Metabolism of water-soluble vitamins and cofactors (Homo sapiens)

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92, 1205, 8143, 74, 12855, 9644, 56, 64, 10641691652, 90, 10851593824, 32, 39, 47, 50...14, 7729, 11712, 20, 13066, 10112435, 861048311, 30912512371, 12644, 56, 64, 10611337, 45, 1161078112, 20, 1306, 9444, 56, 63, 64, 87...80, 8814, 7737, 457, 10, 2338386115133222762834, 70, 10553, 89, 1034, 53, 89, 100, 103...1301, 10232, 39, 47, 1167984, 94981232844, 56, 63, 64, 87...34, 70, 10512, 20, 1303, 67, 109, 110, 1227, 10, 23, 352692, 1208, 18, 38, 42, 46...13, 5744, 56, 10692, 120102, 11836, 40, 60, 73, 93...33, 52, 90, 10821, 25, 11215, 17, 54, 5825, 612, 1325965, 829913, 62, 76, 119, 12519, 7244, 56, 64, 75, 106endosomemitochondrial matrixendosomemitochondrial matrixcytosolcytosollysosomal lumenmitochondrial matrixlysosomal lumenSLC19A2 AMPNa+MTRR Zn2+ MTR PiH2OTHTPA:Mg2+SLC19A3 TCII sulfurated MoCoPXAMTRR:MTRMOCS2 PPCS Na+TPK1 H2O2SLC5A6 FMNCO2unknown proteaseTCN2 cob(II)alaminTCN1H2O2xMOCS2A:2xMOCS2BH2OSLC5A6:PDZD11AMPBtnH2OSLC5A6:PDZD11MOCS3:Zn2+ (red.)PiTCII:CblCblTCII:Cbl:CD320TCIIFLAD1PiCblZn2+ 2xNFS1:2xPXLPPCCA MOCS1-1 CoA-SHcob(I)alaminGSTO1 MyrG-CYB5R3(2-301) CTRB2(34-164) RFK:Mg2+PRSS1(16-18)ENPP2 GIF TCII CYB5A ACACA:2Mn2+MCCC1 AMPPANK3 Mn2+ dADECTRB2(19-31) GSSGMTR MMAB AMPCD320PRSS3 ADPCbl PPiGIFMUT 6xMCCC1:6xMCCC2BCTNSUCC-CoAPPiAdoCblPCCB O2Zn2+ cob(II)alamin2xTRAPADPMoCoATPNADPHTHMNATPGIF:Cbl3xGPHN:3xMg2+PiZn2+ (4Fe-4S)(2+) SLC52A2 VNN1 ATPATP2xENPP1Precursor ZPANK2(111-570)DP-CoANa+Zn2+ NFS1-2 RIBGTPACACB CysS-MOCS3 H+ACP5 MOCS3:Zn2+ (ox.)BCTNPAPcob(I)alamin L-AlaL-LysAMPCTRB2(167-263) cob(II)alamin FAD ENPP3 MMACHC SLC25A19FADTCII:CblPXLPAdoHcyL-LysL-MetCblATPBtn-ACACA MOCS3 PPiADPFood proteins GIF:CblH2Oholo-MOCS1CUBN:AMN:GIF:CblVNN2 PXLP ThTPMMACHC MMADHC PCCB H+FAD MOCOS:PXLPCbl CNCblACACA Cbl H2OGIF BCTNBtn-PCCA L-MM-CoAPPANT6x(Btn-PCCA:PCCB)MTRR:MTR(cob(II)alamin)HLCSCbl TCII:Cbl2xMOCS2-CO-S(1-):2xMOCS2BMPT CUBN PPiADPSVCT1/2TDPKAdoMetSLC23A1 Cbl ENPP1 L-CysBtn2xGSTOs2xPPCSPPiDHvitCMTR NADHMn2+ H+MTRR PPiPC VitCMTR TCN1 FAD Btn-ACACB MOCS3-S-S(1-):Zn2+CUBN:AMN2xPNPO:2xFMNhCBXsBtn-PC TCN1 Btn-ACACB:2Mn2+PDZD11 Na+PXLP GPHN FAD H2OADPPANK4 GSTO2 AMN FMN Mn2+ Na+GIF MMADHCAMN LMBRD1AASDHPPTcob(II)alamin H2OCUBN HCYSH2OMCCC2 SOG-MOCS24x(Btn-PC:Mn2+)ATPNADHATPFAD BtnAMP5-methyl-THFMMACHC:cob(II)alaminBtn-MCCC1 CYB5A:ferrihemeCbl MCCC2 PANK1 MeCbl CblMTRR ADPPCCB H2O2AETCD320 AMPBTDNAD+Zn2+ DHvitCSLC5A6 4x(PC:Mn2+)Btn-PC FMN ATPFood proteinsMMAA FeHM Btn-MCCC1 SLC23A2 Na+AMN Zn2+ Btn-MCCC1 FAD MOCS1A PDXPSLC25A16SLC2A3 Mg2+ TCN1:CblABCD4MCCC2 MTRR Cbl CTRCCoA-SH3xMMABCTRB1(19-31) CblPRSS1,3,CTRB1,2Mn2+ ATPunknown peptidasePDXMMADHC FMN AOX1 Cbl NAD+PPanKPPPATP2xTPK1:Mg2+VNN1,VNN2unknown peptidaseCUBN HLCSCbl unknown peptidaseSLC52A3 MCCC2 PDZD11 PanKhCBXsMn2+ FASNPANK1/3/4NADPHAMPThDPCOASYCYB5A 2xPDXK:2xZn2+FASNNADP+Pantetheine3xPPCDC:3xFMNAdoCbl H2O2MUT O2GLUT1,3PPANTATPBtn-PCCA GIF:CblPPiAdoMetSLC52A1 PPiATPMMAA Mn2+ MTRR:MTR(MeCbl)AMPMoO4(2-)ABCC1ATPPPiCTRB1(34-164) ENPP1 MDASC2xMMAA:2xMUT:AdoCblPPCL-MetPXLNicotinatemetabolismMMACHC MOCS2 ATPCUBN:AMNH+PRSS1(19-247)NADP+H+6x(PCCA:PCCB)CoA-SHATPBTDGIF RIBPPiMetabolism of folateand pterines6x(Btn-MCCC1:MCCC2)PPiPRSS1(16-247)2xENPP1, 2xENPP2,2xENPP3FADCTRB1(167-263) Btn-PCCA CYB5A:hemeHCNMOCS2THMNNH4+PanKMg2+ AMPATPGSHH2OFMN MOCOS FMN MPTPPCDC TCN2 cob(II)alamin THFCbl MMACHC:MMADHC:cob(II)alaminCbl MOCS3 ATPMMACHC:MMADHCACACB:2Mn2+BtnMOCS2 PAPATPFMN CYB5R3:FADATPFMNH2OPXAPBtn-PC Mn2+ ADP(4Fe-4S)(2+) ADPPDXateRFK MTRR:MTR(cob(I)alamin)SOG-MOCS2 L-CysMn2+ ATPSLC52A1,2,3ThDPPNPO PCCB TCIIMg2+ Food proteins:CblTHTPA Zn2+ heme Mg2+ PDXK L-CysBtn-ACACA:2Mn2+ATPSLC2A1 MMACHCTCN1PRSS1(24-247) TCN1:CblADP2xAOX1:cofactorsVitC2xMMAA:2xMUTL-Alaunknowncob(II)alaminreductaseSLC19A2/397979748979785, 12185979797979797979731, 4997781119797948