Signaling by EGFR (Homo sapiens)

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72, 86, 94, 9616, 2833, 5112822481457, 7714, 85, 911421, 8736, 8, 658, 65, 7893342653345627, 6410, 13, 24, 61933, 42, 51, 708139807626, 4557, 7710, 228978937, 79, 9558, 67845436, 5036, 5047, 83604035, 626928, 758948, 8011, 74, 98668221, 876343, 468210, 13, 24, 615225, 27, 42, 49, 51...plasma membranecytosolplasma membraneplasma membraneplasma membraneReversible anti-EGFRplus TKIs PIP3 activates AKTsignalingEGFR E746_A750del EGFR E746_T751delinsA ATPUBC(77-152) RPS27A(1-76) UBB(153-228) UBC(305-380) CDC37 EGFR A289V UBC(457-532) CBL UBB(153-228) UBB(1-76) EGFR E746_S752delinsV ATPH2OUBC(229-304) UBC(77-152) SOS1 UBC(305-380) UBC(533-608) UBA52(1-76) p-6Y-EGFR EGFR G598V EGFR G719S EPN1 PTPN11 UBC(381-456) EGF PiGRB2-1:SOS1EGFR E746_T751delinsA EGFR A289T p-Y371-CBL SPRY1/2EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2p-4Y-PLCG1EGFR L747_P753delinsS EGFR L747_S752del PI(4,5)P2 UBC(229-304) PLCG1 GRB2-1 EGFR L861Q p-Y53-SPRY1 UBA52(1-76) PIK3CAUBC(1-76) EGF CDC37 GRB2-1p-Y850 EPS15 ADPEGF:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1KRAS HSP90AA1 EGF GRB2-1 EGFR V738_K739insKIPVAI EGFR E746_S752delinsV p-6Y-EGFR EGFR E746_A750del EGF:p-6Y-EGFR dimerEGFR G598V EGFR L858R;T790M UBC(229-304) EGF EGFR E746_A750del;T790M EGFR G719A EGFR G719A GRB2-1 UBA52(1-76) DAG and IP3signalingEGFR L747_T751delinsP PTPN11 CBL CSK HGS SH3GL1 ADPSH3GL3 UBB(153-228) EGFR L861Q CDC37 PTPN11PXN PI(3,4,5)P3 p-Y371-CBL H2OEGFR T263P GRB2-1 Ligand-responsiveEGFR mutantsEGFR E746_S752delinsV EGFR L747_S752del Irreversible anti-EGFRplus TKIs EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15SH3KBP1 EGFR A289D HSP90AA1 UbEGFR V738_K739insKIPVAI SH3KBP1 EGFR L861Q CDC37 EGFR E746_S752delinsV Pro-EGFp-Y371-CBL EGFR L747_P753delinsS EGFR G719C EGFR E746_S752delinsV GAB1 CBL CBLEGF:p-6Y-EGFR:GRB2:GAB1:PIK3EGFR D770_N771insNPH p-6Y-EGFR ADPEGFR M766_A767insASV p-Y349,Y350-SHC1 CBL:SPRY1/2EGF GRB2-1 SH3GL2 EGF:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15UBC(1-76) UBC(609-684) p-6Y-EGFR EGFR L747_T751delinsP p-6Y-EGFR KRAS CDC37 EGFR R108K CBL EGFR G719A SH3GL2 EGFR E746_S752delinsV Cetuximab EGF EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMEGF:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2HGS GRB2:GAB1SH3KBP1 SH3GL2 Beta-Pix:CDC42:GTPUBB(77-152) p-4Y-PLCG1 EGF:Ligand-responsive EGFR mutants dimerGeldanamycin Irreversible anti-EGFRplus TKIs UBC(229-304) UBC(305-380) RPS27A(1-76) EGF:Ligand-responsive EGFR mutants:HSP90:CDC37EGFR L747_T751delinsP GRB2-1 UBB(153-228) EGFR L747_A750delinsP EGFR L747_S752del EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2EGF ADAM12 p-6Y-EGFR EGF ARHGEF7 EGF ATPEGF UbUBC(77-152) EGF:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1EGFR D770_N771insNPH CBL:Beta-Pix:CDC42:GTPEGFRvIII mutantdimerSPRY1 UBC(381-456) EGFR D770_N771insNPH ATPUBC(609-684) p-5Y-GAB1 EGF:p-6Y-EGFR:CBLLigand-responsive EGFR mutants resistant to non-covalent TKIs GDPEGFR A289D GDP H2Op-6Y-EGFR UBC(381-456) ARHGEF7 EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15EGFR L747_T751del GAB1PIK3CA HSP90Ubp-Y371-CBL EGFR L747_T751del EGFR L747_P753delinsS ADPCDC42:GTPUBB(77-152) p-Y53-SPRY1 EGFR G719C UBC(77-152) EGF UBC(229-304) p-Y55-SPRY2p-Y371-CBL Irreversible EGFR-specific TKIs EGFEGFR T263P EGFRvIII CDC42 EGF:Ub-p-6Y-EGFR:p-Y371-CBLADPGRB2-1EGFR V738_K739insKIPVAI HGS EGFR A289D UBC(153-228) GRB2:GAB1:PIK3R1p-5Y-GAB1 GTP CDC37 SH3KBP1 SPRY2 EGF CBL EGFR E746_A750del PXN:CSK:SRCEPS15L1 GRB2:GAB1:PIP3SH3GL3 EGFR G719A UBC(533-608) Irreversible anti-EGFRplus TKIs UBA52(1-76) CBL:GRB2SH3GL1 EGFR G719S EGFR T263P UBC(533-608) EGF EGF EGFRUBB(1-76) UBC(381-456) SH3GL1 STAM EGFR R108K EGFR L747_P753delinsS GRB2-1 UBC(1-76) EGF p-Y371-CBL UBB(1-76) p-6Y-EGFR p-Y349,Y350-SHC1 UBB(153-228) p21 RAS:GDPCBL:Beta-PixUBC(1-76) STAM2 ARHGEF7 EGF:p-6Y-EGFR:p-Y371-CBL:GRB2p-6Y-EGFR EGFR G598V GRB2-1 EGFR E746_A750del;T790M EGF:p-6Y-EGFR:GRB2:SOS1EGFR L747_T751delinsP p-6Y-EGFR UBC(153-228) SH3GL2 Ligand-responsiveEGFR mutants dimerEGFR L858R;T790M EGF:EGFRUBB(1-76) EGFR A289V EGFR L861Q UBC(153-228) RPS27A(1-76) EGFR V738_K739insKIPVAI ARHGEF7 UBC(457-532) EGFR R108K UBB(1-76) EGFR L861Q SH3GL2 EPS15 EGFR E746_T751delinsA UBC(609-684) EGFR E746_A750del;T790M EGFR M766_A767insASV EPS15L1 EGF:p-6Y-EGFR:PLCG1EGF EGFR R108K EGFR M766_A767insASV UBC(533-608) UBC(533-608) UBC(457-532) UBC(305-380) RPS27A(1-76) EGFR G719C EGFR R108K HSP90AA1 EGFR D770_N771insNPH EGFR A289T SH3GL1 EPN1 PTPRKEGF EGF UBC(609-684) ARHGEF7 EGFR L858R;T790M UBC(1-76) EGFR E746_T751delinsA UBB(77-152) HSP90AA1 p21 RAS:GTPEGFR D770_N771insNPH UBB(1-76) p-6Y-EGFR EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAMHSP90AA1 RAF/MAP kinasecascadeEGF:p-EGFR dimerdephosphorylated atY1148 (Y1172)GRB2-1 ADPHGS p-6Y-EGFR EGF EGF HGS UBC(229-304) EGF SPRY2 EGFR D770_N771insNPG UBC(77-152) EGFR T263P STAM EGF UBC(381-456) UBC(1-76) EGFRvIIImutant:HSP90:CDC37EGFR L858R;T790M UBC(229-304) GRB2-1 EGFR G719A CDC42 SH3GL1 EPN1 CDC42 STAM2 HSP90:BenzoquinoidansamycinsSHC1EGFR