VEGFR-3 signaling (Rattus norvegicus)

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4ProliferationPermeabilityPlasma membraneSurvivalGene transcriptionTyr1337NO productionMigrationNucleus2223PI3KMapk1Akt1Mapk3Plcg1Flt4ItpkcCasp9Shc12252VegfcFigf1Flt4Grb2Bad_v13Nos3


Description

Vascular endothelial growth factors are crucial for the vascular development and neovascularization in physiological and pathological processes in both embryo and adult. There are three isoforms of the VEGFR receptor found. This figure shows the VEGFR3 pathway as detected in lymphatic endothelial cells. Activation of the receptor results in proliferation, survival, enhanced permeability and migration of the cell.

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Bibliography

  1. Hamada K, Oike Y, Takakura N, Ito Y, Jussila L, Dumont DJ, Alitalo K, Suda T; ''VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.''; Blood, 2000 PubMed Europe PMC
  2. Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K; ''Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.''; EMBO J, 2001 PubMed Europe PMC
  3. Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K; ''Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.''; Oncogene, 1994 PubMed Europe PMC
  4. Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L; ''VEGF-receptor signal transduction.''; Trends Biochem Sci, 2003 PubMed Europe PMC
  5. Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, Petraglia F, Gotta S, Sardone GL, Matteucci G, Terstappen GC, Oliviero S; ''Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity.''; Circ Res, 2010 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
82992view00:55, 17 November 2015Mkutmonfixed unconnected lines
82990view00:54, 17 November 2015Mkutmonfixed unconnected lines
82980view00:01, 17 November 2015Mkutmonfixed outdated identifiers
70135view20:41, 12 July 2013MaintBotconnected lines
67743view11:57, 26 June 2013DdiglesOntology Term : 'vascular endothelial growth factor signaling pathway' added !
58957view18:29, 21 February 2013MaintBotUpdated Ensembl data source
42196view20:52, 7 March 2011KhanspersModified categories
42195view20:51, 7 March 2011KhanspersFixed unconnected lines
41721view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
40373view13:43, 23 February 2011MVlinking lines
40370view13:38, 23 February 2011MVtitle change
40368view13:36, 23 February 2011MVModified description
40365view13:29, 23 February 2011MVVEGFR3 pathway
40363view13:27, 23 February 2011MVVEGFR3 pathway
40354view13:10, 23 February 2011MVPeriodical save, work in progress
40350view13:00, 23 February 2011MVPeriodical save, work in progress
40346view12:50, 23 February 2011MVPeriodical save, work in progress
40342view12:39, 23 February 2011MVPeriodical save, work in progress
40339view12:29, 23 February 2011MVPeriodical save, work in progress
40335view12:19, 23 February 2011MVPeriodical save, work in progress
40332view12:09, 23 February 2011MVPeriodical save, work in progress
40326view11:58, 23 February 2011MVPeriodical save, work in progress
40322view11:48, 23 February 2011MVPeriodical save, work in progress
40316view11:37, 23 February 2011MVNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProductENSRNOG00000028629 (Ensembl)
Bad_v1GeneProductENSRNOG00000021147 (Ensembl)
Casp9GeneProductENSRNOG00000012944 (Ensembl)
FigfGeneProduct360457 (Entrez Gene)
Flt4GeneProduct114110 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
ItpkcGeneProductENSRNOG00000013945 (Ensembl)
Mapk1GeneProductENSRNOG00000001849 (Ensembl)
Mapk3GeneProductENSRNOG00000053583 (Ensembl)
Nos3GeneProductENSRNOG00000009348 (Ensembl)
PI3KGeneProductENSRNOG00000009385 (Ensembl)
Plcg1GeneProductENSRNOG00000051490 (Ensembl)
Shc1GeneProduct85385 (Entrez Gene)
VegfcGeneProduct114111 (Entrez Gene)

Annotated Interactions

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