Opioid Signalling (Homo sapiens)

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11, 20, 2553426, 10, 5112, 3617, 193932, 50818, 34133945, 4923, 412, 15, 27, 295, 46392228, 31, 33395326, 394824443, 44, 473739121, 383040147, 16523528359nucleoplasmcytosolendoplasmic reticulum lumenPLCB4 cAMP:PKA regulatorysubunitPLC-betaPDYN(226-230) GNAI2 GNGT1 GNAL p-S505,S727-PLA2G4APPP3CA GNG12 ADCY5 GNG12 PPP2R1B GNAT2 GNB2 GNAT1 PRKACG Galpha-olf:GDP:Adenylate cyclase (active) complexPLCB1 PRKAR1A p-T34,S137-PPP1R1B ADCY1 ADCY8 Zn2+ ADCY1 Calmodulin:CaMK IVADCY1 cAMPGNGT1 GDP PCCa2+ CAMK4 GNG12 PPP1CAGNGT1 p-S102-PPP1R1B ADCY3 GNAL OPRM1 GTP GNG8 Mg2+ GNAO1 PRKACG GNB5 AMPGNAI1 GNAT2 Adenylate cyclase(Mg2+ cofactor)GNAI2 p-T34,S102-PPP1R1B ADCY1 p-T34,T75,S102-PPP1R1B p-T34-PPP1R1B PDYN(226-230) PRKACB POMC(237-241) ADPDARPP-32phosporylated onT34ADCY2 ADCY9 ADPGTP H2OGNG11 GNAO1 G-protein alpha:GDPFe2+ Protein Kinase A,catalytic subunitsGNG5 GNAI2 DNA G alpha-olf:GDPcomplexPRKAR2B ITPR3 ADCY7 p-T34,T75-PPP1R1B ADRBK1GNAT2 G protein-GDPcomplexGNAI1 ADCY3 GNB3 ADCY2 G protein alpha:GTPcomplexCa2+ OPRM1PI(4,5)P2ADCY9 GNAT3 PRKACA p-T75,S137-PPP1R1B p-S102-PPP1R1B p-T34,T75-PPP1R1B GTP GNG10 PRKAR1B p-S54-PDE4BGNAI3 GNG2 GNAL p-T34-PPP1R1B Mg2+ GNAT3 GNG4 p-T34,T75,S102,S137-PPP1R1B GNG2 I(1,4,5)P3 GNG11 GNAI3 GNG3 p-T34,S102-PPP1R1B p-S505,S727-PLA2G4A POMC(237-267) GNAI1 GNAT3 PPP2R5D p-T34,T75,S137-PPP1R1B ADCY3 GNAT3 ADCY2 (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)PDE4C GNAT3 PRKACA GNB4 GNAT3 GNAZ p-T75-DARPP32sADCY3 ADCY2 GNG7 GNAT3 POMC(237-267) GNG7 ADCY2 GNB3 GNAT2 GNAZ Opioid peptideGNAI1 GNG4 GDP GNAI3 PRKAR1A ATPGNG11 ADCY1 phospho-CaMKIV:CalmodulinCa2+Fe3+ ADCY1 PKA tetramerGNAI1 ADCY4 GNG5 GNAZ H2OITPR1 ADCY4 Mn2+ ADCY4 GDP PLA2G4APP2B catalytic(Fe3+, Zn2+)GNG5 GNAI3 ATPPRKAR2B GNG10 PiGNB1 p-T34,T75-PPP1R1B GNAI2 p-T34,T75-PPP1R1B PRKACA p-T34,S102,S137-PPP1R1B ADCY7 PPP3CC POMC(237-267) ITPR3 ADCY7 p-T75,S102,S137-PPP1R1B GNAI3 ADCY9 GNGT1 Mg2+ GNAI1 GNB2 ADCY2 GDP GNGT2 p-T75,S102-PPP1R1B ADCY5 ADCY6 GNAL GTP p-S137-PPP1R1B GNB5 DARPP-32 (and/orphosphorylated)GNB1 ATPp-S133-CREB1PRKACA ADCY5 GNG3 GNAO1 p-T34,S102,S137-PPP1R1B PDE 4ADCY4 p-T34,S137-PPP1R1B Mg2+ PRKACACa2+ GNB4 GNAT2 p-T75,S102,S137-PPP1R1B OPRM1 ADPGNAT3 p-T34,T75,S102-PPP1R1B GNAI2 p-T34,T75,S102,S137-PPP1R1B Phosphorylated (T34)DARPP-32:PP1AADCY7 GNAT1 ADCY1 ATPITPR1 ADCY6 ARAGNAL GNAT1 CALM1:4xCa2+GNG4 Mg2+ Adenylate cyclase(Mg2+ cofactor)GDP GNB1 PKA catalyticsubunitPRKACB ATPGNAT3 CALM1 PiPiPPP1CA ADCY6 PPP3CB ITPR3 PPP2R1A GNB1 PKA catalyticsubunitPRKCA PCPPP3CB PLCB2 GNAT3 GNG10 GNB4 ADCY7 PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaMGNG11 AHCYL1 GNGT2 GNB3 ADCY3 ADCY2 Galpha-olf:GTP:Adenylate cyclase (active) complexGNAT3 ADCY8 GNAZ GNAI1 ActivePLA2:phosphatidylcholineAHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerGNAZ GNAO1 GNAI2 ADCY5 ADCY4 Ca2+ I(1,4,5)P3(Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)Calmodulin:CaMK IVPRKACG ADCY5 PDE1B active PKC (alpha,gamma, delta)GNB5 PLCB4 GTPp-T75,S102-PPP1R1B PDE4D GNG5 PDE4Bp-T34,T75,S102-PPP1R1B PDE1C cAMPPLCB3 GNG3 ATPPPP3CB ADCY5 ADCY9 ADCY3 ADCY5 ADCY5 GNG13 ATPGNB1 PPP2CA G alpha-olf:GTPGNG10 PRKACA PPP3CC GNB2 p-T34,T75,S137-PPP1R1B ADCY7 POMC(237-241) ADRBK1 p-T34-PPP1R1B GNAT3 GNAT2 CALM1 PPP3R1 p-T34,T75,S102,S137-PPP1R1B H2Op-T75,S137-PPP1R1B GNGT1 G-protein alpha(i):GTP:Adenylatecyclasep-T34,T75,S137-PPP1R1B ADCY7 p-T185,Y187-MAPK1phospho-CREB dimerPPP3 complexITPR2 GNG4 Ca2+PLCB3 GNAT3 p-S29-ADRBK1GNAI2 GNB4 CALM1 GNAT3 PDYN(226-230) GNG8 ADCY4 Opioid:MOR:G-proteincomplexGNG7 ADCY9 GNAI2 p-T75-DARPP32s:PRKACACREB1GNAI2 Ca2+ ADCY9 GTP ADCY4 GNAI2 p-T34,T75,S137-PPP1R1B GNAI1 ADPADCY8 cAMPGNB3 GDP cAMPPC PPiADCY4 POMC(237-267) GNB5 GNAI2 GDP GNAI3 GNB3 PiGNG2 GNAI3 PDE1C PPP1R1B GNAI3 p-T34,T75,S102,S137-PPP1R1B GNG7 GTP ADCY5 ADCY1 PRKACG Opioid:MOR:Gprotein-GTP complexGNAO1 Pip-T75-PPP1R1B ADCY2 GDPGNAI1 GNAT2 ADCY9 IP3 receptorhomotetramerDARPP-32 (for CDK5phosphorylation)GNAI1 ADCY8 p-T34,S102,S137-PPP1R1B GNAT2 GNAO1 GDP GNAT2 cAMP G protein alpha:GTPcomplexActivated PLC beta1/4ADCY3 GNG5 GNAI3 PLCB1 PRKCD POMC(237-241) POMC(237-267) Mg2+ GNAI1 DAGsITPR2 ADCY3 H2OOPRM1 ADCY6 GNG3 GNAI1 GTP NAD+ Cam-PDE 1 homodimerp-S12,S13-CAMK4 Fe3+ ADCY6 CALM1 ADCY9 PDE1B PDE4B active Cam-PDE 1p-T75,S102-PPP1R1B GNAZ p-T75-PPP1R1B G alpha-olf:GDPcomplexPOMC(237-241) ITPR:I(1,4,5)P3tetramerOpioid:MORADCY2 GNAI3 ADPGNG8 ADCY3 PDYN(226-230) PRKCG GNB2 Opioid:MOR:Gprotein-GDP complexCAMK4 GNGT2 p-T34,S137-PPP1R1B GNAT1 Zn2+ Ca2+ (Gialpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)ATPGNAI3 GNAI3 ADCY9 GNAI1 GNG13 GNG12 CALM1 GNB5 GNGT2 OPRM1 CDK5Ca2+ Fe3+ ADCY4 PPP1R1B GNAI1 ADCY5 ADCY8 GTPADPGNG12 PPP3CA GNAI2 GDPPOMC(237-241) G-protein beta-gammacomplexMg2+ Adenylate cyclase(Mg2+ cofactor)Zn2+ GNAI2 ITPR2 ADCY6 ADCY4 GNG4 CALM1 GNAI2 GDP CALM1GNAI3 GNAT1 PDE4A GNAL PRKACB PPiADCY7 GNAT1 ADCY2 PRKACB PRKAR1B PKA catalyticsubunitGNG8 GNG7 Ca2+ ADCY6 PPP2CB ADCY8 H2OADCY8 PDE1A p-T34,S102-PPP1R1B H2OGDP PPP3CA ADCY6 AMPGNG11 p-T75-PPP1R1B Mg2+ ADCY3 p-S102,S137-PPP1R1B ADCY8 GNGT2 ITPR1 GNG2 GNAI3 PDE1A p-S102,S137-PPP1R1B PPP3CC p-S133-CREB1 GNAO1 PDYN(226-230) ADCY1 PRKAR2A GTP GNAL G-protein alpha (i):GTPGTP GNAL GNAT3 GNAI1 GNG8 G-protein alpha(i/o/z/t) subunitPRKACA PP2A-ABdeltaCcomplexADCY9 ADCY8 GTP H2OGNG13 GNG2 GNB2 PRKAR2A Mg2+ GNAZ p-T34,T75,S102-PPP1R1B GNAT1 GNAT1 GNAO1 ADCY6 GNG3 GTP Mg2+ PLCB2 ADCY6 GRK2:calmodulinPRKACB ADCY1 GNAT1 CALM1 ADCY7 GNAZ GNAO1 GNG13 p-T75,S102,S137-PPP1R1B I(1,4,5)P3 GNG10 p-T75,S137-PPP1R1B GNAI2 ADCY8 G-protein alpha(i):GDPGNAZ CAMK4GNAI3 2-Lysophosphatidylcholinep-S137-PPP1R1B ADCY7 Adenylate cyclase(Mg2+ cofactor)PRKACG GNG13 GNB4 3