Nucleotide Excision Repair (Homo sapiens)
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3, 11, 16, 20, 40...
93
1, 2, 23, 54, 100...
88
12, 26, 31, 69, 74...
30, 33, 55, 71
39
35, 47, 78, 79, 85
6, 20, 30, 32, 33, 55...
15, 30, 33, 39, 44...
38, 49, 64, 82
52
52
6, 58, 83
50, 61
27, 46
8, 19, 37, 77
7, 9, 21, 22, 41...
49, 82
93
36
27
42, 61
13, 27
5, 10, 27, 46
60, 62, 97
50, 61
1, 2, 23, 54, 78...
19, 39, 92
27
60, 62, 97
5, 10, 27, 46
5, 13, 27
18, 28, 34, 51, 57...
14, 17, 25, 35, 43...
27, 46
4, 24, 59, 75
35, 47, 78, 79, 85
nucleoplasm
UV-DDB:COP9
Signalosome
POLR2C
UBC(1-76)
UBC(229-304)
UBC(1-76)
ATP
LIG3
UBB(1-76)
GTF2H1
UBA52(1-76)
ACTB(1-375)
RFC2
POLR2F
UBB(153-228)
UBB(77-152)
USP7
CUL4B
ERCC2
UVSSA
MonoUb-K164-PCNA
UVSSA
RPA3
RFC5
USP7
UBB(77-152)
ZNF830
TCEA1
Ub-XPC
RPA2
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2
UBC(229-304)
AQR
CCNH
ERCC1
RBX1
UBE2I
RFC1
ERCC2
RFC2
POLR2K
UBC(1-76)
UBB(1-76)
UBC(153-228)
COPS5
POLR2B
UBE2V2
DDB1
POLR2J
RPS27A(1-76)
COPS6
EP300
RPS27A(1-76)
POLR2I
UBC(457-532)
DDB1
RPA3
RBX1
ERCC3
ISY1
PCNA
COPS8
ERCC2
POLD4
UBC(609-684)
UBC(77-152)
RBX1
CHD1L
RPS27A(1-76)
UBC(1-76)
UBC(1-76)
UBA52(1-76)
POLR2H
GTF2H4
Open bubble damaged DNA template:trimmed nascent mRNA
PAR-PARP2
CETN2
Ub-63-UBA52(1-76)
RPA3
POLE2
Ub-367-UBC(305-380)
GTF2H3
ERCC8:DDB1:CUL4:RBX1
GTF2H1
POLR2E
POLD3
CUL4B
UBC(229-304)
RPS27A(1-76)
PAR-PARP2
DDB1
UBC(77-152)
RPA2
UVSSA
ERCC3
RFC5
GTF2H3
ERCC2
RFC2
excised DNA fragment
with lesion
UBC(1-76)
POLR2F
UBC(153-228)
UBC(457-532)
UBA52(1-76)
POLR2L
POLD2
UBC(457-532)
UBC(77-152)
POLR2D
ADP
UBC(457-532)
CUL4A
UBC(533-608)
UBC(153-228)
CDK7
PRPF19
UBC(1-76)
PRPF19
Ub-ERCC6
UBC(77-152)
POLR2E
POLE
GTF2H1
ERCC4
UBC(77-152)
PIAS1,3
GTF2H5
UBB(153-228)
COPS7B
ribonucleoside
triphosphate
POLD3
ERCC2
UBB(1-76)
UBC(381-456)
TFIIH Core
POLR2B
GTF2H5
COPS2
XAB2
XPA
PPi
PPIE
ERCC8
POLR2H
POLR2H
UBB(1-76)
Ub-XPC
Ub-ERCC6
DDB1
UBA52(1-76)
UBB(153-228)
Ub-291-UBC(229-304)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L
ISY1
POLR2E
GTF2H4
POLR2D
ERCC6
COPS7A
UBC(229-304)
RFC4
POLR2D
POLR2J
XPA
GTF2H3
CUL4A
UBB(1-76)
PPIE
SUMO2
UBB(77-152)
POLR2B
COPS7B
UBA52(1-76)
DDB1
PIAS1
MNAT1
GTF2H3
TC-NER incision
complex:5'-incised
