Mitotic G1-G1/S phases (Homo sapiens)

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4, 12, 19, 83, 86...112, 178, 201411, 36, 53, 21420972, 103, 170201, 226207, 20835, 221201, 2261623, 5, 201, 21030, 44, 48, 57, 65...201, 23621014651162512, 96, 106, 140, 148...1625215180, 198, 21928, 71, 79, 144, 147...5105, 201162, 164, 201, 23718614621221112, 178, 2015, 46184208, 229119, 15414539, 170319, 30, 44, 62, 75...528, 122, 124, 144, 176...15896180, 198212114, 18938, 99, 192, 1981623825, 80, 2393, 2015201, 220, 226105, 173, 20120151109, 188, 21929, 152199, 201, 22624253816210483, 86, 125, 182, 1952128, 32, 74, 117, 134...186126, 20131, 114, 1893140, 761395215186179, 201, 2264126, 201524218610, 207, 208164, 201, 237201, 2365, 162128162171, 21143, 139179, 201, 22640, 76225, 208, 22946cytosolnucleoplasmCDKN1A CCNE2 TFDP1 RBL1 LIN54 MYC:MAXORC2 RBL2:E2F4,E2F5:TFDP1,TFDP2MuvB complexRBBP4 CCNB1 UBC(305-380) CCNE2 ORC2 ORC3 PRIM1 TFDP2 ORC6 RBL2 TYMSCCNA1 gene p-T,p-S-AKTCCND2 SKP2 TFDP1 ORC5 E2F1 TFDP1 CDK6 origin of replication DREAM complex:TOP2Agenecyclin INK4CCND3 TFDP1 p-T172-CDK4 p-Y342-PTK6E2F1:TFDP1,TFDP2:DHFR geneUBC(77-152) MCM6 CDKN1B E2F4 HDAC1CCNA2 p-T187-CDKN1B ORC6 MAX TFDP1 TFDP2 CDC7 CCND2 RBL2:Cyclin E/A:CDK2E2F1 E2F4 ADPRRM2 geneDNA primer POLE4 CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C)DBF4 CCNE:CDK2TFDP1 UBC(457-532) PSMB3 MCM3 LIN9 TFDP1 CDKN1A E2F1:TFDP1,TFDP2:RRM2 geneE2F1:TFDP1,TFDP2:POLA1 geneMCM7 MCM5 ORC4 MCM10 p-Y226,Y393-ABL1 MCM2 TFDP2 ATPp-T160-CDK2 LIN54 CDK1 gene p-T160-CDK2 TFDP1 RNA primer:origin duplex with DNA damage TFDP1 CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C)E2F4 E2F5 ORC1 CCNE2 CCNE2 RBL1 MCM2 CDK4 MCM5 TFDP1 RBBP4 SHFM1 MCM6 RBL1 CCND3 p-S28-LIN52 CCND1 ORC6 CCNE1 CCND2 ORC5 PPP2R1B SKP2 LIN54 UBC(457-532) RBL1:E2F4:TFDP1,TFDP2CCNE1 CDK6 (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2)E2F4 UBC(229-304) CCNA2 PSMC4 Signaling by PTK6UBC(229-304) TFDP2 PSMA4 CCNE1 UBB(77-152) E2F1 E2F3 PRIM2 UBC(305-380) TFDP2 CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)E2F4 E2F4 CCND3 MAX CCND3 CCNE1 E2F1 gene CDC6 CUL1:SKP1:SKP2:CKS1Borigin of replication PSME2 RBL2 p-T305,S472-AKT3 ORC6 UBC(533-608) E2F5 TFDP2 p-Y88-CDKN1B CCND1 MCM6 ADPORC3 H2OCDK6 RPA1-4UBA52(1-76) p-Y88-CDKN1B LIN9 ORC4 MCM2 p-Y77-CDKN1A CDC45 geneMCM7 ORC2 PSMA6 MCM2 ORC3 MYC CDK:DDK:MCM10:activepre-replicativecomplex:CDC45:RPA1-4PSMD14 origin of replication PSMD11 CCND3 CDKN1B UBC(153-228) RBL2HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 geneUBB(1-76) LIN37 RB1:RNA primer-DNAprimer:originduplex