UBC(305-380) UBB(153-228) EGFR G598V Ub-SH3KBP1 UBB(1-76) RPS27A(1-76) EGF:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2UBC(457-532) ADPp-Y371-CBL EGF:p-6Y-EGFR:GRB2:GAB1:PIK3R1EGFR L858R p-6Y-EGFR GRB2-1 EGF STAM2 p-Y55-SPRY2GAB1 EGFR G598V EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1EGFR R108K STAM2 EGFR M766_A767insASV EGFR L747_T751del Geldanamycin Irreversible EGFR-specific TKIs EGFR G719C PI(4,5)P2HSP90AA1 CBLp-Y55-SPRY2 EGF GRB2-1 UBB(1-76) CSKPTPN3SOS1 EGF UBB(77-152) UBC(609-684) EGF PTPN12UBC(381-456) 17-DMAG GRB2-1 p-Y371-CBL UBC(533-608) EGF EPN1UBC(153-228) EGFRvIII SRC-1EGFR M766_A767insASV UBC(533-608) UBB(1-76) UBC(153-228) GTP EGFR G598V SPRY1 SH3KBP1UBC(305-380) EGFR D770_N771insNPG SH3GL1 Ligand-responsiveEGFRmutants:HSP90:CDC37HRAS SHC1 PTPN11 HSP90AA1 UBB(153-228) UBB(77-152) STAM2 UBB(153-228) SH3GL2 UBC(457-532) EGFR G719C PIK3R1 CBL EGFR L861Q SRC-1 p-6Y-EGFR HSP90AA1 EGF:EGFRDimer:Covalent EGFRTKIsEGFR D770_N771insNPH PI(4,5)P2SPRY1 EGFR L858R;T790M EGF UBB(77-152) CBL:SPRY1/2EGFR D770_N771insNPG GRB2-1 CDC37 UBC(229-304) EPS15 SRC-1 CBL HSP90AA1 HSP90AA1 CBL PLCG1EGFR G719A EGFR G719S SH3KBP1 EGFR M766_A767insASV NRAS STAM EGFR L747_P753delinsS UBC(609-684) NRAS CBL GRB2-1 EGFR E746_A750del;T790M EGF p-5Y-GAB1 EGFR L747_T751del CetuximabEGFR D770_N771insNPG EPS15:HGS:STAMp-6Y-EGFR EGF UBC(77-152) EGF:p-6Y-EGFR:CBL:GRB2GTP EGF UBB(77-152) UBC(153-228) RPS27A(1-76) CBL EGF EGFR L747_T751del STAM EGFR V738_K739insKIPVAI p-6Y-EGFR EGFR A289D SPRY1 Herbimycin A SH3GL3 EGF ADAM17 SH3GL2 UBC(305-380) UBC(533-608) SH3GL3 Ubp-6Y-EGFR EGFR L747_A750delinsP SH3KBP1 EGF:EGFR dimerRPS27A(1-76) p-Y317-PAG1UBC(1-76) EGF:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2Herbimycin A ADPUBC(305-380) EGFR UBC(153-228) EGFR D770_N771insNPG p-Y55-SPRY2 p-6Y-EGFR EPS15 EGF PAG1EGF Pip-Y627,Y659-GAB1 SH3KBP1 GRB2-1 p-6Y-EGFR PIK3R1 p-6Y-EGFR Covalent EGFRtyrosine kinaseinhibitorsEGFR L747_A750delinsP EGFR L747_T751delinsP ATPPIK3R1UBA52(1-76) ADAM10(215-824) Sensitiveligand-responsiveEGFRmutants:Non-covalent EGFR TKIsEGF:p-6Y-EGFR:p-Y349,350-SHC1UBA52(1-76) CDC37 CBL SPRY2 17-AAG UBC(153-228) Reversible anti-EGFRplus TKIs 17-DMAG UBC(77-152) GTP UBA52(1-76) GAB1 UBC(457-532) CDC42 UBA52(1-76) LRIG1EGFR L858R EGFR V738_K739insKIPVAI UBC(229-304) SPRY1 GRB2-1 EGFR E746_A750del EGFR L858R EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85EGF:p-6Y-EGFR:SHC1Reversible EGFR-specific TKIs EGFR E746_A750del;T790M SOS1EGFR G719S EGFR L747_T751delinsP UbUBC(77-152) PI(4,5)P2 H2OUBC(609-684) GTP UBB(77-152) UBC(305-380) SH3GL3 