Signaling by VEGF (Homo sapiens)

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46, 84, 93, 13276, 1164, 745, 1098, 997741, 8218, 4078, 125713717112853, 1191, 8635, 58, 92, 1038523, 26, 52, 56, 74...7, 12979, 1234, 745712034, 4531, 6154111210962, 63, 10611815, 22, 87, 97, 12850111273991720679640, 5737269, 881679, 12312029, 6411581, 8428, 39381219, 21, 70, 85, 9141, 82571424, 5912, 15, 19, 22, 47...38803, 306, 49, 72, 108, 114374, 122, 13027, 48, 110106, 11710232, 33, 5124, 65, 12657891071194244, 127endoplasmic reticulum lumencytosolCALM1 pS-SHB ATPp-S665-VE-cadherin CDC42 PRKCB p-6Y-VEGFR2 Ca2+ GDP p-S21,Y420-FYN PIK3R2 p-6Y-VEGFR2 p-S225-SPHK1Ca2+ p-S473-AKT1 VEGFR2 HSP90AA1 HSP90AA1 AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerNCK2 RAC1 p-6Y-VEGFR2 p-4Y-PLCG1FYN VAV1 FAD p-Y173-VAV3 PIK3R1 p-6Y,S732-PTK2 pS-SHB VEGFAdimer:p-6Y-VEGFR2dimer:p-S-SHBVEGFA-165 NOADPFAD p-S1177-eNOS:CaM:HSP90:p-AKT1:BH42xPalmC-MyrG-NOS3 VAV3 VEGFC VEGFA RAC1 VEGFA,VEGFB,PGFdimersADPp-6Y-VEGFR2 PLCG1VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-Y420-FYNVEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1GTP VEGFA-165 GTP p-T497-PRKCA PI3KVEGFAdimer:p-6Y-VEGFR2dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3Kp-Y772,Y814-AXL VEGFA-165 ITPR3 NCK2 DAG:active PKC:Ca+2p-Y172-VAV2 PIK3CA ADPCRK NRP2 VAV1,2,3ADPp-S-AKT:PDPK1:PIP3VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNITPR1 TRIB3 p-6Y-VEGFR2 Ca2+VEGFA-165 RHOA:GTP:Mg2+:Activated ROCK1,ROCK2AKT3 FIGF p-Y419-SRC FAD Ca2+pS-SHB p-6Y-VEGFR2 I(1,4,5)P3 PRKCA VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTPAKT3 ROCK2 VEGFB ADPATPVEGFB VEGFA-165 p-6Y-VEGFR2 VEGFAdimer:p-6Y-VEGFR2dimerABI1 2xPalmC-MyrG-NOS3 PAK2 dimerI(1,4,5)P3CALM1VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1eNOS:CaM:HSP90:p-AKT1NCK2 Protein kinase Acatalytic subunitVEGFA:p-6Y-VEGFR2:p-SHB:PTK2ADPSHC2 MLST8 SRC-1 VEGFA,C,D dimersGTP NCF2 ITGB3 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1VEGFC eNOS:Caveolin-1:CaM:HSP90VEGFA-165 JUP HSP90AA1 p-S21,Y420-FYN heme VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1FIGF p-PKCA,p-PKCB,p-PKCZ,p-PKCDpS-SHB ADPHSP90AA1 RHOA CTNND1 p-6Y-VEGFR2 PIK3CB p-S141,T402-PAK2 ADPVEGFR3 dimer:VEGFC,VEGFD dimersp-6Y-VEGFR2 p-T308,S473-AKT1 F-actin MAPKAP1 p-6Y-VEGFR2 SHBCYBB p-Y12-BCAR1 beta-catenin