damaged DNA:trimmed
nascent mRNA
POLR2I
UBB(77-152)
PAR-PARP2
RBX1
RAD23B
NFRKB
UBC(305-380)
GTF2H3
RFC4
MNAT1
UBC(1-76)
UBB(77-152)
PPIE
UBB(77-152)
MNAT1
POLR2B
RAD23A
UBC(77-152)
DDB1
UBC(305-380)
POLR2C
USP7
USP7
UBC(229-304)
USP7
RAD23B
CCNH
RAD23B
ERCC3
RAD23A
ERCC2
ERCC3
K63polyUb-C87-UBE2N
UBB(1-76)
POLR2I
CDK7
POLD3
POLR2E
EP300
dNTP
XPA
ISY1
RAD23A
UBC(153-228)
POLR2K
PARP1
GTF2H4
UBC(153-228)
RAD23B
ISY1
RPS27A(1-76)
ERCC8
POLR2F
UBB(153-228)
RFC3
POLR2E
POLR2F
POLR2F
RPS27A(1-76)
PCNA
GTF2H5
GTF2H2
UBB(153-228)
UBC(457-532)
GTF2H3
UBC(77-152)
UVSSA
UBC(533-608)
POLE4
MNAT1
USP7
CDK7
POLR2H
TCEA1
UBB(153-228)
UBC(229-304)
POLR2F
RPA1
SUMO1-C93-UBE2I
dsDNA
PAR-DDB2
GTF2H3
TC-NER pre-incision
complex:Open bubble
damaged DNA
template:trimmed
nascent mRNA
ERCC1
damaged DNA substrate:nascent mRNA hybrid
Distorted dsDNA
GTF2H3
UBB(77-152)
CUL4A
UBE2I-G97-SUMO1
RBX1
COPS7A
PAR-DDB2
ERCC2
Ub,p-S2,S5-POLR2A
XPA
CUL4B
GTF2H3
UBC(77-152)
POLE3
UBA52(1-76)
UBC(305-380)
ERCC6
POLR2C
RPA1
ERCC2
CUL4A
UBC(153-228)
UBC(457-532)
POLR2J
RBX1
Ub-443-UBC(381-456)
HMGN1
UBA52(1-76)
POLE3
GTF2H4
GTF2H1
HMGN1
POLR2G
ERCC5
PPIE
UBC(381-456)
COPS8
GTF2H2
USP7
GTF2H4
damaged DNA substrate:nascent mRNA hybrid
UBB(77-152)
GTF2H2
MonoUb-K164-PCNA
RFC5
Ub,p-S2,S5-POLR2A
GTF2H2
RBX1
GTF2H4
CDK7
POLR2G
Ub-215-UBB(153-228)
ERCC2
UBB(1-76)
GTF2H2
UBB(153-228)
RPA3
UBC(533-608)
GTF2H1
RAD23A
POLD1
MNAT1
dNTP
POLR2E
ERCC3
RPA3
RBX1
GTF2H3
Distorted dsDNA
POLK
POLE3
RFC5
ERCC6
UBC(381-456)
UBC(533-608)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300
POLR2L
UBC(305-380)
CUL4A
UBC(533-608)
POLR2C
CCNH
MNAT1
POLR2D
UBC(609-684)
CETN2
UBB(153-228)
UBC(153-228)
PRPF19
CUL4A
POLR2H
UBC(305-380)
CUL4B
RFC4
UBC(457-532)
XAB2
PRPF19
UBC(381-456)
UBB(77-152)
PARP1
RFC3
UBC(381-456)
Ub
UBC(229-304)
GTF2H2
COPS5
GTF2H5
UVSSA
UBC(609-684)
ERCC3
damaged DNA with open bubble structure
PAR-PARP1,PAR-PARP2
dimers
PAR-PARP2
RFC1
CHD1L
POLR2J
RFC1
XPC
PRPF19
CUL4B
POLR2C
GTF2H4
Ub-63-UBC(1-76)
EP300
PAR-DDB2
ERCC6
POLR2J
CUL4A
UBC(229-304)
CUL4B
UBC(305-380)
UBB(1-76)
UBC(77-152)
GTF2H4
UBC(609-684)
DDB1
EP300
ERCC5
UBC(533-608)
UBC(305-380)
ISY1
GTF2H2
RPS27A(1-76)
RPA2
UBC(153-228)
GTF2H4
GTF2H2
POLK
UBC(305-380)
DDB2
RAD23B
POLR2K
