Nucleotide Excision Repair (Homo sapiens)

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3, 11, 16, 20, 40...931, 2, 23, 54, 100...8812, 26, 31, 69, 74...30, 33, 55, 713935, 47, 78, 79, 856, 20, 30, 32, 33, 55...15, 30, 33, 39, 44...38, 49, 64, 8252526, 58, 8350, 6127, 468, 19, 37, 777, 9, 21, 22, 41...49, 8293362742, 6113, 275, 10, 27, 4660, 62, 9750, 611, 2, 23, 54, 78...19, 39, 922760, 62, 975, 10, 27, 465, 13, 2718, 28, 34, 51, 57...14, 17, 25, 35, 43...27, 464, 24, 59, 7535, 47, 78, 79, 85nucleoplasmUV-DDB:COP9SignalosomePOLR2C UBC(1-76) UBC(229-304) UBC(1-76) ATPLIG3 UBB(1-76) GTF2H1 UBA52(1-76) ACTB(1-375) RFC2 POLR2F UBB(153-228) UBB(77-152) USP7 CUL4B ERCC2 UVSSA MonoUb-K164-PCNA UVSSA RPA3 RFC5 USP7 UBB(77-152) ZNF830 TCEA1 Ub-XPC RPA2 Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2UBC(229-304) AQR CCNH ERCC1 RBX1 UBE2IRFC1 ERCC2 RFC2 POLR2K UBC(1-76) UBB(1-76) UBC(153-228) COPS5 POLR2B UBE2V2 DDB1 POLR2J RPS27A(1-76) COPS6 EP300 RPS27A(1-76) POLR2I UBC(457-532) DDB1 RPA3 RBX1 ERCC3 ISY1 PCNA COPS8 ERCC2 POLD4 UBC(609-684) UBC(77-152) RBX1 CHD1LRPS27A(1-76) UBC(1-76) UBC(1-76) UBA52(1-76) POLR2H GTF2H4 Open bubble damaged DNA template:trimmed nascent mRNA PAR-PARP2 CETN2 Ub-63-UBA52(1-76) RPA3 POLE2 Ub-367-UBC(305-380) GTF2H3 ERCC8:DDB1:CUL4:RBX1GTF2H1 POLR2E POLD3 CUL4B UBC(229-304) RPS27A(1-76) PAR-PARP2 DDB1 UBC(77-152) RPA2 UVSSA ERCC3 RFC5 GTF2H3 ERCC2 RFC2 excised DNA fragmentwith lesionUBC(1-76) POLR2F UBC(153-228) UBC(457-532) UBA52(1-76) POLR2L POLD2 UBC(457-532) UBC(77-152) POLR2D ADPUBC(457-532) CUL4A UBC(533-608) UBC(153-228) CDK7 PRPF19 UBC(1-76) PRPF19 Ub-ERCC6 UBC(77-152) POLR2E POLE GTF2H1 ERCC4 UBC(77-152) PIAS1,3GTF2H5 UBB(153-228) COPS7B ribonucleosidetriphosphatePOLD3 ERCC2 UBB(1-76) UBC(381-456) TFIIH CorePOLR2B GTF2H5 COPS2 XAB2 XPA PPiPPIE ERCC8 POLR2H POLR2H UBB(1-76) Ub-XPC Ub-ERCC6 DDB1 UBA52(1-76) UBB(153-228) Ub-291-UBC(229-304) Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1LISY1 POLR2E GTF2H4 POLR2D ERCC6COPS7A UBC(229-304) RFC4 POLR2D POLR2J XPA GTF2H3 CUL4A UBB(1-76) PPIE SUMO2 UBB(77-152) POLR2B COPS7B UBA52(1-76) DDB1 PIAS1 MNAT1 GTF2H3 TC-NER incisioncomplex:5'-inciseddamaged DNA:trimmednascent