with DNAdamageCDK6 p-S28-LIN52 E2F4 CDKN1C E2F1 genep-T160-CDK2 CDC45CDK:DDK:MCM10:activepre-replicativecomplex:CDC45ATPp-T401,S672,S1035-RBL2 PRIM1 CUL1 ORC1 geneMYBL2E2F5 E2F1 CCNA1CCNA CCNA DREAM complex:CDC6geneCCNEUBC(533-608) POLE2 CDKN1AMCM8 CDC6p-T369,S640,S964,S975-RBL1DREAM complex:PCNAgeneATPCDKN2C CDK2 UBC(77-152) E2F5 RPA3 CDC25A geneCCNE1 DREAM complexCyclin E CCNE2 CCND1 p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))ATPCDT1 gene RBL1 gene CDKN1Bp-Y88-CDKN1B CCNH PSMD12 ORC2 ORC4 ORC4 CCNE1 Aborted replicationcomplexRB1PPP2CA PP2ARBBP4 E2F4,E2F5:TFDP1,TFDP2ATPCDC45 TFDP1 CDKN1B TFDP2 LIN37 p-Y91-CDKN1C PSMB4 TK1 geneCDKN1C RBL2 RBL1 MCM5 E2F6 TFDP2 TFDP2 CDKN1B PSMC6 CUL1 CCNE1 gene LIN9 CDK2 CCND2 CDC6 origin of replication CDT1 TFDP2 RBBP4 TFDP2 Cyclin E CDK2CKS1B SKP2 E2F1:TFDP1,TFDP2:CDK1 geneORC5 ADPRPS27A(1-76) HDAC1 E2F1:TFDP1,TFDP2:CCNE1 geneCDKN2C PSMA3 POLA1 gene ORC5 LIN9 PSMF1 TFDP2 PSMD2 CABLES1E2F1,E2F2,E2F3:TFDP1,TFDP2TFDP2 UBC(533-608) CDK1p-Y397-LYN TFDP1 CDC25A gene ORC3 E2F4 CDKN1A UBA52(1-76) MCM4 TFDP2 LIN37 CDK2 RPS27A(1-76) CDK1 POLE LIN37 LIN9 RBL1 CCNA2 CDK4 cyclin PSMD10 CDK6 p-S28-LIN52 CDK4 MCM8 ADPRBL2:E2F4,E2F5:TFDP1,TFDP2LIN9 MCM2-7RBL1PCNA gene UBB(77-152) PP2Ap-MCM2-7SKP1 PiTFDP2 TFDP1 RBL1 geneTFDP1 DNA polymerasealpha:primaseADPORC4 E2F1MCM8 ORC1 gene TFDP2 p-T308,S473-AKT1 CCNE1 MCM7 CDKN1B LIN37 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2E2F1 CyclinB:CDK1:ORC:originof replicationADPRBL1MCM6 Cyclin E:p-T160-CDK2PSMD6 p-T177-CDK6 p16-INK4a E2F4 CDC45 gene CDKN1B p-S795-RB1CCND1 CUL1 MCM10 PPP2R1B CCNA:p-T160-CDK2,CCNE:p-T160-CDK2POLE3 E2F1:TFDP1,TFDP2:TK1geneTFDP1 CCND1 UbPOLA2 MCM6 E2F4 CDKN1A,CDKN1BE2F4:TFDP1,TFDP2CDK2 POLA1 p-T309,S474-AKT2 CCNA2 TOP2APSMD4 TFDP2 PPP2CB CDKN2D ATPCyclin E ORC1MCM5 SKP1 CDK2 TFDP2 CyclinE/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1BCDKN1A RBBP4 CDK2 MCM3 LIN54 MCM6 E2F5 RBL1:E2F4:TFDP1,TFDP2ATPLIN54 p-S28-LIN52 CDC25A gene PSMA5 p-S130-CDKN1A UBC(153-228) UBC(77-152) Cyclin E:p-CDK2MCM10 PSMA2 RBL2 RBL1 p-Y342-PTK6 TFDP2 UBC(229-304) CCNA CUL1:SKP1:SKP2SKP1 p-S28-LIN52 E2F3 TFDP1 E2F1 CCNE2 ORC2 CCNB1 CDKN1BRNA primer-DNAprimer:originduplex with DNAdamagePSMB1 CDK6 HDAC1 PPP2R2A E2F1 FBXO5 gene UbCDC6 ORC1 pre-replicativecomplexE2F1:TFDP1,TFDP2CCND1 CDT1CCNE1 PSMC1 Pi MYC:MAX:CDC25A geneCCND2 MCM6 PSMD3 p-CDK2 p-T401,S672,S1035-RBL2UBC(77-152) ADPLIN37 ATPLIN9 E2F2 CDK1 geneMCM8 E2F4 CDK4 RPA4 E2F5 p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1))PSME1 UBC(381-456) CDC45 origin of replication CDC6 gene PiRBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2CCNE1UBC(1-76) ORC6 CDKN1A p-S28-LIN52 TFDP2 RBL2 CCNE1 RBL1 ADPE2F1 p-S130-CDKN1A PSMC3 CDT1 p-T160-CDK2 MCM3 CCNE1 Ub-p-T401,S672,1035-RBL2RPA2 RNA primer-DNAprimer:originduplexCCNA1 LIN37 DREAM complex:CDC25AgeneRPA4 CDK2 ORC4 origin of replication MCM7 TYMS geneCAKDHFRUBC(1-76) POLA1 geneCKS1B p-Y88-CDKN1B E2F1:TFDP1,TFDP2:CDC6 genePPP2R1A TFDP2 E2F4 p-12Y-JAK2 RBBP4 TFDP1 MCM7 HDAC1:RBL1:E2F4:TFDP1,TFDP2MYC CCNE2 CDKN1B RRM2 gene TFDP2 RNA primer:origin duplex with DNA damage CDKN1B TFDP1 CDK6 p-T160-CDK2 DYRK1ACDKN1B:(CDK4:CCND1,(CDK2:CCNE1))RBL2 CyclinE:p-T160-CDK2:p-RB1RBL2 HDAC1 CDC6 genePOLE TFDP2 TFDP1 E2F1:TFDP1,TFDP2:FBXO5 geneTFDP2 E2F1 PSMB8 CDK2 RBL1:Cyclin E/A:CDK2HDAC1 ORC6 CDKCCNE2 CCNE2 UBC(381-456) Oncogene InducedSenescenceTFDP2 UBB(77-152) E2F1 p-T160-CDK2 HDAC1 RNA primer:origin duplex with DNA damage E2F1 RPA1 SKP1 SKP2 MCM10:pre-replicative complexRB1 ORC1 CDK2 HDAC1 PSMB2 CDKN1A CCNE1 p-T401,S672,S1035-RBL2 Cyclin B:CDK1ORC1 CyclinE:p-T160-CDK2:RB1TK1RBL2 PRIM2 p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)CDC6 gene ORC1 CDK1 E2F1 PSMB7 UBC(609-684) MCM4 FBXO5TFDP2 TFDP1 RBBP4 p-T160-CDK2 CDK4 CDKN1C ORC4 UBC(305-380) RRM2RPS27A(1-76) TFDP2 TFDP1 MCM5 CDC6 PCNA gene TFDP2 ORC1 LIN54 POLE2 CDKN1C CCND1 TFDP2 E2F4 PSMC5 MCM10 UBC(153-228) p-MuvB complexUBC(381-456) UBB(77-152) CDK2 E2F1:TFDP1,TFDP2:ORC1 geneTFDP1 MCM7 CDK4,CDK6:INK4UBC(609-684) TFDP1 RRM2 gene CCNE2 E2F5 UBC(609-684) POLA1 E2F1 MCM8 cyclin CCNE1 RBL2 E2F5 PSMD8 MCM3 PRIM2 MNAT1 E2F1:TFDP1,TFDP2:CCNA1 geneE2F5 TFDP2 MCM3 E2F4 DDKUBC(1-76) ADP26S proteasomeMCM3 POLA1 RBL1 TFDP1 E2F5 TFDP1 Cyclin E PCNAE2F5 LIN9 E2F2 Cyclin E E2F6:(TFDP1,TFDP2):RRM2 geneTFDP2 TFDP2 CCND1 RBBP4 Cyclin E/A:CDK2p-Y419-SRC CDC7 ORC3 ORC3 Cdt1:gemininMYBL2 gene ORC5 Oxidative StressInduced SenescenceCCND3 LIN9 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 genePOLA2 RB1 ORC1 CDKN1A DREAM complex:RBL1geneorigin of replication TOP2A gene CKS1BDNA polymeraseepsilonCDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)CDK2 CKS1B DNA primer ORC4 CCNE1 ADPCyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitinRB1 CDKN2B CCNE1 E2F4 UBB(153-228) RPS27A(1-76) E2F1 E2F1 RBL2 MCM5 cyclin Cyclin DLIN54 origin ofreplicationORC3 CUL1:SKP1:SKP2:CKS1Bp-T145-CDKN1A p-T157-CDKN1B E2F4 RBBP4 ATPPPP2CA p-S28-LIN52 TFDP1 ORC1 CCNA2 CKS1B RBL2 RPA2 CCNE2 MYBL2 geneMCM4 E2F5 CDK4,CDK6CCNA2 geneDNA primer origin of replication E2F4 CDK7 CCNA1 UBC(305-380) E2F5 MCM8 RB1 UBC(381-456) CDKN1A origin of replication CyclinE:CDK2:CDKN1A,CDKN1BTFDP1 