Alzheimers Disease (Homo sapiens)

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1, 3, 8, 11, 13...22124, 52, 7, 2220221929194910Aggr. amyloidC83Calcium overloadLower energy production?Mitochondrial dysfunctionATP depletionCell deathp-alpha-SecretasesAPP-alphaOligomeric intracellular ABNeuronal InjuryNeuronMicrogliaMitochondiral dysfunctionAICDAmyloid Beta (AB)Endoplasmic reticulum (ER)CalciumProteinAPPBP1MIR101JAK-STATCalcium Signaling PathwayNF-kB Modulation of gene expressionHydrogen peroxideNOIronInduction of ApoptosisProtein oxidationIP3RAGECopperOxidative PhosphorylationApoptosisAPP666APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingbeta-Secretasegamma-SecretaseHSD17B10Fall in mitochondrialsAPP-betaC99membrane potentialIncreased ROSDegredationInactivationBIDCYCSCALM1CHPBADCALM2CALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2CHP2ADAM17PSEN2APAF1CASP9CASP3AB AggregationOligomeric ABalpha-synucleinSNCASenileplaqueNACGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4TNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3PSENENATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3CalciumCalciumER stressCAPN1CAPN2TP53CDK5R1NOS1CDK5TAUPPGSK3BCASP3CASP7Paired helical filaments (PHFs)Neurofibrillarytangles (NFTs)ABApoptosisDNA damageInflammationLipid peroxidationONOO-Based on Table 1 from Burgos et al, PLoS ONE 2014 May.15miRNA differentially expressed in AD(measured in cerebrospinal fluid)MIR199BMIR381MIR181B1MIR124-2MIR181DMIR124-1MIR760MIR184MIR136MIR181A1MIR598MIR181A2MIR127MIR34BMIR101-1MIR95MIR488MIR138-2MIR769MIR218-1MIR181B2MIR138-1MIR218-2MIR495MIR708MIR874MIR873MIR129-1MIR129-2MIR139MIR3200MIR431MIR9-1MIR9-2MIR9-3MIR326MIR377MIR433MIR323AMIR134MIR329-1MIR329-2MIR10AMIR33BMIR410MIR708miRNA differentially expressed in AD(measured in blood serum)MIR219-2MIR22MIR125B1MIR1307MIR34CMIR34BMIR887MIR182MIR135A1MIR135A2MIR184MIR127MIR30C2MIR873MIR125AMIR671MIR21MIR1285-2MIR375MIR3176MIR124-3MIR29AMIR29B1MIR29CMIR132MIR34CMIR375MIR124-3MIR9-1MIR138-2MIR138-2MIR132MIR21MIR21MIR21MIR21MIR21MIR1285-2AB


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information. Source: KEGG (http://www.genome.jp/kegg/pathway/hsa/hsa05010.html)

Comments

 
Adapted from KEGG

Quality Tags

Ontology Terms

 

Bibliography

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  3. Hölscher C; ''Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.''; Neurobiol Dis, 1998 PubMed
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  6. Piras S, Furfaro AL, Domenicotti C, Traverso N, Marinari UM, Pronzato MA, Nitti M; ''RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage.''; Oxid Med Cell Longev, 2016 PubMed
  7. Abdelmohsen K, Hutchison ER, Lee EK, Kuwano Y, Kim MM, Masuda K, Srikantan S, Subaran SS, Marasa BS, Mattson MP, Gorospe M; ''miR-375 inhibits differentiation of neurites by lowering HuD levels.''; Mol Cell Biol, 2010 PubMed
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  15. Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T, Shill H, Adler C, Sabbagh M, Villa S, Tembe W, Craig D, Van Keuren-Jensen K; ''Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology.''; PLoS One, 2014 PubMed
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History