GG-NER pre-incision
complex:Open
bubble-dsDNA
RFC4
ERCC3
POLR2C
RPS27A(1-76)
UBC(609-684)
RUVBL1
UBC(305-380)
ERCC8
ZNF830
PPIE
RPS27A(1-76)
POLR2J
UBC(381-456)
UBC(153-228)
CUL4A
UBB(77-152)
PPIE
Ub-63-RPS27A(1-76)
INO80B
POLR2G
CUL4A
GTF2H3
UBB(153-228)
p-S2,S5-POLR2A
POLR2G
POLR2G
UBC(229-304)
damaged DNA with 5' incision
UBB(1-76)
ERCC2
POLR2J
ISY1
Ub-367-UBC(305-380)
RAD23A
POLE4
ERCC2
UBA52(1-76)
UBB(77-152)
POLR2J
POLR2L
AQR
Ub
ERCC2
PCNA
PAR-PARP2
UBC(457-532)
PRPF19
POLR2H
UBC(1-76)
POLR2D
CHD1L
RPA2
UBC(457-532)
UBC(1-76)
RPS27A(1-76)
GTF2H4
TC-NER
post-incision
complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC
RPA1
DDB1
UBC(381-456)
UBC(305-380)
ERCC8
GTF2H1
UBB(77-152)
UBB(153-228)
UBB(153-228)
Ub:ERCC6
POLR2F
EP300
RPS27A(1-76)
UBC(305-380)
UBC(381-456)
POLR2B
UBC(153-228)
Ub-519-UBC(457-532)
RPA3
ERCC5
GTF2H1
GTF2H2
UBB(153-228)
UBC(1-76)
ERCC6
DDB1
GTF2H1
GTF2H1
POLR2F
RFC5
EP300
Ub,p-S2,S5-POLR2A
POLR2E
UBB(1-76)
ACTR5
UBC(533-608)
UBC(153-228)
Ub,p-S2,S5-POLR2A
POLR2I
PAR-PARP2
GTF2H4
XPC:RAD23:CETN2
Ub-139-UBB(77-152)
PAR-PARP1
PAR-PARP1
POLR2K
RBX1
CCNH
DDB1
UBC(609-684)
PAR-DDB2
HMGN1
ERCC8
RPA2
POLK
RBX1
RPS27A(1-76)
Ub-139-UBB(77-152)
UBC(305-380)
COPS4
UBC(457-532)
RPS27A(1-76)
MNAT1
PAR-PARP1
RBX1
USP45
UBC(229-304)
UBC(457-532)
RPA3
PPi
RPA1
damaged DNA with open bubble structure
PAR-PARP2
TC-NER
post-incision
complex:incised
DNA
without
lesion:trimmed
nascent
mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC
UBC(609-684)
GTF2H3
5'-incised damaged DNA:trimmed nascent mRNA
UBC(153-228)
incised DNA without lesion
UBC(609-684)
CDK7
UBC(153-228)
XAB2
COPS6
GTF2H5
POLR2K
UBB(153-228)
EP300
CUL4B
AQR
UBC(609-684)
POLR2K
PPIE
XAB2
UBC(77-152)
RAD23B
ERCC4
ERCC8
UBB(1-76)
UBB(153-228)
UBB(153-228)
Ub-ERCC6
MNAT1
GTF2H2
UBC(533-608)
ERCC5
POLR2E
PAR-PARP2
POLR2D
Distorted dsDNA
UBC(77-152)
RPA3
POLD2
POLR2H
PCNA
RPS27A(1-76)
UVSSA
CUL4B
CHD1L
Ub,SUMO,K63polyUb:XPC:RAD23:CETN2
TC-NER incision
complex
XPA
RBX1
GTF2H5
POLR2B
RBX1
GTF2H4
POLE2
UBC(609-684)
RBX1
COP9 signalosome
Ub-215-UBC(153-228)
XAB2
ERCC6
UBC(153-228)
CUL4A
DDB1
RPS27A(1-76)
Distorted dsDNA
RPA2
POLR2D
POLE3
LIG1,LIG3:XRCC1
POLR2F
UBC(77-152)
TCEA1
ERCC5
GTF2H4
Ub-XPC
DDB1
CUL4B
POLK
PCNA
POLD1