mRNAPOLR2I UBB(77-152) PAR-PARP2 RBX1 RAD23B NFRKB UBC(305-380) GTF2H3 RFC4 MNAT1 UBC(1-76) UBB(77-152) PPIE UBB(77-152) MNAT1 POLR2B RAD23A UBC(77-152) DDB1 UBC(305-380) POLR2C USP7 USP7 UBC(229-304) USP7 RAD23B CCNH RAD23B ERCC3 RAD23A ERCC2 ERCC3 K63polyUb-C87-UBE2N UBB(1-76) POLR2I CDK7 POLD3 POLR2E EP300 dNTPXPA ISY1 RAD23A UBC(153-228) POLR2K PARP1 GTF2H4 UBC(153-228) RAD23B ISY1 RPS27A(1-76) ERCC8 POLR2F UBB(153-228) RFC3 POLR2E POLR2F POLR2F RPS27A(1-76) PCNA GTF2H5 GTF2H2 UBB(153-228) UBC(457-532) GTF2H3 UBC(77-152) UVSSA UBC(533-608) POLE4 MNAT1 USP7 CDK7 POLR2H TCEA1 UBB(153-228) UBC(229-304) POLR2F RPA1 SUMO1-C93-UBE2I dsDNAPAR-DDB2 GTF2H3 TC-NER pre-incisioncomplex:Open bubbledamaged DNAtemplate:trimmednascent mRNAERCC1 damaged DNA substrate:nascent mRNA hybrid Distorted dsDNA GTF2H3 UBB(77-152) CUL4A UBE2I-G97-SUMO1 RBX1 COPS7A PAR-DDB2 ERCC2 Ub,p-S2,S5-POLR2A XPA CUL4B GTF2H3 UBC(77-152) POLE3 UBA52(1-76) UBC(305-380) ERCC6 POLR2C RPA1 ERCC2 CUL4A UBC(153-228) UBC(457-532) POLR2J RBX1 Ub-443-UBC(381-456) HMGN1 UBA52(1-76) POLE3 GTF2H4 GTF2H1 HMGN1 POLR2G ERCC5PPIE UBC(381-456) COPS8 GTF2H2 USP7 GTF2H4 damaged DNA substrate:nascent mRNA hybrid UBB(77-152) GTF2H2 MonoUb-K164-PCNA RFC5 Ub,p-S2,S5-POLR2A GTF2H2 RBX1 GTF2H4 CDK7 POLR2G Ub-215-UBB(153-228) ERCC2 UBB(1-76) GTF2H2 UBB(153-228) RPA3 UBC(533-608) GTF2H1 RAD23A POLD1 MNAT1 dNTPPOLR2E ERCC3 RPA3 RBX1 GTF2H3 Distorted dsDNA POLK POLE3 RFC5 ERCC6 UBC(381-456) UBC(533-608) Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300POLR2L UBC(305-380) CUL4A UBC(533-608) POLR2C CCNH MNAT1 POLR2D UBC(609-684) CETN2 UBB(153-228) UBC(153-228) PRPF19 CUL4A POLR2H UBC(305-380) CUL4B RFC4 UBC(457-532) XAB2 PRPF19 UBC(381-456) UBB(77-152) PARP1 RFC3 UBC(381-456) UbUBC(229-304) GTF2H2 COPS5 GTF2H5 UVSSA UBC(609-684) ERCC3 damaged DNA with open bubble structure PAR-PARP1,PAR-PARP2dimersPAR-PARP2 RFC1 CHD1L POLR2J RFC1 XPC PRPF19 CUL4B POLR2C GTF2H4 Ub-63-UBC(1-76) EP300 PAR-DDB2 ERCC6 POLR2J CUL4A UBC(229-304) CUL4B UBC(305-380) UBB(1-76) UBC(77-152) GTF2H4 UBC(609-684) DDB1 EP300 ERCC5 UBC(533-608) UBC(305-380) ISY1 GTF2H2 RPS27A(1-76) RPA2 UBC(153-228) GTF2H4 GTF2H2 POLK UBC(305-380) DDB2 RAD23B POLR2K GG-NER