Integrated Breast Cancer Pathway (Homo sapiens)

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3222111111115169218102361719252611121311204524144G1SG2MCell CycleBASC Complex1, 8, 18HIPK2RAD50EGFRMAPKsPenicillin GNCOA3CASP3CDH1BAXCERK1NF1AKT1ProteinGADD45APTENcyc-DIMPA1CDC25ADexamethasoneRHOMRE11Conjugated EstrogensFluoxymesteroneCDK7MitomycinFulvestrantFLIP1ATRBADSTK11C9JNK1TCF/LEFCERKApoptosisCycloheximideBAKABC3GProliferative genesRHOSMAD2HDAC1/HDAC2MYCMPIP2E2F1DihydrotestosteroneITPKCRRASVEGFAPPRB/RBMMP1CYP19A1MIR29B1IKKADAG1EstradiolFlutamideARE2F1RaloxifeneBCL2Cell Cycle arrestMYCDNAGCRBADPaclitaxelAQP73TAK1LODC1Cell survival and ProliferationMSH2Cancer DevelopmentGSK3AIRS1BleomycinCBPP53ATMSMCA4RPP38RRASMYT1PlicamycinIPKAAHRCHK1RAD54LMPIP1P65CTNB1Anti-ApoptosisGRNB5MEC1SMAD4RASGEF1ABACH1MIR21UBP21BRCA1WEE1CSNK1DESR1NocodazoleATRATMRALGAPA1PLK1P53JUNPRGDICASP9RAFSIRT1P38ALKB1CIP1HDAC1CASP8TAB1PLK3ERCDK4MSH6PMLWEE1ExemstaneHydrocortisoneMIR21Methyl MethanesulfonateUBIMAKT1STAT1SMAD3SELKBARD1AngiogenesisCREBEP300NCOA2MIR21ATRNFKB1NOXA1TamoxifenMDM2Cell proliferationTetradecanoylphorbol AcetateSMEK2UBP21LetrozoleLapatnibNAB1CorticosteroneSMEK1SMAD7C9JNK1CERK1GRABL1BRAFUBP16PLK3CACDC42CASP3TestosteroneSMAD4ERKLithium ChlorideC9JNK1PPARSP1SMAD7Cell SurvivalSMAD1TSC2RALAQ8NBS1ZMIZ1TSC1BLMMDM2TFPIRRASTGFR1ANXA1XRCC3JUNP13KFOXO1TSC1AURKAIKKAHydroxyureaFADDUBP15SMAD6PAK1PKCB1CDK2RASGRP3P85JAK1ProteasomePIAS1RHEBTRADDAnastrozoleFADDP13RAC1UBE2FJKIP1KRASBMPR1ABMPR2BIDCHK2BARD1DHTDonepezilATF1ANDRBRCA1PHBDCAKDB3KP27RAD51ApoptosisHDAC1MTORfra-1CCND1P85ACTNB1 degradationERAL1TranscriptionRAP1ASMEK1CDK2Gene ExpressionMAXTGFR2AmpicillinBRCA2MIR29B27


This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

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98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress
46412view16:54, 26 January 2012SaibrahiPeriodical save, work in progress
44857view09:53, 6 October 2011MartijnVanIerselOntology Term : 'breast cancer' added !
44468view20:27, 14 September 2011MaintBotModified categories
43855view13:21, 8 August 2011SaibrahiPeriodical save, work in progress
43849view19:54, 5 August 2011SaibrahiPeriodical save, work in progress
43848view19:43, 5 August 2011SaibrahiPeriodical save, work in progress
43847view19:33, 5 August 2011SaibrahiPeriodical save, work in progress
43846view19:22, 5 August 2011SaibrahiPeriodical save, work in progress
43845view18:59, 5 August 2011SaibrahiPeriodical save, work in progress
43831view14:45, 5 August 2011SaibrahiSpecify description
43830view14:37, 5 August 2011SaibrahiPeriodical save, work in progress
43829view14:26, 5 August 2011SaibrahiPeriodical save, work in progress
43828view14:16, 5 August 2011SaibrahiPeriodical save, work in progress
43827view13:55, 5 August 2011SaibrahiSpecify description
43826view13:46, 5 August 2011SaibrahiPeriodical save, work in progress
43823view13:33, 5 August 2011SaibrahiPeriodical save, work in progress
43822view13:23, 5 August 2011SaibrahiPeriodical save, work in progress
43768view20:04, 22 July 2011SaibrahiPeriodical save, work in progress
43767view19:54, 22 July 2011SaibrahiPeriodical save, work in progress

External references


View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
CTNB1 degradation
CTNB1ProteinP35222 (Uniprot-TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl)
Cancer Development
Cell Cycle arrest
Cell Survival
Cell proliferation
Cell survival and Proliferation
Conjugated Estrogens
CorticosteroneMetabolite5753 (PubChem-compound)
CycloheximideMetabolite6197 (PubChem-compound)
DAG1GeneProductENSG00000173402 (Ensembl)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl)
DexamethasoneMetabolite5743 (PubChem-compound)