Bile acid and bile salt metabolism (Homo sapiens)

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6, 14, 26, 414, 5528602823, 50, 6413, 6126602124, 402, 38, 4623, 50, 642, 38, 4621262110, 37, 4223, 50, 641, 3, 16, 31, 58...172626324, 5533, 5628602, 3812, 17, 472, 38, 4623, 50, 64632, 3828262, 3826262, 382833, 562, 38267, 39262, 382, 38, 4682653, 5923, 50, 64349, 22, 25, 30, 36...23, 50, 6427, 622933, 56212634172, 3848, 5226603510, 37, 4248, 522619, 20, 4410, 37, 4210, 37, 422623, 50, 6460262, 3828384, 55604318, 517, 39239, 15, 22, 25, 30...14, 41, 455, 49, 63112653, 5923, 50, 6448, 52endoplasmic reticulum lumennucleoplasmendoplasmic reticulum lumencytosolendoplasmic reticulum lumennucleoplasmendoplasmic reticulum lumenmitochondrial matrixcytosolcytosolendoplasmic reticulum lumenperoxisomal matrixnucleoplasmcytosolmitochondrial matrixendoplasmic reticulum lumenGolgi lumen4CHOL7a,12a,24(S)TONEO2FAD H+H+CCA NR1H4 NADPHNADPHO2NAD+NADPHNADPHAMP5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolCHOLH2Obile salts andacids:FABP63,7,24THCA25(R) THCA-CoANADPHPI4P25(S) DHCA-CoA5bCHOL3a,7a,12a-triolNADP+bile salts and acidscomplexed withalbuminSCP2-1NADP+SLC10A1OSBPL9 NR1H4:DCA,CDCA,LCHANADP+5bCHOL3a,7a,24(s),27-tetrol27OH-CHOLH+TCCA HSD3B7DCA NADPHLCHA NCOA1 H2OCYP27A1CoA-SH3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoAOSBPsAKR1D1CYP8B1 albumin:bile saltcomplexPiH+ALBNR1H4 NAD+NCOA2 THCACYP7A1 TAU GCCA CoA-SHNADP+TetraHCAH2OH+SLC10A2H+O2NADPHTHCA-CoAGCDCA NADP+5beta-cholestan-7alpha-ol-3-one5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentolCHOLCDCA H+5beta-cholestan-7alpha,12alpha,27-triol-3-onePPiNADPHGCCA TCCA CH25H (Fe2+cofactor)TCCA NADHH+Cholest-5-ene-3beta,7alpha,27-triolFe2+ CHOLbile saltsLCHA 25OH-CHOLglycocholate Cytochrome P450(CYP8B1 based)AKR1C1 GCCA LCHA NADHTCDCA glycochenodeoxycholate cholate;chenodeoxycholateTCDCA 4CHOL7aOLONECYP8B1 albumin:bile saltand acid (OATP-A)complexRXRAchenodeoxycholoyl-CoAATP25OH-CHOLNADP+NADPH(24R,25R)3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoAH2OO2H2OO2GCCA CDCA H+HSD3B7RXRA NR1H4 NADPH5beta-cholestan-7alpha,27-diol-3-one3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoAAKR1C4 BAAT3,7,24THCA-CoACytochrome P450(CYP8B1 based)H2OACOX2 TCCA Gly NADP+PiACOX2:FAD25(R) THCA-CoA5beta-cholestan-7alpha,12alpha,24(S)-triol-3-oneAldo-keto reductasefamilyCDCA CHOL3b,7a,25TRIOLCDCA O2TCDCA NADP+CDCA NCOA2 H2ONADP+O2AKR1C1 TCCA ABCC3H+H2OSLCO1A2NADPHSLC27A2NADHDCAGCCA TCCA ADPCytochrome P450(CYP7A1 based)5beta-cholestan-7alpha,24(S)-diol-3-oneH+H+H+OSBPL3 bile saltsglycocholate DCA