De Novo Biosynthesis of Purine Nucleotides (Saccharomyces cerevisiae)

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1-35'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazoleH2Oadenylo-succinate5-phosphoribosyl-n-formylglycineamideH2OIMP5-phospho-ribosyl-glycineamidedADP5'-phosphoribosyl-N-formylglycineamideH2OH2Ofumaratedeoxy-ATPphosphoribosyl-formamido-carboxamidereduced flavodoxinfumarateNH3reduced flavodoxinreduced thioredoxinTHFH2Ooxidized thioredoxin5'-phosphoribosyl-5-aminoimidazoleH2OH2Oreduced thioredoxin5-phosphoribosylamineH2OL-aspartateAMPAMPCO2L-aspartateoxidized flavodoxinphosphoribosyl-carboxy-aminoimidazoleH2Ooxidized flavodoxinNADdeoxy-GTPH2OAMPoxidized thioredoxinphosphateADPATPADE16GDPATPRNR1YNK1ADE8ADPRNR3ADE17ADE6ATPADE5,7phosphateADE5,7ATPADPADPADE2phosphateADE4phosphateATPL-glutamateADPATPRNR2pyrophosphateRNR3RNR1RNR2GUK1NADHATPADPdGDPADE13ADPL-glutamateGUA1IMD4GDPADK1ADK2IMD3ATPADPADPGTPxanthosine-5-phosphateRNR4L-glutamineATPPRPPIMD2L-glutamateL-glutamineADPphosphate10-formyl-THFAICARATPADE12phosphateADE1pyrophosphateGMPATPATPATPRNR4L-glycineADE13L-glutamineGTPpyrophosphateADPATP


Description

The ergosterol biosynthesis pathway is required for generation of a major constituent of the fungal plasma membrane, ergosterol (CITS: [Paltauf])(CITS: [8561481]). This pathway is fungal-specific; plasma membranes of other organisms are composed predominantly of other types of sterol. However, the pathway is not universally present in fungi; for example, Pneumocystis carinii plasma membranes lack ergosterol (CITS: [12531182]). In S. cerevisiae, some steps in the pathway are dispensible while others are essential for viability (CITS: [8277826]). The ergosterol biosynthesis pathway has been the subject of intensive investigation as a target of antifungal drugs (CITS: [11815273]). The major target of azole antifungal drugs is lanosterol 14-alpha demethylase, a member of the cytochrome P450 family known as Erg11 protein in many fungal species. Squalene epoxidase (Erg1p in S. cerevisiae) is the specific target of allylamine drugs such as terbinafine (CITS: [14638499]). Mutations in the genes encoding these enzymes and others in the pathway, as well as alterations in the expression levels of the pathway constituents, can lead to antifungal drug resistance (CITS: [11815273]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Rébora K, Desmoucelles C, Borne F, Pinson B, Daignan-Fornier B; ''Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.''; Mol Cell Biol, 2001 PubMed
  2. Rébora K, Laloo B, Daignan-Fornier B; ''Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.''; Genetics, 2005 PubMed
  3. Escobar-Henriques M, Daignan-Fornier B; ''Transcriptional regulation of the yeast gmp synthesis pathway by its end products.''; J Biol Chem, 2001 PubMed

History

View all...
CompareRevisionActionTimeUserComment
97912view16:16, 23 June 2018EgonwReplaced a salt with a parent ID (from PubChem)
71893view10:20, 22 October 2013Mkutmoncahnged AICAR to metabolite and connected some lines
70262view21:45, 15 July 2013MaintBotupdated to 2013 schema
69821view14:39, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67144view10:12, 26 June 2013Christine ChichesterOntology Term : 'de novo purine biosynthetic pathway' added !
41834view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
36663view23:01, 9 April 2010MaintBot
36627view22:33, 9 April 2010MaintBotDescription and bibliography added from SGD
21107view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo Biosynthesis of Purine Nucleotides]] moved to [[Pathway:WP203]]: Moved to stable identifier
12682view07:57, 17 May 2008MaintBotautomated metabolite conversion
8684view14:06, 7 January 2008MaintBotAdded to category $category
8682view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-formyl-THFMetabolite2800-34-2 (CAS)
ADE12GeneProductS000005164 (SGD)
ADE13GeneProductS000004351 (SGD)
ADE16GeneProductS000004018 (SGD)
ADE17GeneProductS000004727 (SGD)
ADE1GeneProductS000000070 (SGD)
ADE2GeneProductS000005654 (SGD)
ADE4GeneProductS000004915 (SGD)
ADE5,7GeneProductS000003203 (SGD)
ADE6GeneProductS000003293 (SGD)
ADE8GeneProductS000002816 (SGD)
ADK1GeneProductS000002634 (SGD)
ADK2GeneProductS000000972 (SGD)
ADPMetabolite58-64-0 (CAS)
AICARMetabolite3031-94-5 (CAS)
ATPMetabolite1927-31-7 (CAS)
GDPMetabolite146-91-8 (CAS)
GMPMetabolite85-32-5 (CAS)
GTPMetabolite2564-35-4 (CAS)
GUA1GeneProductS000004830 (SGD)
GUK1GeneProductS000001550 (SGD)
IMD2GeneProductS000001259 (SGD)
IMD3GeneProductS000004424 (SGD)
IMD4GeneProductS000004520 (SGD)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-glycineMetabolite56-40-6 (CAS)
NADHMetabolite53-84-9 (CAS)
PRPPMetabolite97-55-2 (CAS)
RNR1GeneProductS000000872 (SGD)
RNR2GeneProductS000003563 (SGD)
RNR3GeneProductS000001328 (SGD)
RNR4GeneProductS000003412 (SGD)
YNK1GeneProductS000001550 (SGD)
dGDPMetabolite644 (PubChem-compound)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
xanthosine-5-phosphateMetabolite523-98-8 (CAS)

Annotated Interactions

No annotated interactions
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