View all...
CompareRevisionActionTimeUserComment
102211view00:06, 11 December 2018Khanspersfixed unconnected interaction
102163view22:07, 4 December 2018Khanspersupdated xrefs for miRNAs
101829view09:35, 12 November 2018EgonwReplaced an old Uniprot data source with the new one.
99069view14:16, 29 October 2018SusanFixed interactions
99043view10:32, 27 October 2018Lovnish.thakurReverted to version '10:25, 27 October 2018' by Lovnish.thakur
99042view10:31, 27 October 2018Lovnish.thakurIncluded RAGE(Receptor for glycosylation end products)interaction with Aβ
99041view10:25, 27 October 2018Lovnish.thakurI have included the Receptor for advanced glycosylation end products(RAGE)in this pathway.Interaction of RAGE with Abeta is also responsible for neuronal damage & inflamation mediated which is mediated by NF-κB & JAK/STAT signaling pathways.
97494view14:02, 23 May 2018Fehrhartfixed connections
97492view13:57, 23 May 2018Fehrhartfixed connections
97491view13:56, 23 May 2018Fehrhartfixed connections
87372view09:56, 22 July 2016MaintBotadded missing graphids
85192view16:05, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
85191view16:01, 23 April 2016EgonwFixed a weird char in a reference.
82906view15:21, 11 November 2015JmeliusCorrect outdated id
79765view02:16, 11 April 2015AlexanderPicoAdded miRNA interactions and refs
79302view19:04, 20 March 2015AlexanderPicoupdated miRNA label
78941view22:47, 16 February 2015KhanspersAdded mir132
78916view21:58, 13 February 2015KhanspersAdded lit ref for mir29
78915view21:54, 13 February 2015KhanspersSpecify description
78914view21:41, 13 February 2015Khanspersfixed incorrect lit ref
78913view21:33, 13 February 2015KhanspersAdded related miRNAs
78911view18:50, 12 February 2015KhanspersAdded mir101
78488view10:28, 7 January 2015MaintBotadded missing graphIds
75217view20:21, 9 May 2014KhanspersAdding lit refs
75209view20:04, 9 May 2014KhanspersAdded states, fixed missing xrefs, changed some pathway nodes to labels
71384view18:40, 17 October 2013MaintBotAutomated update of data sources
63153view20:17, 8 May 2013MaintBotUpdating GPML version
59190view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45384view03:10, 8 October 2011NsalomonisAdded missing edges
45375view21:24, 7 October 2011KhanspersModified categories
45313view20:05, 7 October 2011NsalomonisModified description
45307view20:04, 7 October 2011NsalomonisModified description
45302view20:01, 7 October 2011Nsalomonisfinished initial layout
45300view19:49, 7 October 2011NsalomonisSpecify description
45299view19:44, 7 October 2011NsalomonisPeriodical save, work in progress
45298view19:38, 7 October 2011NsalomonisSpecify description
45297view19:34, 7 October 2011NsalomonisPeriodical save, work in progress
45267view18:48, 7 October 2011NsalomonisSpecify description
45259view18:44, 7 October 2011NsalomonisPeriodical save, work in progress
45240view18:22, 7 October 2011NsalomonisSpecify description
45237view18:13, 7 October 2011NsalomonisPeriodical save, work in progress
45236view18:12, 7 October 2011NsalomonisSpecify description
45235view17:53, 7 October 2011NsalomonisPeriodical save, work in progress
45232view17:43, 7 October 2011NsalomonisPeriodical save, work in progress
45224view17:33, 7 October 2011NsalomonisPeriodical save, work in progress
45210view17:23, 7 October 2011NsalomonisPeriodical save, work in progress
45206view17:13, 7 October 2011NsalomonisPeriodical save, work in progress
45205view17:02, 7 October 2011NsalomonisPeriodical save, work in progress
45169view06:40, 7 October 2011ThomasOntology Term : 'Alzheimers Dementia' added !
45168view06:40, 7 October 2011ThomasOntology Term : 'Alzheimer disease pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
APH1AGeneProductENSG00000117362 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
APP processingPathway
APPBP1GeneProductENSG00000159593 (Ensembl)
APPGeneProductENSG00000142192 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ATP2A1GeneProductENSG00000196296 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BACE1GeneProductENSG00000186318 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CACNA1CGeneProductENSG00000151067 (Ensembl)
