Serotonin and anxiety (Mus musculus)

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6113CHRONICSTRESSNucleuspositive allosteric modulationMiscellaneous genespossibly involvedde Novo synthesisDissociationArcE-boxANXIETY215Ca2+PlekeEF2KeEF2-PAdra1aTHDOCeEF2KPomcCa2+CaMHtr2cFosPpp3caGabra1Fmr1Htr1aeEF2mGluR1ArcTrpv1Ca2+KetanserinHtr2aArcPlcd4PrkcbDOCCrh5661mGluR1434, 64, 5eEF2-PArc1


Benekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been implicated in anxiety related behaviour and may be suitable targets for reducing anxiety response. Benekareddy et al report that treatment with ketanserin (a serotonergic antagonist) during postnatal life blocked the long-lasting effects of maternal separation on anxiety behavior in the open field test and the elevated plus maze. Immediate Early Genes such as Arc have been found to be significantly affected in expression (Benekareddy et al). The downstream and upstream gene products of Arc were partly elucidated and presented in a pathway.


Note that part of this pathway is based on results obtained from research done in rattus norvegicus.

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Ontology Terms



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  1. Bramham CR, Worley PF, Moore MJ, Guzowski JF; ''The immediate early gene arc/arg3.1: regulation, mechanisms, and function.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  2. Reddy DS; ''Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions.''; Neuroscience, 2006 PubMed Europe PMC Scholia
  3. van der Starre PJ, Reneman RS; ''The alpha-adrenergic receptor blocking effect of ketanserin and the interaction between alpha-adrenergic and S2-serotonergic receptor blockade.''; J Cardiovasc Pharmacol, 1988 PubMed Europe PMC Scholia
  4. Shuttleworth TJ, Thompson JL, Mignen O; ''ARC channels: a novel pathway for receptor-activated calcium entry.''; Physiology (Bethesda), 2004 PubMed Europe PMC Scholia
  5. Jensen T, Edwards JG; ''Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons.''; Neurosci Lett, 2012 PubMed Europe PMC Scholia
  6. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA; ''Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.''; Biol Psychiatry, 2011 PubMed Europe PMC Scholia


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101828view09:32, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
95456view14:11, 15 December 2017DeSlChanged 2 additional IDs
95455view14:09, 15 December 2017DeSlchanged kegg ortholog to corresponding Uniprot ID
90850view19:59, 14 December 2016KhanspersModified description
89967view18:29, 6 October 2016Mkutmonfix unconnected lines
89802view11:32, 6 October 2016Mkutmonfixed special character in description
79764view20:02, 10 April 2015EgonwMissed a third annotation of a ortholog as a metabolite.
79760view07:00, 10 April 2015EgonweEF2 and eEF2-P are a gene products.
78416view10:25, 7 January 2015MaintBotadded missing graphIds
71728view20:17, 17 October 2013MaintBotUpdated data sources
70118view19:17, 12 July 2013MaintBotupdated to 2013 schema
68771view16:17, 7 July 2013EgonwFixed PubChem-compound data sources and identifiers.
67639view11:37, 26 June 2013DdiglesOntology Term : 'serotonin signaling pathway' added !
59053view20:55, 21 February 2013MaintBotUpdated Ensembl data source
58137view21:23, 8 February 2013MaintBotModified categories
58136view21:23, 8 February 2013MaintBotModified title
54703view13:29, 7 December 2012Andra
47355view16:44, 15 March 2012BurslemOntology Term : 'altered calcineurin signaling pathway' added !
47354view16:42, 15 March 2012BurslemOntology Term : 'anxiety disorder' added !
47352view16:40, 15 March 2012BurslemOntology Term : 'calcium/calmodulin dependent kinases pathway' added !
47351view16:40, 15 March 2012BurslemOntology Term : 'serotonergic neuron' added !
47350view16:35, 15 March 2012BurslemModified description
47331view14:47, 15 March 2012BurslemDatabase references
47328view14:39, 15 March 2012Burslemdatabase references
47327view14:38, 15 March 2012BurslemDatabase references
47325view14:34, 15 March 2012BurslemAnxiety
47320view14:25, 15 March 2012BurslemPeriodical save, work in progress
47315view14:13, 15 March 2012BurslemPeriodical save, work in progress
47311view14:02, 15 March 2012BurslemGABA receptor, THDOC
47308view13:53, 15 March 2012BurslemPeriodical save, work in progress
47304view13:46, 15 March 2012BurslemArc de novo synthesis
47303view13:43, 15 March 2012BurslemPeriodical save, work in progress
47299view13:37, 15 March 2012BurslemAddition of eEF2
47298view13:33, 15 March 2012BurslemPeriodical save, work in progress
47293view13:23, 15 March 2012BurslemPeriodical save, work in progress
47288view13:12, 15 March 2012BurslemPeriodical save, work in progress
47284view13:02, 15 March 2012BurslemPeriodical save, work in progress
47282view12:52, 15 March 2012BurslemPeriodical save, work in progress
47280view12:42, 15 March 2012BurslemPeriodical save, work in progress
47279view12:32, 15 March 2012BurslemPeriodical save, work in progress
47278view12:22, 15 March 2012BurslemPeriodical save, work in progress
47276view12:11, 15 March 2012BurslemPeriodical save, work in progress
47274view12:05, 15 March 2012BurslemLiterature addition
47272view12:01, 15 March 2012BurslemDecorative changes
47270view11:58, 15 March 2012BurslemPeriodical save, work in progress
47265view11:39, 15 March 2012HelixPeriodical save, work in progress
47258view11:29, 15 March 2012HelixPeriodical save, work in progress
47250view11:19, 15 March 2012HelixPeriodical save, work in progress
47243view11:09, 15 March 2012HelixNew pathway

External references


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NameTypeDatabase referenceComment
Adra1aGeneProductENSMUSG00000045875 (Ensembl)
ArcGeneProductENSMUSG00000022602 (Ensembl)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaMGeneProductENSMUSG00000057897 (Ensembl)
CrhGeneProductENSMUSG00000049796 (Ensembl)
DOCMetabolite6166 (PubChem-compound)
Fmr1GeneProductENSMUSG00000000838 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Gabra1GeneProductENSMUSG00000010803 (Ensembl) GABA a receptor
Htr1aGeneProductENSMUSG00000021721 (Ensembl)
Htr2aGeneProductENSMUSG00000034997 (Ensembl)
Htr2cGeneProductENSMUSG00000041380 (Ensembl)
KetanserinMetabolite3822 (PubChem-compound)
Plcd4GeneProductENSMUSG00000026173 (Ensembl)
PlekGeneProductENSMUSG00000020120 (Ensembl) pleckstrin
PomcGeneProductENSMUSG00000020660 (Ensembl)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl) calcineurin
PrkcbGeneProductENSMUSG00000052889 (Ensembl) Protein kinase C
THDOCMetabolite91475 (PubChem-compound)
Trpv1GeneProductENSMUSG00000005952 (Ensembl)
eEF2-PGeneProductP58252 (Uniprot-TrEMBL)
eEF2KGeneProductENSMUSG00000073853 (Ensembl) Phosphorylates eEF2
eEF2GeneProductP58252 (Uniprot-TrEMBL)
mGluR1GeneProductENSMUSG00000019828 (Ensembl) G-protein-coupled phosphatidylinositol-calcium second messenger system

Annotated Interactions

No annotated interactions
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