IL-9 Signaling Pathway (Homo sapiens)

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STAT1STAT5BMAPK3ProteinIL-9 Signaling PathwayCYCYCYNUNUNUGRB2STAT3PIK3R2PSTAT1STAT5APSTAT1STAT1PSTAT5BPIRS1MAPK1IL9PJAK3STAT1STAT5BPIL2RGMAP2K2PIK3R1JAK1STAT3PSTAT5BIL9RPPMAP2K1PSTAT1STAT1PmRNALigandProteinEnzyme complexReceptorInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


IL-9 is a multifunctional cytokine, belonging to a family of cytokines. IL-9 was initially reported as a T cell growth factor in mice. It is now known to target multiple cell types. It plays an important role in the expansion and recruitment of mast cells in response to intestinal nematode infection or during autoimmune encephalomyelitis. It is also known to act on various cell types known to be involved in asthma including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells. IL-9 can promote the expression of TGF-beta in lipopolysaccharide-induced monocytes and macrophages. IL-9 is also known to play important roles in conditions including airway inflammation, EAE and parasitic infections. Mitogen-activated protein kinase pathway is activated transiently by IL-9, which in turn leads to the growth stimulation of hematopoietic cell lines. IL-9 signals through the heterodimeric receptor composed of a specific chain (IL-9R) and a gamma chain (IL2RG), which is shared between IL-2, IL-4, IL-7, IL15 and IL-21. The IL-9R and IL-2RG associates with JAK1 and JAK3 respectively. Receptor engagement results in JAK1- JAK3 cross phosphorylation and activation of the JAK proteins which leads to the activation of Signal transducer and activator of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in the activation of MEK/ERK signaling cascade.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

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97775view13:38, 7 June 2018AMTanModified description
79264view19:16, 19 March 2015Zarichanged Identifier for STAT5A
78534view10:30, 7 January 2015MaintBotadded missing graphIds
72098view21:39, 24 October 2013Mkutmonadded datasource for "STAT1"
70019view01:51, 12 July 2013AlexanderPicoModified title
67390view10:46, 26 June 2013Christine ChichesterOntology Term : 'interleukin-9 signaling pathway' added !
63215view20:59, 8 May 2013MaintBotUpdating gpml version
48441view14:46, 24 May 2012NetPathModified description
45370view21:00, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45140view01:05, 7 October 2011AlexanderPicofixed db refs
44850view09:48, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44629view18:12, 22 September 2011KhanspersUpdating content to NetSlim
44111view20:34, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44012view22:26, 22 August 2011KhanspersModified description
44011view22:23, 22 August 2011KhanspersUpdating pathway from NetSlim
41033view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35647view21:37, 12 February 2010KhanspersModified description
20723view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-9 NetPath 20]] moved to [[Pathway:WP22]]: Moved to stable identifier
8200view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-9 NetPath 20]] moved to [[Pathway:Homo sapiens:IL-9 NetPath 20]]: Renaming species
7720view16:13, 18 December 2007MaintBotfixed category names
7259view12:41, 4 November 2007MaintBotAdded categories to GPML
6341view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-9_NetPath_20]]

External references


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NameTypeDatabase referenceComment
GRB2Protein2885 (Entrez Gene)
IL2RGProtein3561 (Entrez Gene)
IL9Protein3578 (Entrez Gene)
IL9RProtein3581 (Entrez Gene)
IRS1Protein1025 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)

Annotated Interactions

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