EGFR D770_N771insNPH EPS15L1 RPS27A(1-76) EGF PXN:SRCEGFR L747_S752del UBC(457-532) EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2CDC42 EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTPEPS15 ATPPiUBC(457-532) GRB2-1 EPN1 EGF:p-6Y-EGFR:GRB2:GAB1H2OUBC(457-532) ADAM:Zn2+EGFR L858R;T790M SH3GL3 PIK3R1 UBA52(1-76) EGFR A289T EGFR A289V UBC(609-684) ATPEGFR G719C GAB1 Reversible EGFR-specific TKIs UBC(381-456) EGFR A289T EGFR E746_A750del IPI-504 p-6Y-EGFR SPRY2 BenzoquinoidansamycinsIrreversible EGFR-specific TKIs EPS15L1 UBC(77-152) EPS15L1EGFR A289V EGF EGFRvIIIUBB(153-228) p-6Y-EGFR EGFR UBC(229-304) PiActive dimers ofligand-responsiveEGFR mutantsEGFR A289D p-6Y-EGFR GTP EGF:p-6Y-EGFR:CBL:CIN85CDC37 EGFR D770_N771insNPG UBC(457-532) EGFR T263P EGFR L747_A750delinsP Resistantligand-responsiveEGFR mutantsp-6Y-EGFR SOS1 IPI-504 EGFR L747_S752del EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:EndophilinUBB(153-228) EGFR L858R p-Y371-CBL SPRY2 UBC(381-456) EGFR M766_A767insASV GAB1 UBC(381-456) EGFR T263P EGFR UBC(1-76) p-6Y-EGFR EGFR E746_A750del;T790M EPS15L1 SH3GL1 CDC37 Ub-Beta-Pix:CDC42:GTPEGF UBC(533-608) GTPUBB(77-152) EGFR L747_S752del STAM PI(3,4,5)P3EGFR L747_P753delinsS RPS27A(1-76) UBC(609-684) p-Y371-CBL p-6Y-EGFR Ligand-responsive EGFR mutants sensitive to non-covalent TKIs ARHGEF7 CDC37ATPHSP90AA1 UBC(305-380) PXN EGFR E746_A750del;T790M UBB(1-76) Resistantligand-responsiveEGFRmutants:CovalentEGFR TKIsGAB1 GAB1 EGF p-6Y-EGFR EGFR D770_N771insNPG GRB2-1 EGFR L858R;T790M CDC42 Zn2+ GRB2-1 HRAS UBC(153-228) p-6Y-EGFR EGFR A289D UBC(77-152) SH3KBP1 PiEGFR A289V SPRY1/2EGF UBB(77-152) EGFR E746_A750del UBC(609-684) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR EGFR L747_A750delinsP EGF CDC37 EGFR L858R UbCIN85:endophilinEGFR L858R UBC(381-456) HSP90AA1 EPS15 EGFR L747_T751del p-6Y-EGFR EGFR V738_K739insKIPVAI GRB2:GAB1HGS CBL UBC(1-76) UBA52(1-76) EGFR G719S RPS27A(1-76) STAM EGFR L747_A750delinsP GTP H2O17-AAG EPN1 UBC(153-228) UBC(533-608) EGFR A289V EGFR:CetuximabEGFR E746_T751delinsA PiEGFR A289T EGF:p-6Y-EGFR:p-Y371-CBLNon-covalent EGFRtyrosine kinaseinhibitorsGRB2-1 STAM2 p-4Y-EGFR UBC(1-76) p-6Y-EGFR SH3GL3 EGFR E746_T751delinsA EGFR A289T EGFR G719S 29101010, 8873737310, 887310, 881015291015, 617397732915, 88731510, 73107310, 73737329732910, 73297310737315, 88151515, 88101010, 8810, 73291015, 6115, 61297310915, 6110297315, 61107318, 88151515, 88731010297373159517151015, 8810, 735, 19, 20, 23, 30...15, 612915291515, 88101010, 8810, 7338731510737310, 8817371515, 8810, 8873