RFC3
AQR
UBB(153-228)
UVSSA
PCNA
RPS27A(1-76)
POLD4
POLR2F
POLR2D
CUL4B
GTF2H1
UBC(381-456)
HMGN1
RPA2
UBC(609-684)
GTF2H5
UBC(533-608)
CUL4A
TCEA1
ERCC6
GTF2H2
UBB(153-228)
POLD1
PARP2
CUL4A
POLD3
GTF2H4
UBC(533-608)
MNAT1
POLE3
XAB2
TC-NER pre-incision
complex
ZNF830
PRPF19
UBC(381-456)
GTF2H3
TCEA1
CHD1L
POLR2K
SUMO1
MonoUb-K164-PCNA
damaged DNA substrate:nascent mRNA hybrid
RPA1
ERCC1
UBB(1-76)
Ub-63-UBC(1-76)
UBC(229-304)
ERCC6
UBC(381-456)
POLR2C
CETN2
POLR2L
EP300
Open
bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L
Ub,p-S2,S5-POLR2A
POLE2
PPIE
UBC(533-608)
UBC(77-152)
CCNH
RAD23B
ERCC3
ERCC3
POLR2L
UBC(533-608)
POLR2C
POLR2K
POLR2L
UBA52(1-76)
AQR
POLE
ERCC4
UBC(381-456)
ERCC2
UBB(153-228)
RFC1
POLR2J
ERCC3
POLR2G
PAR-PARP1
POLR2H
TFPT
CETN2
damaged DNA substrate:nascent mRNA hybrid
DDB1
UBC(457-532)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB
UBC(229-304)
CETN2
ERCC8
EP300
POLR2C
PAR-PARP1
GTF2H4
ISY1
POLK
POLR2B
UBA52(1-76)
UBC(77-152)
SUMO3-C93-UBE2I
UBC(77-152)
XAB2
SUMO3
POLR2D
USP7
AQR
UBC(533-608)
MNAT1
UBC(457-532)
H2O
UBC(609-684)
ACTR8
CDK7
POLR2K
Pi
COPS3
K63polyUb:C87-UBE2N:UBE2V2
CCNH
POLR2H
POLR2L
GTF2H2
CUL4A
UBC(229-304)
HMGN1
UBC(77-152)
XPA
POLR2C
TCEA1
GTF2H2
GTF2H3
GTF2H4
RPS27A(1-76)
POLR2H
CDK7
POLR2J
DDB1
MonoUb-K164-PCNA
POLE2
UBB(1-76)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L
RPS27A(1-76)
UBC(381-456)
POLR2D
GTF2H5
DDB1
GTF2H4
XPC
Partially open bubble damaged DNA template:trimmed nascent mRNA
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome
POLR2H
HMGN1
NAD+
UBB(77-152)
SUMO3
UBC(609-684)
ERCC8
Ub-63-UBB(1-76)
UBB(153-228)
POLR2G
RFC4
POLR2I
POLE
UBC(381-456)
PAR-DDB2
POLR2E
ERCC6
RPA3
Distorted dsDNA
XPA
UBC(229-304)
GTF2H1
Ub-291-UBC(229-304)
UBC(1-76)
UBC(1-76)
PAR-DDB2
POLR2J
POLR2F
Ub-XPC
ERCC4
GTF2H5
POLE3
CUL4A
POLR2I
UBC(381-456)
ISY1
RFC2
XRCC1
ERCC5
RPS27A(1-76)
CUL4A
UBC(533-608)
ERCC2
POLR2B
UBC(381-456)
POLR2C
POLD,POLE
XPA
RFC2
ERCC3
UBC(457-532)
CUL4B
UBC(1-76)
CHD1L
UBA52(1-76)
UBC(305-380)
RFC3
POLR2I
GTF2H3
DDB1
5'-incised damaged DNA:trimmed nascent mRNA
UBC(77-152)
damaged DNA with open bubble structure
GTF2H3
dsDNA with transcription bubble
Ub-63-UBA52(1-76)
GTF2H2
POLR2H
UBB(77-152)
POLR2B
POLR2C