L-Citp-5Y,S732-PTK2 JUP p21 RAS:GTPCALM1 Integrin alphaVbeta3ITGAV(31-1048) ADPSRC-1 KRAS H2OPI(4,5)P2BCAR1VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1PI(3,4,5)P3 SRC-1 p-6Y-VEGFR2 FLT4 HSBP1 oligomer pS-SHB p-S144,T423-PAK1 WASF1 DAGs GDPFMN NCK1 2xPalmC-MyrG-NOS3 Zn2+ BAIAP2 PRKCZ GTP p-S473-AKT1 pS-SHB VEGFA pS-SHB GTPp-6Y-VEGFR2 PAK1,2,3 dimerCDC42-GDPVEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYNPKCA,PKCB,PKCD,PKCZPGF BH4 PDPK1:PIP3VEGFAdimer:p-6Y-VEGFR2dimerELMO2 p-S15,S78,S82-HSP27NCK2 NOX2 complexVEGFA CYBA PI(3,4,5)P3 p-6Y-VEGFR2 p-Y420-FYN VEGFA-165 RHOA:GTPp-S665-VE-cadherin-Catenin complexZn2+ VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXLCYFIP2 ADPPIK3R1 RAC1 ITPR3 p-T308,S473-AKT1NCK1 p-T410,T563-PRKCZ FMN PGF SRC-1GTP NRP2:VEGFR1 dimerVEGFA-165 PRKACA VEGFAdimer:p-6Y-VEGFR2dimer:PI3KSPHK1p-T,p-S-AKTCTNNA1 VEGFC,VEGFD dimersNADPHFIGF ITPR3 RASA1FAD p-6Y-VEGFR2 VEGFp-6Y-VEGFR2 RAC1:GTPp-6Y-VEGFR2 WASF2 PRKACG ITPR2 VEGFC ATPATPp-6Y-VEGFR2 Activated ROCK1 VEGFB GDP PTK2B VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2AH+p-T410-PRKCZ p-6Y-VEGFR2 PRKACB CYBB PI(3,4,5)P3VEGFA-165 ADPFAD p-6Y-VEGFR2 p-S472-AKT3 p-6Y,S732-PTK2 ADPp-6Y,S732-PTK2 SHC2VEGFAdimer:p-6Y-VEGFR2dimer:SHBp-Y31,Y118-PXN PI(3,4,5)P3 VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1ATPDOCK1 pS-SHB CDC42 ATPVEGFC RAC1 CDC42 HSP90AA1 p-Y31,Y118-PXN p-Y173-VAV3 NRP1:VEGFR2 dimerp-S21,Y420-FYN p-Y772,Y814-AXL SH2D2A CALM1 VEGFA-165 PDPK1pS-SHB p-Y174-VAV1 PIK3CA VEGFA-165 MAPKAP kinaseSRC-1 GDP p-6Y-VEGFR2 CDC42 FMN ATPVAV3 SH2D2A CTNNA1 VEGFA-165 p-S,2T-MAPKAPK3 ATPPAK3 ROCK2 CALM1 PTK2BVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2BADPCa2+ CALM1:4xCa2+NCK1,NCK2p-6Y-VEGFR2 p-S,T-PAK1,2,3GTPBRK1 VEGFR2:VEGFA,C,DPDPK1 beta-catenin p-6Y-VEGFR2 PAK1 p-Y174-VAV1 MAPK14 ATPNCK1 VEGFR1ATPPDPK1SRC-1 FYNGTP CAV1 NRP1NRAS ELMO2 p-Y12-BCAR1 SRC-1 p-S-AKT:PIP3PTK2B VEGFAdimer:p-6Y-VEGFR2dimer:PLCG1HSP90AA1 Activated ROCK2 VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2Bp-Y419-SRC GTP Mg2+ p-6Y-VEGFR2 MAPKAPK2 PAK2 ATPVEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRKRAC1 p-T180,Y182-MAPK11 HSP90AA1 NCK1 FLT4PIK3CA p-T309,S474-AKT2 SRC-1 FAD HSP90AA1 O2.