Opioid Signalling (Homo sapiens)

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14, 25, 312, 8, 15, 45, 48...17535326, 54, 58197, 34, 435, 10, 21, 6011571135, 4423, 413220405324, 611750, 59132928, 39, 564, 46695742293, 3037554727535318621, 6312, 22, 4033, 3849, 53cytosolnucleoplasmendoplasmic reticulum lumenGNAI1 G alpha-olf:GTPADCY4 ITPR2 GNAZ GNAI1 PPP3CA G-protein alpha:GDPGNAL GNAO1 DARPP-32phosphorylated onT34PRKACAATPCAMK2B Ca2+ p-T34,T75,S102,S137-PPP1R1B p-T287-CAMK2B Mg2+ ADCY6 H2OGNAI3 p-S54-PDE4BG alpha-olf:GDPcomplexADCY7 PRKCD GNAI2 PPP2CB ADCY3 ADCY3 PKA catalyticsubunitPLCB4 PRKAR2B GNAT3 CALM1 G-protein alpha(i/o/z/t) subunitGTP GNAZ OPRM1 p-T286-CaMKIIdodecamer:CALM1:4xCa2+GNG7 Mg2+ GNAI3 GNG2 GNB2 G protein alpha:GTPcomplexPRKAR2B CALM1 ADCY6 PRKACG GNG4 CAMKK2 GNB1 p-T287-CAMK2Gdodecamer:CALM1:4xCa2+GNAL GNAO1 GNAO1 GNB5 p-T287-CAMK2G cAMP AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerPRKACB ADCY3 cAMP CALM1 PRKACG ATPp-T34,S102,S137-PPP1R1B ITPR3 GNB4 (Gialpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)ADCY6 PDE4C ADCY5 GNG8 GNAI3 GNAI1 G-protein alpha(i):GDPADCY5 GNG13 GNAZ GNAI1 GNB3 p-T75,S137-PPP1R1B GNB5 CALM1 H2OCALM1 GNAT3 PDE4D GNAT2 OPRM1 GNAZ GNG2 p-CAMKK1 ADCY9 p-T75-PPP1R1B GNAL OPRM1 PRKACG GNGT2 GNAT3 GNAT1 ITPR3 ITPR2 CaMKIIdodecamer:CALM1:4xCa2+ADCY4 p-T75,S102-PPP1R1B PRKACA H2OPRKAR2A GNG11 PPP1CA PPP2R5D PPP3R1 Mg2+ PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaMGNB5 ADCY4 p-T34,S102-PPP1R1B CAMK2A POMC(237-267) I(1,4,5)P3PRKACB GNG12 GNAT1 p-T287-CAMK2D GNG8 PKA tetramer:4xcAMPG alpha (i): GTPADCY5 GNB2 POMC(237-241) GNG7 Ca2+ GNB4 ADCY1 CaMKII dodecamerAMPPPP2CA ATPGNG7 GNAI2 active PKC (alpha,gamma, delta)p-T200-CAMK4:CALM1:4xCa2+GNAI3 PRKAR2A Activated PLC beta1/4PPiPCGDP GNGT2 PDYN(226-230) PRKACG ADPADCY5 GNG5 CALM1 PRKACA,(PRKACB,PRKACG,PRKX)GNG13 ADCY4 GNAI1 Fe3+ ADCY2 GNAO1 p-CaMKK:CALM1:4xCa2+PPP2R1A GNGT1 Phosphorylated (T34)DARPP-32:PP1ACa2+ GNB1 p-T75,S102,S137-PPP1R1B Opioid peptideGNAI1 PPP3CB GNG13 Mg2+ POMC(237-241) ADCY2 PLCB1 GNG2 GNAT2 GNG10 CAMK2D Mg2+ p-S102-PPP1R1B GNAT3 p-T34-PPP1R1B ATPADCY5 GNAI3 GDP p-T34,T75,S137-PPP1R1B ADCY9 Ca2+ PiADCY1 GNAL ATPCAMK2D Fe3+ CALM1 PRKAR1B Mn2+ CALM1 PPP3 complexPRKACA GNG3 Ca2+ ADCY7 p-T34,T75,S137-PPP1R1B GDP p-T34,T75-PPP1R1B GRK2:CALM1:4xCa2+CALM1:4xCa2+GNG3 GNAL Ca2+ PRKX PLA2G4APiPRKCG G alpha-olf:GDPcomplexPRKACA p-T34,T75-PPP1R1B PPP3CB GNG4 GTPCa2+ GNGT2 GNG8 GNG5 p-T34,T75,S102,S137-PPP1R1B PRKACA ARAADCY8 PPP3CA GTP CALM1 GNAI1 PPP1CAMg2+ ADCY7 GNGT1 GNG3 p-T287-CAMK2Gdodecamer:CALM1:4xCa2+GNAT3 p-T34,T75,S137-PPP1R1B PRKACB GNG5 ATPATPp-S137-PPP1R1B Mg2+ Mg2+ GNAT2 ADCY7 GNAI1 AHCYL1 GNB3 cAMPp-S137-PPP1R1B CAMKK2 CALM1 CaMKK:CALM1:4xCa2+p-T287-CAMK2G GNG2 Galpha-olf:GDP:Adenylate cyclase (active) complexPRKACB Mg2+ activated PDE1B PiADPCa2+GNG13 Ca2+ p-T287-CAMK2Gdodecameractivated PDE1C GNAT2 CAMKK1 ADCY3 PLCB3 CALM1 Ca2+ p-S505,S727-PLA2G4AAdenylate cyclase(Mg2+ cofactor)ATPp-T75,S137-PPP1R1B G protein alpha:GTPcomplexG-betagammaADCY8 p-T34,T75-PPP1R1B PDE1A p-T34,T75,S102-PPP1R1B GDP PPP3CC CALM1:4xCa2+GNAO1 GNAI1 ADCY7 GNAT1 GNAT3 p-T200-CAMK4 PLCB1 ADPCALM1 PLC-betaITPR2 Galpha-olf:GTP:Adenylate cyclase (active) complexGNB4 GNB4 GNG10 ADCY9 GNAT1 cAMP(Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)PRKAR2B activated PDE1dimersADCY2 Ca2+ PRKAR2A H2OGNG3 GDPITPR:I(1,4,5)P3tetramerPiPPiGNAI3 ADCY4 ADCY6 CAMK4 PRKACA GTPPOMC(237-241) GNAI2 GNAT1 ADCY6 ADCY2 PDYN(226-230) GNAI2 GNB5 ADCY6 ADCY2 Adenylate cyclase(Mg2+ cofactor)PPP3CC p-T34,T75-PPP1R1B p-S54-PDE4Bp-T34-PPP1R1B GNAI2 Adenylate cyclase(Mg2+ cofactor)ADCY1 PRKCA GNAT2 GTP OPRM1 p-S12,S13,T200-CAMK4 ADCY1 CAMK4 GNAO1 GNAT3 GNB2 GNAT1 GNAT3 p-T34,S102-PPP1R1B cAMP:PKA regulatorysubunitGNG7 OPRM1GNAZ p-S133-CREB1homodimerCAMK2G PRKACB GNB3 GNGT2 GNAI3 p-T34,T75,S102-PPP1R1B Ca2+ ADCY7 GTP ITPR1 GNG4 GNG11 PPP3CC GNG12 CALM1 Ca2+ DARPP-32 (for CDK5phosphorylation)ADCY4 GNAI2 GNAI1 ADCY1 GNGT1 GNG3 POMC(237-241) ADCY4 ADCY9 GNB1 Zn2+ GNAI3 GNAT3 KPNA2ADPCALM1ADCY8 p-T34,T75,S102-PPP1R1B GNB2 DAGsp-T75-DARPP32s:PRKACAMg2+ CAMKK1 GNAT2 GNG4 GNG7 CAMK2B p-S505,S727-PLA2G4A ADCY7 ADCY9 ADPADCY3 G-protein beta-gammacomplexGNAO1 PLCB2 ADPADCY6 CaMKKPP2B catalytic(Fe3+, Zn2+)Zn2+ GTP p-S102,S137-PPP1R1B Opioid:MOR:G-proteincomplexPKA tetramerADCY3 PRKACA NBEA:PRKAR2APRKAR1B p-S102,S137-PPP1R1B GNAI3 Opioid:MOR:Gprotein-GTP complexGNAI2 PRKAR1B