Integrated Breast Cancer Pathway (Homo sapiens)

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23221511518251619202615824215172111513129151036MBASC ComplexG2Cell CycleSG14, 10, 17AHRATMATRNF1HydrocortisoneCancer DevelopmentNAB1DAG1NOXA1CDC25AAKT1JKIP1BIDAnti-ApoptosisP13Cell survival and ProliferationSMAD4ERKPLK1XRCC3Cell SurvivalAKT1TFPICycloheximideMIR21MPIP1GREP300P85ATCF/LEFP38CIP1BARD1RAP1ASMAD6PlicamycinCDK7SMAD2CERKCell proliferationPaclitaxelSMAD7LetrozoleHDAC1STAT1RPP38AngiogenesisSMEK1PPRB/RBBACH1DihydrotestosteroneTSC2PLK3CABLMBleomycinZMIZ1BADBRCA2TestosteroneFluoxymesteroneERE2F1HDAC1CBPAQP73PTENMAXDexamethasoneTGFR1PHBUBIMATRAURKAHDAC1/HDAC2Methyl MethanesulfonateExemstaneAmpicillinC9JNK1MYCCYP19A1ANXA1BRAFCHK1NCOA3Cell Cycle arrestWEE1TAB1UBP21C9JNK1MIR21LapatnibFADDIKKAATRPLK3CTNB1CorticosteroneCSNK1DKRASHydroxyureaSIRT1MYCTAK1LDCAKDPRLithium ChlorideP65ProteinPIAS1SMEK1SMAD4NocodazoleApoptosisRHOITPKCTGFR2FOXO1MIR29B1PPARBCL2BRCA1PMLCDH1MYT1MRE11DonepezilTSC1MMP1RALAMIR21DHTWEE1EstradiolGDIPAK1Conjugated EstrogensUBP16BAXSP1ApoptosisABC3GRALGAPA1ESR1ERAL1ODC1CASP9BARD1CDC42MAPKsCERK1HIPK2ANDRMPIP2MTORP13KIKKAJUNMDM2P53UBP15TranscriptionJAK1VEGFAATMGSK3ASMAD1JUNRRASALKB1CDK2RASGRP3TamoxifenDNACREBProteasomeP53RAC1B5MEC1IPKAMSH6ARMitomycinSMAD7FLIP1RHOUBE2Ffra-1SELKEGFRCCND1BADCASP8RAD54LCHK2STK11CASP3BMPR1AIRS1SMCA4GCRTetradecanoylphorbol AcetateMDM2BRCA1CDK4ATF1FADDBMPR2RAD51MSH2CTNB1 degradationE2F1Proliferative genesUBP21RAD50AnastrozoleSMAD3FlutamidePenicillin GP85RaloxifenePKCB1C9JNK1ABL1TRADDNCOA2GRNCASP3SMEK2RRASRASGEF1AB3KP27RHEBCERK1cyc-DCDK2Q8NBS1IMPA1Gene ExpressionNFKB1RAFBAKFulvestrantRRASGADD45ATSC114MIR29B2