CDKN1B MCM10ATPPiTranscriptionalactivity ofSMAD2/SMAD3:SMAD4heterotrimerLIN54 PSMD9 E2F1:TFDP1,TFDP2:PCNA geneE2F1 CCND1 DHFR geneCDK2 ORC:origin ofreplicationE2F5 POLE4 ADPDHFR gene MCM3 RBL2 TFDP2 RBL2 MCM5 TFDP2 CDK4,CDK6:CCNDUBB(1-76) TFDP1 POLA2 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 geneCCNA1 geneTFDP1 CDKN1A p-Y88-CDKN1B PSMD5 FBXO5 geneRBL2PPP2CB CUL1 MCM4 TFDP1 TFDP1 CCNA1 CCNA2 gene MCM8 E2F1 TFDP1 ADPCDKN1A,CDKN1BCDKN1ACCND2 DNA polymerasealpha:primase:DNApolymerasealpha:origincomplexTFDP1 DBF4 DREAM complex:E2F1geneCDKN1C CCND1 RBL2 CDK4 MCM2 MCM4 POLE3 CDK1 gene CCND2 GMNN p-T-CDKN1A/BUBB(153-228) CDKN1A,CDKN1B,(CDKN1C)CCNA1 GMNNp-RB1 RBL2 TFDP1 LIN52 E2F1:TFDP1,TFDP2:CDC25A geneCUL1 DBF4 SKP2 TFDP1 RBL2 TK1 gene CDT1 MCM10:activepre-replicativecomplexMCM7 E2F4 Senescence-Associated Secretory Phenotype (SASP)CDC7 ATPMCM5 RBL2 TFDP2 CCNA2UBC(153-228) TFDP1 MCM8 LIN54 ORC3 DNA polymeraseepsilon:origincomplexUBB(153-228) E2F1 gene RBL1:E2F4:DP1/2:Cyclin E/A:CDK2UBC(609-684) PSMD1 UBC(229-304) UBB(1-76) ATPATPE2F1:TFDP1,TFDP2:CDT1 geneTFDP2 CCNA1 CCNE:CDK2PSMA1 E2F5 CDK2 UBB(1-76) PSMD7 CCNE1 geneCDKN2D RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2:CDC6 UBC(533-608) PSMB6 CCND3 p-S130-CDKN1A UBB(153-228) UBC(457-532) TFDP1 PSMB10 H2OHDAC1 CCNE2 TFDP1 ORC5 CKS1B CDK4 ADPSKP1 RPA1 CDT1 geneDNA primer origin of replication CDC6 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2TFDP2 CDC25A gene RBL1 POLA1MCM10 TOP2A genePSMB9 ORC2 TFDP1 POLE3 MCM6 CDC25Ap-S28-LIN52 PIP3 activates AKTsignalingPSMA7 UBA52(1-76) PSMD13 p-T160-CDK2 MCM4 E2F1:TFDP1,TFDP2:CDC45 geneCCNE2 MCM2 E2F1 PSMC2 PCNA geneCyclinE/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1BCCNE1 RBL1 MCM2 POLE2 LIN37 UBC(1-76) CDKN1B E2F4 E2F4 TFDP1 RNA primer PSMB5 DBF4 LIN37 CCNA CDK4 CDK2 ORC5 ORC6 UBC(457-532) CyclinE/A:p-T160-CDK2:CDKN1A,CDKN1BCDK2 TFDP1 E2F4 CDKN1B ORC2 CDK4 origin of replication CDK4 TFDP2 PRIM1 ORC5 PPP2R3B MCM2 p-T187-CDKN1B MCM4 HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 genePSME3 CUL1 TFDP2 ORC2 CCNE1 SKP1 p16-INK4a TFDP2 PPP2R3B p-Y342-PTK6 p-T187-CDKN1B CCNA UBA52(1-76) TFDP2 CDK:DDK:MCM10:activepre-replicativecomplexMCM4 ORC6 POLE RPA3 CDKN2B MCM7 p-T401,S672,1035-RBL2:SCF(Skp2):Cks1E2F4 PPP2R1A MCM3 POLE4 H2OCDC7 SKP2 WEE1E2F5 E2F5 2, 50, 61, 163, 183...51623, 2011, 13-15, 18...13984207, 208119, 15456, 1665220126, 201162216, 2318, 17, 27, 42, 47...772151396, 7, 16, 58, 59, 69...584, 89210201, 23616297201, 2261625162526, 33, 41, 43, 45...212179, 201, 226208, 2295164, 201, 237112, 178, 201518628, 144, 177