Alzheimer's disease and miRNA effects (Homo sapiens)

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IRS2ATG14NeuronER2-4, 6, 7, 12...1951812517, 29, 32108132353228355, 9MicrotubuleLegendMicrogliaAnterograde cargoDecreased energy production?PI3K complexImpairement of autophagyGene mutated in Alzheimer'sNeurofibrillary tanglesAmyloid BetaDefective insulin signalingInsulin resistanceOligomeric Amyloid BetaATP depletionDecreased AB clearanceKinesin 1Nonamyloidogenic APP processingER chaperonesMitochondiral dysfunctionCell deathMPTPFragmentationAPP Intracellular domainNeuronal InjuryULK complexMitochondrial dysfunctionCalcium overloadReduction in LTPAntioxidant responsesAmino acid metabolismImpaired neuronal insulin signalingCa2+beta-amyloid protein 40Cu+ApoptosisRAGECalcium Signaling PathwayMIR101Protein oxidationTNFRSF1AMAPTp50 ATF6Induction of ApoptosisFe2+IP3Oxidative PhosphorylationAPP intracellular domainRTN3NAC fragmentHydrogen peroxideNAE1PI3PNOP3 peptidesuperoxideAPPAGEsWnt signaling pathwayModulation of gene expression22APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingHSD17B10Fall in mitochondrialmembrane potentialIncreased ROSDegredationBIDCYCSCALM1BADPCALM2CALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2ADAM17PSEN2APAF1CASP9CASP3AB AggregationSNCASenile plaqueGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4Aggr. amyloidTNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3ATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3Ca2+Ca2+ER stressCAPN1CAPN2CDK5R1 / p35CDK5R1 / p25NOS1CDK5MAPTPCASP3CASP7Paired helical filamentsNeurofibrillarytanglesApoptosisDNA damageInflammationLipid peroxidationONOO-13Based on Table 1 from Burgos et al, PLoS ONE 2014 May.miRNA differentially expressed in AD(measured in cerebrospinal fluid)MIR199BMIR381MIR181B1MIR124-2MIR181DMIR124-1MIR760MIR184MIR136MIR181A1MIR598MIR181A2MIR127MIR34BMIR101-1MIR95MIR488MIR138-2MIR769MIR218-1MIR181B2MIR138-1MIR218-2MIR495MIR708MIR874MIR873MIR129-1MIR129-2MIR139MIR3200MIR431MIR9-1MIR9-2MIR9-3MIR326MIR377MIR433MIR323AMIR134MIR329-1MIR329-2MIR10AMIR33BMIR410MIR708miRNA differentially expressed in AD(measured in blood serum)MIR219-2MIR22MIR125B1MIR1307MIR34CMIR34BMIR887MIR182MIR135A1MIR135A2MIR184MIR127MIR30C2MIR873MIR125AMIR671MIR21MIR1285-2MIR375MIR3176MIR124-3MIR29AMIR29B1MIR29CMIR132MIR34CMIR375MIR124-3MIR9-1MIR138-2MIR138-2MIR132MIR21MIR21MIR21MIR21MIR21RTN4HyperinsulinemiaSequestration of IDEConcentrated intoendosome/lysosomeINSINSRIRS1PPPIRS4PPIDMCUCa2+Ca2+Ca2+beta-amyloid protein 42beta-amyloid protein 40beta-amyloid protein 42AKT1AKT2AKT3PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3PIP3EIF2AK2MAPK8MAPK9MAPK10GPR83CHUKIKBKBSynaptic dysfunctionImpaired memoryCHRNA7CYBBNOX1NOX4NFKB1RELA(Tau-p)nNRASKRASHRASRAF1ARAFBRAFNOS2TNFIL1AIL1BPTGS2IL6CSF1DKK121DKK2DKK4MTORULK2ULK1ATG13PPATG101RB1CC1BECN1PBECN2PIK3R4NRBF2PIK3C3AMBRA1PATG2AATG2BWIPI1WIPI2PSEN1GSK3Bbeta-amyloid protein 40beta-amyloid protein 42Ca2+Ca2+KLC3KIF5AKIF5BKIF5CKLC1KLC2PKLC4TUBA1BTUBA3ETUBA3DTUBA8TUBA4ATUBA3CTUBA1ATUBAL3TUBA1CTUBB3TUBB4ATUBB4BTUBBTUBB8TUBB2BTUBB2ATUBB1TUBB6Axonal transport defectsWntWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16FZD3FZD8LRP5FZD10FZD7FZD4FZD1LRP6FZD6FZD5FZD9FZD2DVL3FRAT1CSNK1EDVL2DVL1FRAT2TPTEP2-CSNK1EGSK3BCSNK2BCSNK2A1CSNK2A3CSNK2A2APCCSNK1A1AXIN1CSNK1A1LAXIN2APC2CSNK1A1CSNK1A1LCTNNB1PPPPPP3CAPPP3CBPPP3CCPPP3R1PPP3R2GSK3BsAPP alphaAPP-C83APP-C99sAPP betaEIF2S1ATF4DDIT3TRAF2MAP3K5MAP2K7MAPK8MAPK10PPMAPK9PPPPXBP1ER chaperonesERADDDIT3XBP1Proteasome 20SCatalytic Core (p45)PSMA2PSMB1PSMA5PSMB4PSMB2PSMA3PSMA7PSMA1PSMB6PSMA6PSMB5PSMA4PSMB7PSMB3PSMA819S regulatorPSMD8SEM1PSMD1PSMC6PSMC5PSMC4PSMC3PSMC2PSMC1PSMD7PSMD6ADRM1PSMD4PSMD3PSMD2PSMD14PSMD13PSMD12PSMD9PPIFSLC25A4SLC25A5SLC25A6VDAC1VDAC2VDAC3SLC25A31CALML4CALML6APH1BAmyloidogenic APP processingbeta-amyloid protein 40beta-amyloid protein 42Oligomeric Intracellular ABCa2+MAP2K1PPMAP2K2PPMAPK1PPMAPK3PPbeta-amyloid protein 40beta-amyloid protein 42PSEN1PSEN2