Heart Development (Mus musculus)

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3155286267787Second Heart FieldDay 28CTCardiac Reprogramming FactorsRVRAFibroblastLAASLVFirst Heart FieldCardiac Neural CrestGata4Nfatc1Ptpn11Foxh1Tbx2Gata6Tbx5Bmp2Smyd1Nkx2-5Bmp4Irx4VegfcBmp10Tbx1Tbx5ShhNkx2-5Mapk1Hand1Mef2cNfatc3Bhlhe40SrfFgf10SrfPitx2Hey1Tbx2Mef2cNfatc4VegfaBmpr1AFgf8Hey2Tbx20Notch1miR1-1Foxc2Gata4Nfatc2Nkx2-5Foxc1Erbb3Gata4Isl1miR145VegfbSmad4Tbx5Nkx2-5Bmpr2Foxa2Hand2Tbx20Tbx5Bmp2miR143Smad1Gata4Nkx2-5Mef2cCtnnb1Notch1Sternal GenesCombination of First and SecondHeart Fields (Heart Valves)


This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.

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  1. Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O; ''BMP and BMP receptor expression during murine organogenesis.''; Gene Expr Patterns, 2009 PubMed Europe PMC Scholia
  2. Fulcoli FG, Huynh T, Scambler PJ, Baldini A; ''Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.''; PLoS One, 2009 PubMed Europe PMC Scholia
  3. Srivastava D; ''Making or breaking the heart: from lineage determination to morphogenesis.''; Cell, 2006 PubMed Europe PMC Scholia
  4. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D; ''Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.''; Cell, 2010 PubMed Europe PMC Scholia
  5. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D; ''miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.''; Nature, 2009 PubMed Europe PMC Scholia
  6. Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT; ''Development of heart valves requires Gata4 expression in endothelial-derived cells.''; Development, 2006 PubMed Europe PMC Scholia
  7. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D; ''A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
  8. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP; ''An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.''; Cell, 2007 PubMed Europe PMC Scholia


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88634view14:46, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
84685view19:46, 15 March 2016Khanspersswitched interactions for graphical lines
84684view19:45, 15 March 2016KhanspersPeriodical save, work in progress
78407view10:25, 7 January 2015MaintBotadded missing graphIds
77161view21:43, 29 July 2014Khanspersconnected interactions and changed colors to improve readability
69145view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
59049view20:53, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45788view19:40, 10 November 2011Nsalomonisminor symbol changes
45787view19:37, 10 November 2011NsalomonisNew pathway

External references


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NameTypeDatabase referenceComment
Bhlhe40GeneProductENSMUSG00000030103 (Ensembl) In other species, this is BHLHB2
Bmp10GeneProductENSMUSG00000030046 (Ensembl)
Bmp2GeneProductENSMUSG00000027358 (Ensembl)
Bmp4GeneProductENSMUSG00000021835 (Ensembl)
Bmpr1AGeneProductENSMUSG00000021796 (Ensembl)
Bmpr2GeneProductENSMUSG00000067336 (Ensembl)
Ctnnb1GeneProductENSMUSG00000006932 (Ensembl)
Erbb3GeneProductENSMUSG00000018166 (Ensembl)
Fgf10GeneProductENSMUSG00000021732 (Ensembl)
Fgf8GeneProductENSMUSG00000025219 (Ensembl)
Foxa2GeneProductENSMUSG00000037025 (Ensembl)
Foxc1GeneProductENSMUSG00000050295 (Ensembl)
Foxc2GeneProductENSMUSG00000046714 (Ensembl)
Foxh1GeneProductENSMUSG00000033837 (Ensembl)
Gata4GeneProductENSMUSG00000021944 (Ensembl)
Gata6GeneProductENSMUSG00000005836 (Ensembl)
Hand1GeneProductENSMUSG00000037335 (Ensembl)
Hand2GeneProductENSMUSG00000038193 (Ensembl)
Hey1GeneProductENSMUSG00000040289 (Ensembl)
Hey2GeneProductENSMUSG00000019789 (Ensembl)
Irx4GeneProductENSMUSG00000021604 (Ensembl)
Isl1GeneProductENSMUSG00000042258 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mef2cGeneProductENSMUSG00000005583 (Ensembl)
Nfatc1GeneProductENSMUSG00000033016 (Ensembl)
Nfatc2GeneProductENSMUSG00000027544 (Ensembl)
Nfatc3GeneProductENSMUSG00000031902 (Ensembl)
Nfatc4GeneProductENSMUSG00000023411 (Ensembl)
Nkx2-5GeneProductENSMUSG00000015579 (Ensembl)
Notch1GeneProductENSMUSG00000026923 (Ensembl)
Pitx2GeneProductENSMUSG00000028023 (Ensembl)
Ptpn11GeneProductENSMUSG00000043733 (Ensembl)
ShhGeneProductENSMUSG00000002633 (Ensembl)
Smad1GeneProductENSMUSG00000031681 (Ensembl)
Smad4GeneProductENSMUSG00000024515 (Ensembl)
Smyd1GeneProductENSMUSG00000055027 (Ensembl)
SrfGeneProductENSMUSG00000015605 (Ensembl)
Tbx1GeneProductENSMUSG00000037477 (Ensembl)
Tbx20GeneProductENSMUSG00000031965 (Ensembl)
Tbx2GeneProductENSMUSG00000000093 (Ensembl)
Tbx5GeneProductENSMUSG00000018263 (Ensembl)
VegfaGeneProductENSMUSG00000023951 (Ensembl)
VegfbGeneProductENSMUSG00000024962 (Ensembl)
VegfcGeneProductENSMUSG00000031520 (Ensembl)
miR1-1GeneProductENSMUSG00000070144 (Ensembl)
miR143GeneProductENSMUSG00000065445 (Ensembl)
miR145GeneProductENSMUSG00000065592 (Ensembl)

Annotated Interactions

No annotated interactions

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