Integrated Breast Cancer Pathway (Homo sapiens)

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20135231191315221515812101811625241515926272116BASC ComplexSG2G1MCell Cycle4, 10, 17IPKACDH1TGFR2E2F1GADD45ADexamethasoneATMCell SurvivalPenicillin GBleomycinCERKP85ARAC1RHOFLIP1RHEBUBP16CDK2BLMPLK1MMP1DAG1MYCCHK1SELKCell survival and ProliferationUBIMNOXA1NCOA3PHBTAK1LBRAFPlicamycinMAPKsBMPR2GSK3AP53MRE11SMAD3RAP1ABMPR1ALetrozoleP53AngiogenesisDihydrotestosteroneSMAD6ODC1Anti-ApoptosisMIR29B1E2F1STK11TestosteroneMTORHDAC1/HDAC2B5MEC1GRfra-1DHTSMEK1P85RaloxifeneCell Cycle arrestRRASWEE1ATRFulvestrantSMEK1UBP21NF1ERAL1SMAD1ALKB1CREBBADESR1FADDGRNP13KIKKAFOXO1SMAD7FluoxymesteronePLK3CANFKB1CBPExemstaneCDC25APPARCDC42cyc-DUBP15TSC1AKT1CASP3CASP9HydroxyureaCHK2HydrocortisoneRALAIKKAMPIP2Methyl MethanesulfonateJKIP1ANXA1GCRP65EstradiolSMAD2SP1CASP3C9JNK1MYT1NCOA2BADAHRTRADDTSC2CDK4CTNB1 degradationRRASERFlutamideBAKC9JNK1KRASRASGRP3JAK1ERKMYCSMAD4SIRT1SMAD4RAFSTAT1ABC3GCASP8MAXC9JNK1BARD1Proliferative genesCCND1Gene ExpressionApoptosisAnastrozoleBCL2HIPK2BACH1PAK1RASGEF1ARRASIRS1RPP38MIR21CDK2SMAD7P38CYP19A1TCF/LEFCDK7WEE1UBP21CTNB1CIP1ProteasomeCSNK1DNAB1ITPKCCorticosteroneBIDTGFR1TAB1TranscriptionFADDPRATMTetradecanoylphorbol AcetateRHOPTENVEGFADCAKDBRCA2BAXQ8NBS1EP300ATRB3KP27HDAC1TamoxifenDNATSC1PKCB1MSH6ApoptosisBRCA1UBE2FANDRP13RAD50AKT1LapatnibTFPIMDM2CycloheximideRAD54LABL1ProteinRAD51Conjugated EstrogensXRCC3SMCA4GDICancer DevelopmentMDM2MIR21PLK3HDAC1Cell proliferationDonepezilPaclitaxelATRCERK1NocodazoleMitomycinMSH2IMPA1PIAS1AQP73ARPPRB/RBBRCA1RALGAPA1EGFRPMLJUNBARD1CERK1ZMIZ1ATF1Lithium ChlorideMPIP1JUNMIR21AmpicillinAURKASMEK214MIR29B2