-pS-SHB 2xPalmC-MyrG-p-S1177-NOS3 SHB FIGF p-Y31,Y118-PXN WASF2 SRC-1ITPR1 p-6Y-VEGFR2 VEGFA-165 PIP3:VAV1,2,3VEGF dimerFAD S1PSPG MAPKAPK3 CYBA p-S154,T436-PAK3 PRKCD ATPITGAV(31-1048) PXN SRC-1 NCK2 p-Y172-VAV2 PAK3 Unknown GEFBCAR1 NRAS p-T500,T642,S661-PRKCB KRAS p-6Y-VEGFR2 heme Ca2+ pS-SHB ITGAV(31-1048) VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXNELMO1 BAIAP2PAK2 RHOA HSP90AA1 CDC42 NCK1 ADPHSP90AA1 VEGFC p-Y397-PTK2 L-ArgVEGFA-165 NCK2 VEGFA-165 VEGFA-165 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1Mg2+ p-Y173-VAV3 p-4Y-PLCG1 p-6Y,S732-PTK2 RAC1 SH2D2A HSP90AA1VE-cadherin-CatenincomplexVEGFA-165 VEGFA p-Y172-VAV2 VEGFA-165 p-PKCVEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2p-T305,S472-AKT3 ATPCTNND1 MAPK11 p-6Y,S732-PTK2 ATPVEGFA-165 NCK1 RAC1 BH4VEGFA-165 WASF3 p-6Y,S732-PTK2 CYFIP1 PIK3CA NCK1 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTPNOX2complex:RAC1:GTPAKT:PIP3PIK3R1 FMN heme FMN Ca2+ RAC1 p-6Y,S732-PTK2 ABI2 Ca2+ NCF2 NCK1 PAK2 p-T308,S473-AKT1 p-6Y-VEGFR2 SRC-1 SH2D2A VEGFA:p-6Y-VEGFR2:SHC2p-5Y-PTK2 VEGFA-165 SRC-1ABI1 CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNGTP ROCK1 Zn2+ p-Y397-PTK2 ELMO1 PI(3,4,5)P3 p-VAVfamily:PIP3:RAC1:GTPADPFAD Mg2+ GTPp-Y419-SRC SH2D2A ADPp-S472-AKT3 WRC:IRSp53/58:RAC1:GTP:PIP3ADPVAV1 ADPNCK2 PAK2 VEGFA-165 ADPGDPPAK1 VEGFA-165 p-Y173-VAV3 VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXLITGAV(31-1048) VEGFA-165 VEGFA-165 ATPp-6Y-VEGFR2 VEGFA-165 MTOR VEGFR2 RAC1 DOCK180:ELMO1,ELMO2GDPPI(3,4,5)P3 ITPR2 p-Y397-PTK2 p-S474-AKT2 VEGFA-165 VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTPADPMAPK13 p-6Y-VEGFR2 HRAS p-6Y-VEGFR2 PAK2 SH2D2A VEGFR1 dimer:VEGFA,VEGFB, PGF dimersVE-cadherin PI(3,4,5)P3 VAV2 heme VEGFAdimer:p-6Y-VEGFR2dimer:p-4Y-PLCG1p-VAVfamily:PIP3:RAC1:GDPVEGFB p-Y12-BCAR1 CYFIP1 p-T180,Y182-MAPK14 pS-SHB PI(3,4,5)P3CRKNCK1 heme GTP HSP90AA1 HSP90AA1 Ca2+ ATPCALM1 ADPeNOS:Caveolin-1:CaMSRC-1 ADPp-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3ADPp-Y173-VAV3 ATPRASA1 DOCK1 VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:FYNZn2+ p-Y397-PTK2 2xPalmC-MyrG-NOS3 PIK3R2 p-VAVfamily:PIP3:RAC1:GTP:PAK 1-3p-T500,T642,S661-PRKCB PLCG1 pS-SHB AKT1 p-T507,S645,S664-PRKCD p-6Y-VEGFR2 CDC42:GTPVEGFA RHOA:GTP:ROCK1,ROCK2PI(3,4,5)P3 ATPVAV2 VEGFR2PI(3,4,5)P3 PTK2 p-S474-AKT2 ATPheme AXLAKT2 AKT2 BRK1 NRP2VEGFA-165 ATPWAVE RegulatoryComplexVEGFC VEGFA-165 PGF PDPK1 