CACNA1DGeneProductENSG00000157388 (Ensembl)
CACNA1FGeneProductENSG00000102001 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK5R1GeneProductENSG00000176749 (Ensembl)
CHPGeneProduct11261 (Entrez Gene)
CHP2GeneProduct63928 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
Calcium Signaling PathwayPathway
CalciumMetaboliteHMDB00464 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DNA damagePathway
EIF2AK3GeneProductENSG00000172071 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GPCRGeneProduct
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HSD17B10GeneProductENSG00000072506 (Ensembl)
Hydrogen peroxideMetaboliteHMDB03125 (HMDB)
IDEGeneProductENSG00000119912 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IP3MetaboliteHMDB01498 (HMDB)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
IronMetaboliteHMDB00692 (HMDB)
JAK-STATMetaboliteCHEBI:76617 (ChEBI)
LPLGeneProductENSG00000175445 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
Lipid peroxidationPathwayWP1878 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MIR101-1Rna406893 (Entrez Gene)
MIR101GeneProductENSG00000199135 (Ensembl)
MIR10ARna406902 (Entrez Gene)
MIR124-1Rna406907 (Entrez Gene)
MIR124-2Rna406908 (Entrez Gene)
MIR124-3Rna406909 (Entrez Gene)
MIR125ARna406910 (Entrez Gene)
MIR125B1Rna406911 (Entrez Gene)
MIR127RnaENSG00000207608 (Ensembl)
MIR1285-2Rna100302268 (Entrez Gene)
MIR129-1Rna406917 (Entrez Gene)
MIR129-2RnaENSG00000199077 (Ensembl)
MIR1307Rna100302174 (Entrez Gene)
MIR132GeneProduct406921 (Entrez Gene)
MIR134Rna406924 (Entrez Gene)
MIR135A1Rna406925 (Entrez Gene)
MIR135A2Rna406926 (Entrez Gene)
MIR136RnaENSG00000207942 (Ensembl)
MIR138-1Rna406929 (Entrez Gene)
MIR138-2Rna406930 (Entrez Gene)
MIR138-2RnaENSG00000207649 (Ensembl)
MIR139Rna406931 (Entrez Gene)
MIR181A1Rna406995 (Entrez Gene)
MIR181A2Rna406954 (Entrez Gene)
MIR181B1Rna406955 (Entrez Gene)
MIR181B2Rna406956 (Entrez Gene)
MIR181DRna574457 (Entrez Gene)
MIR182Rna406958 (Entrez Gene)
MIR184Rna406960 (Entrez Gene)
MIR199BRna406978 (Entrez Gene)
MIR21Rna406991 (Entrez Gene)
MIR218-1Rna407000 (Entrez Gene)
MIR218-2Rna407001 (Entrez Gene)
MIR219-2Rna407003 (Entrez Gene)
MIR22RnaENSG00000275595 (Ensembl)
MIR29AGeneProductENSG00000284032 (Ensembl)
MIR29B1GeneProduct407024 (Entrez Gene)
MIR29CGeneProductENSG00000284214 (Ensembl)
MIR30C2RnaENSG00000199094 (Ensembl)
MIR3176Rna100423037 (Entrez Gene)
MIR3200Rna100422912 (Entrez Gene)
MIR323ARnaENSG00000199069 (Ensembl)
MIR326Rna442900 (Entrez Gene)
MIR329-1RnaENSG00000207761 (Ensembl)
MIR329-2Rna574409 (Entrez Gene)
MIR33BRna693120 (Entrez Gene)
MIR34BRnaENSG00000207811 (Ensembl)
MIR34CRna407042 (Entrez Gene)
MIR34CRnaENSG00000207562 (Ensembl)
MIR375RnaENSG00000198973 (Ensembl)
MIR377RnaENSG00000199015 (Ensembl)
MIR381RnaENSG00000199020 (Ensembl)
MIR410RnaENSG00000199092 (Ensembl)
MIR431Rna574038 (Entrez Gene)
MIR433RnaENSG00000207569 (Ensembl)
MIR488RnaENSG00000202609 (Ensembl)
MIR495RnaENSG00000207743 (Ensembl)
MIR598RnaENSG00000207600 (Ensembl)
MIR671Rna768213 (Entrez Gene)
MIR708Rna100126333 (Entrez Gene)
MIR760RnaENSG00000211575 (Ensembl)
MIR769Rna768217 (Entrez Gene)
MIR873RnaENSG00000215939 (Ensembl)
MIR874RnaENSG00000216009 (Ensembl)
MIR887RnaENSG00000216077 (Ensembl)
MIR9-1Rna407046 (Entrez Gene)
MIR9-1RnaENSG00000207933 (Ensembl)
MIR9-2Rna407047 (Entrez Gene)
MIR9-3Rna407051 (Entrez Gene)
MIR95Rna407052 (Entrez Gene)
MMEGeneProductENSG00000196549 (Ensembl)
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NCSTNGeneProductENSG00000162736 (Ensembl)
NF-kB MetaboliteQ27087912 (Wikidata)
NOMetaboliteHMDB03378 (HMDB)
NOS1GeneProductENSG00000089250 (Ensembl)
ONOO-MetaboliteHMDB02179 (HMDB)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
ProteinProtein
Protein oxidationPathway
RAGEProteinQ15109 (Uniprot-TrEMBL)
RYR3GeneProductENSG00000198838 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
TAUGeneProductENSG00000186868 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

No annotated interactions
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