Folate Metabolism (Homo sapiens)

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134, 30351, 23840, 80, 90, 116, 174...29345, 174, 263, 279, 29318, 1401572478, 1382952, 2523191567, 111, 269CofactorsMicronutrientsProtein with polymorphismLipoprotein melabolismProcess or metabolism involved in Se PathwaySelenoproteinsCofactor conversionCatalysisOverarching processEnzymesProtein*ReactionTranscription factorStimulationProtein tyrosine nitrationFrom intracellular part to the plasmaProstaglandins metabolismMetabolitesInhibitionConversionLEGENDSelenium statusNegative EffectLipid peroxidationOther proteinsBindingNecessary stimulationCleavageis composed ofGlycogenesisBiomarker forIntracellularNovo purine biosynthetic pathwayMethylation reactionsApoptosisDNA oxidationPlasmaFOLR3NFkB2p53FOLR1MCP1FOLR4PGE1MCP1F2-IsoprostaneF2-Isoprostane8-Isoprostaglandin F2aNFkB1PGE2PGF2aPGE1PGE2SLC19A1SLC46A1Thromboxane B2Thromboxane B2Thromboxane A2RELAPGF2aFOLR28-Isoprostaglandin F2a32264, 111, 250, 279, 302...233354, 8989, 16254, 891042082332171041, 2172289, 106, 2082083233233389, 162MTR*SHMTAHCYMATMTHFD1*MTHFD2DHFRMSR*52, 24348, 7122848, 72, 246, 2575252, 88178, 182, 327319CBS72, 98NADP+NADP+NADP+NADP+NADP+NADP+NADP+CatalaseMPOMPONOS11, 114, 259, 26311, 114, 259, 2631171, 293CysteineCysteinePLGThrombinThrombinPAI-1PLGtPAFactor VIIFactor VIItPAPAI-1199, 326326, 329326, 329294294294294199, 326294294GPX 4H2O2GAR(11S)-hydroxymethylene-THFFGAR5,10-Methenyl-THFDihydrofolate10-Formyl-THF5,10-Methylene-THF(11R)-hydroxymethylene-THF5-Formyl-THF5218252, 25252525252, 2525252, 182Folate5-methyl-THFFolate5-methyl-THF182182, 2467, 22, 79, 94, 104...SOD3SOD3RFK35H2OGPX 3GPX 3CTH72Heme98, 171, 293THF182NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acid182, 255, 257182, 255, 257GPX 2GPX 1RNS29, 293MTHFSMTHFR*GARTSHMT182, 2575252, 25252HomocysteineHomocysteine22, 82, 174, 176, 235...329SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate49, 621, 49, 62GlycineSerineL-ArginineGlycine7952, 8852, 8852, 88HDLHDL/SAALDLRoxLDLSAA2APOBHDL/APOA1APOA1HDL-CVLDL/APOBAPOA1VLDLCholesterolABCA1CholesterolSAA4SAA1SAA3TAGHDL-CVLDLVLDL-TAGAPOBAPOA1-NO2TyrTAGLDLLDLFMNVLDL-TAGACTHDLSRB1oxLDLACT30811, 18, 28, 82, 197112, 140140308188, 231112, 14030814014011, 18, 28, 8241112, 140118, 14019, 308112, 118, 140112, 140140, 197188, 23118811830830811, 18, 28, 8219, 30814032830814011, 18, 28, 82, 197140140308140, 197O2138Cob(I)alamin8-OHdGCob(I)alaminFADFAD8-OHdGCob(II)alamin4815648, 71, 31748, 71, 31715632848, 71ADPADPChlorineMagnesiumChlorineMagnesiumCystathionineS-nitrosohomocysteine176SOD2Serine52, 88ATPZincZincNO2NOO3HOClHNO2NO111, 114, 176, 259114, 259IL6IL1BFibrinogenIL6D-dimerALBHbA1cIL2INSRHBA1FibrinIL4INSTNFaD-dimersICAM-1IL10FibrinogenIL2IL4IFNgIL1BALBCRPIFNgINSHBBTNFaFibrinIL10CSF1HbA1cCSF130219, 63, 15717, 63131161672734012, 64, 174, 32590, 302135, 196, 23540, 63, 174, 196273199, 294167233116, 17480, 196233142, 29416712, 23864, 32512, 238142, 294801, 8, 28, 93, 94, 196302199, 29490, 30216719, 63, 15713Riboflavin191O2Methionine S-AdenosylhomocysteineMethionine S-Adenosylmethionine S-Adenosylhomocysteine S-Adenosylmethionine182, 245, 24648, 182, 193144, 182144, 18248, 182, 193, 319245ADPNitrotyrosineONOO/ONOOHNitrotyrosineTetrahydrobiopterin792929ATPATPFructosamineFructosamineGlucoseGlucose13157, 16713157, 167IronIron5353FLAD135, 242