p-6Y-VEGFR2 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXNeNOS:CaM:HSP90p-T500-PRKCB ATPAXL DAGsRHOA F-actinITPR:I(1,4,5)P3tetramerGTP p-Y12-BCAR1 VEGFA-165 VEGFA-165 p-T507-PRKCD RASA1:p21RAS:GTP:SPGPTK2DAGsp-6Y-VEGFR2 Zn2+ PIK3CB VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3KATPp-6Y-VEGFR2 ADPATPPAK1 2xPalmC-MyrG-NOS3 p-6Y-VEGFR2 p-S1177-eNOS:CaM:HSP90:p-AKT1VEGFAdimer:p-6Y-VEGFR2dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2WASF1 SH2D2A heme HSP90AA1 p-6Y-VEGFR2 ROCK1 MAPK12 ADMApS-SHB CALM1 FIGF VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2GTP p-VAV family:PIP3CYFIP2 O2ITGB3 PI(4,5)P2p-Y130,S141,T402-PAK2 ADPp-T308,S473-AKT1 p-T507,S645,S664-PRKCD AHCYL1 ADPADPVEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3PIK3CB I(1,4,5)P3 ITPR2 PRR5 NCKAP1L ATPFAD HSP90AA1 NCF1 ADPVEGFA-165 heme heme p-Y174-VAV1 GTP SH2D2ApS-SHB p-Y31,Y118-PXN AKT1 CRK p-T308,S473-AKT1 VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1PGF VEGFA-165 NCK2 CAV1 SRC-1 PIK3R2 VEGFA-165 SRC-1 MAP kinase p38 (Mg2+cofactor)NCKAP1 PI(3,4,5)P3 PI(3,4,5)P3 NCF4 ITGB3 PIK3R2 RAF/MAP kinasecascadePI(3,4,5)P3 VEGFR1 NCF4 GTP VEGFA-165 2xPalmC-MyrG-p-S1177-NOS3 RAC1:GTPp-6Y,S732-PTK2 PAK2 CAV1 pS-SHB NAD+ p-6Y-VEGFR2 GTP p-T497,T638,S657-PRKCA p-6Y-VEGFR2 ATPFIGF VEGFR2 VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1HSP27oligomer:F-actinSRC-1 HSP90AA1 ATPp-S141,T402-PAK2 ATPATPGTP HSP90AA1p-6Y-VEGFR2 ITPR1 IP3 receptorhomotetramerABI2 VEGFA-165 2xp-VAVfamily:PIP3:RAC1:GTP:PAK 1-3p-5Y-PTK2 p-Y172-VAV2 BH4 ITGB3 NRP1 NCF1 PIK3CB Ca2+Zn2+ CAV1SRC-1 VEGFAdimer:p-6Y-VEGFR2dimer:SH2D2A:SRC-1NADP+SRC-1 Zn2+ p-Y419-SRC VEGFA-165 PIK3R1 PAK3 NCKAP1L p-Y772,Y814-AXL p-S21,Y420-FYN GTP pS-SHB ADPFMN CALM1 ATPeNOS:Caveolin-1VEGFA-165 p-Y172-VAV2 p-6Y-VEGFR2 ROCK1,ROCK2Phospho-MAP kinasep38 (Mg2+ cofactor)p-Y419-SRC TORC2 complexADPp-6Y-VEGFR2 VEGFA Ca2+ VEGFA-165 p-Y174-VAV1 AKT:PIP3:THEM4/TRIB3WASF3 NCKAP1 PI(3,4,5)P3 THEM4 p-S272,T222,T334-MAPKAPK2 ATPp-Y174-VAV1 PXNp-6Y-VEGFR2 RAC1:GDPVEGFA-165 VEGFA-165 FMN VEGFR1 VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1p-6Y-VEGFR2 VEGFA-165dimer:VEGFR2 dimerp-T410,T563-PRKCZ VEGFA-165 VEGFA-165 NCK2 HRAS RICTOR p-T497,T638,S657-PRKCA p-S21,Y420-FYN 434343434369, 10469, 1044336, 68, 75438, 101834369, 10413, 25, 53, 60, 73...436666435543