PDE4BADCY9 p-T185,Y187-MAPK1ADCY4 ADCY8 GNAT2 GNG5 ADCY5 DARPP-32 (and/orphosphorylated)ADCY8 GNG10 CALM1 p-T34-PPP1R1B H2OITPR1 ADCY5 GNAI3 LPCPCADCY3 GDP PRKAR2A GNAT3 GNAZ p-T286-CAMK2A Zn2+ GNG8 p-T34,S137-PPP1R1B ADCY3 PRKACG GNB4 ADCY1 Ca2+ PRKACB GTP GNG12 GNAT3 ADCY9 p-T75-PPP1R1B p-T287-CAMK2B ADCY8 POMC(237-267) Opioid:MORPDE1 dimersGNAI2 PLCB2 GNAI1 p-S133-CREB1CALM1 GNG11 POMC(237-241) ADCY5 H2OATPPDE4A,C,DGNB3 CALM1:4xCa2+GDP PDYN(226-230) ADCY3 PDE4A Protein Kinase A,catalytic subunitsADCY8 p-T75-PPP1R1B GNAT2 PC PPP3CB p-T34,T75,S102,S137-PPP1R1B GTP p-T75,S102,S137-PPP1R1B (Gialpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)GNAI2 GNG4 p-T34,S102-PPP1R1B GNAI3 GTP CAMK4ADCY6 ADCY2 GNAI1 ATPGNAI3 GDP p-T287-CAMK2G POMC(237-267) GNAI2 Ca2+ GNB1 ActivePLA2:phosphatidylcholineCDK5PRKAR1A p-T34,T75,S137-PPP1R1B ADCY1 GNB5 GNAZ PiPDE1B PLCB4 GNAI2 GNGT1 POMC(237-267) PRKAR2ACa2+ PDE1C ADCY7 GNG11 PI(4,5)P2Fe3+ PLCB3 IP3 receptorhomotetramerGNAL ADCY2 GNAI2 ADCY6 GNAZ GNAT1 cAMPGNAI2 GNAT2 I(1,4,5)P3 GNAT3 PRKAR1A ADCY9 GNAL p-CAMKK2 p-T34,S137-PPP1R1B Ca2+ADCY3 ADCY9 I(1,4,5)P3 GNGT1 ITPR3 GNG10 PP2A-ABdeltaCcomplexADCY8 Ca2+ CAMK4ATPADCY8 p-T34,S137-PPP1R1B ADCY1 GNAI2 CAMK4:KPNA2p-S133-CREB1 CREB1NAD+ p-T34,T75,S102-PPP1R1B p-T34,S102,S137-PPP1R1B GNB3 GNG12 GNAI1 ADCY1 GNAI3 Adenylate cyclase(Mg2+ cofactor)GTP GNAI1 GNB1 POMC(237-267) Opioid:MOR:Gprotein-GDP complexADCY2 p-S12.S13,T200-CAMK4:CALM1:4xCa2+PRKACG GNAI3 GNG13 ADCY1 CALM1 ADCY7 ADCY7 CAMK2G GTP KPNA2GDP ADPp-T75,S102-PPP1R1B PRKACA GDPADCY4 ADCY8 GNAT3 PRKACG ADCY6 GDP ITPR1 GNG11 p-T75-DARPP32sp-T75,S137-PPP1R1B p-T287-CAMK2G GNG8 p-T34,S102,S137-PPP1R1B NBEAGNAT3 GNAZ GNB2 PKA catalyticsubunitGNAI3 NBEA GNAI1 AMPp-S102-PPP1R1B ATPPKA catalyticsubunitGNAI2 GNG10 G-protein alpha(i):GTP:AdenylatecyclasePDYN(226-230) PPP1R1B CAMK2A ADCY5 GNAT1 p-T287-CAMK2Bdodecamer:CALM1:4xCa2+ADCY5 ADCY4 ADPKPNA2 GNG5 p-S29-ADRBK1ADCY2 G protein-GDPcomplexFe2+ ADCY2 GDP activated PDE1A GNAO1 GNAT1 p-T34,T75,S102,S137-PPP1R1B PRKACB GNGT2 p-T75,S102,S137-PPP1R1B Ca2+ GNAL PPP1R1B GRK2 PRKAR1A GNAO1 PPP3CA PDYN(226-230) GNAT3 H2OADPPRKACA GRK2GNG12 PPP2R1B CAMK4:CALM1:4xCa2+Ca2+ GNG2 p-T75,S102-PPP1R1B ADCY9 16361616