POLD4
damaged DNA with open bubble structure
UBC(153-228)
USP7
MNAT1
UBB(1-76)
POLR2F
GTF2H4
PPi
UBE2N:UBE2V2
CUL4A
UBC(229-304)
CUL4A
GTF2H1
UBC(533-608)
p-S2,S5-POLR2A
DDB1
MNAT1
INO80 complex
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L
UBC(153-228)
INO80
CUL4A
POLR2J
Distorted dsDNA
YY1
GTF2H1
UBC(305-380)
UBB(153-228)
PRPF19
UBC(229-304)
ERCC3
GTF2H4
DDB1
GTF2H5
CUL4B
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2
GTF2H2
CUL4A
GTF2H4
CDK7
UBC(609-684)
POLR2G
PARP2
MNAT1
UBA52(1-76)
UBA52(1-76)
POLR2L
UBC(609-684)
CUL4A
Ub,p-S2,S5-POLR2A
DDB1
UBB(1-76)
UBC(609-684)
UBE2I-G92-SUMO3
POLR2H
UBC(229-304)
UBC(533-608)
GTF2H1
RBX1
RFC3
CDK7
RFC2
UVSSA
UBC(305-380)
CUL4B
CUL4B
Ub,p-S2,S5-POLR2A
CUL4A
UBC(457-532)
RNA
Polymerase
II
holoenzyme
complex
(hyperphosphorylated)
POLR2D
TC-NER post-incision
complex:dsDNA with
transcription
bubble
CDK7
UBB(1-76)
CCNH
XAB2
ERCC2
CCNH
POLK
DDB2
POLR2J
XPA
RAD23B
POLR2K
CCNH
UBC(1-76)
COPS4
TCEA1
UBA52(1-76)
POLR2J
RPA1
DDB1
RNF111
p-S2,S5-POLR2A
CUL4A
RPA2
USP7
GTF2H5
ERCC8
UBC(229-304)
UBC(229-304)
INO80D
RPA2
UBE2I-G93-SUMO2
GTF2H5
COPS4
RFC2
ERCC5
CETN2
Ub-XPC
Hyperphosphorylated
RNA Pol II:Damaged
DNA
template:nascent
mRNA hybrid:TFIIH
ERCC3
UBC(229-304)
ERCC3
GTF2H5
RPS27A(1-76)
RPS27A(1-76)
ERCC1
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1
H2O
RPA1
RFC5
UBC(305-380)
POLR2F
ERCC3
UBC(1-76)
AQR
UBA52(1-76)
CDK7
UBC(1-76)
PAR-DDB2
UBA52(1-76)
ERCC3
ZNF830
CUL4A
UBC(1-76)
ZNF830
Ub-595-UBC(533-608)
CCNH
POLR2E
ZNF830
RPA1
UBC(77-152)
POLR2C
UBC(381-456)
PAR-PARP1
GTF2H1
GTF2H5
RFC5
ERCC2
POLD,POLE,POLK
RPA2
POLR2C
GTF2H5
ELL
UBB(1-76)
GPS1
UBB(77-152)
AQR
CUL4B
ZNF830
POLE2
POLD1
UBC(153-228)
RAD23B
GTF2H4
POLE2
UBC(457-532)
RPS27A(1-76)
UBC(1-76)
ZNF830
RPS27A(1-76)
CDK7
UBC(457-532)
UBB(77-152)
UBC(533-608)
UBB(153-228)
MNAT1
DDB1
UBC(381-456)
UBB(1-76)
UBC(609-684)
UBB(77-152)
RFC1
GTF2H2
ERCC4
XPA
Ub-215-UBB(153-228)
LIG1
UBC(533-608)
INO80C
UBB(1-76)
UBC(229-304)
ERCC2
ERCC2
GTF2H3
UBC(381-456)
POLD3
DDB1
POLR2B
POLR2E
CUL4B
XPA
POLR2I
GTF2H1
POLR2I
UBC(533-608)
UBC(153-228)
RPA3
PRPF19
GG-NER incision
complex:Open bubble
dsDNA
MonoUb-K164-PCNA
RPA1
Ub,p-S2,S5-POLR2A
POLR2D
CETN2
CUL4A
UBC(381-456)
GTF2H3
PAR-PARP1
ERCC3