Neural Crest Differentiation (Mus musculus)

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9DifferentiationBmp7RhobMybItgb1Wnt1Tcfap2aZic1Pax3Pax7Dlx5Msx3Msx2Foxd3Snai1Snai2Snail/SlugWnt3aFzd3Gsk3bCtnnb1Tcf7l1Tcf4Gbx2Axin2Axin1Dvl3Dvl2Dvl1Bmp4Smad1Id1Notch1Dll3Notch4Notch2Dll4Notch3Dll1DeltaHey2Twist1Sox10Fgf2Hes5Hes1RbpjHes5Hes1(high)(intermed)Fgfr1Fgfr2Fgfr3Nuclear TFsZic5BmycSox9Sox10Isl1Cdh6Cdh2Cdh1Sox5Ets1EpidermisMesodermNeural plate borderNeuralplatePax3Pax7Nfkb1Cdh7Tcfap2aSnai1Snai2Snail/SlugFoxd3Id1Sox9Nfkb2Premigratory CNCCNeurog1Sox10Phox2bGfapOlig1Olig2Gjb1Ascl1MitfPmp22MpzMbpFoxd3Pax3Lhx1Lhx2Bmp4Fgf8Fgf15Neurons/gliaMelanocytesChondrocytesAutonomicNervousSystemSensoryNeuronsGliaSox10Pax3Pax7Sox5MitfHdac1Hdac2Hdac3Hdac4Hdac5Hdac6Hdac7Hdac8Hdac9Hdac10Hdac11Ctbp2DctSox5Sox9Col2a1Col11a2Mia1Migratory CNCCWnt8aHoxb17Prtg1Olig35Other Implicated2Tbx66Hoxa14Lhx5Tlx2Tcfap2b103Dmbx1Hand188


Description

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing thies pathway, please reference the source publication (PMID: 19575671).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2064(r45837) with a 96% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Arenkiel BR, Gaufo GO, Capecchi MR; ''Hoxb1 neural crest preferentially form glia of the PNS.''; Dev Dyn, 2003 PubMed
  2. Filippi A, Tiso N, Deflorian G, Zecchin E, Bortolussi M, Argenton F; ''The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.''; Proc Natl Acad Sci U S A, 2005 PubMed
  3. Knight RD, Javidan Y, Zhang T, Nelson S, Schilling TF; ''AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.''; Development, 2005 PubMed
  4. Makki N, Capecchi MR; ''Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.''; Dev Biol, 2011 PubMed
  5. Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, Sakai H; ''Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.''; BMC Dev Biol, 2010 PubMed
  6. Callery EM, Thomsen GH, Smith JC; ''A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.''; Dev Biol, 2010 PubMed
  7. Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW; ''Reiterated Wnt signaling during zebrafish neural crest development.''; Development, 2004 PubMed
  8. Ohtoshi A, Bradley A, Behringer RR, Nishijima I; ''Generation and maintenance of Dmbx1 gene-targeted mutant alleles.''; Mamm Genome, 2006 PubMed
  9. Betancur P, Bronner-Fraser M, Sauka-Spengler T; ''Assembling neural crest regulatory circuits into a gene regulatory network.''; Annu Rev Cell Dev Biol, 2010 PubMed
  10. Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I; ''''; , PubMed

