Integrated breast cancer pathway (Homo sapiens)

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141013151078152222513161523171592015241911641226BASC ComplexSG2G1Cell CycleM5, 18, 22XRCC3SMEK1PLK3RASGEF1ANCOA2TFPIANDRUBP16UBE2FNocodazoleMIR29B1STAT1ESR1CDC42AHRDAG1fra-1CDK4CHK2FulvestrantPHBATF1PPRB/RBIRS1MRE11MSH2TGFR2Cell proliferationE2F1KRASPMLTetradecanoylphorbol AcetateRAD51HDAC1/HDAC2CTNB1BAKCASP3HIPK2HDAC1NFKB1GRNDonepezilSMEK2JAK1ATRRAD50Cell survival and ProliferationTSC2BMPR1ASMAD6STK11SIRT1DihydrotestosteroneP85APIAS1Cell Cycle arrestRRASRHOUBP15AURKAAnastrozoleALKB1Cancer DevelopmentMIR21Methyl MethanesulfonatePKCB1AKT1IKKAProteinQ8NBS1DNAMDM2CHK1DHTBAXHydroxyureaP38SMAD7CIP1PAK1BADLapatnibP13KP53Proliferative genesPLK3CAWEE1AQP73BARD1CycloheximideRAD54LMIR21FlutamideP53SMAD1AngiogenesisAKT1PTENPenicillin GGene ExpressionMitomycinGRHydrocortisoneRASGRP3NAB1RPP38CDC25APLK1CERKCERK1SMAD4C9JNK1TamoxifenPPARMDM2RHOCBPMAXERMMP1GDISMAD2B5MEC1TAB1PRExemstaneTestosteroneMAPKsEstradiolMYT1BRAFTGFR1ERAL1ARUBP21MIR21C9JNK1CREBRALASMAD4ANXA1UBP21ATMCYP19A1FLIP1JUNFluoxymesteroneCASP8cyc-DSMAD7RRASAnti-ApoptosisBADSP1BRCA1GADD45ABACH1CDK2RAC1P65PlicamycinRAP1AFADDWEE1ATRMYCEGFRFOXO1RRASC9JNK1CASP3TSC1RaloxifeneHDAC1VEGFAFADDZMIZ1CERK1ABC3GIKKACell SurvivalCCND1MPIP1RALGAPA1DexamethasoneE2F1SMAD3GCRBIDMYCEP300TSC1TRADDTAK1LSELKTCF/LEFPaclitaxelBRCA1ApoptosisABL1NF1TranscriptionRHEBRAFLetrozoleCTNB1 degradationSMCA4IMPA1NCOA3ATMCDH1ODC1IPKABARD1GSK3ADCAKDNOXA1BCL2JKIP1AmpicillinITPKCBleomycinProteasomeMTORP85BMPR2CSNK1DBRCA2MSH6CDK2ApoptosisP13CDK7UBIMMPIP2B3KP27CASP9BLMJUNSMEK1ERKCorticosteroneLithium ChlorideATRConjugated Estrogens21MIR29B2


This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway. This pathway is part the CPTAC Assay Portal.

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123531view06:33, 2 August 2022EgonwMade two pathways clickable
116548view12:47, 7 May 2021EweitzModified title
116285view21:46, 26 April 2021EweitzModified description
113594view09:46, 4 November 2020DeSlUpdated hydrocortisone ID (to drug ID).
110683view13:17, 28 May 2020EgonwAdded missing @Type annotation
108807view15:48, 30 January 2020DeSlReplaced P65 with MAP3K13
108804view15:38, 30 January 2020DeSlUpdated C9JNK1 to ZN655
108802view15:27, 30 January 2020DeSlRemoved B5MEC1; doesn't exist in original database anymore; no replacement; no lit.ref.
108799view15:00, 30 January 2020DeSlUpdated name FOSL2
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress

External references


View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
AngiogenesisPathwayWP1993 (WikiPathways) Example of Angiogenesis PW (homo sapiens)
ApoptosisPathwayWP254 (WikiPathways) Example Pw for apoptosis (homo sapiens)
B3KP27ProteinP15408 (Uniprot-TrEMBL)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)