pre-incisioncomplex:Openbubble-dsDNARFC4 ERCC3 POLR2C RPS27A(1-76) UBC(609-684) RUVBL1 UBC(305-380) ERCC8 ZNF830 PPIE RPS27A(1-76) POLR2J UBC(381-456) UBC(153-228) CUL4A UBB(77-152) PPIE Ub-63-RPS27A(1-76) INO80B POLR2G CUL4A GTF2H3 UBB(153-228) p-S2,S5-POLR2A POLR2G POLR2G UBC(229-304) damaged DNA with 5' incision UBB(1-76) ERCC2 POLR2J ISY1 Ub-367-UBC(305-380) RAD23A POLE4 ERCC2 UBA52(1-76) UBB(77-152) POLR2J POLR2L AQR UbERCC2 PCNA PAR-PARP2 UBC(457-532) PRPF19 POLR2H UBC(1-76) POLR2D CHD1L RPA2 UBC(457-532) UBC(1-76) RPS27A(1-76) GTF2H4 TC-NERpost-incisioncomplex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFCRPA1 DDB1 UBC(381-456) UBC(305-380) ERCC8 GTF2H1 UBB(77-152) UBB(153-228) UBB(153-228) Ub:ERCC6POLR2F EP300 RPS27A(1-76) UBC(305-380) UBC(381-456) POLR2B UBC(153-228) Ub-519-UBC(457-532) RPA3 ERCC5 GTF2H1 GTF2H2 UBB(153-228) UBC(1-76) ERCC6 DDB1 GTF2H1 GTF2H1 POLR2F RFC5 EP300 Ub,p-S2,S5-POLR2A POLR2E UBB(1-76) ACTR5 UBC(533-608) UBC(153-228) Ub,p-S2,S5-POLR2A POLR2I PAR-PARP2 GTF2H4 XPC:RAD23:CETN2Ub-139-UBB(77-152) PAR-PARP1 PAR-PARP1 POLR2K RBX1 CCNH DDB1 UBC(609-684) PAR-DDB2 HMGN1 ERCC8 RPA2 POLK RBX1 RPS27A(1-76) Ub-139-UBB(77-152) UBC(305-380) COPS4 UBC(457-532) RPS27A(1-76) MNAT1 PAR-PARP1 RBX1 USP45UBC(229-304) UBC(457-532) RPA3 PPiRPA1 damaged DNA with open bubble structure PAR-PARP2 TC-NERpost-incisioncomplex:incisedDNAwithoutlesion:trimmednascentmRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFCUBC(609-684) GTF2H3 5'-incised damaged DNA:trimmed nascent mRNA UBC(153-228) incised DNA without lesion UBC(609-684) CDK7 UBC(153-228) XAB2 COPS6 GTF2H5 POLR2K UBB(153-228) EP300CUL4B AQR UBC(609-684) POLR2K PPIE XAB2 UBC(77-152) RAD23B ERCC4 ERCC8 UBB(1-76) UBB(153-228) UBB(153-228) Ub-ERCC6 MNAT1 GTF2H2 UBC(533-608) ERCC5 POLR2E PAR-PARP2 POLR2D Distorted dsDNA UBC(77-152) RPA3 POLD2 POLR2H PCNA RPS27A(1-76) UVSSA CUL4B CHD1L Ub,SUMO,K63polyUb:XPC:RAD23:CETN2TC-NER incisioncomplexXPA RBX1 GTF2H5 POLR2B RBX1 GTF2H4 POLE2 UBC(609-684) RBX1 COP9 signalosomeUb-215-UBC(153-228) XAB2 ERCC6 UBC(153-228) CUL4A DDB1 RPS27A(1-76) Distorted dsDNA RPA2 POLR2D POLE3 LIG1,LIG3:XRCC1POLR2F UBC(77-152) TCEA1 ERCC5 GTF2H4 Ub-XPC DDB1 CUL4B POLK PCNA POLD1 