History

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CompareRevisionActionTimeUserComment
101978view20:04, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
94468view05:55, 12 September 2017AndraOntology Term : 'migratory cranial neural crest cell' added !
94467view05:54, 12 September 2017AndraOntology Term : 'regulatory pathway' added !
94466view01:32, 12 September 2017AlexanderPicoadd mouse versions of Dvl1,2 and 3
94465view01:29, 12 September 2017AlexanderPicoTranslated Entrez ids to Ensembl for consistency
94464view01:26, 12 September 2017AlexanderPicoadd mouse version of Hdac1
69080view18:09, 8 July 2013MaintBotUpdated to 2013 gpml schema
59025view20:40, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
47076view00:08, 15 March 2012KhanspersModified categories
45976view20:55, 1 December 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Ascl1GeneProductENSMUSG00000020052 (Ensembl)
Axin1GeneProductENSMUSG00000024182 (Ensembl)
Axin2GeneProductENSMUSG00000000142 (Ensembl)
Bmp4GeneProductENSMUSG00000021835 (Ensembl)
Bmp7GeneProductENSMUSG00000008999 (Ensembl)
BmycGeneProductENSMUSG00000049086 (Ensembl)
Cdh1GeneProductENSMUSG00000000303 (Ensembl)
Cdh2GeneProductENSMUSG00000024304 (Ensembl)
Cdh6GeneProductENSMUSG00000039385 (Ensembl)
Cdh7GeneProductENSMUSG00000026312 (Ensembl)
Col11a2GeneProductENSMUSG00000024330 (Ensembl)
Col2a1GeneProductENSMUSG00000022483 (Ensembl)
Ctbp2GeneProductENSMUSG00000030970 (Ensembl)
Ctnnb1GeneProductENSMUSG00000006932 (Ensembl)
DctGeneProductENSMUSG00000022129 (Ensembl)
DifferentiationPathway
Dll1GeneProductENSMUSG00000014773 (Ensembl)
Dll3GeneProductENSMUSG00000003436 (Ensembl)
Dll4GeneProductENSMUSG00000027314 (Ensembl)
Dlx5GeneProductENSMUSG00000029755 (Ensembl)
Dmbx1GeneProductENSMUSG00000028707 (Ensembl)
Dvl1GeneProductENSMUSG00000029071 (Ensembl)
Dvl2GeneProductENSMUSG00000020888 (Ensembl)
Dvl3GeneProductENSMUSG00000003233 (Ensembl)
Ets1GeneProductENSMUSG00000032035 (Ensembl)
Fgf15GeneProductENSMUSG00000031073 (Ensembl)
Fgf2GeneProductENSMUSG00000037225 (Ensembl)
Fgf8GeneProductENSMUSG00000025219 (Ensembl)
Fgfr1GeneProductENSMUSG00000031565 (Ensembl)
Fgfr2GeneProductENSMUSG00000030849 (Ensembl)
Fgfr3GeneProductENSMUSG00000054252 (Ensembl)
Foxd3GeneProductENSMUSG00000067261 (Ensembl)
Fzd3GeneProductENSMUSG00000007989 (Ensembl)
Gbx2GeneProductENSMUSG00000034486 (Ensembl)
GfapGeneProductENSMUSG00000020932 (Ensembl)
Gjb1GeneProductENSMUSG00000047797 (Ensembl)
Gsk3bGeneProductENSMUSG00000022812 (Ensembl)
Hand1GeneProductENSMUSG00000037335 (Ensembl)
Hdac10GeneProductENSMUSG00000062906 (Ensembl)
Hdac11GeneProductENSMUSG00000034245 (Ensembl)
Hdac1GeneProductENSMUSG00000028800 (Ensembl)
Hdac2GeneProductENSMUSG00000019777 (Ensembl)
Hdac3GeneProductENSMUSG00000024454 (Ensembl)
Hdac4GeneProductENSMUSG00000026313 (Ensembl)
Hdac5GeneProductENSMUSG00000008855 (Ensembl)
Hdac6GeneProductENSMUSG00000031161 (Ensembl)
Hdac7GeneProductENSMUSG00000022475 (Ensembl)
Hdac8GeneProductENSMUSG00000067567 (Ensembl)
Hdac9GeneProductENSMUSG00000004698 (Ensembl)
Hes1GeneProductENSMUSG00000022528 (Ensembl)
Hes5GeneProductENSMUSG00000048001 (Ensembl)
Hey2GeneProductENSMUSG00000019789 (Ensembl)
Hoxa1GeneProductENSMUSG00000029844 (Ensembl)
Hoxb1GeneProductENSMUSG00000018973 (Ensembl)
Id1GeneProductENSMUSG00000042745 (Ensembl)
Isl1GeneProductENSMUSG00000042258 (Ensembl)
Itgb1GeneProductENSMUSG00000025809 (Ensembl)
Lhx1GeneProductENSMUSG00000018698 (Ensembl)
Lhx2GeneProductENSMUSG00000000247 (Ensembl)
Lhx5GeneProductENSMUSG00000029595 (Ensembl)
MbpGeneProductENSMUSG00000041607 (Ensembl)
Mia1GeneProductENSMUSG00000089661 (Ensembl)
MitfGeneProductENSMUSG00000035158 (Ensembl)
MpzGeneProductENSMUSG00000056569 (Ensembl)
Msx2GeneProductENSMUSG00000021469 (Ensembl)
Msx3GeneProductENSMUSG00000025469 (Ensembl)
MybGeneProductENSMUSG00000019982 (Ensembl)
Neurog1GeneProductENSMUSG00000048904 (Ensembl)
Nfkb1GeneProductENSMUSG00000028163 (Ensembl)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
Notch1GeneProductENSMUSG00000026923 (Ensembl)
Notch2GeneProductENSMUSG00000027878 (Ensembl)
Notch3GeneProductENSMUSG00000038146 (Ensembl)
Notch4GeneProductENSMUSG00000015468 (Ensembl)
Olig1GeneProductENSMUSG00000046160 (Ensembl)
Olig2GeneProductENSMUSG00000039830 (Ensembl)
Olig3GeneProductENSMUSG00000045591 (Ensembl)
Pax3GeneProductENSMUSG00000004872 (Ensembl)
Pax7GeneProductENSMUSG00000028736 (Ensembl)
Phox2bGeneProductENSMUSG00000012520 (Ensembl)
Pmp22GeneProductENSMUSG00000018217 (Ensembl)
PrtgGeneProductENSMUSG00000036030 (Ensembl)
RbpjGeneProductENSMUSG00000039191 (Ensembl)
RhobGeneProductENSMUSG00000054364 (Ensembl)
Smad1GeneProductENSMUSG00000031681 (Ensembl)
Snai1GeneProductENSMUSG00000042821 (Ensembl)
Snai2GeneProductENSMUSG00000022676 (Ensembl)
Sox10GeneProductENSMUSG00000033006 (Ensembl)
Sox5GeneProductENSMUSG00000041540 (Ensembl)
Sox9GeneProductENSMUSG00000000567 (Ensembl)
Tbx6GeneProductENSMUSG00000030699 (Ensembl)
Tcf4GeneProductENSMUSG00000053477 (Ensembl)
Tcf7l1GeneProductENSMUSG00000055799 (Ensembl)
Tcfap2aGeneProductENSMUSG00000021359 (Ensembl)
Tcfap2bGeneProductENSMUSG00000025927 (Ensembl)
Tlx2GeneProductENSMUSG00000068327 (Ensembl)
Twist1GeneProductENSMUSG00000035799 (Ensembl)
Wnt1GeneProductENSMUSG00000022997 (Ensembl)
Wnt3aGeneProductENSMUSG00000009900 (Ensembl)
Wnt8aGeneProductENSMUSG00000012282 (Ensembl)
Zic1GeneProductENSMUSG00000032368 (Ensembl)
Zic5GeneProductENSMUSG00000041703 (Ensembl)

Annotated Interactions

No annotated interactions
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