H+PPi25(S)3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoAO2O25beta-cholestan-3alpha,7alpha,24(S)-triolDHCACYP27A1NCOA2ABCB11NCOA125(S) THCA-CoA4CHOL7a,12a,27TONEAKR1D1NADPHTCCA TCCA 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolbile salts and acids(OATP-A)5beta-cholesten-7alpha, 12alpha-diol-3-one5beta-cholestan-3alpha, 7alpha-diolCytochrome P450(CYP7B1 based)CDCA 24OH-CHOLTCDCA CYP7B1 (24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoATCCA NADP+Gly AMP25OH-CHOLFABP6AMACRNADPHO2RXRA CYP27A1taurocholate THCAAKR1C4 25(R) DHCA-CoACDCA 4CHOL7a,12aDONETCDCA DCA CYP27A1ALB CYP8B1 H+CCA NR1H4FABP6 27OH-CHOLcholatePTGIS CCA 25(R) TetraHCA-CoAATPbile salts and acidsH+5bCHOL3a,7a,24(s)-triolCCA NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAGCCA OSBPL2 TCDCA HSD3B7choloyl-CoA;chenodeoxycholoyl-CoASTARD5 bile saltsH2OCoA-SHCCA O2ATPNADP+ADPglycine; taurineH2OALB H+H+NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA4CHOL7a,27DONEDCA,CDCA,LCHA3alpha,7alpha-dihydroxy-5beta-cholestan-26-alNR1H4 H+Na+24OH-CHOLH2OCYP7A1 NCOA1 CoA-SHLCA H2O5beta-cholestan-3alpha,7alpha,12alpha-triolAKR1C2 STARD5TCCA NADPHPI4PGCCA SLCO1B3GCCA Na+NADP+5beta-cholestan-3alpha,7alpha,26-triolAKR1D1CYP39A1CHOL24OH-CHOL3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-alPTGIS NADP+NADP+ALB:(GCCA, TCCA)CYP7A1 TAU TetraHCANADPH5bCHOL3a,7a,12a,27-tetrolH+O2H+NADPHCDCA CYP7B1 4CHOL7a,24(S)DONEO2NADP+25(R) TetraHCA-CoAH2OCCANAD+Aldo-keto reductasefamilyO2CDCA H+NADP+AMPGCCA, TCCA27HCHOLTCDCA GCCA CoA-SHBAATGCDCA GCDCA choloyl-CoA GCCA chenodeoxycholatebile saltsH+ALB H2Ocholate bile saltsGCDCA OSBPCytochrome P450(CYP8B1 based)DCA chenodeoxycholoyl-CoA H2OPPiSLC27A2GCDCA HSD17B4 dimerNa+Aldo-keto reductasefamilyNADP+25(R) DHCA-CoANADP+GCDCA TCDCA GCCA 3,7,24THCASLC27A5AKR1C3 O2TCCA NADP+RXRA NADP+AKR1C2 NADPHSLC27A5CYP27A1CoA-SH3,7,24THCA-CoACYP27A1ATPtaurochenodeoxycholate NADPHbile saltsNCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA7alpha-hydroxycholesterolOSBPL7 H2OCDCA NCOA1 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol25OH-CHOLNADPHAKR1C3 CYP7B1 NAD+LCHA PTGIS choloyl-CoAGCDCA 5beta-cholestan-3alpha,7alpha-diolCytochrome P450(CYP7B1 based)OSBPL6 glycochenodeoxycholate CYP27A1ALB AKR1C1 ATPNa+5beta-cholestan-3alpha,7alpha,26-triolNADPHH2O2ACOT8glycine; taurineLCAAKR1C3 CCA taurochenodeoxycholate LCHA HSD17B4(2-736) NADPHDHCACYP46A1H+CoA-SHDCA H+SLCO1B1CH25H DCA NADPHH2ONADHNADP+H2OOSBPL1A SLC27A5taurocholate O2H2OH+TCDCA AKR1C2 propionyl CoACHOL7a,24(S)DIOLCDCA STARD5:DCA,LCANAD+NADP+3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-alH2ONCOA2 AKR1C4