RFC3 AQR UBB(153-228) UVSSA PCNA RPS27A(1-76) POLD4 POLR2F POLR2D CUL4B GTF2H1 UBC(381-456) HMGN1RPA2 UBC(609-684) GTF2H5 UBC(533-608) CUL4A TCEA1 ERCC6 GTF2H2 UBB(153-228) POLD1 PARP2 CUL4A POLD3 GTF2H4 UBC(533-608) MNAT1 POLE3 XAB2 TC-NER pre-incisioncomplexZNF830 PRPF19 UBC(381-456) GTF2H3 TCEA1CHD1L POLR2K SUMO1 MonoUb-K164-PCNA damaged DNA substrate:nascent mRNA hybrid RPA1 ERCC1 UBB(1-76) Ub-63-UBC(1-76) UBC(229-304) ERCC6 UBC(381-456) POLR2C CETN2 POLR2L EP300 Openbubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LUb,p-S2,S5-POLR2A POLE2 PPIE UBC(533-608) UBC(77-152) CCNH RAD23B ERCC3 ERCC3 POLR2L UBC(533-608) POLR2C POLR2K POLR2L UBA52(1-76) AQR POLE ERCC4 UBC(381-456) ERCC2 UBB(153-228) RFC1 POLR2J ERCC3 POLR2G PAR-PARP1 POLR2H TFPT CETN2 damaged DNA substrate:nascent mRNA hybrid DDB1 UBC(457-532) Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDBUBC(229-304) CETN2ERCC8 EP300 POLR2C PAR-PARP1 GTF2H4 ISY1 POLK POLR2B UBA52(1-76) UBC(77-152) SUMO3-C93-UBE2I UBC(77-152) XAB2 SUMO3 POLR2D USP7 AQR UBC(533-608) MNAT1 UBC(457-532) H2OUBC(609-684) ACTR8 CDK7 POLR2K PiCOPS3 K63polyUb:C87-UBE2N:UBE2V2CCNH POLR2H POLR2L GTF2H2 CUL4A UBC(229-304) HMGN1 UBC(77-152) XPA POLR2C TCEA1 GTF2H2 GTF2H3 GTF2H4 RPS27A(1-76) POLR2H CDK7 POLR2J DDB1 MonoUb-K164-PCNA POLE2 UBB(1-76) Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1LRPS27A(1-76) UBC(381-456) POLR2D GTF2H5 DDB1 GTF2H4 XPC Partially open bubble damaged DNA template:trimmed nascent mRNA ERCC8:DDB1:CUL4:RBX1:COP9 SignalosomePOLR2H HMGN1 NAD+UBB(77-152) SUMO3 UBC(609-684) ERCC8 Ub-63-UBB(1-76) UBB(153-228) POLR2G RFC4 POLR2I POLE UBC(381-456) PAR-DDB2 POLR2E ERCC6 RPA3 Distorted dsDNA XPA UBC(229-304) GTF2H1 Ub-291-UBC(229-304) UBC(1-76) UBC(1-76) PAR-DDB2 POLR2J POLR2F Ub-XPC ERCC4 GTF2H5 POLE3 CUL4A POLR2I UBC(381-456) ISY1 RFC2 XRCC1 ERCC5 RPS27A(1-76) CUL4A UBC(533-608) ERCC2 POLR2B UBC(381-456) POLR2C POLD,POLE XPA RFC2 ERCC3 UBC(457-532) CUL4B UBC(1-76) CHD1L UBA52(1-76) UBC(305-380) RFC3 POLR2I GTF2H3 DDB1 5'-incised damaged DNA:trimmed nascent mRNA UBC(77-152) damaged DNA with open bubble structure GTF2H3 dsDNA with transcription bubble Ub-63-UBA52(1-76) GTF2H2 POLR2H UBB(77-152) POLR2B POLR2C