
52864view19:31, 23 October 2012Leonjohn2008New pathway

External references


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NameTypeDatabase referenceComment
5-Methyl-THFMetaboliteC00440 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
AHCYGeneProduct191 (Entrez Gene)
ATPMetaboliteC00002 (KEGG Compound)
CBSGeneProduct875 (Entrez Gene)
CSADGeneProduct51380 (Entrez Gene)
CTHGeneProduct1491 (Entrez Gene)
DNA, proteins, metabolites
DNMT1GeneProduct1786 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GOT1GeneProduct2805 (Entrez Gene)
GlutathioneMetaboliteC00051 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
L-HomocysteineMetaboliteC00155 (KEGG Compound)
L-MethionineMetaboliteC00073 (KEGG Compound)
MAT2BGeneProduct27430 (Entrez Gene)
MPSTGeneProduct4357 (Entrez Gene)
MTRGeneProduct4548 (Entrez Gene)
Methylated products
PhosphateMetaboliteC00009 (KEGG Compound)
PyruvateMetaboliteC00022 (KEGG Compound)
S-Adenosylhomocysteine (SAH)MetaboliteC00021 (KEGG Compound)
S-Adenosylmethionine (SAMe)MetaboliteC00019 (KEGG Compound)
TaurineMetaboliteC00245 (KEGG Compound)
Tetrahydrofolate (THF)MetaboliteC00101 (KEGG Compound)

Annotated Interactions

No annotated interactions

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