POLD4 damaged DNA with open bubble structure UBC(153-228) USP7 MNAT1 UBB(1-76) POLR2F GTF2H4 PPiUBE2N:UBE2V2CUL4A UBC(229-304) CUL4A GTF2H1 UBC(533-608) p-S2,S5-POLR2A DDB1 MNAT1 INO80 complexUb,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LUBC(153-228) INO80 CUL4A POLR2J Distorted dsDNA YY1 GTF2H1 UBC(305-380) UBB(153-228) PRPF19 UBC(229-304) ERCC3 GTF2H4 DDB1 GTF2H5 CUL4B Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2GTF2H2 CUL4A GTF2H4 CDK7 UBC(609-684) POLR2G PARP2 MNAT1 UBA52(1-76) UBA52(1-76) POLR2L UBC(609-684) CUL4A Ub,p-S2,S5-POLR2A DDB1 UBB(1-76) UBC(609-684) UBE2I-G92-SUMO3 POLR2H UBC(229-304) UBC(533-608) GTF2H1 RBX1 RFC3 CDK7 RFC2 UVSSA UBC(305-380) CUL4B CUL4B Ub,p-S2,S5-POLR2A CUL4A UBC(457-532) RNAPolymeraseIIholoenzymecomplex(hyperphosphorylated)POLR2D TC-NER post-incisioncomplex:dsDNA withtranscriptionbubbleCDK7 UBB(1-76) CCNH XAB2 ERCC2 CCNH POLK DDB2 POLR2J XPA RAD23B POLR2K CCNH UBC(1-76) COPS4 TCEA1 UBA52(1-76) POLR2J RPA1 DDB1 RNF111p-S2,S5-POLR2A CUL4A RPA2 USP7 GTF2H5 ERCC8 UBC(229-304) UBC(229-304) INO80D RPA2 UBE2I-G93-SUMO2 GTF2H5 COPS4 RFC2 ERCC5 CETN2 Ub-XPC HyperphosphorylatedRNA Pol II:DamagedDNAtemplate:nascentmRNA hybrid:TFIIHERCC3 UBC(229-304) ERCC3 GTF2H5 RPS27A(1-76) RPS27A(1-76) ERCC1Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1H2ORPA1 RFC5 UBC(305-380) POLR2F ERCC3 UBC(1-76) AQR UBA52(1-76) CDK7 UBC(1-76) PAR-DDB2 UBA52(1-76) ERCC3 ZNF830 CUL4A UBC(1-76) ZNF830 Ub-595-UBC(533-608) CCNH POLR2E ZNF830 RPA1 UBC(77-152) POLR2C UBC(381-456) PAR-PARP1 GTF2H1 GTF2H5 RFC5 ERCC2 POLD,POLE,POLKRPA2 POLR2C GTF2H5 ELLUBB(1-76) GPS1 UBB(77-152) AQR CUL4B ZNF830 POLE2 POLD1 UBC(153-228) RAD23B GTF2H4 POLE2 UBC(457-532) RPS27A(1-76) UBC(1-76) ZNF830 RPS27A(1-76) CDK7 UBC(457-532) UBB(77-152) UBC(533-608) UBB(153-228) MNAT1 DDB1 UBC(381-456) UBB(1-76) UBC(609-684) UBB(77-152) RFC1 GTF2H2 ERCC4XPA Ub-215-UBB(153-228) LIG1 UBC(533-608) INO80C UBB(1-76) UBC(229-304) ERCC2 ERCC2 GTF2H3 UBC(381-456) POLD3 DDB1 POLR2B POLR2E CUL4B XPA POLR2I GTF2H1 POLR2I UBC(533-608) UBC(153-228) RPA3 PRPF19 GG-NER incisioncomplex:Open bubbledsDNAMonoUb-K164-PCNA RPA1 Ub,p-S2,S5-POLR2A POLR2D CETN2 CUL4A UBC(381-456) GTF2H3 PAR-PARP1 ERCC3